JP2017514877A5 - - Google Patents

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Publication number
JP2017514877A5
JP2017514877A5 JP2016567002A JP2016567002A JP2017514877A5 JP 2017514877 A5 JP2017514877 A5 JP 2017514877A5 JP 2016567002 A JP2016567002 A JP 2016567002A JP 2016567002 A JP2016567002 A JP 2016567002A JP 2017514877 A5 JP2017514877 A5 JP 2017514877A5
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JP
Japan
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methoxycyclopent
group
similarly
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same structure
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JP2016567002A
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JP6505131B2 (ja
JP2017514877A (ja
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Priority claimed from PCT/GB2015/051312 external-priority patent/WO2015170081A1/en
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Publication of JP2017514877A5 publication Critical patent/JP2017514877A5/ja
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同様に、1−メトキシシクロペンタ−3−イル基と3−メトキシシクロペンタ−1−イル基は、下記のとおり、同一の構造を有する。

JP2016567002A 2014-05-08 2015-05-05 イミダゾ[4,5−c]キノリン−2−オン化合物および癌の処置におけるそれらの使用 Active JP6505131B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461990232P 2014-05-08 2014-05-08
US61/990,232 2014-05-08
PCT/GB2015/051312 WO2015170081A1 (en) 2014-05-08 2015-05-05 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Publications (3)

Publication Number Publication Date
JP2017514877A JP2017514877A (ja) 2017-06-08
JP2017514877A5 true JP2017514877A5 (ja) 2018-06-14
JP6505131B2 JP6505131B2 (ja) 2019-04-24

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ID=53264681

Family Applications (1)

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JP2016567002A Active JP6505131B2 (ja) 2014-05-08 2015-05-05 イミダゾ[4,5−c]キノリン−2−オン化合物および癌の処置におけるそれらの使用

Country Status (38)

Country Link
US (4) US9428503B2 (ja)
EP (1) EP3140303B1 (ja)
JP (1) JP6505131B2 (ja)
KR (1) KR102013021B1 (ja)
CN (1) CN106255692B (ja)
AP (1) AP2016009532A0 (ja)
AR (1) AR100340A1 (ja)
AU (1) AU2015257456B2 (ja)
CA (1) CA2946459C (ja)
CL (1) CL2016002735A1 (ja)
CR (1) CR20160523A (ja)
CY (1) CY1120248T1 (ja)
DK (1) DK3140303T3 (ja)
DO (1) DOP2016000281A (ja)
EA (1) EA031674B1 (ja)
ES (1) ES2670416T3 (ja)
HR (1) HRP20180697T1 (ja)
HU (1) HUE037558T2 (ja)
IL (1) IL248397B (ja)
LT (1) LT3140303T (ja)
MA (1) MA39960A (ja)
MX (1) MX2016014639A (ja)
NI (1) NI201600166A (ja)
NO (1) NO2714752T3 (ja)
NZ (1) NZ726042A (ja)
PE (1) PE20170403A1 (ja)
PH (1) PH12016502168B1 (ja)
PL (1) PL3140303T3 (ja)
PT (1) PT3140303T (ja)
RS (1) RS57223B1 (ja)
SG (1) SG11201609164VA (ja)
SI (1) SI3140303T1 (ja)
SV (1) SV2016005312A (ja)
TN (1) TN2016000458A1 (ja)
TR (1) TR201807101T4 (ja)
TW (1) TWI662034B (ja)
UY (1) UY36112A (ja)
WO (1) WO2015170081A1 (ja)

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GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) * 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
BR112018068347A2 (pt) * 2016-03-21 2019-01-15 Astrazeneca Ab compostos de cinolin-4-amina e seu uso no tratamento de câncer
SG11201807040WA (en) 2016-04-07 2018-09-27 Astrazeneca Ab N,n-dimethyl-3-[[5-(3-methyl-2-oxo-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine oxide as atm (ataxia telangiectasia mutated) kinase modulator for treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JOP20190151B1 (ar) 2016-12-20 2023-09-17 Astrazeneca Ab مركبات أمينو - ترايازولو بيريدين واستخدامها في علاج سرطان
US10874670B2 (en) 2017-01-09 2020-12-29 Impact Therapeutics, Inc. Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof
CN106798741A (zh) * 2017-02-07 2017-06-06 宫英 一种治疗抑郁症的药物组合物
CN106692147A (zh) * 2017-02-07 2017-05-24 李明英 一种治疗男性不育的药物组合物
CN106822123A (zh) * 2017-02-09 2017-06-13 王艳苓 一种治疗心脑血管疾病的药物组合物
CN110312717B (zh) * 2017-02-27 2022-04-12 上海瑛派药业有限公司 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CN111344293A (zh) 2017-09-20 2020-06-26 阿斯利康(瑞典)有限公司 1,3-二氢咪唑并[4,5-c]噌啉-2-酮化合物及其在治疗癌症中的用途
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
KR20210061337A (ko) * 2018-09-14 2021-05-27 수저우 잔롱 파마 리미티드 모세혈관확장성 운동실조증 돌연변이(ATM) 키나제의 선택적 조절제로서의 1-이소프로필-3-메틸-8-(피리딘-3-일)-1,3-디하이드로-2H-이미다조[4,5-c]신놀린-2-온 및 이의 용도
SG11202109451TA (en) * 2019-03-05 2021-09-29 Astrazeneca Ab Fused tricyclic compounds useful as anticancer agents
TW202102497A (zh) * 2019-03-29 2021-01-16 瑞典商阿斯特捷利康公司 化合物及它們在治療癌症中之用途
CN111909147B (zh) * 2019-05-10 2021-07-20 山东轩竹医药科技有限公司 Dna-pk抑制剂
US20220259211A1 (en) * 2019-07-10 2022-08-18 Impact Therapeutics (Shanghai), Inc Substituted pyrazoloquinazolinone compounds and application thereof
KR20220062003A (ko) * 2019-09-12 2022-05-13 임팩트 테라퓨틱스 (상하이), 인코포레이티드 치환된 이미다조퀴녹살린 화합물 및 이의 용도
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
WO2021146127A1 (en) * 2020-01-13 2021-07-22 Zhanggui Wu Use of n2-quincline or isoquinoline substituted purine derivatives in cancer treatment
CN116194109A (zh) 2020-06-24 2023-05-30 阿斯利康(英国)有限公司 抗体-药物缀合物和atm抑制剂的组合
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
AU2021433713A1 (en) * 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof

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PL1687305T3 (pl) 2003-11-21 2008-12-31 Novartis Ag Pochodne 1H-imidazochinolin jako inhibitory kinaz białkowych
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PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
BRPI0910175A2 (pt) 2008-07-01 2017-03-21 Genentech Inc composto de fórmula i e ii, composição farmacêutica, método de inibição do crescimento de células anormais ou de tratamento de um distúrbio hiperproliferativo em um mamífero e método de tratamento de uma doença inflamatória em um mamífero
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CN102399218A (zh) 2010-09-16 2012-04-04 和记黄埔医药(上海)有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
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JP6042060B2 (ja) * 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用

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