JP2017513906A5 - - Google Patents

Info

Publication number

JP2017513906A5

JP2017513906A5 JP2016564193A JP2016564193A JP2017513906A5 JP 2017513906 A5 JP2017513906 A5 JP 2017513906A5 JP 2016564193 A JP2016564193 A JP 2016564193A JP 2016564193 A JP2016564193 A JP 2016564193A JP 2017513906 A5 JP2017513906 A5 JP 2017513906A5

Authority

JP

Japan

Prior art keywords

lactobacillus

bifidobacterium

composition

composition according

hyaluronic acid

Prior art date

2015-04-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 18
• 241000186000 Bifidobacterium Species 0.000 claims 8
• 241000186660 Lactobacillus Species 0.000 claims 7
• 229940039696 lactobacillus Drugs 0.000 claims 7
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
• 229920002674 hyaluronan Polymers 0.000 claims 6
• 229960003160 hyaluronic acid Drugs 0.000 claims 6
• 239000006041 probiotic Substances 0.000 claims 5
• 235000018291 probiotics Nutrition 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 3
• 230000000529 probiotic effect Effects 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 244000199866 Lactobacillus casei Species 0.000 claims 2
• 235000013958 Lactobacillus casei Nutrition 0.000 claims 2
• 229940017800 lactobacillus casei Drugs 0.000 claims 2
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 241000193815 Atopobium minutum Species 0.000 claims 1
• 241000186012 Bifidobacterium breve Species 0.000 claims 1
• 241001608472 Bifidobacterium longum Species 0.000 claims 1
• 241000186148 Bifidobacterium pseudolongum Species 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
• 108010036949 Cyclosporine Proteins 0.000 claims 1
• 241001430190 Eggerthia catenaformis Species 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
• 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims 1
• 240000001929 Lactobacillus brevis Species 0.000 claims 1
• 235000013957 Lactobacillus brevis Nutrition 0.000 claims 1
• 241000186679 Lactobacillus buchneri Species 0.000 claims 1
• 241000186605 Lactobacillus paracasei Species 0.000 claims 1
• 240000006024 Lactobacillus plantarum Species 0.000 claims 1
• 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
• 241000186604 Lactobacillus reuteri Species 0.000 claims 1
• 241001438705 Lactobacillus rogosae Species 0.000 claims 1
• 241000194037 Lactococcus raffinolactis Species 0.000 claims 1
• 241000194017 Streptococcus Species 0.000 claims 1
• 241000194020 Streptococcus thermophilus Species 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 229960002170 azathioprine Drugs 0.000 claims 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
• 229940009291 bifidobacterium longum Drugs 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 229960001265 ciclosporin Drugs 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 239000006071 cream Substances 0.000 claims 1
• 229930182912 cyclosporin Natural products 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 229940039695 lactobacillus acidophilus Drugs 0.000 claims 1
• 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
• 229940001882 lactobacillus reuteri Drugs 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 229960001428 mercaptopurine Drugs 0.000 claims 1
• KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 1
• 229960004963 mesalazine Drugs 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• -1 pomade Substances 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1