JP2017525352A5 - - Google Patents

Download PDF

Info

Publication number
JP2017525352A5
JP2017525352A5 JP2017505223A JP2017505223A JP2017525352A5 JP 2017525352 A5 JP2017525352 A5 JP 2017525352A5 JP 2017505223 A JP2017505223 A JP 2017505223A JP 2017505223 A JP2017505223 A JP 2017505223A JP 2017525352 A5 JP2017525352 A5 JP 2017525352A5
Authority
JP
Japan
Prior art keywords
seq
acid sequence
amino acid
set forth
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017505223A
Other languages
English (en)
Japanese (ja)
Other versions
JP6811706B2 (ja
JP2017525352A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/043182 external-priority patent/WO2016019280A1/en
Publication of JP2017525352A publication Critical patent/JP2017525352A/ja
Publication of JP2017525352A5 publication Critical patent/JP2017525352A5/ja
Application granted granted Critical
Publication of JP6811706B2 publication Critical patent/JP6811706B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017505223A 2014-07-31 2015-07-31 Epha4に対するヒトモノクローナル抗体及びそれらの使用 Active JP6811706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031793P 2014-07-31 2014-07-31
US62/031,793 2014-07-31
PCT/US2015/043182 WO2016019280A1 (en) 2014-07-31 2015-07-31 Human monoclonal antibodies against epha4 and their use

Publications (3)

Publication Number Publication Date
JP2017525352A JP2017525352A (ja) 2017-09-07
JP2017525352A5 true JP2017525352A5 (cg-RX-API-DMAC7.html) 2018-08-16
JP6811706B2 JP6811706B2 (ja) 2021-01-13

Family

ID=55218364

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017505223A Active JP6811706B2 (ja) 2014-07-31 2015-07-31 Epha4に対するヒトモノクローナル抗体及びそれらの使用

Country Status (6)

Country Link
US (2) US10934360B2 (cg-RX-API-DMAC7.html)
EP (2) EP3473271B1 (cg-RX-API-DMAC7.html)
JP (1) JP6811706B2 (cg-RX-API-DMAC7.html)
CN (1) CN106999578B (cg-RX-API-DMAC7.html)
ES (2) ES2925224T3 (cg-RX-API-DMAC7.html)
WO (1) WO2016019280A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2882355T3 (es) 2015-07-10 2021-12-01 Univ Hong Kong Science & Tech Composiciones para su uso en el tratamiento de afecciones neurodegenerativas y neuroinflamatorias
PE20181051A1 (es) * 2015-09-08 2018-07-03 Eisai Randd Man Co Ltd Anticuerpo anti-epha4
US12290516B2 (en) 2017-05-12 2025-05-06 The Hong Kong University Of Science And Technology Heterocyclic compounds as EphA4 inhibitors
CA3139398A1 (en) 2019-07-01 2021-01-07 Eisai R&D Management Co., Ltd. Anti-epha4 antibody
US20230203096A1 (en) * 2020-04-23 2023-06-29 The Regents Of The University Of California Epha4 targeting compounds and methods of use thereof
US11732007B2 (en) 2020-09-28 2023-08-22 The Regents Of The University Of California Therapeutic compounds and methods
EP4268847A4 (en) 2020-12-24 2025-03-26 Eisai R&D Management Co., Ltd. PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
AU2021410893A1 (en) 2020-12-24 2023-06-08 Eisai R&D Management Co., Ltd. Anti-epha4 antibody
CN119823276A (zh) * 2023-10-12 2025-04-15 徕特康(苏州)生物制药有限公司 抗her4抗体及其制备方法和用途

