RU2690853C2 - Производные изохинолинона, полезные для лечения рака - Google Patents

Производные изохинолинона, полезные для лечения рака Download PDF

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Publication number
RU2690853C2
RU2690853C2 RU2017108909A RU2017108909A RU2690853C2 RU 2690853 C2 RU2690853 C2 RU 2690853C2 RU 2017108909 A RU2017108909 A RU 2017108909A RU 2017108909 A RU2017108909 A RU 2017108909A RU 2690853 C2 RU2690853 C2 RU 2690853C2
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RU
Russia
Prior art keywords
compound
added
mmol
halogen
amino
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RU2017108909A
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English (en)
Russian (ru)
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RU2017108909A (ru
RU2017108909A3 (enExample
Inventor
Эль Бахир КАЛУН
Филипп ШМИТТ
Анна КРЮЗИНСКИ
Original Assignee
Пьер Фабр Медикамент
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Publication of RU2017108909A publication Critical patent/RU2017108909A/ru
Publication of RU2017108909A3 publication Critical patent/RU2017108909A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2017108909A 2014-09-02 2015-09-02 Производные изохинолинона, полезные для лечения рака RU2690853C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14306352 2014-09-02
EP14306352.7 2014-09-02
PCT/EP2015/070082 WO2016034642A1 (en) 2014-09-02 2015-09-02 Isoquinolinone derivatives useful in the treatment of cancer

Publications (3)

Publication Number Publication Date
RU2017108909A RU2017108909A (ru) 2018-10-03
RU2017108909A3 RU2017108909A3 (enExample) 2018-12-13
RU2690853C2 true RU2690853C2 (ru) 2019-06-06

Family

ID=51494243

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017108909A RU2690853C2 (ru) 2014-09-02 2015-09-02 Производные изохинолинона, полезные для лечения рака

Country Status (8)

Country Link
US (1) US9944641B2 (enExample)
EP (1) EP3189051A1 (enExample)
JP (1) JP2017525734A (enExample)
CN (1) CN106795154B (enExample)
BR (1) BR112017003651A2 (enExample)
MX (1) MX2017002544A (enExample)
RU (1) RU2690853C2 (enExample)
WO (1) WO2016034642A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3481826T3 (da) * 2016-07-08 2022-01-10 Rigel Pharmaceuticals Inc Tyrosinkinaseinhibitorer
CN106699608A (zh) * 2016-12-26 2017-05-24 常州大学 一种含有强吸电子基团的苯胍及其盐的制备方法
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016152B1 (ru) * 2005-09-30 2012-02-28 Новартис Аг 2-АМИНО-7,8-ДИГИДРО-6Н-ПИРИДО[4,3-d]ПИРИМИДИН-5-ОНЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ, СПОСОБ ТЕРАПИИ С ИХ ПОМОЩЬЮ, КОМПОНЕНТ КОМПОЗИЦИИ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ, 2,4-ДИОКСОПИПЕРИДИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ИХ ПОЛУЧЕНИЯ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2100894A1 (en) * 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
US9029391B2 (en) 2011-01-24 2015-05-12 Viiv Healthcare Uk Limited Isoquinoline compounds and methods for treating HIV
BR112014006643A2 (pt) * 2011-09-20 2017-04-04 Hoffmann La Roche compostos de imidazopiridina, composições e métodos de uso dos mesmos
EP2807166B1 (en) * 2012-01-23 2016-04-06 Boehringer Ingelheim International GmbH 5,8-dihydro-6h-pyrazolo[3,4-h]quinazolines as igf-1r/ir inhibitors
EP2817308B1 (en) * 2012-02-23 2016-09-07 AbbVie Inc. Pyridopyrimidinone inhibitors of kinases
EP2970317A4 (en) * 2013-03-15 2016-11-02 Dana Farber Cancer Inst Inc PYRIMIDODIAZEPINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016152B1 (ru) * 2005-09-30 2012-02-28 Новартис Аг 2-АМИНО-7,8-ДИГИДРО-6Н-ПИРИДО[4,3-d]ПИРИМИДИН-5-ОНЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ, СПОСОБ ТЕРАПИИ С ИХ ПОМОЩЬЮ, КОМПОНЕНТ КОМПОЗИЦИИ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ, 2,4-ДИОКСОПИПЕРИДИНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ИХ ПОЛУЧЕНИЯ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FRESNEAU NATHALIE ET AL: "Synthesis of substituted diazino[c]quinolin-5(6H)-ones, diazino[c] isoquinolin-6(5H)-ones, diazino[c]naphthyridin-6(5H)-ones and diazino[c]naphthyridin-5(6H)-ones ", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol.69, no.26, 28.04.2013, pp.5393-5400, DOI: 10.1016/J.TET.2013.04.104. *

Also Published As

Publication number Publication date
BR112017003651A2 (pt) 2017-12-05
CN106795154A (zh) 2017-05-31
US20170240544A1 (en) 2017-08-24
RU2017108909A (ru) 2018-10-03
JP2017525734A (ja) 2017-09-07
US9944641B2 (en) 2018-04-17
RU2017108909A3 (enExample) 2018-12-13
CN106795154B (zh) 2019-07-05
MX2017002544A (es) 2017-07-19
EP3189051A1 (en) 2017-07-12
WO2016034642A1 (en) 2016-03-10

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Effective date: 20200903