AU2015292311B2 - Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same - Google Patents
Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same Download PDFInfo
- Publication number
- AU2015292311B2 AU2015292311B2 AU2015292311A AU2015292311A AU2015292311B2 AU 2015292311 B2 AU2015292311 B2 AU 2015292311B2 AU 2015292311 A AU2015292311 A AU 2015292311A AU 2015292311 A AU2015292311 A AU 2015292311A AU 2015292311 B2 AU2015292311 B2 AU 2015292311B2
- Authority
- AU
- Australia
- Prior art keywords
- cfdna
- cell
- nucleosome
- sample
- genomic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Data Mining & Analysis (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Evolutionary Computation (AREA)
- Cell Biology (AREA)
- Primary Health Care (AREA)
- Signal Processing (AREA)
- Hospice & Palliative Care (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2022202587A AU2022202587B2 (en) | 2014-07-25 | 2022-04-20 | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029178P | 2014-07-25 | 2014-07-25 | |
| US62/029,178 | 2014-07-25 | ||
| US201462087619P | 2014-12-04 | 2014-12-04 | |
| US62/087,619 | 2014-12-04 | ||
| PCT/US2015/042310 WO2016015058A2 (en) | 2014-07-25 | 2015-07-27 | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022202587A Division AU2022202587B2 (en) | 2014-07-25 | 2022-04-20 | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015292311A1 AU2015292311A1 (en) | 2017-03-09 |
| AU2015292311B2 true AU2015292311B2 (en) | 2022-01-20 |
Family
ID=55163988
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015292311A Active AU2015292311B2 (en) | 2014-07-25 | 2015-07-27 | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
| AU2022202587A Active AU2022202587B2 (en) | 2014-07-25 | 2022-04-20 | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022202587A Active AU2022202587B2 (en) | 2014-07-25 | 2022-04-20 | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20170211143A1 (enExample) |
| EP (2) | EP4358097A1 (enExample) |
| JP (3) | JP2017522908A (enExample) |
| KR (2) | KR102441391B1 (enExample) |
| CN (2) | CN117402950A (enExample) |
| AU (2) | AU2015292311B2 (enExample) |
| CA (1) | CA2956208C (enExample) |
| WO (1) | WO2016015058A2 (enExample) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN110872617A (zh) | 2012-09-04 | 2020-03-10 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| ES2784450T3 (es) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
| TWI727156B (zh) | 2014-07-18 | 2021-05-11 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| WO2016123698A1 (en) * | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| EP4279612B1 (en) | 2015-07-23 | 2025-07-02 | The Chinese University of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
| CN108368548A (zh) * | 2015-11-09 | 2018-08-03 | 普罗格尼迪公司 | 用于确定dna分子的来源的方法 |
| EP3390668A4 (en) | 2015-12-17 | 2020-04-01 | Guardant Health, Inc. | METHODS OF DETERMINING THE NUMBER OF TUMOR GENE COPIES BY ACELLULAR DNA ANALYSIS |
| US11514289B1 (en) * | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| MX2019000037A (es) * | 2016-07-06 | 2019-07-10 | Guardant Health Inc | Metodos para perfilado de fragmentoma de acidos nucleicos libres de celula. |
| CA3030430A1 (en) | 2016-07-15 | 2018-01-18 | The Regents Of The University Of California | Methods of producing nucleic acid libraries |
