JP2017513487A5 - - Google Patents
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- JP2017513487A5 JP2017513487A5 JP2016563054A JP2016563054A JP2017513487A5 JP 2017513487 A5 JP2017513487 A5 JP 2017513487A5 JP 2016563054 A JP2016563054 A JP 2016563054A JP 2016563054 A JP2016563054 A JP 2016563054A JP 2017513487 A5 JP2017513487 A5 JP 2017513487A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction surface
- biosensor
- sample
- functional fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000006243 chemical reaction Methods 0.000 claims description 56
- 108090000790 Enzymes Proteins 0.000 claims description 33
- 102000004190 Enzymes Human genes 0.000 claims description 33
- 239000012634 fragment Substances 0.000 claims description 31
- 235000001014 amino acid Nutrition 0.000 claims description 30
- 150000001413 amino acids Chemical class 0.000 claims description 30
- 230000002503 metabolic effect Effects 0.000 claims description 26
- 210000001124 body fluid Anatomy 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 21
- 239000010839 body fluid Substances 0.000 claims description 13
- 208000030159 metabolic disease Diseases 0.000 claims description 9
- 108010078226 phenylalanine oxidase Proteins 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 239000003638 chemical reducing agent Substances 0.000 claims description 8
- 108091006149 Electron carriers Proteins 0.000 claims description 6
- 238000007254 oxidation reaction Methods 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 5
- 235000000346 sugar Nutrition 0.000 claims description 5
- 241000626621 Geobacillus Species 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- 208000016097 disease of metabolism Diseases 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 238000005286 illumination Methods 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 239000000017 hydrogel Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 3
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 claims description 2
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-Dihydroxybenzaldehyde Natural products OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108010031025 Alanine Dehydrogenase Proteins 0.000 claims description 2
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims description 2
- 101710088194 Dehydrogenase Proteins 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims description 2
- 206010020575 Hyperammonaemia Diseases 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 108010028658 Leucine Dehydrogenase Proteins 0.000 claims description 2
- 208000030162 Maple syrup disease Diseases 0.000 claims description 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims description 2
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims description 2
- 108090000854 Oxidoreductases Proteins 0.000 claims description 2
- 102000004316 Oxidoreductases Human genes 0.000 claims description 2
- 201000011252 Phenylketonuria Diseases 0.000 claims description 2
- 108010092464 Urate Oxidase Proteins 0.000 claims description 2
- 230000023077 detection of light stimulus Effects 0.000 claims description 2
- 238000001962 electrophoresis Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 208000024393 maple syrup urine disease Diseases 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims description 2
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 2
- 230000004043 responsiveness Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 229950003937 tolonium Drugs 0.000 claims description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- KUUVQVSHGLHAKZ-UHFFFAOYSA-N thionine Chemical group C=1C=CC=CSC=CC=1 KUUVQVSHGLHAKZ-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical group [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461981126P | 2014-04-17 | 2014-04-17 | |
| US61/981,126 | 2014-04-17 | ||
| US201562112019P | 2015-02-04 | 2015-02-04 | |
| US62/112,019 | 2015-02-04 | ||
| PCT/US2015/026546 WO2015161301A1 (en) | 2014-04-17 | 2015-04-17 | Device and methods of using device for detection of aminoacidopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513487A JP2017513487A (ja) | 2017-06-01 |
| JP2017513487A5 true JP2017513487A5 (enExample) | 2018-03-15 |
| JP6998658B2 JP6998658B2 (ja) | 2022-01-18 |
Family
ID=54324646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563054A Active JP6998658B2 (ja) | 2014-04-17 | 2015-04-17 | アミノ酸代謝異常の検出のためのデバイス、及びデバイスを使用する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12540348B2 (enExample) |
| EP (1) | EP3132049B1 (enExample) |
| JP (1) | JP6998658B2 (enExample) |
| DK (1) | DK3132049T3 (enExample) |
