|
WO2012129363A2
(en)
|
2011-03-24 |
2012-09-27 |
President And Fellows Of Harvard College |
Single cell nucleic acid detection and analysis
|
|
US9892230B2
(en)
|
2012-03-08 |
2018-02-13 |
The Chinese University Of Hong Kong |
Size-based analysis of fetal or tumor DNA fraction in plasma
|
|
US11261494B2
(en)
|
2012-06-21 |
2022-03-01 |
The Chinese University Of Hong Kong |
Method of measuring a fractional concentration of tumor DNA
|
|
US10876152B2
(en)
|
2012-09-04 |
2020-12-29 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US20160040229A1
(en)
|
2013-08-16 |
2016-02-11 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US11913065B2
(en)
|
2012-09-04 |
2024-02-27 |
Guardent Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
CN104781421B
(zh)
|
2012-09-04 |
2020-06-05 |
夸登特健康公司 |
检测稀有突变和拷贝数变异的系统和方法
|
|
ES2660989T3
(es)
|
2013-12-28 |
2018-03-27 |
Guardant Health, Inc. |
Métodos y sistemas para detectar variantes genéticas
|
|
TWI813141B
(zh)
|
2014-07-18 |
2023-08-21 |
香港中文大學 |
Ｄｎａ混合物中之組織甲基化模式分析
|
|
EP4358097A1
(en)
|
2014-07-25 |
2024-04-24 |
University of Washington |
Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
|
|
US10364467B2
(en)
|
2015-01-13 |
2019-07-30 |
The Chinese University Of Hong Kong |
Using size and number aberrations in plasma DNA for detecting cancer
|
|
WO2016123698A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Uti Limited Partnership |
Diagnostic assay for post-transplant assessment of potential rejection of donor organs
|
|
HUE058263T2
(hu)
|
2015-02-10 |
2022-07-28 |
Univ Hong Kong Chinese |
Mutációk detektálása rákszûrési és magzatelemzési célból
|
|
IL305462A
(en)
|
2015-07-23 |
2023-10-01 |
Univ Hong Kong Chinese |
DNA fragmentation pattern analysis suitable clean
|
|
US20180327825A1
(en)
*
|
2015-11-09 |
2018-11-15 |
Progenity, Inc. |
Methods for determining the origin of dna molecules
|
|
SG11201805119QA
(en)
|
2015-12-17 |
2018-07-30 |
Guardant Health Inc |
Methods to determine tumor gene copy number by analysis of cell-free dna
|
|
US11514289B1
(en)
|
2016-03-09 |
2022-11-29 |
Freenome Holdings, Inc. |
Generating machine learning models using genetic data
|
|
WO2018009723A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Guardant Health, Inc. |
Methods for fragmentome profiling of cell-free nucleic acids
|
|
JP7048105B2
(ja)
|
2016-07-15 |
2022-04-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
核酸ライブラリを生成する方法
|
|
EP3494234B1
(en)
*
|
2016-08-05 |
2025-02-12 |
The Broad Institute, Inc. |
Methods for genome characterization
|
|
EP3461274B1
(en)
|
2016-09-30 |
2020-11-04 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
US9850523B1
(en)
|
2016-09-30 |
2017-12-26 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
WO2018071595A1
(en)
|
2016-10-12 |
2018-04-19 |
Bellwether Bio, Inc. |
Determining cell type origin of circulating cell-free dna with molecular counting
|
|
EP4209598A1
(en)
|
2016-10-19 |
2023-07-12 |
The Chinese University of Hong Kong |
Gestational age assessment by methylation and size profiling of maternal plasma dna
|
|
WO2018081130A1
(en)
|
2016-10-24 |
2018-05-03 |
The Chinese University Of Hong Kong |
Methods and systems for tumor detection
|
|
KR20260032575A
(ko)
|
2016-11-30 |
2026-03-09 |
더 차이니즈 유니버시티 오브 홍콩 |
소변 및 기타 샘플에서의 무세포 dna의 분석
|
|
EP4450648A3
(en)
*
|
2016-12-13 |
2025-01-15 |
Bellwether Bio, Inc. |
Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
|
|
MX2019007444A
(es)
|
2016-12-22 |
2019-08-16 |
Guardant Health Inc |
Metodos y sistemas para analisis de moleculas de acido nucleico.
