|
WO2012129363A2
(en)
|
2011-03-24 |
2012-09-27 |
President And Fellows Of Harvard College |
Single cell nucleic acid detection and analysis
|
|
US9892230B2
(en)
|
2012-03-08 |
2018-02-13 |
The Chinese University Of Hong Kong |
Size-based analysis of fetal or tumor DNA fraction in plasma
|
|
US11261494B2
(en)
|
2012-06-21 |
2022-03-01 |
The Chinese University Of Hong Kong |
Method of measuring a fractional concentration of tumor DNA
|
|
US10876152B2
(en)
|
2012-09-04 |
2020-12-29 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US10041127B2
(en)
|
2012-09-04 |
2018-08-07 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US11913065B2
(en)
|
2012-09-04 |
2024-02-27 |
Guardent Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US20160040229A1
(en)
|
2013-08-16 |
2016-02-11 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
CN106062214B
(zh)
|
2013-12-28 |
2020-06-09 |
夸登特健康公司 |
用于检测遗传变异的方法和系统
|
|
PT3543356T
(pt)
|
2014-07-18 |
2021-10-04 |
Univ Hong Kong Chinese |
Análise dos padrões de metilação de tecidos em mistura de adn
|
|
KR102696857B1
(ko)
|
2014-07-25 |
2024-08-19 |
유니버시티 오브 워싱톤 |
무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
|
|
US10364467B2
(en)
|
2015-01-13 |
2019-07-30 |
The Chinese University Of Hong Kong |
Using size and number aberrations in plasma DNA for detecting cancer
|
|
WO2016123698A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Uti Limited Partnership |
Diagnostic assay for post-transplant assessment of potential rejection of donor organs
|
|
AU2016218631B2
(en)
|
2015-02-10 |
2022-03-10 |
The Chinese University Of Hong Kong |
Detecting mutations for cancer screening and fetal analysis
|
|
ES2960201T3
(es)
|
2015-07-23 |
2024-03-01 |
Univ Hong Kong Chinese |
Análisis de los patrones de fragmentación del ADN acelular
|
|
CN108368548A
(zh)
*
|
2015-11-09 |
2018-08-03 |
普罗格尼迪公司 |
用于确定dna分子的来源的方法
|
|
JP2019507585A
(ja)
|
2015-12-17 |
2019-03-22 |
ガーダント ヘルス, インコーポレイテッド |
無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法
|
|
US11514289B1
(en)
|
2016-03-09 |
2022-11-29 |
Freenome Holdings, Inc. |
Generating machine learning models using genetic data
|
|
JP7448310B2
(ja)
*
|
2016-07-06 |
2024-03-12 |
ガーダント ヘルス, インコーポレイテッド |
セルフリー核酸のフラグメントームプロファイリングのための方法
|
|
JP7048105B2
(ja)
|
2016-07-15 |
2022-04-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
核酸ライブラリを生成する方法
|
|
WO2018027176A1
(en)
|
2016-08-05 |
2018-02-08 |
The Broad Institute, Inc. |
Methods for genome characterization
|
|
US9850523B1
(en)
|
2016-09-30 |
2017-12-26 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
EP3792922A1
(en)
|
2016-09-30 |
2021-03-17 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
EP3526350B1
(en)
*
|
2016-10-12 |
2025-07-16 |
Bellwether Bio, Inc. |
Determining cell type origin of circulating cell-free dna with molecular counting
|
|
IL265769B2
(en)
|
2016-10-19 |
2023-12-01 |
Univ Hong Kong Chinese |
