CA2944262C - Improved stem cell composition - Google Patents
Improved stem cell composition Download PDFInfo
- Publication number
- CA2944262C CA2944262C CA2944262A CA2944262A CA2944262C CA 2944262 C CA2944262 C CA 2944262C CA 2944262 A CA2944262 A CA 2944262A CA 2944262 A CA2944262 A CA 2944262A CA 2944262 C CA2944262 C CA 2944262C
- Authority
- CA
- Canada
- Prior art keywords
- cells
- cell culture
- angl
- population
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014901247A AU2014901247A0 (en) | 2014-04-07 | Improved stem cell composition | |
| AU2014901247 | 2014-04-07 | ||
| PCT/EP2015/057521 WO2015155187A1 (en) | 2014-04-07 | 2015-04-07 | Improved stem cell composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2944262A1 CA2944262A1 (en) | 2015-10-15 |
| CA2944262C true CA2944262C (en) | 2023-08-01 |
Family
ID=53724311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2944262A Active CA2944262C (en) | 2014-04-07 | 2015-04-07 | Improved stem cell composition |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10400218B2 (enExample) |
| EP (2) | EP4137560A1 (enExample) |
| JP (4) | JP6882161B2 (enExample) |
| KR (2) | KR102405663B1 (enExample) |
| CN (2) | CN106459913B (enExample) |
| AU (5) | AU2015243575B2 (enExample) |
| CA (1) | CA2944262C (enExample) |
| SG (2) | SG11201607925SA (enExample) |
| WO (1) | WO2015155187A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| SG11201607925SA (en) | 2014-04-07 | 2016-10-28 | Mesoblast Internat Sarl | Improved stem cell composition |
| AU2015273799B2 (en) * | 2014-06-10 | 2020-07-02 | Mesoblast International Sarl | Treatment of immune disorders |
| JP6231709B1 (ja) * | 2016-05-31 | 2017-11-15 | シスメックス株式会社 | 蛍光画像分析装置および分析方法 |
| JP7398959B2 (ja) * | 2017-05-04 | 2023-12-15 | メゾブラスト・インターナショナル・エスアーエールエル | 向上した免疫抑制作用を有する間葉系前駆または幹細胞 |
| AU2018372631B2 (en) | 2017-11-22 | 2025-06-05 | Mesoblast International Sarl | Cellular compositions and methods of treatment I |
| AU2020245045A1 (en) * | 2019-03-26 | 2021-11-18 | Promethera Therapeutics Sa | Adult liver progenitor cells for treating acute-on-chronic liver failure |
| US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
| EP4181675A4 (en) | 2020-07-18 | 2024-04-24 | Ossium Health, Inc. | PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION |
| WO2022081909A1 (en) | 2020-10-14 | 2022-04-21 | Ossium Health, Inc. | Systems and methods for extraction and cryopreservation of bone marrow |
| CN117279650A (zh) | 2020-12-18 | 2023-12-22 | 奥瑟姆健康公司 | 细胞治疗方法 |
| WO2024121818A1 (en) * | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Method of treating heart failure in subjects with persistent inflammation |
| CN120603930A (zh) * | 2022-12-09 | 2025-09-05 | 迈索布拉斯特国际有限公司 | 条件培养基及其用途 |
| JP2025538783A (ja) * | 2022-12-09 | 2025-11-28 | メゾブラスト・インターナショナル・エスアーエールエル | 事前承認された組成物及び細胞培養方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| AU2005209688A1 (en) * | 1999-07-07 | 2005-10-06 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| EP1600511A4 (en) * | 2003-02-19 | 2006-08-23 | Dnavec Research Inc | METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESS |
| JP2008514188A (ja) * | 2004-09-24 | 2008-05-08 | アンジオブラスト システムズ，インコーポレーテッド | 間葉系前駆細胞（ｍｐｃ）の増殖および／または生存を増強させる方法 |
| KR101682046B1 (ko) | 2005-04-12 | 2016-12-02 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리 |
| WO2007122233A1 (en) * | 2006-04-25 | 2007-11-01 | Vrije Universiteit Brussel | Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells |
| CN101407790B (zh) * | 2008-10-30 | 2010-09-29 | 浙江大学 | 一种增强人骨髓间充质干细胞旁分泌能力的处理方法 |
| EP2258413A1 (en) * | 2009-06-04 | 2010-12-08 | Université Catholique de Louvain | Multi-dimensional biomaterial and method for producing the same. |
| CN102899293A (zh) | 2012-11-01 | 2013-01-30 | 上海市肺科医院 | 促血管生成素1基因修饰的间充质干细胞、及其构建方法与应用 |
| JP6721506B2 (ja) * | 2013-12-18 | 2020-07-15 | アイディーエーシー ホールディングス インコーポレイテッド | 全二重無線システムにおける干渉管理のための方法、装置、およびシステム |
| SG11201607925SA (en) | 2014-04-07 | 2016-10-28 | Mesoblast Internat Sarl | Improved stem cell composition |
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2015
- 2015-04-07 SG SG11201607925SA patent/SG11201607925SA/en unknown
- 2015-04-07 CN CN201580018440.2A patent/CN106459913B/zh active Active
- 2015-04-07 KR KR1020167031018A patent/KR102405663B1/ko active Active
- 2015-04-07 US US15/300,716 patent/US10400218B2/en active Active
- 2015-04-07 SG SG10202000644TA patent/SG10202000644TA/en unknown
- 2015-04-07 EP EP22187396.1A patent/EP4137560A1/en active Pending
- 2015-04-07 WO PCT/EP2015/057521 patent/WO2015155187A1/en not_active Ceased
- 2015-04-07 AU AU2015243575A patent/AU2015243575B2/en active Active
- 2015-04-07 CN CN202110474002.4A patent/CN113337462A/zh active Pending
- 2015-04-07 KR KR1020227018459A patent/KR102577698B1/ko active Active
- 2015-04-07 CA CA2944262A patent/CA2944262C/en active Active
- 2015-04-07 JP JP2017504259A patent/JP6882161B2/ja active Active
- 2015-04-07 EP EP15741940.9A patent/EP3129468B1/en active Active
-
2018
- 2018-01-25 AU AU2018200619A patent/AU2018200619B9/en active Active
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2019
- 2019-06-07 US US16/434,726 patent/US11312941B2/en active Active
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2020
- 2020-03-27 AU AU2020202214A patent/AU2020202214B2/en active Active
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2021
- 2021-02-18 JP JP2021024189A patent/JP7196216B2/ja active Active
-
2022
- 2022-02-01 AU AU2022200640A patent/AU2022200640B2/en active Active
- 2022-03-09 US US17/691,028 patent/US20230030428A1/en not_active Abandoned
- 2022-12-13 JP JP2022198585A patent/JP7571109B2/ja active Active
-
2024
- 2024-05-14 AU AU2024203197A patent/AU2024203197A1/en active Pending
- 2024-10-08 JP JP2024176634A patent/JP2024177516A/ja active Pending
-
2025
- 2025-01-02 US US19/008,517 patent/US20250136944A1/en active Pending
Also Published As
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| JP7279212B2 (ja) | 免疫疾患の治療 | |
| HK40088316A (en) | Improved stem cell composition | |
| HK1227933B (en) | Improved stem cell composition | |
| HK1227933A1 (en) | Improved stem cell composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200331 |
|
| EEER | Examination request |
Effective date: 20200331 |
|
| EEER | Examination request |
Effective date: 20200331 |
|
| EEER | Examination request |
Effective date: 20200331 |
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| EEER | Examination request |
Effective date: 20200331 |
|
| EEER | Examination request |
Effective date: 20200331 |