|
|
MX2019008227A
(es)
|
2017-01-10 |
2020-08-17 |
Juno Therapeutics Inc |
Analisis epigenetico de terapia celular y metodos relacionados.
|
|
SG11201906397UA
(en)
|
2017-01-25 |
2019-08-27 |
Univ Hong Kong Chinese |
Diagnostic applications using nucleic acid fragments
|
|
US11535896B2
(en)
|
2017-05-15 |
2022-12-27 |
Katholieke Universiteit Leuven |
Method for analysing cell-free nucleic acids
|
|
EP3635133A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DETERMINATION OF CANCER TYPE IN A PERSON BY PROBABILISTIC MODELING OF CIRCULATING NUCLEIC ACID FRAGMENT END POINTS
|
|
EP3635134A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS
|
|
US10636512B2
(en)
|
2017-07-14 |
2020-04-28 |
Cofactor Genomics, Inc. |
Immuno-oncology applications using next generation sequencing
|
|
CN111051536A
(zh)
|
2017-07-26 |
2020-04-21 |
香港中文大学 |
利用不含细胞的病毒核酸改善癌症筛选
|
|
WO2019075251A2
(en)
*
|
2017-10-12 |
2019-04-18 |
Nantomics, Llc |
CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS
|
|
CN107545153B
(zh)
*
|
2017-10-25 |
2021-06-11 |
桂林电子科技大学 |
一种基于卷积神经网络的核小体分类预测方法
|
|
CN111386362B
(zh)
*
|
2017-11-27 |
2024-11-12 |
深圳华大生命科学研究院 |
一种体液游离dna的文库构建方法及其应用
|
|
CN108061794B
(zh)
*
|
2017-12-25 |
2020-03-27 |
苏州大学 |
一种无染色、无探针、无损检测细胞或类细胞结构微生物的类型及其周期的方法
|
|
US12590326B2
(en)
|
2018-01-10 |
2026-03-31 |
Guardant Health, Inc. |
Methods for fragmentome profiling of cell-free nucleic acids
|
|
AU2019207900B2
(en)
|
2018-01-12 |
2025-07-10 |
Claret Bioscience, Llc |
Methods and compositions for analyzing nucleic acid
|
|
CN112119166B
(zh)
*
|
2018-03-13 |
2025-08-22 |
耶路撒冷希伯来大学伊萨姆研发有限公司 |
无细胞dna染色质免疫沉淀的诊断应用
|
|
DE202019005627U1
(de)
|
2018-04-02 |
2021-05-31 |
Grail, Inc. |
Methylierungsmarker und gezielte Methylierungssondenpanels
|
|
WO2019209884A1
(en)
*
|
2018-04-23 |
2019-10-31 |
Grail, Inc. |
Methods and systems for screening for conditions
|
|
CN112805563B
(zh)
|
2018-05-18 |
2025-06-13 |
约翰·霍普金斯大学 |
用于评估和/或治疗癌症的无细胞dna
|
|
WO2019236478A1
(en)
*
|
2018-06-04 |
2019-12-12 |
Guardant Health, Inc. |
Methods and systems for determining the cellular origin of cell-free nucleic acids
|
|
WO2019236726A1
(en)
|
2018-06-06 |
2019-12-12 |
The Regents Of The University Of California |
Methods of producing nucleic acid libraries and compositions and kits for practicing same
|
|
CN108796056A
(zh)
*
|
2018-06-28 |
2018-11-13 |
元码基因科技（北京）股份有限公司 |
基于游离dna的目标基因捕获技术进行组织溯源的方法
|
|
WO2020006369A1
(en)
*
|
2018-06-29 |
2020-01-02 |
Guardant Health, Inc. |
Methods and systems for analysis of ctcf binding regions in cell-free dna
|
|
CN108913682A
(zh)
*
|
2018-07-05 |
2018-11-30 |
上海奥测医疗科技有限公司 |
一种制备cfDNA参考品的方法
|
|
WO2020020174A1
(en)
*
|
2018-07-23 |
2020-01-30 |
The Chinese University Of Hong Kong |
Cell-free dna damage analysis and its clinical applications
|
|
CN109448783B
(zh)
*
|
2018-08-07 |
2022-05-13 |
清华大学 |
一种染色质拓扑结构域边界的分析方法
|
|
WO2020069350A1
(en)
|
2018-09-27 |
2020-04-02 |
Grail, Inc. |
Methylation markers and targeted methylation probe panel
|
|
CA3107948A1
(en)
*
|
2018-10-08 |
2020-04-16 |
