JP2017525734A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017525734A5 JP2017525734A5 JP2017512003A JP2017512003A JP2017525734A5 JP 2017525734 A5 JP2017525734 A5 JP 2017525734A5 JP 2017512003 A JP2017512003 A JP 2017512003A JP 2017512003 A JP2017512003 A JP 2017512003A JP 2017525734 A5 JP2017525734 A5 JP 2017525734A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- cyano
- alkoxy
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000005843 halogen group Chemical group 0.000 claims 36
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 21
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 21
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 20
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 125000005842 heteroatom Chemical group 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 8
- -1 R 16 Chemical compound 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical compound C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14306352.7 | 2014-09-02 | ||
| EP14306352 | 2014-09-02 | ||
| PCT/EP2015/070082 WO2016034642A1 (en) | 2014-09-02 | 2015-09-02 | Isoquinolinone derivatives useful in the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525734A JP2017525734A (ja) | 2017-09-07 |
| JP2017525734A5 true JP2017525734A5 (enExample) | 2018-10-11 |
Family
ID=51494243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512003A Pending JP2017525734A (ja) | 2014-09-02 | 2015-09-02 | 癌の治療において有用なイソキノリノン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9944641B2 (enExample) |
| EP (1) | EP3189051A1 (enExample) |
| JP (1) | JP2017525734A (enExample) |
| CN (1) | CN106795154B (enExample) |
| BR (1) | BR112017003651A2 (enExample) |
| MX (1) | MX2017002544A (enExample) |
| RU (1) | RU2690853C2 (enExample) |
| WO (1) | WO2016034642A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130623B2 (en) * | 2016-07-08 | 2018-11-20 | Rigel Pharmaceuticals, Inc. | Tyrosine kinase inhibitors |
| CN106699608A (zh) * | 2016-12-26 | 2017-05-24 | 常州大学 | 一种含有强吸电子基团的苯胍及其盐的制备方法 |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2783B1 (en) * | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
| EP2100894A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| WO2012102985A1 (en) | 2011-01-24 | 2012-08-02 | Glaxosmithkline Llc | Isoquinoline compounds and methods for treating hiv |
| HK1198365A1 (en) | 2011-09-20 | 2015-04-10 | F. Hoffmann-La Roche Ag | Imidazopyridine compounds, compositions and methods of use |
| JP6128133B2 (ja) * | 2012-01-23 | 2017-05-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン |
| JP2015511245A (ja) * | 2012-02-23 | 2015-04-16 | アッヴィ・インコーポレイテッド | ピリドピリミジノン系キナーゼ阻害薬 |
| JP6553589B2 (ja) * | 2013-03-15 | 2019-07-31 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | ピリミド−ジアゼピノン化合物および障害の治療方法 |
-
2015
- 2015-09-02 MX MX2017002544A patent/MX2017002544A/es unknown
- 2015-09-02 BR BR112017003651A patent/BR112017003651A2/pt not_active IP Right Cessation
- 2015-09-02 WO PCT/EP2015/070082 patent/WO2016034642A1/en not_active Ceased
- 2015-09-02 JP JP2017512003A patent/JP2017525734A/ja active Pending
- 2015-09-02 RU RU2017108909A patent/RU2690853C2/ru not_active IP Right Cessation
- 2015-09-02 EP EP15762963.5A patent/EP3189051A1/en not_active Withdrawn
- 2015-09-02 CN CN201580047253.7A patent/CN106795154B/zh not_active Expired - Fee Related
- 2015-09-02 US US15/507,941 patent/US9944641B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018127728A (ru) | Слитые трициклические гетероциклические соединения в качестве ингибиторов интегразы вич | |
| ZA202006378B (en) | N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof | |
| JP2019500387A5 (enExample) | ||
| JP2014501766A5 (enExample) | ||
| JP2010524932A5 (enExample) | ||
| JP2014506599A5 (enExample) | ||
| JP2014503574A5 (enExample) | ||
| JP2017519781A5 (enExample) | ||
| JP2016518437A5 (enExample) | ||
| JP2014521688A5 (enExample) | ||
| JP2016513660A5 (enExample) | ||
| RU2013108641A (ru) | Способ лечения офтальмологических заболеваний с использованием соединений ингибиторов киназы в пролекарственных формах | |
| JP2014037426A5 (enExample) | ||
| NZ627750A (en) | Carbamate compounds and of making and using same | |
| CN113784963A (zh) | 用作ret激酶抑制剂的化合物及其应用 | |
| JP2016519165A5 (enExample) | ||
| CN112020496A (zh) | 作为rho激酶抑制剂的苯并吡唑类化合物 | |
| RU2015146957A (ru) | Производные доластатина 10 и ауристатинов | |
| JP2018502101A5 (enExample) | ||
| MXPA04002338A (es) | Derivados de carbazol y su uso como antagonistas receptores del npy5. | |
| MX2020008570A (es) | Inhibidores de arginasa y sus metodos de uso. | |
| JP2003508524A5 (enExample) | ||
| JP2019505595A5 (enExample) | ||
| JP2018529690A5 (enExample) | ||
| RU2017117559A (ru) | Бензопроизводные с шестичленным кольцом в качестве ингибитора dpp-4 и их применение |