JP2017524019A5 - - Google Patents
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- Publication number
- JP2017524019A5 JP2017524019A5 JP2017508504A JP2017508504A JP2017524019A5 JP 2017524019 A5 JP2017524019 A5 JP 2017524019A5 JP 2017508504 A JP2017508504 A JP 2017508504A JP 2017508504 A JP2017508504 A JP 2017508504A JP 2017524019 A5 JP2017524019 A5 JP 2017524019A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- ylmethyl
- triazole
- imidazol
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005843 halogen group Chemical group 0.000 claims description 131
- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000003545 alkoxy group Chemical group 0.000 claims description 53
- 150000001875 compounds Chemical class 0.000 claims description 47
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 45
- 229910052736 halogen Inorganic materials 0.000 claims description 43
- 150000002367 halogens Chemical class 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 37
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 36
- 239000012453 solvate Substances 0.000 claims description 36
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 32
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 31
- 125000001424 substituent group Chemical group 0.000 claims description 31
- 150000001204 N-oxides Chemical class 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 23
- 208000035475 disorder Diseases 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 20
- -1 3,5-dicyclopropyl- [1,2,4] triazol-1-ylmethyl Chemical group 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 108010054200 NR2B NMDA receptor Proteins 0.000 claims description 8
- 229910052731 fluorine Inorganic materials 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 6
- 206010015037 epilepsy Diseases 0.000 claims description 6
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- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims description 5
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- 208000002193 Pain Diseases 0.000 claims description 4
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- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- YUDVHEROTXDJBH-UHFFFAOYSA-N C1(CCC1)C=1N(C=CN=1)CC=1N=NN(C=1)C1=CC(=C(C=C1)Cl)Cl Chemical compound C1(CCC1)C=1N(C=CN=1)CC=1N=NN(C=1)C1=CC(=C(C=C1)Cl)Cl YUDVHEROTXDJBH-UHFFFAOYSA-N 0.000 claims 1
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- UZRIQFGTVHJEPZ-UHFFFAOYSA-N NC=1N(C=CN=1)CC=1N=NN(C=1)C1=CC(=C(C=C1)F)C(F)F Chemical compound NC=1N(C=CN=1)CC=1N=NN(C=1)C1=CC(=C(C=C1)F)C(F)F UZRIQFGTVHJEPZ-UHFFFAOYSA-N 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 claims 1
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- 238000000034 method Methods 0.000 description 6
- JRLJHLTZFBRDJM-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)triazole Chemical compound C1=C(Cl)C(Cl)=CC=C1N1N=NC=C1 JRLJHLTZFBRDJM-UHFFFAOYSA-N 0.000 description 1
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| DK3180315T3 (da) | 2014-08-15 | 2020-04-06 | Janssen Pharmaceuticals Inc | Pyrazoler |
| PT3180329T (pt) | 2014-08-15 | 2020-06-08 | Janssen Pharmaceuticals Inc | Triazóis como inibidores do recetor nr2b |
| SI3319963T1 (sl) | 2015-07-09 | 2020-02-28 | Janssen Pharmaceutica Nv | Substituirani 4-azaindoli in njihova uporaba kot modulatorji receptorja GLUN2B |
| EP3414233A1 (en) | 2016-02-10 | 2018-12-19 | Janssen Pharmaceutica NV | Substituted 1,2,3-triazoles as nr2b-selective nmda modulators |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途 |
| MY199104A (en) * | 2016-12-14 | 2023-10-13 | Sk Biopharmaceuticals Co Ltd | Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder |
| EP3774732A4 (en) | 2018-04-04 | 2022-02-09 | Janssen Pharmaceutica NV | PYRIDINE AND SUBSTITUTED PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS |
| PH12021552839A1 (en) | 2019-06-14 | 2022-10-03 | Janssen Pharmaceutica Nv | Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators |
| EP3983073A1 (en) | 2019-06-14 | 2022-04-20 | Janssen Pharmaceutica NV | Substituted pyrazolo[4,3-b]pyridines and their use as glun2b receptor modulators |
| AU2020293584A1 (en) | 2019-06-14 | 2022-01-20 | Janssen Pharmaceutica Nv | Pyridine carbamates and their use as GluN2B receptor modulators |
| CA3142998A1 (en) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Pyrazine carbamates and their use as glun2b receptor modulators |
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| US6610723B2 (en) * | 2001-01-29 | 2003-08-26 | Hoffmann-La Roche Inc. | Imidazole derivatives |
| KR20040111445A (ko) | 2002-03-28 | 2004-12-31 | 에자이 가부시키가이샤 | 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌 |
| US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| KR20070027503A (ko) | 2004-02-18 | 2007-03-09 | 아스트라제네카 아베 | 트리아졸 화합물 및 대사성 글루타메이트 수용체길항제로서 이들의 용도 |
| WO2007115231A2 (en) | 2006-03-30 | 2007-10-11 | Chemocentryx, Inc. | Cxcr4 modulators |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| KR20100017372A (ko) | 2007-05-25 | 2010-02-16 | 애보트 게엠베하 운트 콤파니 카게 | 향대사성 글루타메이트 수용체 2（ｍｇｌｕ2 수용체）의 포지티브 조절자로서의 헤테로사이클릭 화합물 |
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| EP2215073A4 (en) | 2007-10-31 | 2011-04-06 | Merck Sharp & Dohme | SLEEP MODULATION WITH NR2B RECEPTOR ANTAGONISTS |
| CA2719749A1 (en) * | 2008-03-27 | 2009-10-01 | Evotec Neurosciences Gmbh | Methods for treating disorders using nmda nr2b-subtype selective antagonist |
| WO2010016490A1 (ja) | 2008-08-05 | 2010-02-11 | 第一三共株式会社 | イミダゾピリジン－２－オン誘導体 |
| US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| MX2011003691A (es) | 2008-10-16 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico. |
| AU2009324894B2 (en) | 2008-11-25 | 2015-04-09 | University Of Rochester | MLK inhibitors and methods of use |
| US8969342B2 (en) * | 2009-03-20 | 2015-03-03 | Brandeis University | Compounds and methods for treating mammalian gastrointestinal microbial infections |
| EP2579717A4 (en) | 2010-06-09 | 2013-12-11 | Merck Sharp & Dohme | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 |
| WO2013130855A1 (en) | 2012-03-02 | 2013-09-06 | Takeda Pharmaceutical Company Limited | Indazole derivatives |
| WO2014124651A1 (en) | 2013-02-15 | 2014-08-21 | Københavns Universitet | Pyrrolidine-2-carboxylic acid derivatives as iglur antagonists |
| JP2016516710A (ja) | 2013-03-13 | 2016-06-09 | アッヴィ・インコーポレイテッド | ピリジン系ｃｄｋ９キナーゼ阻害薬 |
| PT3180329T (pt) | 2014-08-15 | 2020-06-08 | Janssen Pharmaceuticals Inc | Triazóis como inibidores do recetor nr2b |
| DK3180315T3 (da) | 2014-08-15 | 2020-04-06 | Janssen Pharmaceuticals Inc | Pyrazoler |
| SI3319963T1 (sl) | 2015-07-09 | 2020-02-28 | Janssen Pharmaceutica Nv | Substituirani 4-azaindoli in njihova uporaba kot modulatorji receptorja GLUN2B |
| EP3414233A1 (en) | 2016-02-10 | 2018-12-19 | Janssen Pharmaceutica NV | Substituted 1,2,3-triazoles as nr2b-selective nmda modulators |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途 |
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