Freenome Holdings, Inc. |
Transcription factor profiling
|
|
CN111172263A
(zh)
*
|
2018-11-12 |
2020-05-19 |
北京医院 |
一种应用于无创产前检测的参考物质及其制备方法
|
|
CN121575489A
(zh)
*
|
2018-11-21 |
2026-02-27 |
卡里乌斯公司 |
感染性疾病的检测和预测
|
|
US20200199685A1
(en)
|
2018-12-17 |
2020-06-25 |
Guardant Health, Inc. |
Determination of a physiological condition with nucleic acid fragment endpoints
|
|
CN113366122B
(zh)
*
|
2018-12-19 |
2024-01-12 |
香港中文大学 |
游离dna末端特征
|
|
US11657897B2
(en)
*
|
2018-12-31 |
2023-05-23 |
Nvidia Corporation |
Denoising ATAC-seq data with deep learning
|
|
EP3914731A1
(en)
*
|
2019-01-24 |
2021-12-01 |
Illumina, Inc. |
Methods and systems for monitoring organ health and disease
|
|
WO2020160414A1
(en)
|
2019-01-31 |
2020-08-06 |
Guardant Health, Inc. |
Compositions and methods for isolating cell-free dna
|
|
CN109841265B
(zh)
*
|
2019-02-22 |
2021-09-21 |
清华大学 |
使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
|
|
WO2020198942A1
(zh)
*
|
2019-03-29 |
2020-10-08 |
中国科学技术大学 |
基于峰聚类的单细胞染色质可及性测序数据分析方法和系统
|
|
EP3976822A1
(en)
|
2019-05-31 |
2022-04-06 |
Guardant Health, Inc. |
Methods and systems for improving patient monitoring after surgery
|
|
CN110272985B
(zh)
*
|
2019-06-26 |
2021-08-17 |
广州市雄基生物信息技术有限公司 |
基于外周血血浆游离dna高通量测序技术的肿瘤筛查试剂盒及其系统与方法
|
|
US11891653B2
(en)
|
2019-09-30 |
2024-02-06 |
Guardant Health, Inc. |
Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
|
|
EP4041888A4
(en)
|
2019-10-11 |
2023-11-01 |
Guardant Health, Inc. |
USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION
|
|
CN110739027B
(zh)
*
|
2019-10-23 |
2023-04-18 |
深圳吉因加医学检验实验室 |
一种基于染色质区域覆盖深度的癌症组织定位方法及系统
|
|
EP4617375A3
(en)
|
2019-11-26 |
2025-10-29 |
Guardant Health, Inc. |
Methods, compositions and systems for improving the binding of methylated polynucleotides
|
|
US20210189494A1
(en)
*
|
2019-12-18 |
2021-06-24 |
The Chinese University Of Hong Kong |
Cell-free dna fragmentation and nucleases
|
|
EP4077715A4
(en)
*
|
2019-12-19 |
2024-09-25 |
Agency for Science, Technology and Research |
METHOD FOR ESTIMATING CIRCULATING TUMOR DNA BURDEN AND RELATED KITS AND METHODS
|
|
EP4077735A4
(en)
*
|
2019-12-20 |
2024-01-24 |
AccuraGen Holdings Limited |
METHOD AND SYSTEMS FOR DETECTING DISEASES
|
|
WO2021130356A1
(en)
|
2019-12-24 |
2021-07-01 |
Vib Vzw |
Disease detection in liquid biopsies
|
|
EP4087942A4
(en)
*
|
2020-01-08 |
2024-01-24 |
The Chinese University Of Hong Kong |
Biterminal dna fragment types in cell-free samples and uses thereof
|
|
WO2021141220A1
(ko)
*
|
2020-01-09 |
2021-07-15 |
서울대학교 산학협력단 |
ATAC-seq 데이터 정규화 및 이의 활용 방법
|
|
CN111254194B
(zh)
*
|
2020-01-13 |
2021-09-07 |
东南大学 |
基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用
|
|
CN115428088A
(zh)
*
|
2020-02-13 |
2022-12-02 |
10X基因组学有限公司 |
用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
|
|
US11211144B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Methods and systems for refining copy number variation in a liquid biopsy assay
|
|
US11211147B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