| US11788135B2 (en) | 2016-08-05 | 2023-10-17 | The Broad Institute, Inc. | Methods for genome characterization |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| ES2840003T3 (es) | 2016-09-30 | 2021-07-06 | Guardant Health Inc | Métodos para análisis multi-resolución de ácidos nucleicos libres de células |
| WO2018071595A1 (en) | 2016-10-12 | 2018-04-19 | Bellwether Bio, Inc. | Determining cell type origin of circulating cell-free dna with molecular counting |
| EP3529377B1 (en) | 2016-10-19 | 2023-04-05 | The Chinese University Of Hong Kong | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| WO2018081130A1 (en) | 2016-10-24 | 2018-05-03 | The Chinese University Of Hong Kong | Methods and systems for tumor detection |
| JP2020503003A (ja) | 2016-11-30 | 2020-01-30 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 尿および他のサンプルにおける無細胞dnaの分析 |
| WO2018112100A2 (en) | 2016-12-13 | 2018-06-21 | Bellwether Bio, Inc. | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample |
| KR20240158369A (ko) | 2016-12-22 | 2024-11-04 | 가던트 헬쓰, 인크. | 핵산 분자를 분석하기 위한 방법 및 시스템 |
| JP7429338B2 (ja) | 2017-01-10 | 2024-02-08 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法および関連方法のエピジェネティック解析 |
| AU2018212272B2 (en) | 2017-01-25 | 2022-04-28 | Grail, Inc. | Diagnostic applications using nucleic acid fragments |
| ES2989479T3 (es) | 2017-05-15 | 2024-11-26 | Univ Leuven Kath | Método para analizar ácidos nucleicos libres de células |
| WO2018227211A1 (en) * | 2017-06-09 | 2018-12-13 | Bellwether Bio, Inc. | Diagnosis of cancer or other physiological condition using circulating nucleic acid fragment sentinel endpoints |
| EP3635133A4 (en) * | 2017-06-09 | 2021-03-03 | Bellwether Bio, Inc. | DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| CN111051536A (zh) | 2017-07-26 | 2020-04-21 | 香港中文大学 | 利用不含细胞的病毒核酸改善癌症筛选 |
| WO2019075251A2 (en) * | 2017-10-12 | 2019-04-18 | Nantomics, Llc | CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS |
| CN107545153B (zh) * | 2017-10-25 | 2021-06-11 | 桂林电子科技大学 | 一种基于卷积神经网络的核小体分类预测方法 |
| EP3719182B1 (en) * | 2017-11-27 | 2022-11-23 | BGI Shenzhen | Method for constructing library of cell-free dnas in body fluids and application thereof |
| CN108061794B (zh) * | 2017-12-25 | 2020-03-27 | 苏州大学 | 一种无染色、无探针、无损检测细胞或类细胞结构微生物的类型及其周期的方法 |
| CA3087001A1 (en) | 2018-01-12 | 2019-07-18 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| EP3765638A2 (en) * | 2018-03-13 | 2021-01-20 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Diagnostic use of cell free dna chromatin immunoprecipitation |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| WO2019209884A1 (en) * | 2018-04-23 | 2019-10-31 | Grail, Inc. | Methods and systems for screening for conditions |
| KR20210045953A (ko) * | 2018-05-18 | 2021-04-27 | 더 존스 홉킨스 유니버시티 | 암의 평가 및/또는 치료를 위한 무 세포 dna |
| EP3802878A1 (en) * | 2018-06-04 | 2021-04-14 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free nucleic acids |
| AU2019280712B2 (en) | 2018-06-06 | 2025-11-20 | The Regents Of The University Of California | Methods of producing nucleic acid libraries and compositions and kits for practicing same |
| CN108796056A (zh) * | 2018-06-28 | 2018-11-13 | 元码基因科技(北京)股份有限公司 | 基于游离dna的目标基因捕获技术进行组织溯源的方法 |
| WO2020006369A1 (en) * | 2018-06-29 | 2020-01-02 | Guardant Health, Inc. | Methods and systems for analysis of ctcf binding regions in cell-free dna |
| CN108913682A (zh) * | 2018-07-05 | 2018-11-30 | 上海奥测医疗科技有限公司 | 一种制备cfDNA参考品的方法 |
| KR20210039406A (ko) * | 2018-07-23 | 2021-04-09 | 더 차이니즈 유니버시티 오브 홍콩 | 세포-프리 dna 손상 분석 및 이의 임상적 적용 |
