JP2017522908A5 - - Google Patents
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- JP2017522908A5 JP2017522908A5 JP2017525327A JP2017525327A JP2017522908A5 JP 2017522908 A5 JP2017522908 A5 JP 2017522908A5 JP 2017525327 A JP2017525327 A JP 2017525327A JP 2017525327 A JP2017525327 A JP 2017525327A JP 2017522908 A5 JP2017522908 A5 JP 2017522908A5
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- Prior art keywords
- cfdna
- determining
- function
- fragments
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000010099 disease Diseases 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
Claims (1)
- 対象者における疾患又は異常を識別する方法であって、
当該対象者からの生物学的サンプルからセルフリーDNA(cfDNA)を単離する工程であって、当該単離cfDNAが複数のcfDNAフラグメントを含む、前記工程；
当該複数のcfDNAフラグメントの少なくとも一部分に付随する配列を決定する工程；
当該複数のcfDNAフラグメントの少なくともいくつかのcfDNAフラグメント末端に対する参照ゲノム内のゲノム上の場所を当該cfDNAフラグメント配列の関数として決定する工程；
当該cfDNAを生じる組織及び/又は細胞タイプの少なくともいくつかを、当該cfDNAフラグメント末端の少なくともいくつかのゲノム上の場所の関数として決定する工程；及び
当該疾患又は異常を、当該cfDNAを生じると決定された組織及び/又は細胞タイプの関数と認定する工程を含む、
前記方法。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029178P | 2014-07-25 | 2014-07-25 | |
| US62/029,178 | 2014-07-25 | ||
| US201462087619P | 2014-12-04 | 2014-12-04 | |
| US62/087,619 | 2014-12-04 | ||
| PCT/US2015/042310 WO2016015058A2 (en) | 2014-07-25 | 2015-07-27 | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020203304A Division JP2021045161A (ja) | 2014-07-25 | 2020-12-08 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522908A JP2017522908A (ja) | 2017-08-17 |
| JP2017522908A5 true JP2017522908A5 (ja) | 2018-09-06 |
Family
ID=55163988
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525327A Pending JP2017522908A (ja) | 2014-07-25 | 2015-07-27 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
| JP2020203304A Pending JP2021045161A (ja) | 2014-07-25 | 2020-12-08 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
| JP2023082794A Pending JP2023123420A (ja) | 2014-07-25 | 2023-05-19 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020203304A Pending JP2021045161A (ja) | 2014-07-25 | 2020-12-08 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
| JP2023082794A Pending JP2023123420A (ja) | 2014-07-25 | 2023-05-19 | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20170211143A1 (ja) |
| EP (2) | EP4358097A1 (ja) |
| JP (3) | JP2017522908A (ja) |
| KR (2) | KR20220127359A (ja) |
| CN (2) | CN117402950A (ja) |
| AU (1) | AU2015292311B2 (ja) |
| CA (1) | CA2956208A1 (ja) |
| WO (1) | WO2016015058A2 (ja) |
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-
2015
- 2015-07-27 US US15/329,228 patent/US20170211143A1/en not_active Abandoned
- 2015-07-27 JP JP2017525327A patent/JP2017522908A/ja active Pending
- 2015-07-27 EP EP23197187.0A patent/EP4358097A1/en active Pending
- 2015-07-27 KR KR1020227030533A patent/KR20220127359A/ko active IP Right Grant
- 2015-07-27 WO PCT/US2015/042310 patent/WO2016015058A2/en active Application Filing
- 2015-07-27 AU AU2015292311A patent/AU2015292311B2/en active Active
- 2015-07-27 KR KR1020177004904A patent/KR102441391B1/ko active IP Right Grant
- 2015-07-27 CA CA2956208A patent/CA2956208A1/en active Pending
- 2015-07-27 CN CN202311109971.5A patent/CN117402950A/zh active Pending
- 2015-07-27 CN CN201580052170.7A patent/CN107002122B/zh active Active
- 2015-07-27 EP EP15824425.1A patent/EP3172341A4/en not_active Withdrawn
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2018
- 2018-10-15 US US16/160,990 patent/US20190127794A1/en not_active Abandoned
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2020
- 2020-05-21 US US16/880,884 patent/US11352670B2/en active Active
- 2020-12-08 JP JP2020203304A patent/JP2021045161A/ja active Pending
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2022
- 2022-06-06 US US17/805,656 patent/US20230212672A1/en active Pending
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- 2023-05-19 JP JP2023082794A patent/JP2023123420A/ja active Pending
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