|
WO2012129363A2
(en)
|
2011-03-24 |
2012-09-27 |
President And Fellows Of Harvard College |
Single cell nucleic acid detection and analysis
|
|
US9892230B2
(en)
|
2012-03-08 |
2018-02-13 |
The Chinese University Of Hong Kong |
Size-based analysis of fetal or tumor DNA fraction in plasma
|
|
US11261494B2
(en)
|
2012-06-21 |
2022-03-01 |
The Chinese University Of Hong Kong |
Method of measuring a fractional concentration of tumor DNA
|
|
US11913065B2
(en)
|
2012-09-04 |
2024-02-27 |
Guardent Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
CA2883901C
(en)
|
2012-09-04 |
2023-04-11 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US20160040229A1
(en)
|
2013-08-16 |
2016-02-11 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US10876152B2
(en)
|
2012-09-04 |
2020-12-29 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
JP6571665B2
(ja)
|
2013-12-28 |
2019-09-04 |
ガーダント ヘルス， インコーポレイテッド |
遺伝的バリアントを検出するための方法およびシステム
|
|
TWI895765B
(zh)
|
2014-07-18 |
2025-09-01 |
香港中文大學 |
Dna混合物中之組織甲基化模式分析
|
|
CN107002122B
(zh)
|
2014-07-25 |
2023-09-19 |
华盛顿大学 |
确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
|
|
US10364467B2
(en)
|
2015-01-13 |
2019-07-30 |
The Chinese University Of Hong Kong |
Using size and number aberrations in plasma DNA for detecting cancer
|
|
WO2016123698A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Uti Limited Partnership |
Diagnostic assay for post-transplant assessment of potential rejection of donor organs
|
|
EP4012715B1
(en)
|
2015-02-10 |
2025-09-24 |
The Chinese University Of Hong Kong |
Detecting mutations for cancer screening and fetal analysis
|
|
US10453556B2
(en)
|
2015-07-23 |
2019-10-22 |
The Chinese University Of Hong Kong |
Analysis of fragmentation patterns of cell-free DNA
|
|
WO2017083366A1
(en)
*
|
2015-11-09 |
2017-05-18 |
Progenity, Inc. |
Methods for determining the origin of dna molecules
|
|
CN108603228B
(zh)
|
2015-12-17 |
2023-09-01 |
夸登特健康公司 |
通过分析无细胞dna确定肿瘤基因拷贝数的方法
|
|
US11514289B1
(en)
*
|
2016-03-09 |
2022-11-29 |
Freenome Holdings, Inc. |
Generating machine learning models using genetic data
|
|
MX2019000037A
(es)
*
|
2016-07-06 |
2019-07-10 |
Guardant Health Inc |
Metodos para perfilado de fragmentoma de acidos nucleicos libres de celula.
|
|
JP7048105B2
(ja)
|
2016-07-15 |
2022-04-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
核酸ライブラリを生成する方法
|
|
US11788135B2
(en)
|
2016-08-05 |
2023-10-17 |
The Broad Institute, Inc. |
Methods for genome characterization
|
|
US9850523B1
(en)
|
2016-09-30 |
2017-12-26 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
US20200013482A1
(en)
|
2016-09-30 |
2020-01-09 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
EP4656736A2
(en)
|
2016-10-12 |
2025-12-03 |
Bellwether Bio, Inc. |
Determining cell type origin of circulating cell-free dna with molecular counting
|
|
EP3529377B1
(en)
|
2016-10-19 |
2023-04-05 |
The Chinese University Of Hong Kong |
Gestational age assessment by methylation and size profiling of maternal plasma dna
|
|
EP3535415A4
(en)
|
2016-10-24 |
2020-07-01 |
The Chinese University of Hong Kong |
TUMOR DETECTION METHODS AND SYSTEMS
|
|
IL266347B2
(en)
|
2016-11-30 |
2025-01-01 |
Univ Hong Kong Chinese |
Analysis of cell-free DNA in urine and other samples
|
|
US20190309374A1
(en)
|
2016-12-13 |
2019-10-10 |
Bellwether Bio, Inc. |
Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
|
|
MX2019007444A
(es)
|
2016-12-22 |
2019-08-16 |
Guardant Health Inc |
Metodos y sistemas para analisis de moleculas de acido nucleico.