| CN109448783B (zh) * | 2018-08-07 | 2022-05-13 | 清华大学 | 一种染色质拓扑结构域边界的分析方法 |
| WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| SG11202100960RA (en) * | 2018-10-08 | 2021-02-25 | Freenome Holdings Inc | Transcription factor profiling |
| CN111172263A (zh) * | 2018-11-12 | 2020-05-19 | 北京医院 | 一种应用于无创产前检测的参考物质及其制备方法 |
| CA3118742A1 (en) * | 2018-11-21 | 2020-05-28 | Karius, Inc. | Detection and prediction of infectious disease |
| US20200199685A1 (en) | 2018-12-17 | 2020-06-25 | Guardant Health, Inc. | Determination of a physiological condition with nucleic acid fragment endpoints |
| ES2968457T3 (es) * | 2018-12-19 | 2024-05-09 | Univ Hong Kong Chinese | Características de los extremos del ADN extracelular circulante |
| US11657897B2 (en) * | 2018-12-31 | 2023-05-23 | Nvidia Corporation | Denoising ATAC-seq data with deep learning |
| EP4632078A2 (en) * | 2019-01-24 | 2025-10-15 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| CN113661249B (zh) | 2019-01-31 | 2025-07-01 | 夸登特健康公司 | 用于分离无细胞dna的组合物和方法 |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| WO2020198942A1 (zh) * | 2019-03-29 | 2020-10-08 | 中国科学技术大学 | 基于峰聚类的单细胞染色质可及性测序数据分析方法和系统 |
| EP3976822A1 (en) | 2019-05-31 | 2022-04-06 | Guardant Health, Inc. | Methods and systems for improving patient monitoring after surgery |
| CN110272985B (zh) * | 2019-06-26 | 2021-08-17 | 广州市雄基生物信息技术有限公司 | 基于外周血血浆游离dna高通量测序技术的肿瘤筛查试剂盒及其系统与方法 |
| EP4041919A1 (en) | 2019-09-30 | 2022-08-17 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free dna in methylation partitioning assays |
| CN110739027B (zh) * | 2019-10-23 | 2023-04-18 | 深圳吉因加医学检验实验室 | 一种基于染色质区域覆盖深度的癌症组织定位方法及系统 |
| ES3031713T3 (en) | 2019-11-26 | 2025-07-10 | Guardant Health Inc | Methods, compositions and systems for improving the binding of methylated polynucleotides |
| EP4524971A3 (en) * | 2019-12-18 | 2025-06-11 | The Chinese University of Hong Kong | Cell-free dna fragmentation and nucleases |
| US20220389513A1 (en) * | 2019-12-19 | 2022-12-08 | Agency For Science, Technology And Research | A Method of Estimating a Circulating Tumor DNA Burden and Related Kits and Methods |
| EP4077735A4 (en) * | 2019-12-20 | 2024-01-24 | AccuraGen Holdings Limited | METHOD AND SYSTEMS FOR DETECTING DISEASES |
| EP4081655A1 (en) | 2019-12-24 | 2022-11-02 | Vib Vzw | Disease detection in liquid biopsies |
| JP2023510318A (ja) * | 2020-01-08 | 2023-03-13 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 無細胞試料の二末端dna断片タイプおよびその用途 |
| US20230053409A1 (en) * | 2020-01-09 | 2023-02-23 | Seoul National University R&Db Foundation | Atac-seq data normalization and method for utilizing same |
| CN111254194B (zh) * | 2020-01-13 | 2021-09-07 | 东南大学 | 基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用 |
| CN115428088A (zh) * | 2020-02-13 | 2022-12-02 | 10X基因组学有限公司 | 用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法 |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| CN113362897A (zh) * | 2020-03-06 | 2021-09-07 | 福建和瑞基因科技有限公司 | 基于核小体分布特征的肿瘤标志物筛选方法及应用 |
| CA3177127A1 (en) | 2020-04-30 | 2021-11-04 | Guardant Health, Inc. | Methods for sequence determination using partitioned nucleic acids |
| CA3179853A1 (en) * | 2020-05-22 | 2021-11-25 | Diana ABDUEVA | Methods for characterizing cell-free nucleic acid fragments |
| CN111724860B (zh) * | 2020-06-18 | 2021-03-16 | 深圳吉因加医学检验实验室 | 一种基于测序数据识别染色质开放区域的方法及装置 |
