JP2017512842A5 - - Google Patents
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- Publication number
- JP2017512842A5 JP2017512842A5 JP2017504259A JP2017504259A JP2017512842A5 JP 2017512842 A5 JP2017512842 A5 JP 2017512842A5 JP 2017504259 A JP2017504259 A JP 2017504259A JP 2017504259 A JP2017504259 A JP 2017504259A JP 2017512842 A5 JP2017512842 A5 JP 2017512842A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- ang1
- cells
- vegf
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 15
- 102100034594 Angiopoietin-1 Human genes 0.000 claims 14
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 11
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 9
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 9
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 9
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 6
- 239000012894 fetal calf serum Substances 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical group OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 150000000996 L-ascorbic acids Chemical class 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 239000006143 cell culture medium Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 108010048154 Angiopoietin-1 Proteins 0.000 claims 1
- 102000009088 Angiopoietin-1 Human genes 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 239000011612 calcitriol Substances 0.000 claims 1
- 244000309466 calf Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014901247 | 2014-04-07 | ||
| AU2014901247A AU2014901247A0 (en) | 2014-04-07 | Improved stem cell composition | |
| PCT/EP2015/057521 WO2015155187A1 (en) | 2014-04-07 | 2015-04-07 | Improved stem cell composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021024189A Division JP7196216B2 (ja) | 2014-04-07 | 2021-02-18 | 改善された幹細胞組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512842A JP2017512842A (ja) | 2017-05-25 |
| JP2017512842A5 true JP2017512842A5 (enExample) | 2018-05-31 |
| JP6882161B2 JP6882161B2 (ja) | 2021-06-02 |
Family
ID=53724311
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504259A Active JP6882161B2 (ja) | 2014-04-07 | 2015-04-07 | 改善された幹細胞組成物 |
| JP2021024189A Active JP7196216B2 (ja) | 2014-04-07 | 2021-02-18 | 改善された幹細胞組成物 |
| JP2022198585A Active JP7571109B2 (ja) | 2014-04-07 | 2022-12-13 | 改善された幹細胞組成物 |
| JP2024176634A Pending JP2024177516A (ja) | 2014-04-07 | 2024-10-08 | 改善された幹細胞組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021024189A Active JP7196216B2 (ja) | 2014-04-07 | 2021-02-18 | 改善された幹細胞組成物 |
| JP2022198585A Active JP7571109B2 (ja) | 2014-04-07 | 2022-12-13 | 改善された幹細胞組成物 |
| JP2024176634A Pending JP2024177516A (ja) | 2014-04-07 | 2024-10-08 | 改善された幹細胞組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10400218B2 (enExample) |
| EP (2) | EP3129468B1 (enExample) |
| JP (4) | JP6882161B2 (enExample) |
| KR (2) | KR102405663B1 (enExample) |
| CN (2) | CN106459913B (enExample) |
| AU (5) | AU2015243575B2 (enExample) |
| CA (1) | CA2944262C (enExample) |
| SG (2) | SG11201607925SA (enExample) |
| WO (1) | WO2015155187A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012048099A2 (en) | 2010-10-08 | 2012-04-12 | Osiris Therapeutics, Inc. | Nanoparticle-loaded cells |
| JP6882161B2 (ja) * | 2014-04-07 | 2021-06-02 | メゾブラスト・インターナショナル・エスアーエールエル | 改善された幹細胞組成物 |
| KR102865313B1 (ko) * | 2014-06-10 | 2025-09-29 | 메조블라스트 인터내셔널 에스에이알엘 | 면역 장애의 치료 |
| JP6231709B1 (ja) * | 2016-05-31 | 2017-11-15 | シスメックス株式会社 | 蛍光画像分析装置および分析方法 |
| US20200325450A1 (en) * | 2017-05-04 | 2020-10-15 | Mesoblast International Sàrl | Mesenchymal lineage precursor or stem cells with enhanced immunosuppression |
| US12473547B2 (en) | 2017-11-22 | 2025-11-18 | Mesoblast International Sàrl | Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer |
| CN113677790B (zh) * | 2019-03-26 | 2024-05-24 | 普罗米瑟拉疗法公司 | 用于治疗慢加急性肝衰竭的成体肝祖细胞 |
| US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
| WO2022020210A1 (en) | 2020-07-18 | 2022-01-27 | Ossium Health, Inc. | Permeation of whole vertebral bodies with a cryoprotectant using vacuum assisted diffusion |
| CN116583594B (zh) | 2020-10-14 | 2025-05-23 | 奥瑟姆健康公司 | 用于骨髓的提取和低温保藏的系统和方法 |
| WO2022133282A1 (en) | 2020-12-18 | 2022-06-23 | Ossium Health, Inc. | Methods of cell therapies |
| WO2024121820A1 (en) * | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Pre-licensed composition and cell culture methods |
| AU2023389703A1 (en) * | 2022-12-09 | 2025-07-10 | Mesoblast International Sarl | Conditioned media and use of the same |
| KR20250116745A (ko) * | 2022-12-09 | 2025-08-01 | 메조블라스트 인터내셔널 에스에이알엘 | 지속적인 염증을 가진 대상체에서 심부전을 치료하는 방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| AU2005209688A1 (en) * | 1999-07-07 | 2005-10-06 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
| WO2004074494A1 (ja) * | 2003-02-19 | 2004-09-02 | Dnavec Research Inc. | 虚血疾患の治療方法 |
| KR20130100225A (ko) * | 2004-09-24 | 2013-09-09 | 안지오블라스트 시스템스 인코퍼레이티드 | 간엽 전구세포의 증식 및/또는 생존성 증강 방법 |
| US8367405B2 (en) | 2005-04-12 | 2013-02-05 | Mesoblast, Inc. | Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase |
| WO2007122233A1 (en) * | 2006-04-25 | 2007-11-01 | Vrije Universiteit Brussel | Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells |
| CN101407790B (zh) * | 2008-10-30 | 2010-09-29 | 浙江大学 | 一种增强人骨髓间充质干细胞旁分泌能力的处理方法 |
| EP2258413A1 (en) * | 2009-06-04 | 2010-12-08 | Université Catholique de Louvain | Multi-dimensional biomaterial and method for producing the same. |
| CN102899293A (zh) | 2012-11-01 | 2013-01-30 | 上海市肺科医院 | 促血管生成素1基因修饰的间充质干细胞、及其构建方法与应用 |
| WO2015094914A1 (en) * | 2013-12-18 | 2015-06-25 | Interdigital Patent Holdings, Inc. | Methods, apparatus and systems for interference management in a full duplex radio system |
| JP6882161B2 (ja) * | 2014-04-07 | 2021-06-02 | メゾブラスト・インターナショナル・エスアーエールエル | 改善された幹細胞組成物 |
-
2015
- 2015-04-07 JP JP2017504259A patent/JP6882161B2/ja active Active
- 2015-04-07 US US15/300,716 patent/US10400218B2/en active Active
- 2015-04-07 EP EP15741940.9A patent/EP3129468B1/en active Active
- 2015-04-07 WO PCT/EP2015/057521 patent/WO2015155187A1/en not_active Ceased
- 2015-04-07 AU AU2015243575A patent/AU2015243575B2/en active Active
- 2015-04-07 KR KR1020167031018A patent/KR102405663B1/ko active Active
- 2015-04-07 SG SG11201607925SA patent/SG11201607925SA/en unknown
- 2015-04-07 CN CN201580018440.2A patent/CN106459913B/zh active Active
- 2015-04-07 SG SG10202000644TA patent/SG10202000644TA/en unknown
- 2015-04-07 KR KR1020227018459A patent/KR102577698B1/ko active Active
- 2015-04-07 CA CA2944262A patent/CA2944262C/en active Active
- 2015-04-07 EP EP22187396.1A patent/EP4137560A1/en active Pending
- 2015-04-07 CN CN202110474002.4A patent/CN113337462A/zh active Pending
-
2018
- 2018-01-25 AU AU2018200619A patent/AU2018200619B9/en active Active
-
2019
- 2019-06-07 US US16/434,726 patent/US11312941B2/en active Active
-
2020
- 2020-03-27 AU AU2020202214A patent/AU2020202214B2/en active Active
-
2021
- 2021-02-18 JP JP2021024189A patent/JP7196216B2/ja active Active
-
2022
- 2022-02-01 AU AU2022200640A patent/AU2022200640B2/en active Active
- 2022-03-09 US US17/691,028 patent/US20230030428A1/en not_active Abandoned
- 2022-12-13 JP JP2022198585A patent/JP7571109B2/ja active Active
-
2024
- 2024-05-14 AU AU2024203197A patent/AU2024203197A1/en active Pending
- 2024-10-08 JP JP2024176634A patent/JP2024177516A/ja active Pending
-
2025
- 2025-01-02 US US19/008,517 patent/US20250136944A1/en active Pending
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