|
GB335768A
(en)
|
1929-10-24 |
1930-10-02 |
Jacoviac Maurice |
Improvements in protecting devices for gramophone disc records
|
|
US4938949A
(en)
|
1988-09-12 |
1990-07-03 |
University Of New York |
Treatment of damaged bone marrow and dosage units therefor
|
|
ATE102631T1
(de)
|
1988-11-11 |
1994-03-15 |
Medical Res Council |
Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
WO1994002610A1
(en)
|
1992-07-17 |
1994-02-03 |
Dana-Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
DE69330523D1
(de)
|
1992-08-21 |
2001-09-06 |
Vrije Universiteit Brussel Bru |
Immunoglobuline ohne leichte ketten
|
|
ES2162863T3
(es)
|
1993-04-29 |
2002-01-16 |
Unilever Nv |
Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
|
|
ES2155854T3
(es)
|
1993-06-09 |
2001-06-01 |
Unilever Nv |
Procedimiento de produccion de proteinas de fusion que comprende fragmentos de scfv con la ayuda de un molde transformado.
|
|
FR2708622B1
(fr)
|
1993-08-02 |
1997-04-18 |
Raymond Hamers |
Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
DE69435112D1
(de)
|
1993-09-10 |
2008-08-21 |
Univ Columbia |
Verwendung von grünem fluoreszenzprotein
|
|
WO1995021191A1
(en)
|
1994-02-04 |
1995-08-10 |
William Ward |
Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
|
|
WO1995022618A1
(en)
|
1994-02-22 |
1995-08-24 |
Dana-Farber Cancer Institute |
Nucleic acid delivery system, method of synthesis and uses thereof
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
US5693492A
(en)
|
1995-05-05 |
1997-12-02 |
Merck & Co., Inc. |
DNA encoding glutamate gated chloride channels
|
|
CA2232727C
(en)
|
1995-09-22 |
2002-03-26 |
Novo Nordisk A/S |
Novel variants of green fluorescent protein, gfp
|
|
US6027881A
(en)
|
1996-05-08 |
2000-02-22 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
|
|
ES2294799T3
(es)
|
1996-06-27 |
2008-04-01 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. |
Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana.
|
|
US6124128A
(en)
|
1996-08-16 |
2000-09-26 |
The Regents Of The University Of California |
Long wavelength engineered fluorescent proteins
|
|
WO1998021355A1
(en)
|
1996-11-15 |
1998-05-22 |
Life Technologies, Inc. |
Mutants of green fluorescent protein
|
|
AU7298398A
(en)
|
1996-11-19 |
1998-06-10 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US6329516B1
(en)
|
1997-04-28 |
2001-12-11 |
Fmc Corporation |
Lepidopteran GABA-gated chloride channels
|
|
BR9813276A
(pt)
|
1997-10-27 |
2000-08-22 |
Unilever Nv |
Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma
|
|
WO1999037681A2
(en)
|
1998-01-26 |
1999-07-29 |
Unilever Plc |
Method for producing antibody fragments
|
|
CN1316910A
(zh)
|
1998-02-19 |
2001-10-10 |
埃克斯西特治疗公司 |
用于调节淋巴细胞活化的组合物及方法
|
|
EP0967284A1
(en)
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
BR9916765A
(pt)
|
1999-01-05 |
2001-09-25 |
Unilever Nv |
Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico
|
|
WO2000043507A1
(en)
|
1999-01-19 |
2000-07-27 |
Unilever Plc |
Method for producing antibody fragments
|
|
WO2000046383A2
(en)
|
1999-02-05 |
2000-08-10 |
Rijksuniversiteit Leiden |
Method of modulating metabolite biosynthesis in recombinant cells
|
|
AU784108B2
(en)
|
1999-03-15 |
2006-02-02 |
University Of British Columbia, The |
Methods and reagents for modulating cholesterol levels
|
|
AP1447A
(en)
|
1999-04-22 |
2005-08-12 |
Unilever Plc |
Inhibition of viral infection using monovalent antigen-binding proteins.
|
|
CA2375781A1
(en)
|
1999-06-18 |
2000-12-28 |
Cv Therapeutics, Inc. |
Compositions and methods for increasing cholesterol efflux and raising hdl using atp binding cassette transporter protein abci
|
|
EP1198572A2
(en)
|
1999-08-02 |
2002-04-24 |
Keygene N.V. |
Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants
|
|
GB9922124D0
(en)
|
1999-09-17 |
1999-11-17 |
Pfizer Ltd |
Phosphodiesterase enzymes
|
|
US6479280B1
(en)
|
1999-09-24 |
2002-11-12 |
Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw |
Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
|
|
US6849425B1
(en)
|
1999-10-14 |
2005-02-01 |
Ixsys, Inc. |
Methods of optimizing antibody variable region binding affinity
|
|
DE19955408A1
(de)
|
1999-11-18 |
2001-05-23 |
Bayer Ag |
GABA-B-Rezeptoren
|
|
ES2331051T3
(es)
|
1999-11-29 |
2009-12-21 |
Bac Ip B.V. |
Inmovilizacion de moleculas de union de antigenos de un dominio.