|
|
US11475981B2
(en)
|
2020-02-18 |
2022-10-18 |
Tempus Labs, Inc. |
Methods and systems for dynamic variant thresholding in a liquid biopsy assay
|
|
CN113362897A
(zh)
*
|
2020-03-06 |
2021-09-07 |
福建和瑞基因科技有限公司 |
基于核小体分布特征的肿瘤标志物筛选方法及应用
|
|
EP4143338A1
(en)
|
2020-04-30 |
2023-03-08 |
Guardant Health, Inc. |
Methods for sequence determination using partitioned nucleic acids
|
|
WO2021236993A1
(en)
|
2020-05-22 |
2021-11-25 |
Bloodq, Inc. |
Methods for characterizing cell-free nucleic acid fragments
|
|
CN111724860B
(zh)
*
|
2020-06-18 |
2021-03-16 |
深圳吉因加医学检验实验室 |
一种基于测序数据识别染色质开放区域的方法及装置
|
|
WO2023282916A1
(en)
|
2021-07-09 |
2023-01-12 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
EP4179111B1
(en)
|
2020-07-10 |
2024-04-03 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
CN111881418B
(zh)
*
|
2020-07-27 |
2023-05-16 |
中国农业科学院农业信息研究所 |
一种基于二分法的大豆气象产量预测方法及系统
|
|
EP4585697A3
(en)
|
2020-07-30 |
2025-08-06 |
Guardant Health, Inc. |
Methods for isolating cell-free dna
|
|
CN112085067B
(zh)
*
|
2020-08-17 |
2022-07-12 |
浙江大学 |
一种高通量筛选dna损伤反应抑制剂的方法
|
|
EP4205126A1
(en)
|
2020-08-25 |
2023-07-05 |
Guardant Health, Inc. |
Methods and systems for predicting an origin of a variant
|
|
WO2022061080A1
(en)
*
|
2020-09-17 |
2022-03-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions
|
|
EP4222278A1
(en)
|
2020-09-30 |
2023-08-09 |
Guardant Health, Inc. |
Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease
|
|
JP2023547620A
(ja)
|
2020-10-23 |
2023-11-13 |
ガーダント ヘルス， インコーポレイテッド |
分配および塩基変換を使用してｄｎａを解析するための組成物および方法
|
|
EP4251765A1
(en)
|
2020-11-30 |
2023-10-04 |
Guardant Health, Inc. |
Compositions and methods for enriching methylated polynucleotides
|
|
WO2022140629A1
(en)
|
2020-12-23 |
2022-06-30 |
Guardant Health, Inc. |
Methods and systems for analyzing methylated polynucleotides
|
|
TW202242145A
(zh)
*
|
2020-12-29 |
2022-11-01 |
比利時商比利時意志有限公司 |
核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
|
|
WO2022173698A1
(en)
*
|
2021-02-09 |
2022-08-18 |
Illumina, Inc. |
Methods and systems for monitoring organ health and disease
|
|
WO2022174109A1
(en)
|
2021-02-12 |
2022-08-18 |
Guardant Health, Inc. |
Methods and compositions for detecting nucleic acid variants
|
|
WO2022204730A1
(en)
|
2021-03-25 |
2022-09-29 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
EP4320618A4
(en)
*
|
2021-04-08 |
2025-08-27 |
Fred Hutchinson Cancer Center |
METHOD FOR ANALYZING CELL-FREE DNA SEQUENCE DATA TO EXAMINE NUCLEOSOME PROTECTION AND CHROMATIN ACCESSIBILITY
|
|
CA3214321A1
(en)
*
|
2021-04-08 |
2022-10-13 |
Nicholas C. Dracopoli |
Method of detecting cancer using genome-wide cfdna fragmentation profiles
|
|
JP2024523401A
(ja)
|
2021-06-21 |
2024-06-28 |
ガーダント ヘルス， インコーポレイテッド |
コピー数情報に基づく組織起源分析のための方法および組成物
|
|
WO2023056065A1
(en)
|
2021-09-30 |
2023-04-06 |
Guardant Health, Inc. |
Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
|
|
WO2023197004A1
(en)
|
2022-04-07 |
2023-10-12 |
Guardant Health, Inc. |
Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
