JP2017511876A5 - - Google Patents
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- JP2017511876A5 JP2017511876A5 JP2016548691A JP2016548691A JP2017511876A5 JP 2017511876 A5 JP2017511876 A5 JP 2017511876A5 JP 2016548691 A JP2016548691 A JP 2016548691A JP 2016548691 A JP2016548691 A JP 2016548691A JP 2017511876 A5 JP2017511876 A5 JP 2017511876A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- cd49a
- msc
- differentiated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 11
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims 10
- 102100025323 Integrin alpha-1 Human genes 0.000 claims 10
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 6
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 6
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 6
- 230000004069 differentiation Effects 0.000 claims 6
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 5
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000003900 neurotrophic factor Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000048238 Neuregulin-1 Human genes 0.000 claims 3
- 108090000556 Neuregulin-1 Proteins 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims 1
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 1
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 1
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 229940035722 triiodothyronine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461938172P | 2014-02-11 | 2014-02-11 | |
| US61/938,172 | 2014-02-11 | ||
| PCT/IL2015/050159 WO2015121859A1 (en) | 2014-02-11 | 2015-02-11 | Method of qualifying cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511876A JP2017511876A (ja) | 2017-04-27 |
| JP2017511876A5 true JP2017511876A5 (enExample) | 2018-01-11 |
| JP6628253B2 JP6628253B2 (ja) | 2020-01-08 |
Family
ID=52682791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548691A Active JP6628253B2 (ja) | 2014-02-11 | 2015-02-11 | 細胞の適性を判定する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10564149B2 (enExample) |
| EP (1) | EP3105587B1 (enExample) |
| JP (1) | JP6628253B2 (enExample) |
| BR (1) | BR112016018489A2 (enExample) |
| CA (1) | CA2937305C (enExample) |
| IL (1) | IL246943B (enExample) |
| WO (1) | WO2015121859A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
| EP3105587B1 (en) | 2014-02-11 | 2023-09-06 | Brainstorm Cell Therapeutics Ltd. | Method of qualifying cells |
| WO2017038784A1 (ja) | 2015-08-28 | 2017-03-09 | ロート製薬株式会社 | Ｒｏｒ１陽性の間葉系幹細胞及びその調製方法、ｒｏｒ１陽性の間葉系幹細胞を含む医薬組成物及びその調製方法、並びにｒｏｒ１陽性の間葉系幹細胞を用いる疾患の予防又は治療方法 |
| JP6153653B2 (ja) * | 2015-12-07 | 2017-06-28 | 株式会社Ｃｅｌｌｓ Ｐｏｗｅｒ | 幹細胞培養方法 |
| AU2017235446A1 (en) * | 2016-03-16 | 2018-11-08 | Cell Medicine, Inc. | Mesenchymal stem cells with enhanced efficacy |
| KR20220126789A (ko) | 2016-07-18 | 2022-09-16 | 브레인스톰 셀 세라퓨틱스 리미티드 | 근위축성 측색 경화증 (als)의 치료 방법 |
| CN108559729B (zh) * | 2018-02-05 | 2022-01-14 | 上海科技大学 | Fam49基因及其编码蛋白的应用 |
| KR20200142045A (ko) | 2018-04-10 | 2020-12-21 | 브레인스톰 셀 세라퓨틱스 리미티드 | 세포 타입 특이적인 엑소좀 및 그 용도 |
| EP3850108A4 (en) * | 2018-10-18 | 2022-08-03 | Quadrant Biosciences Inc. | Molecular and functional characterization of early-stage parkinson's disease and treatments therein |
| WO2020086667A1 (en) | 2018-10-25 | 2020-04-30 | American University | Method for promoting adipocyte differentiation and obesity-related disease treatment |
| CN111979186B (zh) * | 2020-08-21 | 2022-04-08 | 遵义医科大学附属医院 | 一种快速高效体外扩增人间充质干细胞的方法及应用 |
| US20220347349A1 (en) * | 2021-04-30 | 2022-11-03 | Stemcellago Inc. | Engineered cartilage |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| JP3948971B2 (ja) | 2001-08-30 | 2007-07-25 | サンバイオ，インコーポレイティド | Ｎｏｔｃｈ遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法 |
| CA2475288C (en) | 2002-02-06 | 2014-09-02 | Sanbio, Inc. | Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene |
| IL152905A0 (en) | 2002-11-17 | 2003-06-24 | Univ Ramot | Dopaminergic markers induction in neuronal-like cells isolated from adult human bone marrow stromal cells: implications for novel gene therapy strategy for parkinsons disease |
| ES2524996T3 (es) * | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC |
| US20100021434A1 (en) | 2005-12-08 | 2010-01-28 | Ramot At Tel Aviv University Ltd. | Isolated Oligodendrocyte-Like Cells and Populations Comprising Same for the Treatment of CNS Diseases |
| DK2285951T3 (en) | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| US20100184033A1 (en) * | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| EP2554176B1 (en) * | 2011-08-04 | 2016-07-27 | ETHIANUM Betriebsgesellschaft mbH & Co. KG | Means for liver regeneration |
| DE102011121982B3 (de) * | 2011-12-22 | 2013-04-18 | Dietmar Hopp Stiftung GmbH | Mesenchymale Stammzellen aus Fettgewebe (ADSC) zur Rekonstruktion von Haut und Weichteilgewebe |
| US9745551B2 (en) * | 2012-07-12 | 2017-08-29 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
| EP3105587B1 (en) | 2014-02-11 | 2023-09-06 | Brainstorm Cell Therapeutics Ltd. | Method of qualifying cells |
-
2015
- 2015-02-11 EP EP15710010.8A patent/EP3105587B1/en active Active
- 2015-02-11 US US15/113,105 patent/US10564149B2/en active Active
- 2015-02-11 CA CA2937305A patent/CA2937305C/en not_active Expired - Fee Related
- 2015-02-11 JP JP2016548691A patent/JP6628253B2/ja active Active
- 2015-02-11 BR BR112016018489A patent/BR112016018489A2/pt not_active Application Discontinuation
- 2015-02-11 WO PCT/IL2015/050159 patent/WO2015121859A1/en not_active Ceased
-
2016
- 2016-07-25 IL IL246943A patent/IL246943B/en active IP Right Grant
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