| WO2023282916A1 (en) | 2021-07-09 | 2023-01-12 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
| ES2987661T3 (es) | 2020-07-10 | 2024-11-15 | Guardant Health Inc | Métodos de detección de reordenamientos genómicos utilizando ácidos nucleicos libres de células |
| CN111881418B (zh) * | 2020-07-27 | 2023-05-16 | 中国农业科学院农业信息研究所 | 一种基于二分法的大豆气象产量预测方法及系统 |
| ES3018032T3 (en) | 2020-07-30 | 2025-05-14 | Guardant Health Inc | Methods for isolating cell-free dna |
| CN112085067B (zh) * | 2020-08-17 | 2022-07-12 | 浙江大学 | 一种高通量筛选dna损伤反应抑制剂的方法 |
| JP2023540221A (ja) | 2020-08-25 | 2023-09-22 | ガーダント ヘルス, インコーポレイテッド | バリアントの起源を予測するための方法およびシステム |
| EP4214329A4 (en) * | 2020-09-17 | 2024-12-04 | The Regents of the University of Colorado, a body corporate | Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions |
| CA3193183A1 (en) | 2020-09-30 | 2022-04-07 | Andrew Kennedy | Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease |
| EP4232599A1 (en) | 2020-10-23 | 2023-08-30 | Guardant Health, Inc. | Compositions and methods for analyzing dna using partitioning and base conversion |
| EP4251765A1 (en) | 2020-11-30 | 2023-10-04 | Guardant Health, Inc. | Compositions and methods for enriching methylated polynucleotides |
| WO2022140629A1 (en) | 2020-12-23 | 2022-06-30 | Guardant Health, Inc. | Methods and systems for analyzing methylated polynucleotides |
| TW202242145A (zh) * | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| WO2022173698A1 (en) * | 2021-02-09 | 2022-08-18 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| WO2022174109A1 (en) | 2021-02-12 | 2022-08-18 | Guardant Health, Inc. | Methods and compositions for detecting nucleic acid variants |
| JP2024511425A (ja) | 2021-03-25 | 2024-03-13 | ガーダント ヘルス, インコーポレイテッド | 免疫細胞dnaを定量するための方法および組成物 |
| IL307524A (en) * | 2021-04-08 | 2023-12-01 | Delfi Diagnostics Inc | Method of detecting cancer using genome-wide cfdna fragmentation profiles |
| AU2022255198A1 (en) * | 2021-04-08 | 2023-11-23 | Fred Hutchinson Cancer Center | Cell-free dna sequence data analysis method to examine nucleosome protection and chromatin accessibility |
| WO2022271730A1 (en) | 2021-06-21 | 2022-12-29 | Guardant Health, Inc. | Methods and compositions for copy-number informed tissue-of-origin analysis |
| WO2023056065A1 (en) | 2021-09-30 | 2023-04-06 | Guardant Health, Inc. | Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements |
| WO2023197004A1 (en) | 2022-04-07 | 2023-10-12 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| GB202205710D0 (en) | 2022-04-19 | 2022-06-01 | Univ Of Essex Enterprises Limited | Cell-free DNA-based methods |
| EP4547857A1 (en) | 2022-06-30 | 2025-05-07 | Guardant Health, Inc. | Enrichment of aberrantly methylated dna |
| WO2024056720A1 (en) | 2022-09-13 | 2024-03-21 | Medizinische Universität Graz | Determining of health status and treatment monitoring with cell-free dna |
| JP2025532196A (ja) | 2022-09-27 | 2025-09-29 | ガーダント ヘルス, インコーポレイテッド | 免疫細胞dnaを定量するための方法 |
| EP4638782A2 (en) | 2022-12-22 | 2025-10-29 | Guardant Health, Inc. | Integrated targeted and whole genome somatic and dna methylation sequencing workflows |
| WO2024137880A2 (en) | 2022-12-22 | 2024-06-27 | Guardant Health, Inc. | Methods involving methylation preserving amplification with error correction |
| WO2024233502A1 (en) | 2023-05-05 | 2024-11-14 | Guardant Health, Inc. | Cell-free dna blood-based test for cancer screening |