|
|
WO2018132518A1
(en)
|
2017-01-10 |
2018-07-19 |
Juno Therapeutics, Inc. |
Epigenetic analysis of cell therapy and related methods
|
|
MY197535A
(en)
|
2017-01-25 |
2023-06-21 |
Univ Hong Kong Chinese |
Diagnostic applications using nucleic acid fragments
|
|
WO2018210877A1
(en)
|
2017-05-15 |
2018-11-22 |
Katholieke Universiteit Leuven |
Method for analysing cell-free nucleic acids
|
|
WO2018227211A1
(en)
*
|
2017-06-09 |
2018-12-13 |
Bellwether Bio, Inc. |
Diagnosis of cancer or other physiological condition using circulating nucleic acid fragment sentinel endpoints
|
|
EP3635133A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT
|
|
US10636512B2
(en)
|
2017-07-14 |
2020-04-28 |
Cofactor Genomics, Inc. |
Immuno-oncology applications using next generation sequencing
|
|
EP3658684B1
(en)
|
2017-07-26 |
2023-08-30 |
The Chinese University Of Hong Kong |
Enhancement of cancer screening using cell-free viral nucleic acids
|
|
WO2019075251A2
(en)
*
|
2017-10-12 |
2019-04-18 |
Nantomics, Llc |
CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS
|
|
CN107545153B
(zh)
*
|
2017-10-25 |
2021-06-11 |
桂林电子科技大学 |
一种基于卷积神经网络的核小体分类预测方法
|
|
WO2019024341A1
(zh)
*
|
2017-11-27 |
2019-02-07 |
深圳华大生命科学研究院 |
一种体液游离dna的文库构建方法及其应用
|
|
CN108061794B
(zh)
*
|
2017-12-25 |
2020-03-27 |
苏州大学 |
一种无染色、无探针、无损检测细胞或类细胞结构微生物的类型及其周期的方法
|
|
CN111954720A
(zh)
|
2018-01-12 |
2020-11-17 |
克拉雷特生物科学有限责任公司 |
用于分析核酸的方法和组合物
|
|
CN112119166B
(zh)
*
|
2018-03-13 |
2025-08-22 |
耶路撒冷希伯来大学伊萨姆研发有限公司 |
无细胞dna染色质免疫沉淀的诊断应用
|
|
CN112236520B
(zh)
|
2018-04-02 |
2025-01-24 |
格里尔公司 |
甲基化标记和标靶甲基化探针板
|
|
WO2019209884A1
(en)
*
|
2018-04-23 |
2019-10-31 |
Grail, Inc. |
Methods and systems for screening for conditions
|
|
US20210198747A1
(en)
*
|
2018-05-18 |
2021-07-01 |
The Johns Hopkins University |
Cell-free dna for assessing and/or treating cancer
|
|
US20190385700A1
(en)
*
|
2018-06-04 |
2019-12-19 |
Guardant Health, Inc. |
METHODS AND SYSTEMS FOR DETERMINING The CELLULAR ORIGIN OF CELL-FREE NUCLEIC ACIDS
|
|
KR102767028B1
(ko)
|
2018-06-06 |
2025-02-13 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
핵산 라이브러리의 생성 방법 및 이를 실행하기 위한 조성물 및 키트
|
|
CN108796056A
(zh)
*
|
2018-06-28 |
2018-11-13 |
元码基因科技（北京）股份有限公司 |
基于游离dna的目标基因捕获技术进行组织溯源的方法
|
|
WO2020006369A1
(en)
*
|
2018-06-29 |
2020-01-02 |
Guardant Health, Inc. |
Methods and systems for analysis of ctcf binding regions in cell-free dna
|
|
CN108913682A
(zh)
*
|
2018-07-05 |
2018-11-30 |
上海奥测医疗科技有限公司 |
一种制备cfDNA参考品的方法
|
|
SG11202100564PA
(en)
*
|
2018-07-23 |
2021-02-25 |
Univ Hong Kong Chinese |
Cell-free dna damage analysis and its clinical applications
|
|
CN109448783B
(zh)
*
|
2018-08-07 |
2022-05-13 |
清华大学 |
一种染色质拓扑结构域边界的分析方法
|
|
WO2020069350A1
(en)
|
2018-09-27 |
2020-04-02 |
Grail, Inc. |