| WO (1) | WO2015161301A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10792339B2 (en) * | 2015-07-17 | 2020-10-06 | Children's National Medical Center | Methods and compositions for treating phenylketonuria |
| US20200064351A1 (en) * | 2017-05-05 | 2020-02-27 | Analytical Diagnostic Solutions, Inc. | Point-of-care device for the quantitative determination of branched-chain amino acids in biological samples |
| WO2019071240A1 (en) | 2017-10-06 | 2019-04-11 | The Research Foundation For The State University For The State Of New York | AQUEOUS AND NONAQUEOUS SELECTIVE OPTICAL DETECTION OF FREE SULPHITES |
| WO2019079301A2 (en) | 2017-10-18 | 2019-04-25 | Group K Diagnostics, Inc. | MONOLAYER MICROFLUIDIC DEVICE AND METHODS OF MAKING AND USING SAME |
| USD879999S1 (en) | 2018-11-02 | 2020-03-31 | Group K Diagnostics, Inc. | Microfluidic device |
| EP3946714A1 (en) * | 2019-03-29 | 2022-02-09 | Palogen, Inc. | Nanopore device and methods of biosynthesis using same |
| WO2021019552A1 (en) * | 2019-07-27 | 2021-02-04 | Indian Institute Of Technology, Kharagpur | System for estimation of plasma glucose by integrated paper-based device and method thereof |
| US20210208134A1 (en) * | 2020-01-03 | 2021-07-08 | Louay Khaled Fakhro | Systems and methods of optically determining analyte concentrations |
| CN115702336A (zh) * | 2020-06-26 | 2023-02-14 | 松下控股株式会社 | 输出装置、方法、程序以及显示装置 |
| US11964278B2 (en) * | 2020-09-08 | 2024-04-23 | Dartmouth Ocean Technologies Inc. | Microfluidic chip, systems, and methods for capturing of environmental DNA |
| JP7709328B2 (ja) * | 2021-07-27 | 2025-07-16 | キヤノン株式会社 | 情報処理装置および方法およびプログラム |
| IT202300013677A1 (it) * | 2023-06-30 | 2024-12-30 | Univ Degli Studi Di Catania | Metodo e dispositivo per la rilevazione di fenilalanina nel plasma |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1981A (en) | 1841-02-18 | backus | ||
| WO1997029208A1 (fr) * | 1996-02-09 | 1997-08-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Procede de dosage de l'ammoniaque et composition correspondante |
| US4254222A (en) | 1978-07-19 | 1981-03-03 | Owen Oliver E | Semi-quantitative assay of lactic acid and β-hydroxy butyrate |
| US4351899A (en) | 1978-07-19 | 1982-09-28 | Owen Oliver E | Semi-quantitative assay of metabolic acids |
| US4849345A (en) * | 1985-04-17 | 1989-07-18 | Sagami Chemical Research Center | L-phenylalanine dehydrogenase and use thereof |
| JPH0672883B2 (ja) * | 1985-06-19 | 1994-09-14 | コニカ株式会社 | 分析素子 |
| US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
| US5041733A (en) * | 1987-03-20 | 1991-08-20 | Agency Of Industrial Science & Technology | Method and apparatus for identifying chromosomes or cells |
| US5128015A (en) | 1988-03-15 | 1992-07-07 | Tall Oak Ventures | Method and apparatus for amperometric diagnostic analysis |
| US4999632A (en) | 1989-12-15 | 1991-03-12 | Boehringer Mannheim Corporation | Analog to digital conversion with noise reduction |
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| US5190863A (en) * | 1990-06-29 | 1993-03-02 | Miles Inc. | Composition for determining the presence or concentration of D-β-hydroxybutyrate |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5353351A (en) | 1992-06-09 | 1994-10-04 | At&T Bell Laboratories | Secure teleconferencing |
| US5510245A (en) * | 1992-09-08 | 1996-04-23 | Bayer Corporation | Composition and method of assaying for ketone bodies |
| DE4318519C2 (de) | 1993-06-03 | 1996-11-28 | Fraunhofer Ges Forschung | Elektrochemischer Sensor |
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| JP5083768B2 (ja) | 2008-01-17 | 2012-11-28 | 国立大学法人 東京医科歯科大学 | バイオセンサシステム |
| JP5701528B2 (ja) | 2010-07-16 | 2015-04-15 | オリンパス株式会社 | 生体状態量測定装置 |
| US20120231489A1 (en) * | 2011-03-11 | 2012-09-13 | Florida State University Research Foundation | Iridescent surfaces and apparatus for real time measurement of liquid and cellular adhesion |
| KR101355127B1 (ko) * | 2011-09-30 | 2014-01-29 | 주식회사 아이센스 | 전기화학적 바이오센서용 산화환원반응 시약조성물 및 이를 포함하는 바이오센서 |
| US10392646B2 (en) * | 2012-10-17 | 2019-08-27 | University Of Maryland, College Park | Device and methods of using device for detection of aminoacidopathies |
| EP2922964A2 (en) * | 2012-11-21 | 2015-09-30 | Oslo Universitetssykehus HF | Systems and methods for monitoring biological fluids |
-
2015
- 2015-04-17 EP EP15779256.5A patent/EP3132049B1/en active Active
- 2015-04-17 WO PCT/US2015/026546 patent/WO2015161301A1/en not_active Ceased
- 2015-04-17 US US15/304,852 patent/US12540348B2/en active Active
- 2015-04-17 DK DK15779256.5T patent/DK3132049T3/da active
- 2015-04-17 JP JP2016563054A patent/JP6998658B2/ja active Active
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