JP2017517261A5 - - Google Patents

Download PDF

Info

Publication number
JP2017517261A5
JP2017517261A5 JP2016569420A JP2016569420A JP2017517261A5 JP 2017517261 A5 JP2017517261 A5 JP 2017517261A5 JP 2016569420 A JP2016569420 A JP 2016569420A JP 2016569420 A JP2016569420 A JP 2016569420A JP 2017517261 A5 JP2017517261 A5 JP 2017517261A5
Authority
JP
Japan
Prior art keywords
deoxyuridine
aptamer
protein
seq
methyluridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016569420A
Other languages
English (en)
Japanese (ja)
Other versions
JP6824041B2 (ja
JP2017517261A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/033355 external-priority patent/WO2015184372A1/en
Publication of JP2017517261A publication Critical patent/JP2017517261A/ja
Publication of JP2017517261A5 publication Critical patent/JP2017517261A5/ja
Application granted granted Critical
Publication of JP6824041B2 publication Critical patent/JP6824041B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016569420A 2014-05-30 2015-05-29 ３つのタンパク質を補体成分に結合するための核酸化合物 Expired - Fee Related JP6824041B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462005300P 2014-05-30 2014-05-30
US62/005,300 2014-05-30
PCT/US2015/033355 WO2015184372A1 (en) 2014-05-30 2015-05-29 Nucleic acid compounds for binding to complement component 3 protein

Publications (3)

Publication Number Publication Date
JP2017517261A JP2017517261A (ja) 2017-06-29
JP2017517261A5 true JP2017517261A5 (enExample) 2019-03-14
JP6824041B2 JP6824041B2 (ja) 2021-02-03

Family

ID=53398218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016569420A Expired - Fee Related JP6824041B2 (ja) 2014-05-30 2015-05-29 ３つのタンパク質を補体成分に結合するための核酸化合物

Country Status (8)

Country Link
US (2) US11466275B2 (enExample)
EP (1) EP3149173B1 (enExample)
JP (1) JP6824041B2 (enExample)
CN (2) CN106459979B (enExample)
CA (1) CA2949246C (enExample)
ES (1) ES2664179T3 (enExample)
NO (1) NO2718257T3 (enExample)
WO (1) WO2015184372A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3013534T3 (en) * 2016-07-01 2025-04-14 Somalogic Operating Co Inc Oligonucleotides comprising modified nucleosides
US12202848B2 (en) * 2019-10-18 2025-01-21 Fujifilm Wako Pure Chemical Corporation Phosphoramidite activator

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395888B1 (en) 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
US6140490A (en) 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
AU2994997A (en) * 1996-05-07 1997-11-26 T Cell Sciences, Inc. Aptamers for complement protein c3b
US20020082227A1 (en) * 1999-09-30 2002-06-27 Scott Henry Use of oligonucleotides for inhibition of complement activation
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
SI1994171T1 (sl) * 2006-01-17 2015-07-31 Somalogic, Inc. Multipleksirane analize testnih vzorcev
US7947447B2 (en) * 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8927509B2 (en) * 2008-05-20 2015-01-06 The Research Foundation Of State University Of New York Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
EP2558586B1 (en) 2010-04-12 2016-10-12 Somalogic, Inc. APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS
ES2629183T3 (es) * 2011-03-10 2017-08-07 Somalogic, Inc. Aptámeros para diagnóstico de Clostridium difficile
CN104220453B (zh) 2012-04-03 2018-03-09 诺沃姆德治疗公司 人源化的嵌合抗因子c3抗体及其用途
US10975393B2 (en) * 2016-08-24 2021-04-13 Sangamo Therapeutics, Inc. Engineered target specific nucleases
PH12022550056A1 (en) * 2019-07-11 2023-04-12 Memorial Sloan Kettering Cancer Center Dll3-targeting antibodies and uses thereof

Similar Documents

Publication Publication Date Title
Kohlberger et al. SELEX: Critical factors and optimization strategies for successful aptamer selection
Marušič et al. G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
KR20230028375A (ko) 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법
Morris et al. High affinity ligands from in vitro selection: complex targets
EP3049523B1 (en) Multiaptamer target detection
Zimmermann et al. Genomic SELEX: a discovery tool for genomic aptamers
Thakur et al. Regulation of BRCA1 transcription by specific single-stranded DNA binding factors
US20130116129A1 (en) Method for detecting target molecules
Joeng et al. ssDNA aptamers that recognize diclofenac and 2-anilinophenylacetic acid
JP2021520221A (ja) 新規小分子活性化ｒｎａ
CN110938632A (zh) 一种特异结合tnf-r1的适配体及其筛选方法和应用
Cao et al. Evolution of a gastric carcinoma cell-specific DNA aptamer by live cell-SELEX
Kuepper et al. Constrained peptides mimic a viral suppressor of RNA silencing
JP2019527043A (ja) 修飾ヌクレオシドを含むオリゴヌクレオチド
Liu et al. NAP-seq reveals multiple classes of structured noncoding RNAs with regulatory functions
US20220112490A1 (en) Method for suppressing protein translation reaction using staple nucleic acid
Chandran et al. Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing
JP2017517261A5 (enExample)
Tang et al. Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
Kotkowiak et al. Novel isoguanine derivative of unlocked nucleic acid—Investigations of thermodynamics and biological potential of modified thrombin binding aptamer
JP2018029601A (ja) アプタマーの製造方法
Huang et al. A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells
US20200157537A1 (en) Modulating RNA Interactions with Polycomb Repressive Complex 1 (PRC1)
JP7776924B2 (ja) 変異ＦＵＳの発現を選択的に抑制する修飾ｓｉＲＮＡ
TWI695068B (zh) 用於結合生長分化因子１１的核酸化合物