Estimation of gestational age using methylation and size profile of maternal plasma DNA
|
|
SG11201903509QA
(en)
|
2016-10-24 |
2019-05-30 |
Univ Hong Kong Chinese |
Methods and systems for tumor detection
|
|
CA3039685A1
(en)
|
2016-11-30 |
2018-06-07 |
The Chinese University Of Hong Kong |
Analysis of cell-free dna in urine and other samples
|
|
ES2983411T3
(es)
*
|
2016-12-13 |
2024-10-23 |
Bellwether Bio Inc |
Determinación de un estado fisiológico en un individuo analizando los puntos finales de fragmentos de ADN libre de células en una muestra biológica
|
|
WO2018119452A2
(en)
|
2016-12-22 |
2018-06-28 |
Guardant Health, Inc. |
Methods and systems for analyzing nucleic acid molecules
|
|
US11821027B2
(en)
|
2017-01-10 |
2023-11-21 |
Juno Therapeutics, Inc. |
Epigenetic analysis of cell therapy and related methods
|
|
EP3574108B1
(en)
|
2017-01-25 |
2024-08-28 |
The Chinese University Of Hong Kong |
Diagnostic applications using nucleic acid fragments
|
|
CA3063627A1
(en)
|
2017-05-15 |
2018-11-22 |
Katholieke Universiteit Leuven |
Method for analysing cell-free nucleic acids
|
|
EP3635134A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS
|
|
EP3635133A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT
|
|
US10636512B2
(en)
|
2017-07-14 |
2020-04-28 |
Cofactor Genomics, Inc. |
Immuno-oncology applications using next generation sequencing
|
|
CN111051536A
(zh)
|
2017-07-26 |
2020-04-21 |
香港中文大学 |
利用不含细胞的病毒核酸改善癌症筛选
|
|
WO2019075251A2
(en)
*
|
2017-10-12 |
2019-04-18 |
Nantomics, Llc |
CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS
|
|
CN107545153B
(zh)
*
|
2017-10-25 |
2021-06-11 |
桂林电子科技大学 |
一种基于卷积神经网络的核小体分类预测方法
|
|
WO2019024341A1
(zh)
|
2017-11-27 |
2019-02-07 |
深圳华大生命科学研究院 |
一种体液游离dna的文库构建方法及其应用
|
|
CN108061794B
(zh)
*
|
2017-12-25 |
2020-03-27 |
苏州大学 |
一种无染色、无探针、无损检测细胞或类细胞结构微生物的类型及其周期的方法
|
|
US11584929B2
(en)
|
2018-01-12 |
2023-02-21 |
Claret Bioscience, Llc |
Methods and compositions for analyzing nucleic acid
|
|
US11781183B2
(en)
*
|
2018-03-13 |
2023-10-10 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Diagnostic use of cell free DNA chromatin immunoprecipitation
|
|
AU2019249422B2
(en)
|
2018-04-02 |
2025-09-25 |
Grail, Inc. |
Methylation markers and targeted methylation probe panels
|
|
WO2019209884A1
(en)
*
|
2018-04-23 |
2019-10-31 |
Grail, Inc. |
Methods and systems for screening for conditions
|
|
CN120608151A
(zh)
*
|
2018-05-18 |
2025-09-09 |
约翰·霍普金斯大学 |
用于评估和/或治疗癌症的无细胞dna
|
|
JP2021526791A
(ja)
*
|
2018-06-04 |
2021-10-11 |
ガーダント ヘルス, インコーポレイテッド |
セルフリー核酸の細胞起源を決定するための方法およびシステム
|
|
JP7537748B2
(ja)
|
2018-06-06 |
2024-08-21 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
核酸ライブラリを生成する方法ならびにそれを実施するための組成物およびキット
|
|
CN108796056A
(zh)
*
|
2018-06-28 |
2018-11-13 |
元码基因科技(北京)股份有限公司 |
基于游离dna的目标基因捕获技术进行组织溯源的方法
|
|
WO2020006369A1
(en)
*
|
2018-06-29 |
2020-01-02 |
Guardant Health, Inc. |
Methods and systems for analysis of ctcf binding regions in cell-free dna
