CN106795154B - 用于治疗癌症的异喹啉酮衍生物 - Google Patents

用于治疗癌症的异喹啉酮衍生物 Download PDF

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Publication number
CN106795154B
CN106795154B CN201580047253.7A CN201580047253A CN106795154B CN 106795154 B CN106795154 B CN 106795154B CN 201580047253 A CN201580047253 A CN 201580047253A CN 106795154 B CN106795154 B CN 106795154B
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China
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compound
added
halogen
alkyl
mmol
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Expired - Fee Related
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CN201580047253.7A
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English (en)
Chinese (zh)
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CN106795154A (zh
Inventor
E·B·卡卢
P·施米特
A·克鲁琴斯基
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Pierre Fabre Medicament SA
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Pierre Fabre Medicament SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580047253.7A 2014-09-02 2015-09-02 用于治疗癌症的异喹啉酮衍生物 Expired - Fee Related CN106795154B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14306352.7 2014-09-02
EP14306352 2014-09-02
PCT/EP2015/070082 WO2016034642A1 (en) 2014-09-02 2015-09-02 Isoquinolinone derivatives useful in the treatment of cancer

Publications (2)

Publication Number Publication Date
CN106795154A CN106795154A (zh) 2017-05-31
CN106795154B true CN106795154B (zh) 2019-07-05

Family

ID=51494243

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CN201580047253.7A Expired - Fee Related CN106795154B (zh) 2014-09-02 2015-09-02 用于治疗癌症的异喹啉酮衍生物

Country Status (8)

Country Link
US (1) US9944641B2 (enExample)
EP (1) EP3189051A1 (enExample)
JP (1) JP2017525734A (enExample)
CN (1) CN106795154B (enExample)
BR (1) BR112017003651A2 (enExample)
MX (1) MX2017002544A (enExample)
RU (1) RU2690853C2 (enExample)
WO (1) WO2016034642A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2903526T3 (es) * 2016-07-08 2022-04-04 Rigel Pharmaceuticals Inc Inhibidores de tirosina cinasa
CN106699608A (zh) * 2016-12-26 2017-05-24 常州大学 一种含有强吸电子基团的苯胍及其盐的制备方法
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013041539A1 (en) * 2011-09-20 2013-03-28 F. Hoffmann-La Roche Ag Imidazopyridine compounds, compositions and methods of use
WO2013126656A1 (en) * 2012-02-23 2013-08-29 Abbvie Inc. Pyridopyrimidinone inhibitors of kinases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
EP2100894A1 (en) * 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
US9029391B2 (en) 2011-01-24 2015-05-12 Viiv Healthcare Uk Limited Isoquinoline compounds and methods for treating HIV
EP2807166B1 (en) * 2012-01-23 2016-04-06 Boehringer Ingelheim International GmbH 5,8-dihydro-6h-pyrazolo[3,4-h]quinazolines as igf-1r/ir inhibitors
EP3388436B1 (en) * 2013-03-15 2020-08-12 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013041539A1 (en) * 2011-09-20 2013-03-28 F. Hoffmann-La Roche Ag Imidazopyridine compounds, compositions and methods of use
WO2013126656A1 (en) * 2012-02-23 2013-08-29 Abbvie Inc. Pyridopyrimidinone inhibitors of kinases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis of substituted diazino[c]quinolin-5(6H)-ones, diazino[c]isoquinolin-6(5H)-ones, diazino[c]naphthyridin-6(5H)-ones and diazino[c]naphthyridin-5(6H)-ones;Nathalie Fresneau, et al.;《Tetrahedron》;20130428;第69卷(第26期);5393-5400 *

Also Published As

Publication number Publication date
CN106795154A (zh) 2017-05-31
BR112017003651A2 (pt) 2017-12-05
JP2017525734A (ja) 2017-09-07
US9944641B2 (en) 2018-04-17
RU2690853C2 (ru) 2019-06-06
RU2017108909A3 (enExample) 2018-12-13
US20170240544A1 (en) 2017-08-24
RU2017108909A (ru) 2018-10-03
MX2017002544A (es) 2017-07-19
EP3189051A1 (en) 2017-07-12
WO2016034642A1 (en) 2016-03-10

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