KR102405663B1 - 개선된 줄기 세포 조성물 - Google Patents

개선된 줄기 세포 조성물 Download PDF

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KR102405663B1
KR102405663B1 KR1020167031018A KR20167031018A KR102405663B1 KR 102405663 B1 KR102405663 B1 KR 102405663B1 KR 1020167031018 A KR1020167031018 A KR 1020167031018A KR 20167031018 A KR20167031018 A KR 20167031018A KR 102405663 B1 KR102405663 B1 KR 102405663B1
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KR20160145066A (ko
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실비우 이떼스쿠
폴 시몬스
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메조블라스트 인터내셔널 에스에이알엘
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/135Platelet-derived growth factor [PDGF]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2301Interleukin-1 (IL-1)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/25Tumour necrosing factors [TNF]
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020167031018A 2014-04-07 2015-04-07 개선된 줄기 세포 조성물 Active KR102405663B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227018459A KR102577698B1 (ko) 2014-04-07 2015-04-07 개선된 줄기 세포 조성물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2014901247A AU2014901247A0 (en) 2014-04-07 Improved stem cell composition
AU2014901247 2014-04-07
PCT/EP2015/057521 WO2015155187A1 (en) 2014-04-07 2015-04-07 Improved stem cell composition

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KR20160145066A KR20160145066A (ko) 2016-12-19
KR102405663B1 true KR102405663B1 (ko) 2022-06-07

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KR1020227018459A Active KR102577698B1 (ko) 2014-04-07 2015-04-07 개선된 줄기 세포 조성물

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US (4) US10400218B2 (enExample)
EP (2) EP4137560A1 (enExample)
JP (4) JP6882161B2 (enExample)
KR (2) KR102405663B1 (enExample)
CN (2) CN106459913B (enExample)
AU (5) AU2015243575B2 (enExample)
CA (1) CA2944262C (enExample)
SG (2) SG11201607925SA (enExample)
WO (1) WO2015155187A1 (enExample)

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US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
SG11201607925SA (en) 2014-04-07 2016-10-28 Mesoblast Internat Sarl Improved stem cell composition
AU2015273799B2 (en) * 2014-06-10 2020-07-02 Mesoblast International Sarl Treatment of immune disorders
JP6231709B1 (ja) * 2016-05-31 2017-11-15 シスメックス株式会社 蛍光画像分析装置および分析方法
JP7398959B2 (ja) * 2017-05-04 2023-12-15 メゾブラスト・インターナショナル・エスアーエールエル 向上した免疫抑制作用を有する間葉系前駆または幹細胞
AU2018372631B2 (en) 2017-11-22 2025-06-05 Mesoblast International Sarl Cellular compositions and methods of treatment I
AU2020245045A1 (en) * 2019-03-26 2021-11-18 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health, Inc. PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION
WO2022081909A1 (en) 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN117279650A (zh) 2020-12-18 2023-12-22 奥瑟姆健康公司 细胞治疗方法
WO2024121818A1 (en) * 2022-12-09 2024-06-13 Mesoblast International Sarl Method of treating heart failure in subjects with persistent inflammation
CN120603930A (zh) * 2022-12-09 2025-09-05 迈索布拉斯特国际有限公司 条件培养基及其用途
JP2025538783A (ja) * 2022-12-09 2025-11-28 メゾブラスト・インターナショナル・エスアーエールエル 事前承認された組成物及び細胞培養方法

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US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1998030679A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
AU2005209688A1 (en) * 1999-07-07 2005-10-06 Angioblast Systems, Inc. Mesenchymal precursor cell
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
EP1600511A4 (en) * 2003-02-19 2006-08-23 Dnavec Research Inc METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESS
JP2008514188A (ja) * 2004-09-24 2008-05-08 アンジオブラスト システムズ,インコーポレーテッド 間葉系前駆細胞(mpc)の増殖および/または生存を増強させる方法
KR101682046B1 (ko) 2005-04-12 2016-12-02 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리
WO2007122233A1 (en) * 2006-04-25 2007-11-01 Vrije Universiteit Brussel Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells
CN101407790B (zh) * 2008-10-30 2010-09-29 浙江大学 一种增强人骨髓间充质干细胞旁分泌能力的处理方法
EP2258413A1 (en) * 2009-06-04 2010-12-08 Université Catholique de Louvain Multi-dimensional biomaterial and method for producing the same.
CN102899293A (zh) 2012-11-01 2013-01-30 上海市肺科医院 促血管生成素1基因修饰的间充质干细胞、及其构建方法与应用
JP6721506B2 (ja) * 2013-12-18 2020-07-15 アイディーエーシー ホールディングス インコーポレイテッド 全二重無線システムにおける干渉管理のための方法、装置、およびシステム
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Also Published As

Publication number Publication date
KR20160145066A (ko) 2016-12-19
US20250136944A1 (en) 2025-05-01
AU2022200640B2 (en) 2024-02-15
AU2018200619A1 (en) 2018-02-15
AU2020202214B2 (en) 2021-11-18
AU2015243575B2 (en) 2017-11-02
CA2944262C (en) 2023-08-01
EP3129468B1 (en) 2022-09-21
CN113337462A (zh) 2021-09-03
AU2015243575A1 (en) 2016-10-13
US20190345452A1 (en) 2019-11-14
SG10202000644TA (en) 2020-03-30
US20230030428A1 (en) 2023-02-02
JP2023021279A (ja) 2023-02-10
CN106459913A (zh) 2017-02-22
JP7196216B2 (ja) 2022-12-26
KR20220080023A (ko) 2022-06-14
JP7571109B2 (ja) 2024-10-22
EP4137560A1 (en) 2023-02-22
SG11201607925SA (en) 2016-10-28
US10400218B2 (en) 2019-09-03
AU2018200619B2 (en) 2020-01-02
AU2020202214A1 (en) 2020-04-16
JP6882161B2 (ja) 2021-06-02
KR102577698B1 (ko) 2023-09-12
EP3129468A1 (en) 2017-02-15
JP2024177516A (ja) 2024-12-19
CN106459913B (zh) 2021-05-18
CA2944262A1 (en) 2015-10-15
JP2017512842A (ja) 2017-05-25
AU2022200640A1 (en) 2022-02-24
JP2021080272A (ja) 2021-05-27
AU2024203197A1 (en) 2024-05-30
US11312941B2 (en) 2022-04-26
WO2015155187A1 (en) 2015-10-15
US20170107495A1 (en) 2017-04-20
AU2018200619B9 (en) 2020-05-07

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