AU2015243575B2 - Improved stem cell composition - Google Patents

Improved stem cell composition Download PDF

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Publication number
AU2015243575B2
AU2015243575B2 AU2015243575A AU2015243575A AU2015243575B2 AU 2015243575 B2 AU2015243575 B2 AU 2015243575B2 AU 2015243575 A AU2015243575 A AU 2015243575A AU 2015243575 A AU2015243575 A AU 2015243575A AU 2015243575 B2 AU2015243575 B2 AU 2015243575B2
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AU
Australia
Prior art keywords
stem cells
cells
angl
composition
vegf
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AU2015243575A
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AU2015243575A1 (en
Inventor
Silviu Itescu
Paul Simmons
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Mesoblast International SARL
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Mesoblast International SARL
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Priority claimed from AU2014901247A external-priority patent/AU2014901247A0/en
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Publication of AU2015243575A1 publication Critical patent/AU2015243575A1/en
Application granted granted Critical
Publication of AU2015243575B2 publication Critical patent/AU2015243575B2/en
Priority to AU2018200619A priority Critical patent/AU2018200619B9/en
Priority to AU2020202214A priority patent/AU2020202214B2/en
Priority to AU2022200640A priority patent/AU2022200640B2/en
Priority to AU2024203197A priority patent/AU2024203197A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2301—Interleukin-1 (IL-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2015243575A 2014-04-07 2015-04-07 Improved stem cell composition Active AU2015243575B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2018200619A AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition
AU2024203197A AU2024203197A1 (en) 2014-04-07 2024-05-14 Improved stem cell composition

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2014901247A AU2014901247A0 (en) 2014-04-07 Improved stem cell composition
AU2014901247 2014-04-07
PCT/EP2015/057521 WO2015155187A1 (en) 2014-04-07 2015-04-07 Improved stem cell composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018200619A Division AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition

Publications (2)

Publication Number Publication Date
AU2015243575A1 AU2015243575A1 (en) 2016-10-13
AU2015243575B2 true AU2015243575B2 (en) 2017-11-02

Family

ID=53724311

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2015243575A Active AU2015243575B2 (en) 2014-04-07 2015-04-07 Improved stem cell composition
AU2018200619A Active AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A Active AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A Active AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition
AU2024203197A Pending AU2024203197A1 (en) 2014-04-07 2024-05-14 Improved stem cell composition

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2018200619A Active AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A Active AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A Active AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition
AU2024203197A Pending AU2024203197A1 (en) 2014-04-07 2024-05-14 Improved stem cell composition

Country Status (9)

Country Link
US (4) US10400218B2 (enExample)
EP (2) EP4137560A1 (enExample)
JP (4) JP6882161B2 (enExample)
KR (2) KR102405663B1 (enExample)
CN (2) CN106459913B (enExample)
AU (5) AU2015243575B2 (enExample)
CA (1) CA2944262C (enExample)
SG (2) SG11201607925SA (enExample)
WO (1) WO2015155187A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
SG11201607925SA (en) 2014-04-07 2016-10-28 Mesoblast Internat Sarl Improved stem cell composition
AU2015273799B2 (en) * 2014-06-10 2020-07-02 Mesoblast International Sarl Treatment of immune disorders
JP6231709B1 (ja) * 2016-05-31 2017-11-15 シスメックス株式会社 蛍光画像分析装置および分析方法
JP7398959B2 (ja) * 2017-05-04 2023-12-15 メゾブラスト・インターナショナル・エスアーエールエル 向上した免疫抑制作用を有する間葉系前駆または幹細胞
AU2018372631B2 (en) 2017-11-22 2025-06-05 Mesoblast International Sarl Cellular compositions and methods of treatment I
AU2020245045A1 (en) * 2019-03-26 2021-11-18 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health, Inc. PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION
WO2022081909A1 (en) 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN117279650A (zh) 2020-12-18 2023-12-22 奥瑟姆健康公司 细胞治疗方法
WO2024121818A1 (en) * 2022-12-09 2024-06-13 Mesoblast International Sarl Method of treating heart failure in subjects with persistent inflammation
CN120603930A (zh) * 2022-12-09 2025-09-05 迈索布拉斯特国际有限公司 条件培养基及其用途
JP2025538783A (ja) * 2022-12-09 2025-11-28 メゾブラスト・インターナショナル・エスアーエールエル 事前承認された組成物及び細胞培養方法

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US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1998030679A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
AU2005209688A1 (en) * 1999-07-07 2005-10-06 Angioblast Systems, Inc. Mesenchymal precursor cell
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
EP1600511A4 (en) * 2003-02-19 2006-08-23 Dnavec Research Inc METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESS
JP2008514188A (ja) * 2004-09-24 2008-05-08 アンジオブラスト システムズ，インコーポレーテッド 間葉系前駆細胞（ｍｐｃ）の増殖および／または生存を増強させる方法
KR101682046B1 (ko) 2005-04-12 2016-12-02 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리
WO2007122233A1 (en) * 2006-04-25 2007-11-01 Vrije Universiteit Brussel Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells
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X. FANG ET AL, JOURNAL OF BIOLOGICAL CHEMISTRY, (20100820), vol. 285, no. 34, doi:10.1074/jbc.M110.119917, ISSN 0021-9258, pages 26211 - 26222 *

Also Published As

Publication number Publication date
KR20160145066A (ko) 2016-12-19
KR102405663B1 (ko) 2022-06-07
US20250136944A1 (en) 2025-05-01
AU2022200640B2 (en) 2024-02-15
AU2018200619A1 (en) 2018-02-15
AU2020202214B2 (en) 2021-11-18
CA2944262C (en) 2023-08-01
EP3129468B1 (en) 2022-09-21
CN113337462A (zh) 2021-09-03
AU2015243575A1 (en) 2016-10-13
US20190345452A1 (en) 2019-11-14
SG10202000644TA (en) 2020-03-30
US20230030428A1 (en) 2023-02-02
JP2023021279A (ja) 2023-02-10
CN106459913A (zh) 2017-02-22
JP7196216B2 (ja) 2022-12-26
KR20220080023A (ko) 2022-06-14
JP7571109B2 (ja) 2024-10-22
EP4137560A1 (en) 2023-02-22
SG11201607925SA (en) 2016-10-28
US10400218B2 (en) 2019-09-03
AU2018200619B2 (en) 2020-01-02
AU2020202214A1 (en) 2020-04-16
JP6882161B2 (ja) 2021-06-02
KR102577698B1 (ko) 2023-09-12
EP3129468A1 (en) 2017-02-15
JP2024177516A (ja) 2024-12-19
CN106459913B (zh) 2021-05-18
CA2944262A1 (en) 2015-10-15
JP2017512842A (ja) 2017-05-25
AU2022200640A1 (en) 2022-02-24
JP2021080272A (ja) 2021-05-27
AU2024203197A1 (en) 2024-05-30
US11312941B2 (en) 2022-04-26
WO2015155187A1 (en) 2015-10-15
US20170107495A1 (en) 2017-04-20
AU2018200619B9 (en) 2020-05-07

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