JP2017521057A5 - - Google Patents
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- JP2017521057A5 JP2017521057A5 JP2016572251A JP2016572251A JP2017521057A5 JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5 JP 2016572251 A JP2016572251 A JP 2016572251A JP 2016572251 A JP2016572251 A JP 2016572251A JP 2017521057 A5 JP2017521057 A5 JP 2017521057A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- culture
- cell culture
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims 49
- 238000004113 cell culture Methods 0.000 claims 28
- 239000001963 growth medium Substances 0.000 claims 18
- 210000004962 mammalian cell Anatomy 0.000 claims 13
- 230000010412 perfusion Effects 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 238000010257 thawing Methods 0.000 claims 4
- 238000003306 harvesting Methods 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000011437 continuous method Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 8
- 239000012528 membrane Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009553P | 2014-06-09 | 2014-06-09 | |
| US62/009,553 | 2014-06-09 | ||
| PCT/US2015/034709 WO2015191462A1 (en) | 2014-06-09 | 2015-06-08 | Seed train processes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Division JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521057A JP2017521057A (ja) | 2017-08-03 |
| JP2017521057A5 true JP2017521057A5 (enExample) | 2018-07-12 |
| JP6784600B2 JP6784600B2 (ja) | 2020-11-11 |
Family
ID=53477008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572251A Active JP6784600B2 (ja) | 2014-06-09 | 2015-06-08 | シードトレイン法およびその使用 |
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177043A Active JP7089000B2 (ja) | 2014-06-09 | 2020-10-22 | シードトレイン法およびその使用 |
| JP2022092635A Active JP7360504B2 (ja) | 2014-06-09 | 2022-06-08 | シードトレイン法およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10570367B2 (enExample) |
| EP (3) | EP3858983B1 (enExample) |
| JP (3) | JP6784600B2 (enExample) |
| KR (2) | KR102416402B1 (enExample) |
| CN (2) | CN106574249B (enExample) |
| AU (3) | AU2015274897B2 (enExample) |
| BR (1) | BR112016028891B1 (enExample) |
| CA (1) | CA2951551C (enExample) |
| CY (1) | CY1122803T1 (enExample) |
| DK (1) | DK3152299T3 (enExample) |
| ES (2) | ES3043610T3 (enExample) |
| HU (1) | HUE047683T2 (enExample) |
| IL (3) | IL290096B2 (enExample) |
| MX (2) | MX373323B (enExample) |
| RU (1) | RU2694327C2 (enExample) |
| SG (1) | SG11201610216UA (enExample) |
| TW (3) | TWI776235B (enExample) |
| WO (1) | WO2015191462A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| HUE042094T2 (hu) | 2013-02-22 | 2019-06-28 | Genzyme Corp | Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
| EP3368176A2 (en) * | 2015-10-26 | 2018-09-05 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
| WO2018116967A1 (ja) * | 2016-12-22 | 2018-06-28 | 東亞合成株式会社 | 接着剤組成物並びにこれを用いたカバーレイフィルム、ボンディングシート、銅張積層板及び電磁波シールド材 |
| US20200255785A1 (en) * | 2017-09-15 | 2020-08-13 | Bristol-Myers Squibb Company | Online biomass capacitance monitoring during large scale production of polypeptides of interest |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP3650528A1 (en) | 2018-11-08 | 2020-05-13 | Aglaris Ltd | Cell culture system and method |
| JP7365419B2 (ja) * | 2019-01-25 | 2023-10-19 | エンゼン・バイオサイエンシズ・リミテッド | 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス |
| SG11202107441RA (en) * | 2019-02-15 | 2021-08-30 | Just Evotec Biologics Inc | Automated biomanufacturing systems, facilities, and processes |
| EP3976762A1 (en) * | 2019-05-24 | 2022-04-06 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
| GB201908612D0 (en) * | 2019-06-17 | 2019-07-31 | Ge Healthcare Bio Sciences Ab | A method for separating biomolecules |