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US498298A (en) 1893-05-30 Range
US3060165A (en) 1962-10-23 Preparation of toxic ricin
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4486414A (en) 1983-03-21 1984-12-04 Arizona Board Of Reagents Dolastatins A and B cell growth inhibitory substances
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5079163A (en) 1985-03-29 1992-01-07 Cetus Corporation Recombinant ricin toxin fragments
US4689401A (en) 1986-03-06 1987-08-25 Cetus Corporation Method of recovering microbially produced recombinant ricin toxin a chain
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4816444A (en) 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5792458A (en) 1987-10-05 1998-08-11 The United States Of America As Represented By The Department Of Health And Human Services Mutant diphtheria toxin conjugates
US5208021A (en) 1987-10-05 1993-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of preparing diphtheria immunotoxins
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
WO1990001069A1 (en) 1988-07-20 1990-02-08 Segev Diagnostics, Inc. Process for amplifying and detecting nucleic acid sequences
US5076973A (en) 1988-10-24 1991-12-31 Arizona Board Of Regents Synthesis of dolastatin 3
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4978744A (en) 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US4879278A (en) 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US4986988A (en) 1989-05-18 1991-01-22 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5138036A (en) 1989-11-13 1992-08-11 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
DK0531434T3 (da) 1990-05-11 2000-01-31 Us Health Forbedrede Pseudomonas-exotoksiner med lav dyretoksicitet og høj cytocidal aktivitet
US5608039A (en) 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
WO1993017668A1 (en) 1992-03-12 1993-09-16 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
DE69333951D1 (de) 1992-06-18 2006-02-02 Us Gov Health & Human Serv Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5662907A (en) 1992-08-07 1997-09-02 Cytel Corporation Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
EP0671926B1 (en) 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5410024A (en) 1993-01-21 1995-04-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide amides
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
DE69524105T2 (de) 1994-07-15 2002-07-18 Organon Teknika B.V., Boxtel Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5504191A (en) 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5521284A (en) 1994-08-01 1996-05-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide amides and esters
US5554725A (en) 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5599902A (en) 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
JP3053222B2 (ja) 1995-04-20 2000-06-19 ファイザー・インコーポレーテッド Mmpおよびtnf抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
GB9520822D0 (en) 1995-10-11 1995-12-13 Wellcome Found Therapeutically active compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PT780386E (pt) 1995-12-20 2003-02-28 Hoffmann La Roche Inibidores de metaloprotease de matriz
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
PT912559E (pt) 1996-07-13 2003-03-31 Glaxo Group Ltd Compostos heterociclicos fundidos como inibidores de proteina tirosina quinase
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
CN1230185A (zh) 1996-07-13 1999-09-29 葛兰素集团有限公司 双环芳杂环化合物用作蛋白质酪氨酸激酶的抑制剂
AU712973B2 (en) 1996-07-18 1999-11-18 Pfizer Inc. Phosphinate based inhibitors of matrix metalloproteases
TW328661B (en) 1996-07-26 1998-03-21 Oki Electric Ind Co Ltd The semiconductor apparatus
AU711585B2 (en) 1996-08-23 1999-10-14 Pfizer Inc. Arylsulfonylamino hydroxamic acid derivatives
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
AU5131998A (en) 1997-01-06 1998-08-03 Pfizer Inc. Cyclic sulfone derivatives
PL335027A1 (en) 1997-02-03 2000-03-27 Pfizer Prod Inc Derivatives of arylsulphonylamino hydroxamic acid
BR9807824A (pt) 1997-02-07 2000-03-08 Pfizer Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
JP3710489B2 (ja) 1997-02-11 2005-10-26 ファイザー・インク アリールスルホニルヒドロキサム酸誘導体
EP0973540B1 (en) 1997-02-25 2005-11-02 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
JP2002511852A (ja) 1997-05-07 2002-04-16 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体
EP0984692A4 (en) 1997-05-30 2001-02-21 Merck & Co Inc ANGIOGENESIS INHIBITORS
AU8816298A (en) 1997-08-22 1999-03-16 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
AU744939B2 (en) 1997-09-26 2002-03-07 Merck & Co., Inc. Novel angiogenesis inhibitors
WO1999022596A1 (en) 1997-11-03 1999-05-14 Long Roger H Attractants for trapping flies
KR100446363B1 (ko) 1997-11-11 2004-09-01 화이자 프로덕츠 인코포레이티드 항암제로 유용한 티에노피리미딘 및 티에노피리딘 유도체
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
DE19755016A1 (de) 1997-12-11 1999-06-17 Bayer Ag Substituierte 2,4-Diamino-1,3,5-triazine
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
US6296843B1 (en) 1998-04-03 2001-10-02 The Penn State Research Foundation Mutagenized IL 13-based chimeric molecules
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
EP1082305A4 (en) 1998-05-29 2001-09-26 Sugen Inc PYRROL SUBSTITUTED 2-INDOLINONE EFFECTIVE AS A PROTEIN KINASE INHIBITOR
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
CN101227921A (zh) * 2003-06-06 2008-07-23 医学免疫公司 EphA4和EphA4调节剂用于诊断、治疗和预防癌症的用途
CA2528549A1 (en) * 2003-06-06 2005-06-02 Medimmune, Inc. Use of epha4 and modulator of epha4 for diagnosis, treatment and prevention of cancer
KR101520209B1 (ko) 2003-11-06 2015-05-13 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
US20080063640A1 (en) * 2004-02-27 2008-03-13 Oncotherapy Science, Inc. Pin-Prc Transition Genes
CN101065151B (zh) 2004-09-23 2014-12-10 健泰科生物技术公司 半胱氨酸改造的抗体和偶联物
ES2372537T3 (es) 2005-07-29 2012-01-23 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Exotoxinas de pseudomonas mutadas con antigenicidad reducida.
CN101309933A (zh) * 2005-09-07 2008-11-19 米迪缪尼有限公司 毒素偶联的Eph受体抗体
JP2009531273A (ja) * 2006-02-28 2009-09-03 オンコセラピー・サイエンス株式会社 抗EphA4抗体のエフェクター機能を用いて細胞を障害する方法
HRP20141236T1 (hr) 2007-09-04 2015-02-27 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health Office of Technology Transfer DELECIJE U DOMENI II PSEUDOMONAS EGZOTOKSINA „A“ KOJIMA SE SMANJUJE NESPECIFIČNA TOKSIČNOST
WO2010141974A1 (en) * 2009-06-10 2010-12-16 The University Of Melbourne Therapeutic applications
JP2010285413A (ja) * 2009-06-10 2010-12-24 Univ Of Melbourne 治療用途
WO2011032022A1 (en) 2009-09-11 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Improved pseudomonas exotoxin a with reduced immunogenicity
JP2013505944A (ja) 2009-09-24 2013-02-21 シアトル ジェネティックス, インコーポレイテッド Dr5リガンド薬物結合体
WO2011106723A2 (en) 2010-02-26 2011-09-01 Lpath, Inc. Anti-paf antibodies
EP2653552B1 (en) * 2010-12-17 2016-10-19 Eisai R&D Management Co., Ltd. SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR
US9629830B2 (en) * 2013-07-17 2017-04-25 The Hong Kong University Of Science And Technology EphA4 inhibitors as neuroprotective agents
ES2882355T3 (es) * 2015-07-10 2021-12-01 Univ Hong Kong Science & Tech Composiciones para su uso en el tratamiento de afecciones neurodegenerativas y neuroinflamatorias
US12290516B2 (en) * 2017-05-12 2025-05-06 The Hong Kong University Of Science And Technology Heterocyclic compounds as EphA4 inhibitors