| WO2025029475A1 (en) | 2023-07-28 | 2025-02-06 | Guardant Health, Inc. | Methods to enrich nucleotide variants by negative selection |
| WO2025038399A1 (en) | 2023-08-11 | 2025-02-20 | Guardant Health, Inc. | Methylated enrichment methods for single-molecule genetic and epigenetic sequencing |
| CN117230165A (zh) * | 2023-09-01 | 2023-12-15 | 深圳湾实验室 | 一种无创产前检测胎儿染色体拷贝数异常的优化方法 |
| WO2025064706A1 (en) | 2023-09-19 | 2025-03-27 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| WO2025076452A1 (en) | 2023-10-06 | 2025-04-10 | Guardant Health, Inc. | Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules |
| WO2025137389A2 (en) | 2023-12-22 | 2025-06-26 | Guardant Health, Inc. | Methods for targeted single-molecule genetic and epigenetic sequencing |
| WO2025207817A1 (en) | 2024-03-26 | 2025-10-02 | Guardant Health, Inc. | Method of determining the likelihood of a disease by combining biomarkers and imaging |
| WO2025208044A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for cancer detection using molecular patterns |
| WO2025235889A1 (en) | 2024-05-10 | 2025-11-13 | Guardant Health, Inc. | Methods involving multiplexed pooled pcr |
| WO2025250544A1 (en) | 2024-05-31 | 2025-12-04 | Guardant Health, Inc. | Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013177086A1 (en) * | 2012-05-21 | 2013-11-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0016742D0 (en) * | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| JP2002272497A (ja) | 2001-03-15 | 2002-09-24 | Venture Link Co Ltd | 癌の診断方法、およびその診断用ベクター |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| EP1524321B2 (en) | 2003-10-16 | 2014-07-23 | Sequenom, Inc. | Non-invasive detection of fetal genetic traits |
| US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
| EP2423334A3 (en) | 2006-02-02 | 2012-04-18 | The Board of Trustees of The Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| DK1996728T3 (da) | 2006-02-28 | 2011-08-15 | Univ Louisville Res Found | Detektering af føtale chromosomale abnormiteter under anvendelse af tandem-enkeltnukleotid-polymorfismer |
| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US7842482B2 (en) | 2007-02-26 | 2010-11-30 | The Chinese University Of Hong Kong | Methods and kits for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| KR102458210B1 (ko) | 2007-07-23 | 2022-10-24 | 더 차이니즈 유니버시티 오브 홍콩 | 핵산 서열 불균형의 결정 |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US8748100B2 (en) | 2007-08-30 | 2014-06-10 | The Chinese University Of Hong Kong | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences |
| WO2009051842A2 (en) | 2007-10-18 | 2009-04-23 | The Johns Hopkins University | Detection of cancer by measuring genomic copy number and strand length in cell-free dna |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| ES2620012T3 (es) | 2008-09-20 | 2017-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnóstico no invasivo de la aneuploidia fetal por secuenciación |
| US8835110B2 (en) | 2008-11-04 | 2014-09-16 | The Johns Hopkins University | DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy |
| AU2010230417B2 (en) | 2009-03-31 | 2013-10-10 | Oridis Biomarkers Gmbh | Method for diagnosis of cancer and monitoring of cancer treatments |
| WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
| LT3783110T (lt) | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US8620593B2 (en) | 2009-11-06 | 2013-12-31 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