| US11713442B2 (en) * | 2019-06-17 | 2023-08-01 | Deka Products Limited Partnership | System and method for cell and tissue preparation |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP3831924A1 (en) * | 2019-12-03 | 2021-06-09 | Sartorius Stedim Data Analytics AB | Adapting control of a cell culture in a production scale vessel with regard to a starting medium |
| TW202405159A (zh) * | 2022-06-28 | 2024-02-01 | 美商安進公司 | 用於治療性產品製造的靈活的設施配置 |
| JP2025527931A (ja) * | 2022-09-06 | 2025-08-22 | アムジェン インコーポレイテッド | 大規模バイオリアクタシステム及び方法 |
| IL322954A (en) * | 2023-03-13 | 2025-10-01 | Amgen Inc | Systems and methods for optimizing seed crops |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| RU2058992C1 (ru) * | 1993-07-14 | 1996-04-27 | Антипин Георгий Васильевич | Способ получения кормового белка и устройство для его осуществления |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| RU2215748C2 (ru) * | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| ES2276853T3 (es) | 2000-12-20 | 2007-07-01 | Bayer Pharmaceuticals Corporation | Dispositivo y procedimiento para expansion en serie de semillas de celulas de mamifero. |
| JP2005509406A (ja) | 2001-05-09 | 2005-04-14 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 哺乳動物細胞株のための低温保存袋アセンブリー |
| AU2002333739B2 (en) | 2001-08-31 | 2007-08-02 | Bayer Intellectual Property Gmbh | A unit and a process for carrying out high cell density fermentation |
| HUP0402158A2 (hu) | 2001-10-02 | 2005-01-28 | Novo Nordisk Health Care Ag | Rekombináns fehérjék előállítási eljárása eukarióta sejtekben |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| US6953692B2 (en) * | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US20050019914A1 (en) * | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| BE1016538A3 (fr) | 2004-02-20 | 2007-01-09 | Cesco Bioengineering Co Ltd | Appareil et procede pour la preparation et la mise en culture de cellules. |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| EP1789528A4 (en) | 2004-09-16 | 2011-07-20 | Becton Dickinson Co | BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION |
| NZ588616A (en) | 2004-09-30 | 2012-05-25 | Bayer Healthcare Llc | An apparatus for separating a protein of interest comprising a purification system integrated with a particle removal system |
| US20080199958A1 (en) | 2005-06-15 | 2008-08-21 | Amprotein Corporation | Suspension Culture Vessels |
| WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| WO2008024769A2 (en) | 2006-08-21 | 2008-02-28 | Raven Biotechnologies, Inc. | Intensified perfusion production method |
| US20080207487A1 (en) | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| WO2008106515A1 (en) | 2007-02-27 | 2008-09-04 | The Board Of Trustees Of The University Of Illinois | Insert device for multiwell plate |
| DK2126093T3 (da) * | 2007-03-02 | 2013-01-07 | Boehringer Ingelheim Pharma | Forbedring af proteinfremstilling |
| CN101678244B (zh) | 2007-04-17 | 2013-06-19 | 深度控股有限公司 | 用于连续膜吸附的方法和装置 |
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| EP2188371B1 (en) | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
| US20090233334A1 (en) | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
| DE102008019691A1 (de) | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
| US20100076380A1 (en) | 2008-06-16 | 2010-03-25 | Amprotein Corporation | Bioreactors |
| US8728479B2 (en) | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| MX382080B (es) | 2009-07-06 | 2025-03-13 | Genentech Inc | Método para cultivar células eucariónticas. |
| US20130260419A1 (en) * | 2010-12-06 | 2013-10-03 | Thomas C. Ransohoff | Continuous processing methods for biological products |