Methylation markers and targeted methylation probe panel
|
|
KR20210073526A
(ko)
*
|
2018-10-08 |
2021-06-18 |
프리놈 홀딩스, 인크. |
전사 인자 프로파일링
|
|
CN111172263A
(zh)
*
|
2018-11-12 |
2020-05-19 |
北京医院 |
一种应用于无创产前检测的参考物质及其制备方法
|
|
CA3118742A1
(en)
*
|
2018-11-21 |
2020-05-28 |
Karius, Inc. |
Detection and prediction of infectious disease
|
|
US20200199685A1
(en)
|
2018-12-17 |
2020-06-25 |
Guardant Health, Inc. |
Determination of a physiological condition with nucleic acid fragment endpoints
|
|
KR20210113237A
(ko)
*
|
2018-12-19 |
2021-09-15 |
더 차이니즈 유니버시티 오브 홍콩 |
무 세포 dna 말단 특성
|
|
US11657897B2
(en)
*
|
2018-12-31 |
2023-05-23 |
Nvidia Corporation |
Denoising ATAC-seq data with deep learning
|
|
CN112424372A
(zh)
*
|
2019-01-24 |
2021-02-26 |
Illumina公司 |
用于监测器官健康和疾病的方法和系统
|
|
ES3013495T3
(en)
|
2019-01-31 |
2025-04-14 |
Guardant Health Inc |
Method for isolating and sequencing cell-free dna
|
|
CN109841265B
(zh)
*
|
2019-02-22 |
2021-09-21 |
清华大学 |
使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
|
|
WO2020198942A1
(zh)
*
|
2019-03-29 |
2020-10-08 |
中国科学技术大学 |
基于峰聚类的单细胞染色质可及性测序数据分析方法和系统
|
|
WO2020243722A1
(en)
|
2019-05-31 |
2020-12-03 |
Guardant Health, Inc. |
Methods and systems for improving patient monitoring after surgery
|
|
CN110272985B
(zh)
*
|
2019-06-26 |
2021-08-17 |
广州市雄基生物信息技术有限公司 |
基于外周血血浆游离dna高通量测序技术的肿瘤筛查试剂盒及其系统与方法
|
|
US11891653B2
(en)
|
2019-09-30 |
2024-02-06 |
Guardant Health, Inc. |
Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
|
|
CN110739027B
(zh)
*
|
2019-10-23 |
2023-04-18 |
深圳吉因加医学检验实验室 |
一种基于染色质区域覆盖深度的癌症组织定位方法及系统
|
|
ES3031713T3
(en)
|
2019-11-26 |
2025-07-10 |
Guardant Health Inc |
Methods, compositions and systems for improving the binding of methylated polynucleotides
|
|
CA3161683A1
(en)
*
|
2019-12-18 |
2021-06-24 |
The Chinese University Of Hong Kong |
Cell-free dna fragmentation and nucleases
|
|
WO2021126091A1
(en)
*
|
2019-12-19 |
2021-06-24 |
Agency For Science, Technology And Research |
A method of estimating a circulating tumor dna burden and related kits and methods
|
|
WO2021127208A1
(en)
*
|
2019-12-20 |
2021-06-24 |
Accuragen Holdings Limited |
Methods and systems for disease detection
|
|
WO2021130356A1
(en)
|
2019-12-24 |
2021-07-01 |
Vib Vzw |
Disease detection in liquid biopsies
|
|
EP4087942A4
(en)
*
|
2020-01-08 |
2024-01-24 |
The Chinese University Of Hong Kong |
Biterminal dna fragment types in cell-free samples and uses thereof
|
|
US20230053409A1
(en)
*
|
2020-01-09 |
2023-02-23 |
Seoul National University R&Db Foundation |
Atac-seq data normalization and method for utilizing same
|
|
CN111254194B
(zh)
*
|
2020-01-13 |
2021-09-07 |
东南大学 |
基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用
|
|
US12421558B2
(en)
*
|
2020-02-13 |
