JP2017523983A5 - - Google Patents
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- Publication number
- JP2017523983A5 JP2017523983A5 JP2017505869A JP2017505869A JP2017523983A5 JP 2017523983 A5 JP2017523983 A5 JP 2017523983A5 JP 2017505869 A JP2017505869 A JP 2017505869A JP 2017505869 A JP2017505869 A JP 2017505869A JP 2017523983 A5 JP2017523983 A5 JP 2017523983A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- gel
- nanoparticles
- polymer
- lutein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 76
- 229920000642 polymer Polymers 0.000 claims description 69
- 239000002105 nanoparticle Substances 0.000 claims description 49
- 239000000499 gel Substances 0.000 claims description 37
- 235000012680 lutein Nutrition 0.000 claims description 32
- 239000001656 lutein Substances 0.000 claims description 32
- 229960005375 lutein Drugs 0.000 claims description 32
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 32
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 32
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 32
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 32
- 239000000227 bioadhesive Substances 0.000 claims description 29
- 210000001519 tissue Anatomy 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 28
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 239000003963 antioxidant agent Substances 0.000 claims description 23
- 235000006708 antioxidants Nutrition 0.000 claims description 23
- 239000000017 hydrogel Substances 0.000 claims description 18
- 235000021466 carotenoid Nutrition 0.000 claims description 15
- 150000001747 carotenoids Chemical class 0.000 claims description 15
- 230000003078 antioxidant effect Effects 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 241000124008 Mammalia Species 0.000 claims description 12
- 210000004087 cornea Anatomy 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 208000002177 Cataract Diseases 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 208000002780 macular degeneration Diseases 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 8
- 229920001059 synthetic polymer Polymers 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- 229920002494 Zein Polymers 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 239000005019 zein Substances 0.000 claims description 5
- 229940093612 zein Drugs 0.000 claims description 5
- 210000000795 conjunctiva Anatomy 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 3
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 3
- 235000013734 beta-carotene Nutrition 0.000 claims description 3
- 239000011648 beta-carotene Substances 0.000 claims description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 3
- 229960002747 betacarotene Drugs 0.000 claims description 3
- 235000012661 lycopene Nutrition 0.000 claims description 3
- 239000001751 lycopene Substances 0.000 claims description 3
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 3
- 229960004999 lycopene Drugs 0.000 claims description 3
- 210000004877 mucosa Anatomy 0.000 claims description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 3
- 235000020944 retinol Nutrition 0.000 claims description 3
- 239000011607 retinol Substances 0.000 claims description 3
- 229960003471 retinol Drugs 0.000 claims description 3
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229960000502 poloxamer Drugs 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- 210000001525 retina Anatomy 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035683P | 2014-08-11 | 2014-08-11 | |
| US62/035,683 | 2014-08-11 | ||
| US201562172455P | 2015-06-08 | 2015-06-08 | |
| US62/172,455 | 2015-06-08 | ||
| PCT/US2015/044483 WO2016025394A2 (en) | 2014-08-11 | 2015-08-10 | Delivery of bioactive, nanoencapsulated antioxidants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523983A JP2017523983A (ja) | 2017-08-24 |
| JP2017523983A5 true JP2017523983A5 (https=) | 2018-09-20 |
| JP6668327B2 JP6668327B2 (ja) | 2020-03-18 |
Family
ID=55304745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505869A Active JP6668327B2 (ja) | 2014-08-11 | 2015-08-10 | 生理活性で、ナノカプセル化された抗酸化物質の送達 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10292943B2 (https=) |
| EP (1) | EP3179988A4 (https=) |
| JP (1) | JP6668327B2 (https=) |
| KR (1) | KR102218883B1 (https=) |
| AP (1) | AP2017009684A0 (https=) |
| AU (1) | AU2015301945B2 (https=) |
| BR (1) | BR112017002580A2 (https=) |
| CA (1) | CA2992879C (https=) |
| EA (1) | EA035620B1 (https=) |
| MX (1) | MX388028B (https=) |
| WO (1) | WO2016025394A2 (https=) |
