JP2017518364A5 - - Google Patents

Download PDF

Info

Publication number
JP2017518364A5
JP2017518364A5 JP2017512873A JP2017512873A JP2017518364A5 JP 2017518364 A5 JP2017518364 A5 JP 2017518364A5 JP 2017512873 A JP2017512873 A JP 2017512873A JP 2017512873 A JP2017512873 A JP 2017512873A JP 2017518364 A5 JP2017518364 A5 JP 2017518364A5
Authority
JP
Japan
Prior art keywords
antibody
seq
pharmaceutical composition
subject
cdrs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017512873A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017518364A (ja
JP6836500B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/031117 external-priority patent/WO2015175957A1/en
Publication of JP2017518364A publication Critical patent/JP2017518364A/ja
Publication of JP2017518364A5 publication Critical patent/JP2017518364A5/ja
Application granted granted Critical
Publication of JP6836500B2 publication Critical patent/JP6836500B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017512873A 2014-05-16 2015-05-15 自己免疫状態および炎症状態を治療するための方法および組成物 Active JP6836500B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461994239P 2014-05-16 2014-05-16
US61/994,239 2014-05-16
US201462014504P 2014-06-19 2014-06-19
US62/014,504 2014-06-19
PCT/US2015/031117 WO2015175957A1 (en) 2014-05-16 2015-05-15 Methods and compositions for treating autoimmune and inflammatory conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021017236A Division JP7222004B2 (ja) 2014-05-16 2021-02-05 自己免疫状態および炎症状態を治療するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2017518364A JP2017518364A (ja) 2017-07-06
JP2017518364A5 true JP2017518364A5 (https=) 2018-06-21
JP6836500B2 JP6836500B2 (ja) 2021-03-03

Family

ID=54480787

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017512873A Active JP6836500B2 (ja) 2014-05-16 2015-05-15 自己免疫状態および炎症状態を治療するための方法および組成物
JP2021017236A Active JP7222004B2 (ja) 2014-05-16 2021-02-05 自己免疫状態および炎症状態を治療するための方法および組成物
JP2023014370A Active JP7663616B2 (ja) 2014-05-16 2023-02-02 自己免疫状態および炎症状態を治療するための方法および組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021017236A Active JP7222004B2 (ja) 2014-05-16 2021-02-05 自己免疫状態および炎症状態を治療するための方法および組成物
JP2023014370A Active JP7663616B2 (ja) 2014-05-16 2023-02-02 自己免疫状態および炎症状態を治療するための方法および組成物

Country Status (8)