Similar Documents

Publication Publication Date Title
JP2017525352A5 (cg-RX-API-DMAC7.html)
JP2019535670A5 (cg-RX-API-DMAC7.html)
JP2018064569A5 (cg-RX-API-DMAC7.html)
JP2020534830A5 (cg-RX-API-DMAC7.html)
JP2016500655A5 (cg-RX-API-DMAC7.html)
JP2020063262A5 (cg-RX-API-DMAC7.html)
JP2020515249A5 (cg-RX-API-DMAC7.html)
JP2017048240A5 (cg-RX-API-DMAC7.html)
JP2017526339A5 (cg-RX-API-DMAC7.html)
JP2019507135A5 (cg-RX-API-DMAC7.html)
RU2015100231A (ru) Способ отбора и получения селективных и мультиспецифических терапевтических молекул с заданными свойствами, включающих по меньшей мере две различные нацеливающие группировки, и их применения
JP2019110906A5 (cg-RX-API-DMAC7.html)
JP2015526387A5 (cg-RX-API-DMAC7.html)
JP2020503870A5 (cg-RX-API-DMAC7.html)
HRP20241502T1 (hr) Bispecifična tetravalentna protutijela i postupci za njihovu proizvodnju i uporabu
JP2015172045A5 (cg-RX-API-DMAC7.html)
JP2017519501A5 (cg-RX-API-DMAC7.html)
JP2008538289A5 (cg-RX-API-DMAC7.html)
JP2014113150A5 (cg-RX-API-DMAC7.html)
JP2010535713A5 (cg-RX-API-DMAC7.html)
HRP20170879T1 (hr) Genetski proizvodi koji su diferencijalno izraženi u tumorima i njihova primjena
EA201401134A1 (ru) Hla-рестиктированные пептидоспецифические антигенсвязывающие белки
JP2013506428A5 (cg-RX-API-DMAC7.html)
JP2018504105A5 (cg-RX-API-DMAC7.html)
JP2020058359A5 (cg-RX-API-DMAC7.html)