| ZA (1) | ZA201700987B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX388028B (es) * | 2014-08-11 | 2025-03-19 | Univ Louisiana State | Suministro de antioxidantes bioactivos, nanoencapsulados. |
| WO2019148140A2 (en) * | 2018-01-26 | 2019-08-01 | Wu Joseph C | Implantable biomaterials that enhance stem cell survival and function |
| CA3174213A1 (en) * | 2019-06-14 | 2020-12-17 | Daniela Oana Trambitas | Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas |
| CA3181943A1 (en) * | 2020-05-11 | 2021-11-18 | Op2Lysis | Slow release plasminogen activator formulation for use in the treatment of thrombotic or haemorrhagic disease |
| US11253481B1 (en) | 2021-07-12 | 2022-02-22 | King Abdulaziz University | Self-nanoemulsifying 3D-printed tablet composition and method of use thereof |
| US11298321B1 (en) | 2021-07-12 | 2022-04-12 | King Abdulaziz University | Methods for treating metabolic disorder |
| KR102824097B1 (ko) | 2022-12-07 | 2025-06-24 | 주식회사 엘지생활건강 | 바이오틴이 담지된 나노파티클 및 이의 제조 방법, 및 이의 용도 |
| WO2025106389A1 (en) * | 2023-11-13 | 2025-05-22 | Universitatea De Medicină Şi Farmacie Iluiu Haţieganu | New forms of lutein and their uses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0386960A3 (en) | 1989-03-07 | 1991-10-23 | American Cyanamid Company | Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings |
| US6573299B1 (en) | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
| US6703039B2 (en) * | 2000-12-06 | 2004-03-09 | Bausch & Lomb Incorporated | Reversible gelling system for ocular drug delivery |
| DE10141018A1 (de) * | 2001-08-22 | 2003-03-13 | Eth Zuerich Eidgenoessische Te | Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges |
| US20040009212A1 (en) | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| EP1534202B1 (en) * | 2002-06-05 | 2009-03-11 | University Of Florida Research Foundation, Inc. | Ophthalmic drug delivery system |
| MX2008004981A (es) * | 2005-10-16 | 2008-10-17 | Lycored Ltd | Composiciones para el tratamiento de enfermedades de los ojos. |
| US9707185B2 (en) | 2007-05-07 | 2017-07-18 | Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College | Water-soluble nanoparticles containing water-insoluble compounds |
| BR112013000675B1 (pt) * | 2010-07-16 | 2021-07-20 | Universidad De Navarra | Nanopartícula, processo para produzir uma nanopartícula compreendendo uma matriz de zeína e um aminoácido básico, composição e produto alimentar |
| JP5829685B2 (ja) * | 2010-09-03 | 2015-12-09 | サンテン・エス・エー・エス | 眼の疾患を処置するための油中水型エマルション |
| BR112013021731A2 (pt) * | 2011-02-25 | 2016-11-01 | Univ South Dakota | nanopartícula;composição farmacêutica ou cosmética;utilização; método para melhorar a estabilidade de um retinóide;método para melhorar a dispersibilidade de um retinóide; método para proporcinar a libertação sustentada de um retinóide; método para aumentar a penetração na pele de um retinóide;método para aumentar a acumulação de tumor de encapsulamento de droga;método para reduzir a acumulação de drogas em tecidos de rolamento não tumorais; método para reduzir a toxicidade de um retinóide;método para reduzir a irritação da pele classificação de um retinóide aplicado topicamente encapsulante compreendendo uma pluralidade de nanopartículas;método de preparação de uma nanopartícula |
| US20120231072A1 (en) * | 2011-03-11 | 2012-09-13 | Chemisches Institut Schaefer Ag | Thermo-responsive hydrogel compositions |
| CN103845278B (zh) * | 2012-11-30 | 2016-06-22 | 沈阳药科大学 | 一种叶黄素眼用纳米乳-温度敏感型原位凝胶及其制备方法 |
| MX388028B (es) * | 2014-08-11 | 2025-03-19 | Univ Louisiana State | Suministro de antioxidantes bioactivos, nanoencapsulados. |
-
2015
- 2015-08-10 MX MX2017001903A patent/MX388028B/es unknown
- 2015-08-10 KR KR1020177003119A patent/KR102218883B1/ko active Active
- 2015-08-10 EP EP15831551.5A patent/EP3179988A4/en active Pending
- 2015-08-10 CA CA2992879A patent/CA2992879C/en active Active
- 2015-08-10 US US15/502,415 patent/US10292943B2/en active Active
- 2015-08-10 BR BR112017002580-9A patent/BR112017002580A2/en not_active Application Discontinuation
- 2015-08-10 WO PCT/US2015/044483 patent/WO2016025394A2/en not_active Ceased
- 2015-08-10 AU AU2015301945A patent/AU2015301945B2/en active Active
- 2015-08-10 EA EA201790361A patent/EA035620B1/ru unknown
- 2015-08-10 JP JP2017505869A patent/JP6668327B2/ja active Active
- 2015-08-10 AP AP2017009684A patent/AP2017009684A0/en unknown
-
2017
- 2017-02-03 ZA ZA2017/00987A patent/ZA201700987B/en unknown
-
2019
- 2019-04-30 US US16/399,388 patent/US10952974B2/en active Active
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