| SG191745A1 (en) | 2011-01-17 | 2013-08-30 | Hoffmann La Roche | Separation apparatus and use thereof |
| EP2707488B1 (en) | 2011-05-12 | 2017-11-15 | ProBioGen AG | Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase |
| IL315908A (en) * | 2011-07-01 | 2024-11-01 | Amgen Inc | Mammalian cell culture |
| AR089231A1 (es) * | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
| WO2013116449A1 (en) | 2012-02-02 | 2013-08-08 | Corning Incorporated | Automatic continuous perfusion cell culture microplate consumables |
| SG10201607963SA (en) | 2012-04-01 | 2016-11-29 | Emd Millipore Corp | Cell culture and gradient migration assay method and devices |
| CN104903436B (zh) | 2012-10-23 | 2018-03-30 | 建新公司 | 灌注培养方法及其用途 |
| HUE042094T2 (hu) | 2013-02-22 | 2019-06-28 | Genzyme Corp | Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk |
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN118388581A (zh) | 2013-03-08 | 2024-07-26 | 建新公司 | 治疗性蛋白药物物质的整合连续制造 |
| US10188099B2 (en) | 2013-03-15 | 2019-01-29 | Genzyme Corporation | High density cell banking methods |
| BR122021001466B1 (pt) | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| JP2017500017A (ja) * | 2013-12-20 | 2017-01-05 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| EA039148B1 (ru) | 2014-06-04 | 2021-12-10 | Эмджен Инк. | Способ сбора рекомбинантного белка |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
-
2015
- 2015-06-05 TW TW109131864A patent/TWI776235B/zh active
- 2015-06-05 TW TW104118240A patent/TWI707949B/zh active
- 2015-06-05 TW TW111129481A patent/TW202246486A/zh unknown
- 2015-06-08 ES ES21161811T patent/ES3043610T3/es active Active
- 2015-06-08 SG SG11201610216UA patent/SG11201610216UA/en unknown
- 2015-06-08 EP EP21161811.1A patent/EP3858983B1/en active Active
- 2015-06-08 AU AU2015274897A patent/AU2015274897B2/en active Active
- 2015-06-08 CN CN201580042488.7A patent/CN106574249B/zh active Active
- 2015-06-08 IL IL290096A patent/IL290096B2/en unknown
- 2015-06-08 CA CA2951551A patent/CA2951551C/en active Active
- 2015-06-08 BR BR112016028891-2A patent/BR112016028891B1/pt active IP Right Grant
- 2015-06-08 HU HUE15730933A patent/HUE047683T2/hu unknown
- 2015-06-08 US US14/733,630 patent/US10570367B2/en active Active
- 2015-06-08 EP EP15730933.7A patent/EP3152299B1/en not_active Revoked
- 2015-06-08 CN CN202010299662.9A patent/CN111575225B/zh active Active
- 2015-06-08 KR KR1020177000249A patent/KR102416402B1/ko active Active
- 2015-06-08 DK DK15730933.7T patent/DK3152299T3/da active
- 2015-06-08 EP EP19209942.2A patent/EP3628730A1/en active Pending
- 2015-06-08 WO PCT/US2015/034709 patent/WO2015191462A1/en not_active Ceased
- 2015-06-08 JP JP2016572251A patent/JP6784600B2/ja active Active
- 2015-06-08 ES ES15730933T patent/ES2773630T3/es active Active
- 2015-06-08 RU RU2016151316A patent/RU2694327C2/ru active
- 2015-06-08 KR KR1020227022305A patent/KR102584375B1/ko active Active
- 2015-06-08 MX MX2016016301A patent/MX373323B/es active IP Right Grant
-
2016
- 2016-12-08 IL IL249452A patent/IL249452B/en active IP Right Grant
- 2016-12-08 MX MX2020004073A patent/MX2020004073A/es unknown
-
2020
- 2020-02-19 CY CY20201100157T patent/CY1122803T1/el unknown
- 2020-02-24 US US16/799,592 patent/US20200377850A1/en not_active Abandoned
- 2020-10-22 JP JP2020177043A patent/JP7089000B2/ja active Active
-
2021
- 2021-03-18 IL IL281626A patent/IL281626B/en unknown
- 2021-10-05 AU AU2021245116A patent/AU2021245116B2/en active Active
-
2022
- 2022-06-08 JP JP2022092635A patent/JP7360504B2/ja active Active
-
2023
- 2023-06-15 AU AU2023203734A patent/AU2023203734A1/en not_active Abandoned
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