|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4563304A
(en)
|
1981-02-27 |
1986-01-07 |
Pharmacia Fine Chemicals Ab |
Pyridine compounds modifying proteins, polypeptides or polysaccharides
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
ES2284161T3
(es)
|
1990-01-12 |
2007-11-01 |
Amgen Fremont Inc. |
Generacion de anticuerpos xenogenicos.
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
CA2076465C
(en)
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
ATE549918T1
(de)
|
1996-12-03 |
2012-04-15 |
Amgen Fremont Inc |
Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
|
|
TR199902553T2
(xx)
|
1997-04-14 |
2000-03-21 |
Micromet Gesellschaft F�R Biomedizinische Forschung Mbh |
�nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�.
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
IL145941A
(en)
*
|
1999-04-28 |
2007-08-19 |
Univ Texas |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
US6995145B1
(en)
*
|
1999-06-04 |
2006-02-07 |
Au Jessie L-S |
Methods and compositions for modulating drug activity through telomere damage
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
GB0202319D0
(en)
|
2002-02-01 |
2002-03-20 |
Calex Electronics Ltd |
Apparatus
|
|
IL163668A0
(en)
*
|
2002-02-22 |
2005-12-18 |
New River Pharmaceuticals Inc |
Use of peptide-drug conjugation to reduce inter-subject variability ofdrug serum levels
|
|
US20090068178A1
(en)
*
|
2002-05-08 |
2009-03-12 |
Genentech, Inc. |
Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin
|
|
HUE026914T2
(en)
|
2002-11-07 |
2016-08-29 |
Immunogen Inc |
Anti-CD33 antibodies and a method of treating acute myeloid leukemia
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7374762B2
(en)
*
|
2003-05-14 |
2008-05-20 |
Immunogen, Inc. |
Drug conjugate composition
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
KR101145506B1
(ko)
|
2003-05-20 |
2012-05-15 |
이뮤노젠 아이엔씨 |
새로운 메이탠시노이드를 포함하는 개선된 세포독성체
|
|
KR101672664B1
(ko)
|
2003-07-21 |
2016-11-04 |
이뮤노젠 아이엔씨 |
인간화된 항체 또는 그의 항원결정기 결합절편
|
|
US7834155B2
(en)
|
2003-07-21 |
2010-11-16 |
Immunogen Inc. |
CA6 antigen-specific cytotoxic conjugate and methods of using the same
|
|
MXPA06014065A
(es)
|
2004-06-01 |
2007-01-31 |
Genentech Inc |
Conjugados de droga-anticuerpo y metodos.
|
|
PL1819359T3
(pl)
*
|
2004-12-09 |
2015-08-31 |
Janssen Biotech Inc |
Immunokoniugaty skierowane przeciw integrynie, metody ich wytwarzania oraz ich zastosowanie
|
|
US20110166319A1
(en)
*
|
2005-02-11 |
2011-07-07 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
|
WO2007002422A1
(en)
|
2005-06-23 |
2007-01-04 |
Georgia Tech Research Corporation |
Systems and methods for integrated plasma processing of waste
|
|
CA2615761A1
(en)
|
2005-08-22 |
2007-03-01 |
Immunogen, Inc. |
Humanized anti-ca6 antibodies and methods of using the same
|
|
EP3539572A1
(en)
*
|
2005-08-24 |
2019-09-18 |
ImmunoGen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
|
ATE527262T1
(de)
*
|
2006-01-25 |
2011-10-15 |
Sanofi Sa |
Neue tomaymycin derivate enhaltende zytotoxische mittel
|
|
JP2009525986A
(ja)
*
|
2006-02-03 |
2009-07-16 |
メディミューン，エルエルシー |
タンパク質製剤
|
|
WO2007140371A2
(en)
*
|
2006-05-30 |
2007-12-06 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
DK2099823T4
(da)
*
|
2006-12-01 |
2022-05-09 |
Seagen Inc |
Målbindingsmiddelvarianter og anvendelser deraf
|
|
CN104497143B
(zh)
|
2007-03-29 |
2020-08-25 |
健玛保 |
双特异性抗体及其制造方法
|
|
US20090163698A1
(en)
*
|
2007-05-11 |
2009-06-25 |
John Joseph Grigsby |
Method for Preparing Antibody Conjugates
|
|
US7576505B2
(en)
*
|
2007-06-21 |
2009-08-18 |
Jack Chen |
Device for finding a home position for a moveable member
|
|
US20090208979A1
(en)
*
|
2008-02-14 |
2009-08-20 |
Technion Research And Development Foundation Ltd. |
Method for identifying antipsychotic drug candidates
|
|
EP2281006B1
(en)
|
2008-04-30 |
2017-08-02 |
Immunogen, Inc. |
Cross-linkers and their uses
|
|
RU2487877C2
(ru)
|
2008-04-30 |
2013-07-20 |
Иммьюноджен, Инк. |
Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры)
|
|
BRPI1013990A2
(pt)
*
|
2009-05-06 |
2019-04-30 |
Biotest Ag |
método para tratar uma doença , e, combinação anticâncer
|
|
UY32914A
(es)
*
|
2009-10-02 |
2011-04-29 |
Sanofi Aventis |
Anticuerpos que se usan específicamente al receptor epha2
|
|
JP2013506709A
(ja)
*
|
2009-10-06 |
2013-02-28 |
イミュノジェン・インコーポレーテッド |
有効なコンジュゲートおよび親水性リンカー
|
|
AR080301A1
(es)
|
2010-02-24 |
2012-03-28 |
Immunogen Inc |
Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos
|
|
MX338932B
(es)
|
2010-03-12 |
2016-05-06 |
Immunogen Inc |
Moleculas de union cd37 y sus inmunoconjugados.
