JP2017521436A5 - - Google Patents
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- JP2017521436A5 JP2017521436A5 JP2017501154A JP2017501154A JP2017521436A5 JP 2017521436 A5 JP2017521436 A5 JP 2017521436A5 JP 2017501154 A JP2017501154 A JP 2017501154A JP 2017501154 A JP2017501154 A JP 2017501154A JP 2017521436 A5 JP2017521436 A5 JP 2017521436A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- heteroatoms
- alkyl group
- membered ring
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005842 heteroatom Chemical group 0.000 claims description 16
- 229910052717 sulfur Inorganic materials 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 3
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410317076.7A CN105330698B (zh) | 2014-07-04 | 2014-07-04 | 螺环芳基磷氧化物和硫化物 |
| CN201410317076.7 | 2014-07-04 | ||
| CN201510350019 | 2015-06-23 | ||
| CN201510350019.3 | 2015-06-23 | ||
| PCT/CN2015/082605 WO2016000581A1 (zh) | 2014-07-04 | 2015-06-29 | 螺环芳基磷氧化物和芳基磷硫化物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521436A JP2017521436A (ja) | 2017-08-03 |
| JP2017521436A5 true JP2017521436A5 (OSRAM) | 2019-02-14 |
| JP6487527B2 JP6487527B2 (ja) | 2019-03-20 |
Family
ID=55018447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501154A Active JP6487527B2 (ja) | 2014-07-04 | 2015-06-29 | スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ） |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10053477B2 (OSRAM) |
| EP (1) | EP3165530B1 (OSRAM) |
| JP (1) | JP6487527B2 (OSRAM) |
| ES (1) | ES2714576T3 (OSRAM) |
| PL (1) | PL3165530T3 (OSRAM) |
| TW (1) | TWI571471B (OSRAM) |
| WO (1) | WO2016000581A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10053477B2 (en) | 2014-07-04 | 2018-08-21 | Qilu Pharmaceutical Co., Ltd. | Spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide |
| JP6717457B2 (ja) | 2017-01-23 | 2020-07-01 | シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド | Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体 |
| WO2019027860A1 (en) * | 2017-08-01 | 2019-02-07 | Boehringer Ingelheim International Gmbh | INTERMEDIATE COMPOUNDS AND METHODS |
| JP7085242B2 (ja) * | 2017-12-21 | 2022-06-16 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのアリールホスフィンオキシド |
| WO2019120121A1 (zh) * | 2017-12-21 | 2019-06-27 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制激酶活性的二苯氨基嘧啶类化合物 |
| US11046720B2 (en) * | 2018-04-20 | 2021-06-29 | Guizhou Inochini Technology Co., Ltd | Dimethylphosphine oxide compound |
| WO2020147702A1 (en) * | 2019-01-17 | 2020-07-23 | Betta Pharmaceuticals Co., Ltd | Egfr inhibitors, compositions and methods thereof |
| IL293965A (en) | 2019-12-19 | 2022-08-01 | Janssen Pharmaceutica Nv | History of Spiro straight chain transformed |
| EP4306115A4 (en) * | 2021-07-05 | 2024-11-20 | Qilu Pharmaceutical Co., Ltd. | Pharmaceutical composition, and preparation method therefor and application thereof |
| WO2023078411A1 (zh) * | 2021-11-05 | 2023-05-11 | 南京明德新药研发有限公司 | 氮杂螺环化合物 |
| CN118338913A (zh) * | 2022-01-18 | 2024-07-12 | 齐鲁制药有限公司 | 螺环芳基磷氧化物与抗vegf抗体的药物组合 |
| TW202339767A (zh) * | 2022-01-18 | 2023-10-16 | 大陸商齊魯製藥有限公司 | 螺環芳基磷氧化物與抗ｅｇｆｒ抗體的聯用藥物組合物及其用途 |
| CN118891264A (zh) * | 2022-08-01 | 2024-11-01 | 齐鲁制药有限公司 | 螺环胺类芳基磷氧化合物的晶型及其制备方法 |
| WO2025202955A1 (en) | 2024-03-28 | 2025-10-02 | Pi Industries Ltd. | Fused bicyclic compounds and their use as pest control agents |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| US9273077B2 (en) * | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PL2300013T5 (pl) | 2008-05-21 | 2025-04-28 | Takeda Pharmaceutical Company Limited | Pochodne fosforu jako inhibitor kinazy |
| JP2013509412A (ja) * | 2009-11-02 | 2013-03-14 | アボット・ラボラトリーズ | 多標的キナーゼ阻害における新規な足場としてのイミダゾピリジン類 |
| US20130288240A1 (en) * | 2010-05-21 | 2013-10-31 | Cell Signaling Technology, Inc. | Alk and ros kinase in cancer |
| BR112013008816A2 (pt) | 2010-10-14 | 2016-06-28 | Ariad Pharma Inc | método de tratamento de câncer direcionado ao egfr resistente à erlotinibe ou gefitinibe, ou uso de um sal farmacêuticamente aceito em um indivíduo |
| FR2974088A1 (fr) | 2011-04-12 | 2012-10-19 | Pf Medicament | Composes pyrazolo[3,4-b]pyridines tri- et tetracycliques comme agent anticancereux |
| CN102731413A (zh) | 2011-04-15 | 2012-10-17 | 上海医药工业研究院 | 一种脲类化合物、其制备方法、其中间体及其应用 |
| WO2013138210A1 (en) | 2012-03-14 | 2013-09-19 | Ning Xi | Substituted cyclic compounds and methods of use |
| WO2013148857A1 (en) | 2012-03-28 | 2013-10-03 | Synta Pharmaceuticals Corp. | Triazole derivatives as hsp90 inhibitors |
| JP6469567B2 (ja) * | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| US20130310340A1 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| WO2013177092A1 (en) | 2012-05-23 | 2013-11-28 | Sunshine Lake Pharma Co., Ltd. | Substituted alkynyl pyridine compounds and methods of use |
| WO2013192512A1 (en) | 2012-06-22 | 2013-12-27 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| WO2014002922A1 (ja) | 2012-06-26 | 2014-01-03 | アステラス製薬株式会社 | 抗癌剤の併用による癌治療方法 |
| EP2867233A1 (en) | 2012-07-03 | 2015-05-06 | Aurigene Discovery Technologies Limited | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
| KR101446742B1 (ko) | 2012-08-10 | 2014-10-01 | 한국화학연구원 | Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| AU2013307383A1 (en) | 2012-08-27 | 2015-03-26 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Aminoheteroaryl compounds as MTH1 inhibitors |
| US10053477B2 (en) | 2014-07-04 | 2018-08-21 | Qilu Pharmaceutical Co., Ltd. | Spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide |
-
2015
- 2015-06-29 US US15/322,854 patent/US10053477B2/en active Active
- 2015-06-29 EP EP15814466.7A patent/EP3165530B1/en active Active
- 2015-06-29 JP JP2017501154A patent/JP6487527B2/ja active Active
- 2015-06-29 ES ES15814466T patent/ES2714576T3/es active Active
- 2015-06-29 PL PL15814466T patent/PL3165530T3/pl unknown
- 2015-06-29 WO PCT/CN2015/082605 patent/WO2016000581A1/zh not_active Ceased
- 2015-07-01 TW TW104121403A patent/TWI571471B/zh active
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