|
|
CN108913682A
(zh)
*
|
2018-07-05 |
2018-11-30 |
上海奥测医疗科技有限公司 |
一种制备cfDNA参考品的方法
|
|
WO2020020174A1
(en)
*
|
2018-07-23 |
2020-01-30 |
The Chinese University Of Hong Kong |
Cell-free dna damage analysis and its clinical applications
|
|
CN109448783B
(zh)
*
|
2018-08-07 |
2022-05-13 |
清华大学 |
一种染色质拓扑结构域边界的分析方法
|
|
WO2020069350A1
(en)
|
2018-09-27 |
2020-04-02 |
Grail, Inc. |
Methylation markers and targeted methylation probe panel
|
|
CN112740239B
(zh)
*
|
2018-10-08 |
2025-02-28 |
福瑞诺姆控股公司 |
转录因子分析
|
|
CN111172263A
(zh)
*
|
2018-11-12 |
2020-05-19 |
北京医院 |
一种应用于无创产前检测的参考物质及其制备方法
|
|
CN113227468A
(zh)
*
|
2018-11-21 |
2021-08-06 |
卡里乌斯公司 |
感染性疾病的检测和预测
|
|
US20200199685A1
(en)
|
2018-12-17 |
2020-06-25 |
Guardant Health, Inc. |
Determination of a physiological condition with nucleic acid fragment endpoints
|
|
TWI868095B
(zh)
*
|
2018-12-19 |
2025-01-01 |
香港中文大學 |
游離dna末端特徵
|
|
US11657897B2
(en)
*
|
2018-12-31 |
2023-05-23 |
Nvidia Corporation |
Denoising ATAC-seq data with deep learning
|
|
JP2022517456A
(ja)
*
|
2019-01-24 |
2022-03-09 |
イルミナ インコーポレイテッド |
臓器健康および疾患をモニタリングするための方法およびシステム
|
|
JP7573536B2
(ja)
|
2019-01-31 |
2024-10-25 |
ガーダント ヘルス, インコーポレイテッド |
無細胞dnaを単離するための組成物および方法
|
|
CN109841265B
(zh)
*
|
2019-02-22 |
2021-09-21 |
清华大学 |
使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
|
|
WO2020198942A1
(zh)
*
|
2019-03-29 |
2020-10-08 |
中国科学技术大学 |
基于峰聚类的单细胞染色质可及性测序数据分析方法和系统
|
|
EP3976822A1
(en)
|
2019-05-31 |
2022-04-06 |
Guardant Health, Inc. |
Methods and systems for improving patient monitoring after surgery
|
|
CN110272985B
(zh)
*
|
2019-06-26 |
2021-08-17 |
广州市雄基生物信息技术有限公司 |
基于外周血血浆游离dna高通量测序技术的肿瘤筛查试剂盒及其系统与方法
|
|
US11891653B2
(en)
|
2019-09-30 |
2024-02-06 |
Guardant Health, Inc. |
Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
|
|
CN110739027B
(zh)
*
|
2019-10-23 |
2023-04-18 |
深圳吉因加医学检验实验室 |
一种基于染色质区域覆盖深度的癌症组织定位方法及系统
|
|
ES3031713T3
(en)
|
2019-11-26 |
2025-07-10 |
Guardant Health Inc |
Methods, compositions and systems for improving the binding of methylated polynucleotides
|
|
WO2021121368A1
(en)
*
|
2019-12-18 |
2021-06-24 |
The Chinese University Of Hong Kong |
Cell-free dna fragmentation and nucleases
|
|
CN115066500A
(zh)
*
|
2019-12-19 |
2022-09-16 |
新加坡科技研究局 |
估计循环肿瘤dna负荷的方法以及相关的试剂盒和方法
|
|
EP4077735A4
(en)
*
|
2019-12-20 |
2024-01-24 |
AccuraGen Holdings Limited |
METHOD AND SYSTEMS FOR DETECTING DISEASES
|
|
EP4081655A1
(en)
|
2019-12-24 |
2022-11-02 |
Vib Vzw |
Disease detection in liquid biopsies
|
|
CA3162089A1
(en)
*
|
2020-01-08 |
2021-07-15 |
Yuk-Ming Dennis Lo |
Biterminal dna fragment types in cell-free samples and uses thereof
|
|
US20230053409A1
(en)
*
|
2020-01-09 |
2023-02-23 |
Seoul National University R&Db Foundation |
Atac-seq data normalization and method for utilizing same
|
|
CN111254194B
(zh)
*
|
2020-01-13 |
2021-09-07 |
东南大学 |
基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用