|
|
US7358096B1
(en)
|
1999-11-29 |
2008-04-15 |
Conopco, Inc. |
Immobilisation of proteins
|
|
JP2003518075A
(ja)
|
1999-12-24 |
2003-06-03 |
ジェネンテック・インコーポレーテッド |
生理活性化合物の消失半減期延長のための方法及び組成物
|
|
EP1134231B1
(en)
|
2000-03-14 |
2009-04-15 |
Unilever N.V. |
Antibody heavy chain variable domains against human dietary lipases, and their uses
|
|
US20030190598A1
(en)
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
EP1360207B1
(en)
|
2000-12-13 |
2011-06-22 |
Bac Ip B.V. |
Protein arrays of camelid heavy-chain immunoglobulin variable domains
|
|
US7054297B1
(en)
|
2000-12-28 |
2006-05-30 |
Cisco Technology, Inc. |
Distribution of packets to high data rate communications devices using multicast protocols
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
EP2316951A1
(en)
|
2001-01-17 |
2011-05-04 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2440582A1
(en)
|
2001-03-09 |
2002-10-03 |
Dyax Corp. |
Serum albumin binding moieties
|
|
WO2003002609A2
(en)
|
2001-06-28 |
2003-01-09 |
Domantis Limited |
Dual-specific ligand and its use
|
|
US20060073141A1
(en)
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
EP1425694A2
(en)
|
2001-08-03 |
2004-06-09 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
WO2003025020A1
(en)
|
2001-09-13 |
2003-03-27 |
Institute For Antibodies Co., Ltd. |
Method of constructing camel antibody library
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
AU2002351896A1
(en)
|
2001-12-11 |
2003-06-23 |
Ablynx N.V. |
Method for displaying loops from immunoglobulin domains in different contexts
|
|
US20050037358A1
(en)
|
2001-12-21 |
2005-02-17 |
Serge Muyldermans |
Method for cloning of variable domain sequences
|
|
WO2003055527A2
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
AU2003244817B2
(en)
|
2002-06-28 |
2010-08-26 |
Domantis Limited |
Antigen-binding immunoglobulin single variable domains and dual-specific constructs
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
AU2003284891A1
(en)
|
2002-10-23 |
2004-05-13 |
Ludwig Institute For Cancer Research |
A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
|
|
AU2003286002B2
(en)
|
2002-11-08 |
2011-06-16 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
JP2006519763A
(ja)
|
2002-11-08 |
2006-08-31 |
アブリンクス エン．ヴェー． |
治療用ポリペプチドの投与法およびそのためのポリペプチド
|
|
US20060228355A1
(en)
|
2003-11-07 |
2006-10-12 |
Toon Laeremans |
Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
KR101025143B1
(ko)
|
2002-12-31 |
2011-04-01 |
넥타르 테라퓨틱스 |
가수분해상으로 안정한 말레이미드－종결 중합체
|
|
EP2390270A1
(en)
|
2003-01-10 |
2011-11-30 |
Ablynx N.V. |
Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation
|
|
US7461263B2
(en)
|
2003-01-23 |
2008-12-02 |
Unspam, Llc. |
Method and apparatus for a non-revealing do-not-contact list system
|
|
DE602004017726D1
(de)
|
2003-06-30 |
2008-12-24 |
Domantis Ltd |
Pegylierte Single-domain-antikörper (dAb)
|
|
WO2005018629A1
(en)
|
2003-08-12 |
2005-03-03 |
Yarbrough William M |
Treatment for acne vulgaris and method of use
|
|
US7207410B2
(en)
|
2004-04-29 |
2007-04-24 |
Daimlerchrysler Corporation |
Apparatus and method for enhanced impact sensing
|
|
US7180370B2
(en)
|
2004-09-01 |
2007-02-20 |
Micron Technology, Inc. |
CMOS amplifiers with frequency compensating capacitors
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
JP5113523B2
(ja)
|
2004-10-13 |
2013-01-09 |
アブリンクス ナームローゼ フェンノートシャップ |
アミロイド−βに対するナノ抗体及びアルツハイマー病のような神経変性疾患の治療のためのナノ抗体ＴＭを含むポリペプチド
|
|
WO2006079372A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
EP2949668B1
(en)
|
2005-05-18 |
2019-08-14 |
Ablynx N.V. |
Improved nanobodies tm against tumor necrosis factor-alpha
|
|
BRPI0609797B8
(pt)
|
2005-05-20 |
2021-05-25 |
Ablynx Nv |
nanocorpos melhorados para o tratamento de desordens mediadas por agregação
|
|
AU2007285695B2
(en)
|
2006-08-18 |
2012-05-24 |
Ablynx N.V. |
Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling
|
|
EP2069402A2
(en)
|
2006-09-08 |
2009-06-17 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
EP2086998B1
(en)
|
2006-10-11 |
2011-12-07 |
Ablynx N.V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and use thereof
|
|
US20080267949A1
(en)
|
2006-12-05 |
2008-10-30 |
Ablynx N.V. |
Peptides capable of binding to serum proteins
|
|
US20110118185A9
(en)
|
2007-02-21 |
2011-05-19 |
Ablynx N.V. |
Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
|
|
MX2009012650A
(es)
|
2007-05-24 |
2010-02-18 |
Ablynx Nv |
Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos.
|
|
AU2008328779B2
(en)
|
2007-11-27 |
2014-06-05 |
Ablynx N.V. |
Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors
|
|
MX2011010681A
(es)
|
2009-04-10 |
2012-01-20 |
Ablynx Nv |
Secuencias mejoradas de aminoacidos dirigidas contra il-6r y polipeptidos que comprenden el mismo para el tratamiento de enfermedades y trastornos relacionados con il-6r.
|
|
CN102180950B
(zh)
*
|
2011-02-24 |
2013-06-05 |
华中科技大学同济医学院附属协和医院 |
一种人源性电压门控钾通道1.3免疫原性肽段及其用途
|
|
DK2723769T4
(da)
|
2011-06-23 |
2022-09-05 |
Ablynx Nv |
Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
|
|
EP3466972A1
(en)
|
2011-06-23 |
2019-04-10 |
Ablynx NV |
Serum albumin binding proteins
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|