Country Link
US (2) US10993990B2 (https=)
EP (1) EP3142691A4 (https=)
JP (3) JP6836500B2 (https=)
CN (1) CN106659774A (https=)
AU (3) AU2015258875B2 (https=)
CA (2) CA3185180A1 (https=)
IL (2) IL300029A (https=)
WO (1) WO2015175957A1 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2012021512A2 (en) 2010-08-10 2012-02-16 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
KR102717969B1 (ko) 2014-02-21 2024-10-15 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) 글리코타겟팅 치료제
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
KR20200031571A (ko) * 2017-05-29 2020-03-24 가마맵스 파마 암 연관 면역억제의 억제제
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности
CN119613548A (zh) * 2018-06-13 2025-03-14 鸿运华宁(杭州)生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质,以及其药物组合物和应用
CN109620952A (zh) * 2019-01-04 2019-04-16 北京中台恒基生物技术有限公司 一种肿瘤疫苗及其制备方法
CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
JP7546924B2 (ja) * 2019-03-01 2024-09-09 国立大学法人 筑波大学 アレルギー疾患を処置することに用いるための組成物
WO2020236875A1 (en) * 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
CA3152181A1 (en) * 2019-08-23 2021-03-04 Unm Rainforest Innovations Non-opioid compositions and therapies for pain management
CN111544592B (zh) * 2020-03-13 2022-05-03 中山大学附属第一医院 模式识别受体Dectin-1抑制剂对受体移植物的免疫保护及诱导免疫耐受的应用
CA3186753A1 (en) 2020-07-20 2022-01-27 John Mumm Dual cytokine fusion proteins comprising il-10
US12122839B2 (en) 2020-08-05 2024-10-22 Synthekine, Inc. IFNGR binding synthetic cytokines and methods of use
BR112023001723A2 (pt) 2020-08-05 2023-05-02 Synthekine Inc Moléculas de ligação à gp130 e métodos de uso
AU2021322238A1 (en) 2020-08-05 2023-03-23 Synthekine, Inc. Compositions and methods related to IL27 receptor binding
JP7819178B2 (ja) 2020-08-05 2026-02-24 シンセカイン インコーポレイテッド IL10Rb結合分子および使用方法
WO2022032006A2 (en) 2020-08-05 2022-02-10 Synthekine, Inc. Il2rb binding molecules and methods of use
US12012457B1 (en) 2020-08-05 2024-06-18 Synthekine, Inc. IL23R binding molecules and methods of use
US12018085B2 (en) 2020-08-05 2024-06-25 Synthekine, Inc. Interferon-gamma R2 (IFNGR2) binding molecules comprising single-domain antibodies and method of use thereof to treat autoimmune and inflammatory diseases
US11859001B2 (en) 2020-08-05 2024-01-02 Synthekine, Inc. IL12RB1-Binding molecules and methods of use
WO2022031884A2 (en) 2020-08-05 2022-02-10 Synthekine, Inc. Il2rg binding molecules and methods of use
WO2022032025A1 (en) * 2020-08-05 2022-02-10 Synthekine, Inc. Ifngr binding synthetic cytokines and methods of use
JP7743500B2 (ja) 2020-08-05 2025-09-24 シンセカイン インコーポレイテッド Il10受容体結合性分子および使用方法
US12291572B2 (en) 2020-08-05 2025-05-06 Synthekine, Inc. IL12 receptor synthetic cytokines and methods of use
WO2022032045A1 (en) 2020-08-05 2022-02-10 Synthekine, Inc. IL10Rα/IL2Rγ SYNTHETIC CYTOKINES
KR102846963B1 (ko) 2020-08-05 2025-08-18 신테카인, 인크. IL27Rα 결합 분자 및 사용 방법
KR20230061394A (ko) 2020-08-05 2023-05-08 신테카인, 인크. IL10Ra 결합 분자 및 사용 방법
JP2023543266A (ja) * 2020-09-25 2023-10-13 ザ・ユニバーシティ・オブ・シカゴ 抗炎症性サイトカインおよび使用の方法
CN112694532B (zh) * 2021-01-12 2023-04-18 倍而达药业(苏州)有限公司 抗Siglec-15的抗体或其抗原结合片段及应用
CN114316060B (zh) * 2021-12-15 2023-06-13 北京市肿瘤防治研究所 抗人cd19与cd206双特异性抗体及其制备方法和应用
FR3139339B1 (fr) * 2022-09-01 2025-10-24 Asfalia Biologics Conjugués peptidiques et leur utilisation pour promouvoir l’immunotolérance aux nucleases cas dans une thérapie génique par ingenierie du genome
EP4709761A2 (en) * 2023-05-11 2026-03-18 Elixiron Immunotherapeutics (Hong Kong) Limited A combination comprising lag-3 targeting moiety and interleukin-10
EP4719457A2 (en) * 2023-06-02 2026-04-08 Synthekine, Inc. Fused il10 polypeptides
WO2025049885A1 (en) * 2023-09-01 2025-03-06 The Regents Of The University Of Michigan Long-lived brain delivery of anti-inflammatory agents