|
|
CN115428088A
(zh)
*
|
2020-02-13 |
2022-12-02 |
10X基因组学有限公司 |
用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
|
|
US11475981B2
(en)
|
2020-02-18 |
2022-10-18 |
Tempus Labs, Inc. |
Methods and systems for dynamic variant thresholding in a liquid biopsy assay
|
|
US11211147B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
|
|
US11211144B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Methods and systems for refining copy number variation in a liquid biopsy assay
|
|
CN113362897A
(zh)
*
|
2020-03-06 |
2021-09-07 |
福建和瑞基因科技有限公司 |
基于核小体分布特征的肿瘤标志物筛选方法及应用
|
|
WO2021222828A1
(en)
|
2020-04-30 |
2021-11-04 |
Guardant Health, Inc. |
Methods for sequence determination using partitioned nucleic acids
|
|
EP4154255A4
(en)
*
|
2020-05-22 |
2024-07-17 |
Aqtual, Inc. |
METHODS FOR CHARACTERIZING CELL-FREE NUCLEIC ACID FRAGMENTS
|
|
CN111724860B
(zh)
*
|
2020-06-18 |
2021-03-16 |
深圳吉因加医学检验实验室 |
一种基于测序数据识别染色质开放区域的方法及装置
|
|
EP4407042A3
(en)
|
2020-07-10 |
2024-09-18 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
WO2023282916A1
(en)
|
2021-07-09 |
2023-01-12 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
CN111881418B
(zh)
*
|
2020-07-27 |
2023-05-16 |
中国农业科学院农业信息研究所 |
一种基于二分法的大豆气象产量预测方法及系统
|
|
EP4189111B1
(en)
|
2020-07-30 |
2025-02-19 |
Guardant Health, Inc. |
Methods for isolating cell-free dna
|
|
CN112085067B
(zh)
*
|
2020-08-17 |
2022-07-12 |
浙江大学 |
一种高通量筛选dna损伤反应抑制剂的方法
|
|
WO2022046947A1
(en)
|
2020-08-25 |
2022-03-03 |
Guardant Health, Inc. |
Methods and systems for predicting an origin of a variant
|
|
WO2022061080A1
(en)
*
|
2020-09-17 |
2022-03-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions
|
|
CA3193090A1
(en)
|
2020-09-30 |
2022-04-07 |
Guardant Health, Inc. |
Methods and systems to improve the signal to noise ratio of dna methylation partitioning assays
|
|
WO2022087309A1
(en)
|
2020-10-23 |
2022-04-28 |
Guardant Health, Inc. |
Compositions and methods for analyzing dna using partitioning and base conversion
|
|
WO2022115810A1
(en)
|
2020-11-30 |
2022-06-02 |
Guardant Health, Inc. |
Compositions and methods for enriching methylated polynucleotides
|
|
WO2022140629A1
(en)
|
2020-12-23 |
2022-06-30 |
Guardant Health, Inc. |
Methods and systems for analyzing methylated polynucleotides
|
|
TW202242145A
(zh)
*
|
2020-12-29 |
2022-11-01 |
比利時商比利時意志有限公司 |
核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
|
|
US20230175064A1
(en)
*
|
2021-02-09 |
2023-06-08 |
Illumina, Inc. |
Methods and systems for monitoring organ health and disease
|
|
EP4291679B1
(en)
|
2021-02-12 |
2026-02-04 |
Guardant Health, Inc. |
Methods for detecting nucleic acid variants
|
|
WO2022204730A1
(en)
|
2021-03-25 |
2022-09-29 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
EP4320277A4
(en)
*
|
2021-04-08 |
2025-03-05 |
Delfi Diagnostics, Inc. |
CANCER DETECTION METHOD USING GENOME-WIDE CELL-FREE DNA FRAGMENTATION PROFILES
|