| WO2011103236A2 (en) * | 2010-02-18 | 2011-08-25 | The Johns Hopkins University | Personalized tumor biomarkers |
| WO2012027483A2 (en) * | 2010-08-24 | 2012-03-01 | Bio Dx, Inc. | Defining diagnostic and therapeutic targets of conserved free floating fetal dna in maternal circulating blood |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| EA038374B1 (ru) | 2010-11-30 | 2021-08-17 | Те Чайниз Юниверсити Ов Гонконг | Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком |
| EP2758538B1 (en) | 2011-09-22 | 2018-10-31 | Lineage Biosciences, Inc. | Methods for analyzing heterogeneous samples |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013060762A1 (en) | 2011-10-25 | 2013-05-02 | Roche Diagnostics Gmbh | Method for diagnosing a disease based on plasma-dna distribution |
| US9757458B2 (en) | 2011-12-05 | 2017-09-12 | Immunomedics, Inc. | Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells |
| WO2013113012A2 (en) | 2012-01-27 | 2013-08-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| EP3757210B1 (en) * | 2012-03-02 | 2022-08-24 | Sequenom, Inc. | Methods for enriching cancer nucleic acid from a biological sample |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013138527A1 (en) | 2012-03-13 | 2013-09-19 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
| US20150105267A1 (en) * | 2012-05-24 | 2015-04-16 | University Of Washington Through Its Center For Commercialization | Whole genome sequencing of a human fetus |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| CN110872617A (zh) | 2012-09-04 | 2020-03-10 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| WO2014039729A1 (en) * | 2012-09-05 | 2014-03-13 | Stamatoyannopoulos John A | Methods and compositions related to regulation of nucleic acids |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| BR112015006183B1 (pt) | 2012-09-20 | 2022-04-26 | The Chinese University Of Hong Kong | Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal |
| CN105555968B (zh) * | 2013-05-24 | 2020-10-23 | 塞昆纳姆股份有限公司 | 遗传变异的非侵入性评估方法和过程 |
| ES2704682T5 (es) * | 2013-05-29 | 2023-11-10 | Chronix Biomedical | Detección y cuantificación de ADN extracelular del donante en la circulación de receptores de trasplantes de órganos |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| EP3561075A1 (en) * | 2014-04-21 | 2019-10-30 | Natera, Inc. | Detecting mutations in tumour biopsies and cell-free samples |
| EP3149199B1 (en) * | 2014-05-30 | 2020-03-25 | Verinata Health, Inc. | Detecting, optionally fetal, sub-chromosomal aneuploidies and copy number variations |
| TWI727156B (zh) | 2014-07-18 | 2021-05-11 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
| US10319463B2 (en) | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| EP4279612B1 (en) | 2015-07-23 | 2025-07-02 | The Chinese University of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
-
2015
- 2015-07-27 EP EP23197187.0A patent/EP4358097A1/en active Pending
- 2015-07-27 KR KR1020177004904A patent/KR102441391B1/ko active Active
- 2015-07-27 JP JP2017525327A patent/JP2017522908A/ja active Pending
- 2015-07-27 US US15/329,228 patent/US20170211143A1/en not_active Abandoned
- 2015-07-27 EP EP15824425.1A patent/EP3172341A4/en not_active Withdrawn
- 2015-07-27 CN CN202311109971.5A patent/CN117402950A/zh active Pending
- 2015-07-27 AU AU2015292311A patent/AU2015292311B2/en active Active
- 2015-07-27 WO PCT/US2015/042310 patent/WO2016015058A2/en not_active Ceased