|
|
GB202205710D0
(en)
|
2022-04-19 |
2022-06-01 |
Univ Of Essex Enterprises Limited |
Cell-free DNA-based methods
|
|
JP2025522763A
(ja)
|
2022-06-30 |
2025-07-17 |
ガーダント ヘルス， インコーポレイテッド |
異常にメチル化されたｄｎａの富化
|
|
WO2024056720A1
(en)
|
2022-09-13 |
2024-03-21 |
Medizinische Universität Graz |
Determining of health status and treatment monitoring with cell-free dna
|
|
EP4594522A2
(en)
|
2022-09-27 |
2025-08-06 |
Guardant Health, Inc. |
Methods for quantifying immune cell dna
|
|
WO2024138180A2
(en)
|
2022-12-22 |
2024-06-27 |
Guardant Health, Inc. |
Integrated targeted and whole genome somatic and dna methylation sequencing workflows
|
|
EP4638781A2
(en)
|
2022-12-22 |
2025-10-29 |
Guardant Health, Inc. |
Methods involving methylation preserving amplification with error correction
|
|
WO2024233502A1
(en)
|
2023-05-05 |
2024-11-14 |
Guardant Health, Inc. |
Cell-free dna blood-based test for cancer screening
|
|
WO2025029475A1
(en)
|
2023-07-28 |
2025-02-06 |
Guardant Health, Inc. |
Methods to enrich nucleotide variants by negative selection
|
|
WO2025038399A1
(en)
|
2023-08-11 |
2025-02-20 |
Guardant Health, Inc. |
Methylated enrichment methods for single-molecule genetic and epigenetic sequencing
|
|
CN117230165A
(zh)
*
|
2023-09-01 |
2023-12-15 |
深圳湾实验室 |
一种无创产前检测胎儿染色体拷贝数异常的优化方法
|
|
WO2025064706A1
(en)
|
2023-09-19 |
2025-03-27 |
Guardant Health, Inc. |
Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
|
|
WO2025076452A1
(en)
|
2023-10-06 |
2025-04-10 |
Guardant Health, Inc. |
Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules
|
|
WO2025137389A2
(en)
|
2023-12-22 |
2025-06-26 |
Guardant Health, Inc. |
Methods for targeted single-molecule genetic and epigenetic sequencing
|
|
WO2025207817A1
(en)
|
2024-03-26 |
2025-10-02 |
Guardant Health, Inc. |
Method of determining the likelihood of a disease by combining biomarkers and imaging
|
|
WO2025208044A1
(en)
|
2024-03-28 |
2025-10-02 |
Guardant Health, Inc. |
Methods for cancer detection using molecular patterns
|
|
WO2025235889A1
(en)
|
2024-05-10 |
2025-11-13 |
Guardant Health, Inc. |
Methods involving multiplexed pooled pcr
|
|
WO2025250544A1
(en)
|
2024-05-31 |
2025-12-04 |
Guardant Health, Inc. |
Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna
|
|
WO2026015607A1
(en)
|
2024-07-09 |
2026-01-15 |
Guardant Health, Inc. |
Methods for partitioning hyper-, hypo-, and non-methylated dna
|
|
WO2026043718A1
(en)
|
2024-08-21 |
2026-02-26 |
Guardant Health, Inc. |
Methods to monitor patients treated with a cancer vaccine
|
|
WO2026060266A1
(en)
|
2024-09-13 |
2026-03-19 |
Guardant Health, Inc. |
Use of copy number variants for the identification of false positive tumor calls
|
|
WO2026073140A1
(en)
|
2024-09-27 |
2026-04-02 |
Guardant Health, Inc. |
Framework to identify genomic regions indicative of one or more biological conditions
|
|
WO2026076332A1
(en)
|
2024-10-03 |
2026-04-09 |
Guardant Health, Inc. |
Methods involving multi-modal tumor variant identification and tracking of tumor molecules
|