|
WO2022217096A2
(en)
*
|
2021-04-08 |
2022-10-13 |
Ha Gavin |
Cell-free dna sequence data analysis method to examine nucleosome protection and chromatin accessibility
|
|
JP2024523401A
(ja)
|
2021-06-21 |
2024-06-28 |
ガーダント ヘルス, インコーポレイテッド |
コピー数情報に基づく組織起源分析のための方法および組成物
|
|
EP4409024A1
(en)
|
2021-09-30 |
2024-08-07 |
Guardant Health, Inc. |
Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
|
|
CA3246524A1
(en)
|
2022-04-07 |
2023-10-12 |
Guardant Health, Inc. |
TUMOR PRESENCE DETECTION BASED ON THE METHYLATION STATE OF ACELLULAR NUCLEIC ACID MOLECULES
|
|
GB202205710D0
(en)
|
2022-04-19 |
2022-06-01 |
Univ Of Essex Enterprises Limited |
Cell-free DNA-based methods
|
|
EP4547857A1
(en)
|
2022-06-30 |
2025-05-07 |
Guardant Health, Inc. |
Enrichment of aberrantly methylated dna
|
|
WO2024056720A1
(en)
|
2022-09-13 |
2024-03-21 |
Medizinische Universität Graz |
Determining of health status and treatment monitoring with cell-free dna
|
|
JP2025532196A
(ja)
|
2022-09-27 |
2025-09-29 |
ガーダント ヘルス, インコーポレイテッド |
免疫細胞dnaを定量するための方法
|
|
JP2025542260A
(ja)
|
2022-12-22 |
2025-12-25 |
ガーダント ヘルス, インコーポレイテッド |
エラー補正を伴うメチル化保存増幅を含む方法
|
|
WO2024138180A2
(en)
|
2022-12-22 |
2024-06-27 |
Guardant Health, Inc. |
Integrated targeted and whole genome somatic and dna methylation sequencing workflows
|
|
WO2024233502A1
(en)
|
2023-05-05 |
2024-11-14 |
Guardant Health, Inc. |
Cell-free dna blood-based test for cancer screening
|
|
WO2025029475A1
(en)
|
2023-07-28 |
2025-02-06 |
Guardant Health, Inc. |
Methods to enrich nucleotide variants by negative selection
|
|
WO2025038399A1
(en)
|
2023-08-11 |
2025-02-20 |
Guardant Health, Inc. |
Methylated enrichment methods for single-molecule genetic and epigenetic sequencing
|
|
CN117230165A
(zh)
*
|
2023-09-01 |
2023-12-15 |
深圳湾实验室 |
一种无创产前检测胎儿染色体拷贝数异常的优化方法
|
|
WO2025064706A1
(en)
|
2023-09-19 |
2025-03-27 |
Guardant Health, Inc. |
Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules
|
|
WO2025076452A1
(en)
|
2023-10-06 |
2025-04-10 |
Guardant Health, Inc. |
Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules
|
|
WO2025137389A2
(en)
|
2023-12-22 |
2025-06-26 |
Guardant Health, Inc. |
Methods for targeted single-molecule genetic and epigenetic sequencing
|
|
WO2025207817A1
(en)
|
2024-03-26 |
2025-10-02 |
Guardant Health, Inc. |
Method of determining the likelihood of a disease by combining biomarkers and imaging
|
|
WO2025208044A1
(en)
|
2024-03-28 |
2025-10-02 |
Guardant Health, Inc. |
Methods for cancer detection using molecular patterns
|
|
WO2025235889A1
(en)
|
2024-05-10 |
2025-11-13 |
Guardant Health, Inc. |
Methods involving multiplexed pooled pcr
|
|
WO2025250544A1
(en)
|
2024-05-31 |
2025-12-04 |
Guardant Health, Inc. |
Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna
|
|
WO2026015607A1
(en)
|
2024-07-09 |
2026-01-15 |
Guardant Health, Inc. |
Methods for partitioning hyper-, hypo-, and non-methylated dna
|