2025-09-23 |
10X Genomics, Inc. |
Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
|
|
US11211147B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
|
|
US11475981B2
(en)
|
2020-02-18 |
2022-10-18 |
Tempus Labs, Inc. |
Methods and systems for dynamic variant thresholding in a liquid biopsy assay
|
|
US11211144B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Methods and systems for refining copy number variation in a liquid biopsy assay
|
|
CN113362897A
(zh)
*
|
2020-03-06 |
2021-09-07 |
福建和瑞基因科技有限公司 |
基于核小体分布特征的肿瘤标志物筛选方法及应用
|
|
EP4143338A1
(en)
|
2020-04-30 |
2023-03-08 |
Guardant Health, Inc. |
Methods for sequence determination using partitioned nucleic acids
|
|
IL298458A
(en)
*
|
2020-05-22 |
2023-01-01 |
Aqtual Inc |
Methods for characterizing cell-free nucleic acid fragments
|
|
CN111724860B
(zh)
*
|
2020-06-18 |
2021-03-16 |
深圳吉因加医学检验实验室 |
一种基于测序数据识别染色质开放区域的方法及装置
|
|
EP4179111B1
(en)
|
2020-07-10 |
2024-04-03 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
WO2023282916A1
(en)
|
2021-07-09 |
2023-01-12 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
CN111881418B
(zh)
*
|
2020-07-27 |
2023-05-16 |
中国农业科学院农业信息研究所 |
一种基于二分法的大豆气象产量预测方法及系统
|
|
EP4189111B1
(en)
|
2020-07-30 |
2025-02-19 |
Guardant Health, Inc. |
Methods for isolating cell-free dna
|
|
CN112085067B
(zh)
*
|
2020-08-17 |
2022-07-12 |
浙江大学 |
一种高通量筛选dna损伤反应抑制剂的方法
|
|
WO2022046947A1
(en)
|
2020-08-25 |
2022-03-03 |
Guardant Health, Inc. |
Methods and systems for predicting an origin of a variant
|
|
WO2022061080A1
(en)
*
|
2020-09-17 |
2022-03-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions
|
|
EP4222278A1
(en)
|
2020-09-30 |
2023-08-09 |
Guardant Health, Inc. |
Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease
|
|
CA3195797A1
(en)
|
2020-10-23 |
2022-04-28 |
Andrew Kennedy |
Compositions and methods for analyzing dna using partitioning and base conversion
|
|
EP4251765A1
(en)
|
2020-11-30 |
2023-10-04 |
Guardant Health, Inc. |
Compositions and methods for enriching methylated polynucleotides
|
|
WO2022140629A1
(en)
|
2020-12-23 |
2022-06-30 |
Guardant Health, Inc. |
Methods and systems for analyzing methylated polynucleotides
|
|
TW202242145A
(zh)
*
|
2020-12-29 |
2022-11-01 |
比利時商比利時意志有限公司 |
核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
|
|
EP4291681A1
(en)
*
|
2021-02-09 |
2023-12-20 |
Illumina, Inc. |
Methods and systems for monitoring organ health and disease
|
|
EP4291679A1
(en)
|
2021-02-12 |
2023-12-20 |
Guardant Health, Inc. |
Methods and compositions for detecting nucleic acid variants
|
|
WO2022204730A1
(en)
|
2021-03-25 |
2022-09-29 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
CA3214391A1
(en)
*
|
2021-04-08 |
2022-10-13 |
Gavin HA |
