JP2017518276A5 - - Google Patents

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JP2017518276A5
JP2017518276A5 JP2016565402A JP2016565402A JP2017518276A5 JP 2017518276 A5 JP2017518276 A5 JP 2017518276A5 JP 2016565402 A JP2016565402 A JP 2016565402A JP 2016565402 A JP2016565402 A JP 2016565402A JP 2017518276 A5 JP2017518276 A5 JP 2017518276A5
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pyrazolo
pyrimidin
fluoro
phenyl
amino
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JP2016565402A
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JP2017518276A (ja
JP6670756B2 (ja
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Priority claimed from CN201410175783.7A external-priority patent/CN105017256A/zh
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JP2016565402A 2014-04-29 2015-04-27 ブルトン型チロシンキナーゼ(btk)インヒビターとしての多フルオロ置換化合物 Active JP6670756B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410175783.7A CN105017256A (zh) 2014-04-29 2014-04-29 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
CN201410175783.7 2014-04-29
PCT/CN2015/000290 WO2015165279A1 (zh) 2014-04-29 2015-04-27 多氟化合物作为布鲁顿酪氨酸激酶抑制剂

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JP2019220363A Division JP7005582B2 (ja) 2014-04-29 2019-12-05 ブルトン型チロシンキナーゼ(btk)インヒビターとしての多フルオロ置換化合物

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JP2017518276A JP2017518276A (ja) 2017-07-06
JP2017518276A5 true JP2017518276A5 (https=) 2018-06-14
JP6670756B2 JP6670756B2 (ja) 2020-03-25

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JP2016565402A Active JP6670756B2 (ja) 2014-04-29 2015-04-27 ブルトン型チロシンキナーゼ(btk)インヒビターとしての多フルオロ置換化合物
JP2019220363A Active JP7005582B2 (ja) 2014-04-29 2019-12-05 ブルトン型チロシンキナーゼ(btk)インヒビターとしての多フルオロ置換化合物

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JP2019220363A Active JP7005582B2 (ja) 2014-04-29 2019-12-05 ブルトン型チロシンキナーゼ(btk)インヒビターとしての多フルオロ置換化合物

Country Status (13)

