CN110643610A - 用于结合补体组分3蛋白的核酸化合物 - Google Patents

用于结合补体组分3蛋白的核酸化合物 Download PDF

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Publication number
CN110643610A
CN110643610A CN201910922493.7A CN201910922493A CN110643610A CN 110643610 A CN110643610 A CN 110643610A CN 201910922493 A CN201910922493 A CN 201910922493A CN 110643610 A CN110643610 A CN 110643610A
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aptamer
nucleotides
deoxyuridine
length
protein
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Chinese (zh)
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丹尼尔·W·德罗莱
张弛
丹尼尔·J·奥康奈尔
沙希·古普塔
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Somalogic Inc
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Somalogic Inc
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CN201910922493.7A 2014-05-30 2015-05-29 用于结合补体组分3蛋白的核酸化合物 Pending CN110643610A (zh)

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US201462005300P 2014-05-30 2014-05-30
US62/005,300 2014-05-30
CN201580028344.6A CN106459979B (zh) 2014-05-30 2015-05-29 用于结合补体组分3蛋白的核酸化合物

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US (2) US11466275B2 (enExample)
EP (1) EP3149173B1 (enExample)
JP (1) JP6824041B2 (enExample)
CN (2) CN110643610A (enExample)
CA (1) CA2949246C (enExample)
ES (1) ES2664179T3 (enExample)
NO (1) NO2718257T3 (enExample)
WO (1) WO2015184372A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3478843B1 (en) * 2016-07-01 2021-08-04 Somalogic, Inc. Oligonucleotides comprising modified nucleosides
JP7452549B2 (ja) * 2019-10-18 2024-03-19 富士フイルム和光純薬株式会社 ホスホロアミダイト活性化剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
CN110418841A (zh) * 2016-08-24 2019-11-05 桑格摩生物治疗股份有限公司 工程化的靶特异性核酸酶
CN114341182A (zh) * 2019-07-11 2022-04-12 纪念斯隆凯特琳癌症中心 Dll3靶向抗体及其用途

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US6140490A (en) * 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
US6395888B1 (en) 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
WO1997042317A1 (en) 1996-05-07 1997-11-13 T Cell Sciences, Inc. APTAMERS FOR COMPLEMENT PROTEIN C3b
US20020082227A1 (en) * 1999-09-30 2002-06-27 Scott Henry Use of oligonucleotides for inhibition of complement activation
EP2613147B1 (en) * 2006-01-17 2015-03-11 Somalogic, Inc. Detection methods using aptamers
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) * 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8927509B2 (en) * 2008-05-20 2015-01-06 The Research Foundation Of State University Of New York Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
AU2011240774B2 (en) 2010-04-12 2014-04-10 Otsuka Pharmaceutical Co., Ltd. Aptamers to beta-NGF and their use in treating beta-NGF mediated diseases and disorders
ES2629183T3 (es) * 2011-03-10 2017-08-07 Somalogic, Inc. Aptámeros para diagnóstico de Clostridium difficile
CN104220453B (zh) * 2012-04-03 2018-03-09 诺沃姆德治疗公司 人源化的嵌合抗因子c3抗体及其用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
CN110418841A (zh) * 2016-08-24 2019-11-05 桑格摩生物治疗股份有限公司 工程化的靶特异性核酸酶
CN114341182A (zh) * 2019-07-11 2022-04-12 纪念斯隆凯特琳癌症中心 Dll3靶向抗体及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张浩等: "定点突变技术的研究进展", 《免疫学杂志》 *

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JP2017517261A (ja) 2017-06-29
CA2949246A1 (en) 2015-12-03
CN106459979B (zh) 2020-07-21
JP6824041B2 (ja) 2021-02-03
EP3149173B1 (en) 2018-02-07
CN106459979A (zh) 2017-02-22
ES2664179T3 (es) 2018-04-18
US11466275B2 (en) 2022-10-11
US20170166895A1 (en) 2017-06-15
US20230093170A1 (en) 2023-03-23
EP3149173A1 (en) 2017-04-05
WO2015184372A1 (en) 2015-12-03
NO2718257T3 (enExample) 2018-04-14
CA2949246C (en) 2023-06-27

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