|
|
JP6040148B2
(ja)
|
2010-04-20 |
2016-12-07 |
ゲンマブ エー／エス |
ヘテロ二量体抗体Ｆｃ含有タンパク質およびその産生方法
|
|
KR20140008308A
(ko)
|
2010-10-29 |
2014-01-21 |
이뮤노젠 아이엔씨 |
신규한 egfr-결합 분자 및 이의 면역컨쥬게이트
|
|
KR20140010076A
(ko)
*
|
2011-02-15 |
2014-01-23 |
이뮤노젠 아이엔씨 |
세포독성 벤조다이아제핀 유도체
|
|
CN105999293B
(zh)
*
|
2011-04-01 |
2019-07-23 |
德彪发姆国际有限公司 |
Cd37结合分子及其免疫缀合物
|
|
PL2694106T3
(pl)
|
2011-04-01 |
2018-06-29 |
Immunogen, Inc. |
Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1
|
|
US20120282282A1
(en)
|
2011-04-04 |
2012-11-08 |
Immunogen, Inc. |
Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
|
|
MX350954B
(es)
|
2011-06-21 |
2017-09-26 |
Immunogen Inc |
Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos.
|
|
EP2550975A1
(en)
*
|
2011-07-29 |
2013-01-30 |
Sanofi |
Combination therapy for the treatment of CD19+ B-cell malignancies symptoms comprising an anti-CD19 maytansinoid immunoconjugate and rituximab
|
|
ES2806146T3
(es)
|
2011-09-22 |
2021-02-16 |
Amgen Inc |
Proteínas de unión al antígeno CD27L
|
|
KR20140105765A
(ko)
|
2011-11-21 |
2014-09-02 |
이뮤노젠 아이엔씨 |
EGfr 항체 세포독성제 접합체에 의한 EGfr 치료에 내성을 나타내는 종양의 치료 방법
|
|
RU2661083C2
(ru)
*
|
2012-10-04 |
2018-07-11 |
Иммуноджен, Инк. |
Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент
|
|
HRP20170743T1
(hr)
*
|
2012-11-20 |
2017-07-28 |
Sanofi |
Anti-ceacam5 protutijela i njihova uporaba
|
|
MX2015010682A
(es)
*
|
2013-02-22 |
2016-05-31 |
Stemcentrx Inc |
Nuevos conjugados de anticuerpos y usos de los mismos.
|
|
US20160347856A1
(en)
*
|
2013-08-02 |
2016-12-01 |
Sanofi |
Use of Anti-MUC1 Maytansinoid Immunoconjugate Antibody for the Treatment of Solid Tumors
|
|
AU2015311951B2
(en)
*
|
2014-09-02 |
2021-04-08 |
Immunogen, Inc. |
Methods for formulating antibody drug conjugate compositions
|
|
TW201609152A
(zh)
*
|
2014-09-03 |
2016-03-16 |
免疫原公司 |
包含細胞結合劑及細胞毒性劑之偶聯物
|
|
PT3189056T
(pt)
*
|
2014-09-03 |
2020-09-04 |
Immunogen Inc |
Derivados citotóxicos de benzodiazepina
|
|
TW201613930A
(en)
*
|
2014-09-03 |
2016-04-16 |
Immunogen Inc |
Cytotoxic benzodiazepine derivatives
|
|
JP2016052860A
(ja)
|
2014-09-04 |
2016-04-14 |
株式会社東海理化電機製作所 |
タイヤ位置登録システム
|