Country Link
US (3) US9532990B2 (https=)
EP (1) EP3138842B1 (https=)
JP (2) JP6670756B2 (https=)
KR (2) KR102669966B1 (https=)
CN (3) CN105017256A (https=)
AU (1) AU2015252654C1 (https=)
BR (1) BR112016025132A2 (https=)
CA (1) CA2947338C (https=)
EA (2) EA037227B1 (https=)
ES (1) ES2857251T3 (https=)
IL (1) IL248546B (https=)
MX (2) MX2021013118A (https=)
WO (1) WO2015165279A1 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10124003B2 (en) 2013-07-18 2018-11-13 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for FGFR inhibitor-resistant cancer
AU2014291161B2 (en) 2013-07-18 2018-04-26 Taiho Pharmaceutical Co., Ltd. Antitumor drug for intermittent administration of FGFR inhibitor
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
EP3221320A4 (en) * 2014-11-19 2018-04-25 Sun Pharmaceutical Industries Ltd A process for the preparation of ibrutinib
JP6681922B2 (ja) * 2015-02-12 2020-04-15 上▲海▼度▲徳▼医▲藥▼科技有限公司 イブルチニブの製造方法
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途
US9717745B2 (en) 2015-03-19 2017-08-01 Zhejiang DTRM Biopharma Co. Ltd. Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
CN106146511A (zh) * 2015-04-03 2016-11-23 安润医药科技(苏州)有限公司 吡唑并嘧啶衍生物、制备方法、药物组合物及用途
CN106146512B (zh) * 2015-04-09 2018-07-17 北京睿创康泰医药研究院有限公司 依鲁替尼的制备方法
WO2016168704A1 (en) 2015-04-16 2016-10-20 Icahn School Of Medicine At Mount Sinai Ksr antagonists
EP3424505A4 (en) 2016-03-04 2019-10-16 Taiho Pharmaceutical Co., Ltd. PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
CN108884068B (zh) * 2016-03-24 2021-02-26 特殊治疗有限公司 作为dub抑制剂的1-氰基-吡咯烷衍生物
WO2018002958A1 (en) 2016-06-30 2018-01-04 Sun Pharma Advanced Research Company Limited Novel hydrazide containing compounds as btk inhibitors
CN106146518A (zh) * 2016-06-30 2016-11-23 苏州爱玛特生物科技有限公司 一种布鲁顿酪氨酸激酶抑制剂中间体及其制备方法
GB201616511D0 (en) 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
WO2018090792A1 (zh) * 2016-11-15 2018-05-24 杭州和正医药有限公司 一种选择性布鲁顿酪氨酸激酶抑制剂及其应用
CA3045339A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
CN106831788B (zh) * 2017-01-22 2020-10-30 鲁南制药集团股份有限公司 伊布替尼精制方法
WO2018175512A1 (en) 2017-03-22 2018-09-27 Suzhou Baijibugong Pharmaceutical Technology Co. Ltd. Bruton's tyrosine kinase inhibitors
CN107501270B (zh) * 2017-09-01 2019-06-28 宏腾建设集团有限公司 一种含有磺酰吖丙啶结构的化合物、药物组合物以及其应用
TW201922256A (zh) 2017-10-27 2019-06-16 中國大陸商浙江導明醫藥科技有限公司 治療淋巴樣惡性疾病之方法
CN109970740A (zh) * 2017-12-27 2019-07-05 广东众生药业股份有限公司 4-氨基-嘧啶并氮杂环衍生物及其制备方法和用途
JP6918204B2 (ja) 2018-03-19 2021-08-11 大鵬薬品工業株式会社 アルキル硫酸ナトリウムを含む医薬組成物
CN110964016B (zh) 2018-09-29 2021-05-28 南京药捷安康生物科技有限公司 氨基降茨烷衍生物及其制备方法与应用
US20210388002A1 (en) * 2018-11-09 2021-12-16 Taiho Pharmaceutical Co., Ltd. Dimethoxybenzene compound analogs, methods for analyzing said compounds and standard products of said compounds
CN111171035B (zh) * 2018-11-13 2021-03-30 山东大学 4-苯氧基苯基吡唑并嘧啶酰胺衍生物的制备方法和应用
CN111454268B (zh) * 2019-01-18 2023-09-08 明慧医药(上海)有限公司 作为布鲁顿酪氨酸激酶抑制剂的环状分子
CN113574051A (zh) 2019-03-15 2021-10-29 拜耳公司 特定取代的3-苯基-5-螺环戊基-3-吡咯啉-2-酮及其作为除草剂的用途
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN112142745B (zh) * 2019-06-27 2023-03-21 杭州和正医药有限公司 一种酪蛋白激酶1ε抑制剂、药物组合物及其应用
WO2021038540A1 (en) 2019-08-31 2021-03-04 Sun Pharma Advanced Research Company Limited Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
FI4036095T3 (fi) * 2019-09-26 2024-02-14 Jumbo Drug Bank Co Ltd 4-Fluori-1H-pyratsolo[3,4-c]pyridiinijohdannaisia selektiivisinä Brutonin tyrosiinikinaasin (BTK) inhibiittoreina B-solulymfooman ja autoimmuunitautien hoitamiseksi
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP3865535A1 (en) 2020-02-11 2021-08-18 Bosti Trading Ltd. New method of synthesis of chitosan derivatives and uses thereof
TW202144465A (zh) 2020-02-11 2021-12-01 瑞士商諾和席卓股份有限公司 合成聚葡萄胺糖衍生物之新方法及其用途