Cell-free dna sequence data analysis method to examine nucleosome protection and chromatin accessibility
|
|
BR112023020307A2
(pt)
*
|
2021-04-08 |
2023-11-21 |
Delfi Diagnostics Inc |
Método de detecção de câncer usando perfis de fragmentação de cfdna de amplo genoma
|
|
EP4359562A1
(en)
|
2021-06-21 |
2024-05-01 |
Guardant Health, Inc. |
Methods and compositions for copy-number informed tissue-of-origin analysis
|
|
EP4409024A1
(en)
|
2021-09-30 |
2024-08-07 |
Guardant Health, Inc. |
Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
|
|
JP2025513786A
(ja)
|
2022-04-07 |
2025-04-30 |
ガーダント ヘルス， インコーポレイテッド |
無細胞核酸分子のメチル化状態に基づいた腫瘍の存在の検出
|
|
GB202205710D0
(en)
|
2022-04-19 |
2022-06-01 |
Univ Of Essex Enterprises Limited |
Cell-free DNA-based methods
|
|
WO2024006908A1
(en)
|
2022-06-30 |
2024-01-04 |
Guardant Health, Inc. |
Enrichment of aberrantly methylated dna
|
|
WO2024056720A1
(en)
|
2022-09-13 |
2024-03-21 |
Medizinische Universität Graz |
Determining of health status and treatment monitoring with cell-free dna
|
|
WO2024073508A2
(en)
|
2022-09-27 |
2024-04-04 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
EP4638782A2
(en)
|
2022-12-22 |
2025-10-29 |
Guardant Health, Inc. |
Integrated targeted and whole genome somatic and dna methylation sequencing workflows
|
|
EP4638781A2
(en)
|
2022-12-22 |
2025-10-29 |
Guardant Health, Inc. |
Methods involving methylation preserving amplification with error correction
|
|
WO2024233502A1
(en)
|
2023-05-05 |
2024-11-14 |
Guardant Health, Inc. |
Cell-free dna blood-based test for cancer screening
|
|
WO2025029475A1
(en)
|
2023-07-28 |
2025-02-06 |
Guardant Health, Inc. |
Methods to enrich nucleotide variants by negative selection
|
|
WO2025038399A1
(en)
|
2023-08-11 |
2025-02-20 |
Guardant Health, Inc. |
Methylated enrichment methods for single-molecule genetic and epigenetic sequencing
|
|
CN117230165A
(zh)
*
|
2023-09-01 |
2023-12-15 |
深圳湾实验室 |
一种无创产前检测胎儿染色体拷贝数异常的优化方法
|
|
WO2025064706A1
(en)
|
2023-09-19 |
2025-03-27 |
Guardant Health, Inc. |
Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
|
|
WO2025076452A1
(en)
|
2023-10-06 |
2025-04-10 |
Guardant Health, Inc. |
Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules
|
|
WO2025137389A2
(en)
|
2023-12-22 |
2025-06-26 |
Guardant Health, Inc. |
Methods for targeted single-molecule genetic and epigenetic sequencing
|
|
WO2025207817A1
(en)
|
2024-03-26 |
2025-10-02 |
Guardant Health, Inc. |
Method of determining the likelihood of a disease by combining biomarkers and imaging
|
|
WO2025208044A1
(en)
|
2024-03-28 |
2025-10-02 |
Guardant Health, Inc. |
Methods for cancer detection using molecular patterns
|
|
WO2025235889A1
(en)
|
2024-05-10 |
2025-11-13 |
Guardant Health, Inc. |
Methods involving multiplexed pooled pcr
|