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3949064A (en) 1973-10-26 1976-04-06 Baxter Laboratories, Inc. Method of detecting antigens or antibodies
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
DE69434931T2 (de) 1993-04-02 2007-11-22 Rigel Pharmaceuticals, Inc., South San Francisco Methode zur selektiven inaktivierung der viralen replication
US20040258688A1 (en) 1995-01-31 2004-12-23 Daniel Hawiger Enhanced antigen delivery and modulation of the immune response therefrom
CA2231582A1 (en) 1995-10-17 1997-04-24 Genencor International, Inc. Enzymatic array and process of making same
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
FR2748479A1 (fr) 1996-05-10 1997-11-14 Pasteur Institut Polypeptide comportant un nouveau domaine cohesine de type ii, composition enzymatique en comportant et fragments d'adn codant pour ces polypeptides
US6046158A (en) 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
AR014891A1 (es) 1997-07-09 2001-04-11 Schering Corp Genes aislados de proteinas de membranas de mamiferos; reactivos relacionados
US6777546B2 (en) 1997-10-07 2004-08-17 Loma Linda University Methods and substances for preventing and treating autoimmune disease
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
US5945308A (en) 1998-04-03 1999-08-31 Incyte Pharmaceuticals, Inc. Human oxidized LDL receptor
JP2000157282A (ja) 1998-11-30 2000-06-13 Toyota Central Res & Dev Lab Inc 酵素配列複合体及び固定化酵素配列複合体とそれらの製造方法、担体分子及び酵素
WO2000056901A2 (en) 1999-03-24 2000-09-28 Board Of Regents, The University Of Texas System Linear and circular expression elements
EP1046651A1 (en) 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
ES2217891T3 (es) 1999-04-21 2004-11-01 Basf Aktiengesellschaft Mezcla de diesteres de acido adipico o ftalico con nonanoles isomericos.
AU785198B2 (en) * 1999-11-15 2006-11-02 Miltenyi Biotec B.V. & Co. KG Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognised thereby and cells obtained thereby
CA2401993A1 (en) 2000-03-02 2001-09-07 Abgenix, Inc. Human monoclonal antibodies against oxidized ldl receptor and pharmaceutical uses thereof
US20060222633A1 (en) * 2000-05-11 2006-10-05 Yale University Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
FR2816060A1 (fr) 2000-10-27 2002-05-03 Pf Medicament Procede d'identification de nouvelles molecules se liant au recepteur lox et utilisation de ces molecules
AU2002332598A1 (en) 2001-08-22 2003-03-10 Shengfeng Li Compositions and methods for generating antigen-binding units
US20050106700A1 (en) 2001-10-11 2005-05-19 Tsuyoshi Nomura Method of purifying recombinant fused protein and method of producing protein using the same
WO2003036895A1 (en) 2001-10-25 2003-05-01 Renesas Technology Corp. Semiconductor integrated circuit for communication, modulating/demodulating device, and communication diagnosing method
WO2003046012A1 (en) 2001-11-30 2003-06-05 Crucell Holland B.V. Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their production or generation
WO2003073827A2 (en) 2002-02-28 2003-09-12 Corixa Corporation Methods of modulating dendritic cells using adjuvants
US6738985B2 (en) 2002-05-14 2004-05-25 David S. Hahn Disposable sweatband liner
US20040091503A1 (en) 2002-08-20 2004-05-13 Genitrix, Llc Lectin compositions and methods for modulating an immune response to an antigen
JP2004236504A (ja) 2003-02-03 2004-08-26 Toyota Central Res & Dev Lab Inc 酵素配列複合体及び固定化酵素配列複合体とそれらの製造方法、担体分子及び酵素
JP2006521387A (ja) 2003-03-04 2006-09-21 アレクシオン ファーマシューティカルズ, インコーポレイテッド 寛容誘導抗原提示細胞による抗原提示の誘導によって自己免疫疾患を治療する方法
US20050064509A1 (en) 2003-09-23 2005-03-24 The Regents Of The University Of California Use of templated self assembly to create novel multifunctional species
US20060019342A1 (en) 2004-06-25 2006-01-26 Medimmune, Inc. Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
EP1874824A4 (en) 2005-04-06 2009-12-30 Ibc Pharmaceuticals Inc METHODS OF GENERATING STABLE COMPOUND RELATED COMPLEXES OF HOMODIMERS, HOMOTRATEERS OR DIMER SIZES AND USES THEREOF
US7666596B2 (en) 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
EP1929032A4 (en) 2005-09-30 2009-11-04 Oklahoma Med Res Found REGULATION OF GOOD LIKE RECEPTORS ON STEM CELLS
GB0605735D0 (en) 2006-03-22 2006-05-03 Immunobiology Ltd Composition and method for mediating an immune response
EA200802289A1 (ru) * 2006-05-08 2009-04-28 Филоджен Спа Направляемые к мишени антителами цитокины для терапии
KR20090114430A (ko) 2007-02-02 2009-11-03 베일러 리서치 인스티튜트 항원-제시 세포 상에서 발현된 dcir에 대한 항원 표적화에 기초한 백신
US7786267B2 (en) 2007-02-02 2010-08-31 Baylor Research Institute Multivariable antigens complexed with targeting humanized monoclonal antibody
TWI422594B (zh) * 2007-02-02 2014-01-11 Baylor Res Inst 經由樹狀細胞去唾液酸糖蛋白受體(dc-asgpr)接合抗原呈現細胞之藥劑
MX2009008926A (es) 2007-02-23 2009-09-14 Baylor Res Inst Aplicaciones terapeuticas de activacion de celulas que presentan antigeno humano por medio de detectina a-1.
NZ579257A (en) 2007-02-23 2011-05-27 Baylor Res Inst Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1)
FR2933816B1 (fr) * 2008-07-10 2015-08-21 Commissariat Energie Atomique Dispositif a coupleur selectif en longueur d'onde pour collection de la lumiere emise par une source laser.
NZ592420A (en) * 2008-10-02 2012-12-21 Emergent Product Dev Seattle Cd86 antagonist multi-target binding proteins
WO2011044452A2 (en) * 2009-10-08 2011-04-14 President And Fellows Of Harvard College Methods and compositions for amelioration of autoimmune disease using fusion proteins of anti-dendritic cell receptor antibody to peptide sequences
CA2794499A1 (en) * 2010-04-01 2011-10-06 Immumomedics, Inc. Antibody-based depletion of antigen-presenting cells and dendritic cells
MX2012012833A (es) * 2010-05-07 2012-11-30 Baylor Res Inst Cebado cruzado de celulas t cd8 positivas humanos moderada por inmunoreceptores de celulas dendriticas (dcir).
BR112013002940A2 (pt) 2010-08-13 2019-09-24 Baylor Res Institute adjuvantes de nova vacina baseados no direcionamento dos adjuvantes para os anticorpos diretamente às células que apresentam antígenos
US20120121592A1 (en) * 2010-10-13 2012-05-17 Baylor Research Institute Targeting Antigens to Human Dendritic Cells Via DC-Asialoglycoprotein Receptor to Produce IL-10 Regulatory T-Cells
AR083400A1 (es) * 2010-10-13 2013-02-21 Baylor Res Inst Direccionamiento de los antigenos a las celulas dendriticas humanas a traves del receptor de asialoglicoproteinas dc para producir celulas t reguladoras con il-10
JP2013540162A (ja) * 2010-10-22 2013-10-31 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 抗原特異的な寛容を誘導する微粒子およびその使用
TW201247706A (en) 2011-03-08 2012-12-01 Baylor Res Inst Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
WO2012129227A1 (en) 2011-03-22 2012-09-27 Baylor Research Institute Dendritic cells (dcs) targeting for tuberculosis (tb) vaccine
CA2831294A1 (en) 2011-03-25 2012-10-04 Baylor Research Institute Compositions and methods to immunize against hepatitis c virus
TW201247700A (en) 2011-05-05 2012-12-01 Baylor Res Inst Immunoglobulin-like transcript (ILT) receptors as CD8 antagonists
CA2876285A1 (en) * 2012-08-08 2014-02-13 Roche Glycart Ag Interleukin-10 fusion proteins and uses thereof
EP2882775B1 (en) * 2012-08-09 2018-02-14 Roche Glycart AG Asgpr antibodies and uses thereof
CA2916694C (en) * 2013-06-28 2023-01-17 Baylor Research Institute Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis

Similar Documents

Publication Publication Date Title
JP2017518364A5 (https=)
JP7507790B2 (ja) EpCAM結合タンパク質および使用方法
JP7489316B2 (ja) Pd-li抗原結合部位を有するfc結合断片
TWI771361B (zh) 人程序性死亡受體pd-1的單株抗體及其片段
JP2022065073A (ja) Bcma結合分子及びその使用方法
CN110511278B (zh) 抗b7-h6抗体、融合蛋白及其使用方法
TW202005984A (zh) 結合pd-l1及cd137的抗體分子
EP3892634A1 (en) Anti-cd40 antibody, antigen binding fragment and pharmaceutical use thereof
TWI844524B (zh) 靶向edb之il-12組合物
US12428493B2 (en) Antibodies that bind PSMA and gamma-delta T cell receptors
CN107949571A (zh) 调控免疫反应的方法及抗体
CN110709421A (zh) 针对ox40和ctla-4的双特异性抗体
WO2018165895A1 (zh) Ctla4抗体、其药物组合物及其用途
US10934331B2 (en) Methods for enhancing immune responsiveness in an individual toward a target cancer cell population comprising apoptotic cells
TW202221021A (zh) 改良之抗原結合受體
CN116801889A (zh) 包含具有多特异性抗体的离体武装t细胞的组合物和其用途
JP7644151B2 (ja) 抗pd-1抗体および融合タンパク質
WO2022002009A1 (zh) 靶向ox40的抗体及其制备方法和应用
CN110343180B (zh) 抗ctla-4抗体及其应用
EP4516909A1 (en) Cd19-targeting chimeric antigen receptor and use thereof
US20230257474A1 (en) Uveal melanoma treatment using sea-cd40
CA3259869A1 (en) DOSING REGIMEN FOR CD19-TARGETED CANCER IMMUNOTHERAPY
WO2021011912A1 (en) Combination of integrin-targeting knottin-fc fusion and anti-cd47 antibody for the treatment of cancer
JP2025514847A (ja) Fas軸拮抗薬及びTreg細胞枯渇剤拮抗薬を含む癌の治療のための併用療法
TWI790193B (zh) 調控免疫反應之方法及抗體