AU2020436612A1 (en) * 2020-03-16 2022-09-01 Flash Therapeutics, Llc Compounds for treating or inhibiting recurrence of acute myeloid leukemia
EP4161933A1 (en) 2020-06-08 2023-04-12 Halia Therapeutics, Inc. Inhibitors of nek7 kinase
CN113943294A (zh) * 2020-07-15 2022-01-18 成都海博为药业有限公司 一种作为btk抑制剂的化合物及其制备方法与用途
WO2022081512A1 (en) * 2020-10-12 2022-04-21 Synubi Pharmaceuticals Llc Compositions and methods of treatment of neuroinflammatory diseases with bruton's tyrosine kinase inhibitors
CN112574046A (zh) * 2020-12-17 2021-03-30 深圳市华先医药科技有限公司 一种制备(1r,3s)-3-氨基环戊醇盐酸盐的方法
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
US20240139326A1 (en) * 2020-12-23 2024-05-02 Yeda Research And Development Co. Ltd. Methacrylamides protein binders and uses thereof
EP4501327A3 (en) * 2021-02-03 2025-10-15 Accutar Biotechnology Inc. Substituted pyrrolopyrimidine and pyrazolopyrimidine as bruton s tyrosinekinase (btk) degraders
EP4376612A2 (en) 2021-08-06 2024-06-05 Novochizol SA Preparation of composite gels, polymer scaffolds, aggregates and films comprising soluble cross-linked chitosan & uses thereof
AR126678A1 (es) 2021-08-06 2023-11-01 Novochizol Sa Composiciones para el cuidado de las plantas y usos de las mismas
CN114605418B (zh) * 2022-03-15 2023-09-05 广东医科大学附属医院 一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
CN117430610A (zh) * 2023-10-11 2024-01-23 宁夏医科大学 一种氘代稠合杂环化合物及其制备方法和应用
CN117903141B (zh) * 2023-12-19 2024-11-05 江苏长泰药业股份有限公司 一种化合物及其盐、在制备治疗癌症药物和激酶抑制剂中的用途、治疗癌症的药物
WO2025202889A1 (en) * 2024-03-28 2025-10-02 Array Biopharma Inc. Her2 mutation inhibitors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127470A1 (en) * 1998-12-23 2004-07-01 Pharmacia Corporation Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist
GB0402143D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
DK2526933T3 (en) * 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
EP1921149A1 (en) 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
SG10202107066WA (en) 2007-03-28 2021-07-29 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
CA2730930C (en) * 2008-07-16 2015-01-13 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
US7718662B1 (en) * 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
CN102115476A (zh) * 2011-03-23 2011-07-06 常州大学 一种2H-吡唑并[3,4-d]嘧啶衍生物及合成方法
WO2012158795A1 (en) * 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
PL2710005T3 (pl) * 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
JP2014520863A (ja) * 2011-07-13 2014-08-25 ファーマサイクリックス,インク. Bruton型チロシンキナーゼの阻害剤
WO2013191965A1 (en) * 2012-06-18 2013-12-27 Principia Biopharma Inc. Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases
JP6261580B2 (ja) * 2012-07-30 2018-01-17 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化イブルチニブ
CA2880505A1 (en) * 2012-07-31 2014-02-06 Safe Wire Holding, Llc Depth controlled jamshidi needle
WO2014022569A1 (en) * 2012-08-03 2014-02-06 Principia Biopharma Inc. Treatment of dry eye
SI2892900T1 (en) 2012-09-10 2018-01-31 Principia Biopharma Inc. Pyrazolopyrimidine compounds as kinase inhibitors
US9479134B2 (en) * 2013-03-04 2016-10-25 Texas Instruments Incorporated Position detecting system
WO2014143807A2 (en) 2013-03-15 2014-09-18 Stromatt Scott Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
CU24400B1 (es) 2013-04-08 2019-04-04 Bayer Pharma AG Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas
EP2983670A4 (en) 2013-04-08 2017-03-08 Pharmacyclics LLC Ibrutinib combination therapy
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2014187319A1 (en) * 2013-05-21 2014-11-27 Jiangsu Medolution Ltd Substituted pyrazolopyrimidines as kinases inhibitors
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途

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