- 2015-07-27 CN CN201580052170.7A patent/CN107002122B/zh active Active
- 2015-07-27 CA CA2956208A patent/CA2956208C/en active Active
- 2015-07-27 KR KR1020227030533A patent/KR102696857B1/ko active Active
-
2018
- 2018-10-15 US US16/160,990 patent/US20190127794A1/en not_active Abandoned
-
2020
- 2020-05-21 US US16/880,884 patent/US11352670B2/en active Active
- 2020-12-08 JP JP2020203304A patent/JP2021045161A/ja active Pending
-
2022
- 2022-04-20 AU AU2022202587A patent/AU2022202587B2/en active Active
- 2022-06-06 US US17/805,656 patent/US20230212672A1/en active Pending
-
2023
- 2023-05-19 JP JP2023082794A patent/JP7681641B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013177086A1 (en) * | 2012-05-21 | 2013-11-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
Non-Patent Citations (3)
| Title |
|---|
| CLAUDIA H. D. METZ ET AL, "Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma", CANCER MEDICINE, GB, (2013-02-14), vol. 2, no. 2, pages 208 - 215 * |
| R. J. LEARY ET AL, "Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing", SCIENCE TRANSLATIONAL MEDICINE, US, (2010-02-24), vol. 2, no. 20, 4, pages 20ra14 - 20ra14 * |
| T. FORSHEW ET AL, "Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA", SCIENCE TRANSLATIONAL MEDICINE, US, (2012-05-30), vol. 4, no. 136, pages 136ra68 - 136ra68 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11352670B2 (en) | 2022-06-07 |
| JP7681641B2 (ja) | 2025-05-22 |
| US20230212672A1 (en) | 2023-07-06 |
| CN117402950A (zh) | 2024-01-16 |
| CN107002122B (zh) | 2023-09-19 |
| JP2017522908A (ja) | 2017-08-17 |
| AU2022202587B2 (en) | 2024-07-04 |
| EP3172341A4 (en) | 2018-03-28 |
| JP2023123420A (ja) | 2023-09-05 |
| JP2021045161A (ja) | 2021-03-25 |
| KR102696857B1 (ko) | 2024-08-19 |
| KR102441391B1 (ko) | 2022-09-07 |
| KR20170044660A (ko) | 2017-04-25 |
| US20210010081A1 (en) | 2021-01-14 |
| CA2956208C (en) | 2025-07-08 |
| EP3172341A2 (en) | 2017-05-31 |
| CN107002122A (zh) | 2017-08-01 |
| AU2022202587A1 (en) | 2022-05-26 |
| CA2956208A1 (en) | 2016-01-28 |
| WO2016015058A3 (en) | 2016-03-17 |
| EP4358097A1 (en) | 2024-04-24 |
| AU2015292311A1 (en) | 2017-03-09 |
| KR20220127359A (ko) | 2022-09-19 |
| WO2016015058A2 (en) | 2016-01-28 |
| US20190127794A1 (en) | 2019-05-02 |
| US20170211143A1 (en) | 2017-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11352670B2 (en) | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same | |
| Snyder et al. | Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin | |
| CN113096726B (zh) | 使用无细胞dna片段尺寸以确定拷贝数变异 | |
| KR101795124B1 (ko) | 복제 수 변이를 검측하기 위한 방법 및 시스템 | |
| RU2018121254A (ru) | Высокоэффективное построение библиотек днк | |
| CN113337604A (zh) | 循环核酸肿瘤标志物的鉴别和用途 | |
| EP3555311B1 (en) | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample | |
| WO2014039729A1 (en) | Methods and compositions related to regulation of nucleic acids | |
| CN105793438B (zh) | 未知序列的双股线性核酸的全长扩增方法 | |
| US20220403467A1 (en) | Determining cell type origin of circulating cell-free dna with molecular counting | |
| HK40110787A (en) | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same | |
| TW202237856A (zh) | 使用尿液及其他dna特徵之方法 | |
| US20250364139A1 (en) | Tumor marker selection and detection | |
| US20250361564A1 (en) | Orthogonal validation of tumor assays | |
| CN108796056A (zh) | 基于游离dna的目标基因捕获技术进行组织溯源的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |