CA2937305C - Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells - Google Patents
Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells Download PDFInfo
- Publication number
- CA2937305C CA2937305C CA2937305A CA2937305A CA2937305C CA 2937305 C CA2937305 C CA 2937305C CA 2937305 A CA2937305 A CA 2937305A CA 2937305 A CA2937305 A CA 2937305A CA 2937305 C CA2937305 C CA 2937305C
- Authority
- CA
- Canada
- Prior art keywords
- cells
- diseases
- fold
- msc
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims abstract description 88
- 210000001185 bone marrow Anatomy 0.000 title claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 12
- 210000004027 cell Anatomy 0.000 claims abstract description 240
- 102100025323 Integrin alpha-1 Human genes 0.000 claims abstract description 60
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims abstract description 58
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims abstract description 21
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims abstract description 21
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims abstract description 15
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims abstract description 15
- 108090000556 Neuregulin-1 Proteins 0.000 claims abstract description 10
- 102000048238 Neuregulin-1 Human genes 0.000 claims abstract 2
- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 44
- 102000007072 Nerve Growth Factors Human genes 0.000 claims description 43
- 239000003900 neurotrophic factor Substances 0.000 claims description 43
- 239000002609 medium Substances 0.000 claims description 39
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims description 16
- 241000282414 Homo sapiens Species 0.000 claims description 15
- 239000001963 growth medium Substances 0.000 claims description 14
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 12
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 12
- 238000000684 flow cytometry Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- APIXJSLKIYYUKG-UHFFFAOYSA-N 3 Isobutyl 1 methylxanthine Chemical compound O=C1N(C)C(=O)N(CC(C)C)C2=C1N=CN2 APIXJSLKIYYUKG-UHFFFAOYSA-N 0.000 claims description 6
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 5
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 5
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 5
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims description 5
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 5
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 5
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims description 5
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 5
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 5
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims description 5
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 5
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 5
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 5
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 4
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 4
- 102100037241 Endoglin Human genes 0.000 claims description 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 4
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims description 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 4
- 239000002458 cell surface marker Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 56
- 230000001225 therapeutic effect Effects 0.000 abstract description 19
- 108090000623 proteins and genes Proteins 0.000 description 66
- 230000004069 differentiation Effects 0.000 description 50
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 48
- 201000010099 disease Diseases 0.000 description 46
- 102000004169 proteins and genes Human genes 0.000 description 38
- 235000018102 proteins Nutrition 0.000 description 35
- 230000001363 autoimmune Effects 0.000 description 21
- 208000023275 Autoimmune disease Diseases 0.000 description 20
- 208000026935 allergic disease Diseases 0.000 description 20
- 206010020751 Hypersensitivity Diseases 0.000 description 18
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 18
- 210000005087 mononuclear cell Anatomy 0.000 description 15
- 208000015122 neurodegenerative disease Diseases 0.000 description 15
- 239000000463 material Substances 0.000 description 14
- 230000004770 neurodegeneration Effects 0.000 description 14
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 108090000765 processed proteins & peptides Proteins 0.000 description 14
- 238000012258 culturing Methods 0.000 description 13
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 12
- 230000002757 inflammatory effect Effects 0.000 description 11
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 10
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 10
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 10
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 10
- 230000009610 hypersensitivity Effects 0.000 description 10
- 239000006166 lysate Substances 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 10
- 238000012286 ELISA Assay Methods 0.000 description 9
- 101710194460 Growth/differentiation factor 15 Proteins 0.000 description 9
- 102000004890 Interleukin-8 Human genes 0.000 description 9
- 108090001007 Interleukin-8 Proteins 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 206010025135 lupus erythematosus Diseases 0.000 description 9
- 201000006417 multiple sclerosis Diseases 0.000 description 9
- 229920001184 polypeptide Polymers 0.000 description 9
- 210000000130 stem cell Anatomy 0.000 description 9
- 230000035899 viability Effects 0.000 description 9
- 208000012902 Nervous system disease Diseases 0.000 description 8
- 102400000058 Neuregulin-1 Human genes 0.000 description 8
- 208000025966 Neurological disease Diseases 0.000 description 8
- 230000007815 allergy Effects 0.000 description 8
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 8
- 229940096397 interleukin-8 Drugs 0.000 description 8
- 206010008027 Cerebellar atrophy Diseases 0.000 description 7
- 239000012981 Hank's balanced salt solution Substances 0.000 description 7
- 210000001744 T-lymphocyte Anatomy 0.000 description 7
- 230000001464 adherent effect Effects 0.000 description 7
- 230000005784 autoimmunity Effects 0.000 description 7
- 239000012228 culture supernatant Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000002519 immonomodulatory effect Effects 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 230000001404 mediated effect Effects 0.000 description 7
- 206010028417 myasthenia gravis Diseases 0.000 description 7
- 201000001119 neuropathy Diseases 0.000 description 7
- 230000007823 neuropathy Effects 0.000 description 7
- 230000028327 secretion Effects 0.000 description 7
- 208000011580 syndromic disease Diseases 0.000 description 7
- 208000031212 Autoimmune polyendocrinopathy Diseases 0.000 description 6
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 6
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 6
- 206010052779 Transplant rejections Diseases 0.000 description 6
- 108090000631 Trypsin Proteins 0.000 description 6
- 102000004142 Trypsin Human genes 0.000 description 6
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 6
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 229940095074 cyclic amp Drugs 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000000762 glandular Effects 0.000 description 6
- 230000006698 induction Effects 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- 230000003248 secreting effect Effects 0.000 description 6
- 239000012588 trypsin Substances 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 208000035473 Communicable disease Diseases 0.000 description 5
- 230000004543 DNA replication Effects 0.000 description 5
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 5
- 208000000509 infertility Diseases 0.000 description 5
- 230000036512 infertility Effects 0.000 description 5
- 230000002438 mitochondrial effect Effects 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 230000000750 progressive effect Effects 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 102100038778 Amphiregulin Human genes 0.000 description 4
- 208000023328 Basedow disease Diseases 0.000 description 4
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 4
- 208000024172 Cardiovascular disease Diseases 0.000 description 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 4
- 208000015023 Graves' disease Diseases 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 4
- 208000001718 Immediate Hypersensitivity Diseases 0.000 description 4
- 206010025323 Lymphomas Diseases 0.000 description 4
- 208000001089 Multiple system atrophy Diseases 0.000 description 4
- 201000002481 Myositis Diseases 0.000 description 4
- 206010028665 Myxoedema Diseases 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- 108090000854 Oxidoreductases Proteins 0.000 description 4
- 201000011152 Pemphigus Diseases 0.000 description 4
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 4
- 206010072148 Stiff-Person syndrome Diseases 0.000 description 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 4
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 4
- -1 TrypLEI'M) Proteins 0.000 description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 4
- 206010045240 Type I hypersensitivity Diseases 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 208000010216 atopic IgE responsiveness Diseases 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 208000018631 connective tissue disease Diseases 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 208000032625 disorder of ear Diseases 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 206010014599 encephalitis Diseases 0.000 description 4
- 229940126864 fibroblast growth factor Drugs 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000003500 gene array Methods 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 208000027866 inflammatory disease Diseases 0.000 description 4
- 208000019423 liver disease Diseases 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 208000003786 myxedema Diseases 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- 230000002611 ovarian Effects 0.000 description 4
- 210000004623 platelet-rich plasma Anatomy 0.000 description 4
- 201000007094 prostatitis Diseases 0.000 description 4
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 229940035722 triiodothyronine Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 3
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 3
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 3
- 102100032912 CD44 antigen Human genes 0.000 description 3
- 108010084457 Cathepsins Proteins 0.000 description 3
- 102000005600 Cathepsins Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 102100022874 Dexamethasone-induced Ras-related protein 1 Human genes 0.000 description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- 101000809450 Homo sapiens Amphiregulin Proteins 0.000 description 3
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 3
- 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 description 3
- 101000620808 Homo sapiens Dexamethasone-induced Ras-related protein 1 Proteins 0.000 description 3
- 208000000209 Isaacs syndrome Diseases 0.000 description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- 229930182816 L-glutamine Natural products 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 208000012654 Primary biliary cholangitis Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 102000008847 Serpin Human genes 0.000 description 3
- 108050000761 Serpin Proteins 0.000 description 3
- 102100030416 Stromelysin-1 Human genes 0.000 description 3
- 208000024799 Thyroid disease Diseases 0.000 description 3
- CJGYSWNGNKCJSB-YVLZZHOMSA-M [(4ar,6r,7r,7ar)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate Chemical compound C([C@H]1O2)OP([O-])(=O)O[C@H]1[C@@H](OC(=O)CCC)[C@@H]2N1C(N=CN=C2NC(=O)CCC)=C2N=C1 CJGYSWNGNKCJSB-YVLZZHOMSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 3
- 239000001099 ammonium carbonate Substances 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000000469 anti-sperm effect Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 208000010928 autoimmune thyroid disease Diseases 0.000 description 3
- 230000030833 cell death Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000000432 density-gradient centrifugation Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 230000002518 glial effect Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 231100000535 infertility Toxicity 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 102000006495 integrins Human genes 0.000 description 3
- 108010044426 integrins Proteins 0.000 description 3
- 208000028774 intestinal disease Diseases 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 238000010369 molecular cloning Methods 0.000 description 3
- 210000002161 motor neuron Anatomy 0.000 description 3
- 230000002956 necrotizing effect Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 239000003001 serine protease inhibitor Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- 102000005602 Aldo-Keto Reductases Human genes 0.000 description 2
- 108010084469 Aldo-Keto Reductases Proteins 0.000 description 2
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 description 2
- 206010001935 American trypanosomiasis Diseases 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 description 2
- 208000008037 Arthrogryposis Diseases 0.000 description 2
- 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 208000024699 Chagas disease Diseases 0.000 description 2
- 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- 206010008748 Chorea Diseases 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- 208000015943 Coeliac disease Diseases 0.000 description 2
- 102100027995 Collagenase 3 Human genes 0.000 description 2
- 102100022133 Complement C3 Human genes 0.000 description 2
- 108010078010 Complement C3c Proteins 0.000 description 2
- 102100033777 Complement C4-B Human genes 0.000 description 2
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 2
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 2
- 102100033711 DNA replication licensing factor MCM7 Human genes 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 229920001917 Ficoll Polymers 0.000 description 2
- 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 2
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 description 2
- 206010018364 Glomerulonephritis Diseases 0.000 description 2
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 description 2
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 2
- 208000027761 Hepatic autoimmune disease Diseases 0.000 description 2
- 206010019755 Hepatitis chronic active Diseases 0.000 description 2
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 description 2
- 101000975428 Homo sapiens Inositol 1,4,5-trisphosphate receptor type 1 Proteins 0.000 description 2
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 2
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 2
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 description 2
- 101001138006 Homo sapiens Purine nucleoside phosphorylase LACC1 Proteins 0.000 description 2
- 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 description 2
- 101000830894 Homo sapiens Targeting protein for Xklp2 Proteins 0.000 description 2
- 101000801701 Homo sapiens Tropomyosin alpha-1 chain Proteins 0.000 description 2
- 102100024039 Inositol 1,4,5-trisphosphate receptor type 1 Human genes 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
- 108010041341 Integrin alpha1 Proteins 0.000 description 2
- 102000000510 Integrin alpha3 Human genes 0.000 description 2
- 108010041357 Integrin alpha3 Proteins 0.000 description 2
- 102000008070 Interferon-gamma Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 102100039065 Interleukin-1 beta Human genes 0.000 description 2
- 208000026492 Isaac syndrome Diseases 0.000 description 2
- 102100033542 Keratin-associated protein 2-3 Human genes 0.000 description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 2
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 2
- 208000021642 Muscular disease Diseases 0.000 description 2
- 206010028424 Myasthenic syndrome Diseases 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 239000012580 N-2 Supplement Substances 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010029240 Neuritis Diseases 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 208000003435 Optic Neuritis Diseases 0.000 description 2
- 208000016222 Pancreatic disease Diseases 0.000 description 2
- 102100040156 Pappalysin-1 Human genes 0.000 description 2
- 206010034277 Pemphigoid Diseases 0.000 description 2
- 208000027086 Pemphigus foliaceus Diseases 0.000 description 2
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 description 2
- 102100033076 Prostaglandin E synthase Human genes 0.000 description 2
- 102100020863 Purine nucleoside phosphorylase LACC1 Human genes 0.000 description 2
- 206010071141 Rasmussen encephalitis Diseases 0.000 description 2
- 208000004160 Rasmussen subacute encephalitis Diseases 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 241000272534 Struthio camelus Species 0.000 description 2
- 201000009594 Systemic Scleroderma Diseases 0.000 description 2
- 208000018359 Systemic autoimmune disease Diseases 0.000 description 2
- 206010042953 Systemic sclerosis Diseases 0.000 description 2
- 208000001106 Takayasu Arteritis Diseases 0.000 description 2
- 102100024813 Targeting protein for Xklp2 Human genes 0.000 description 2
- 206010043561 Thrombocytopenic purpura Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 208000000323 Tourette Syndrome Diseases 0.000 description 2
- 208000016620 Tourette disease Diseases 0.000 description 2
- 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 description 2
- 102000004243 Tubulin Human genes 0.000 description 2
- 108090000704 Tubulin Proteins 0.000 description 2
- 206010054000 Type II hypersensitivity Diseases 0.000 description 2
- 208000024780 Urticaria Diseases 0.000 description 2
- 229960004308 acetylcysteine Drugs 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 230000011759 adipose tissue development Effects 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000002617 apheresis Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 208000025150 arthrogryposis multiplex congenita Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 2
- 201000004339 autoimmune neuropathy Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000009583 bone marrow aspiration Methods 0.000 description 2
- 208000000594 bullous pemphigoid Diseases 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 208000012601 choreatic disease Diseases 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 201000005637 crescentic glomerulonephritis Diseases 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000001177 diphosphate Substances 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- 201000007850 distal arthrogryposis Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000003027 ear inner Anatomy 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 229960000301 factor viii Drugs 0.000 description 2
- 231100000562 fetal loss Toxicity 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 2
- 229960002743 glutamine Drugs 0.000 description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 description 2
- 208000007475 hemolytic anemia Diseases 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 229940116978 human epidermal growth factor Drugs 0.000 description 2
- 230000002631 hypothermal effect Effects 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960003130 interferon gamma Drugs 0.000 description 2
- 201000006334 interstitial nephritis Diseases 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 206010063344 microscopic polyangiitis Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 201000008383 nephritis Diseases 0.000 description 2
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000004409 osteocyte Anatomy 0.000 description 2
- 208000015124 ovarian disease Diseases 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 201000001976 pemphigus vulgaris Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000005059 placental tissue Anatomy 0.000 description 2
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 229940054269 sodium pyruvate Drugs 0.000 description 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010043778 thyroiditis Diseases 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000008026 type II hypersensitivity Effects 0.000 description 2
- 230000005951 type IV hypersensitivity Effects 0.000 description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- QBACGOWRJDBXSG-ONEGZZNKSA-N (e)-n-[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound N1=CN=C2C=NC(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(Cl)C(Br)=C1 QBACGOWRJDBXSG-ONEGZZNKSA-N 0.000 description 1
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 description 1
- MXCVHSXCXPHOLP-UHFFFAOYSA-N 4-oxo-6-propylchromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=CC(CCC)=CC=C21 MXCVHSXCXPHOLP-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 102400001130 70 kDa lysosomal alpha-glucosidase Human genes 0.000 description 1
- 101800004983 70 kDa lysosomal alpha-glucosidase Proteins 0.000 description 1
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 description 1
- 108091022885 ADAM Proteins 0.000 description 1
- 102000029791 ADAM Human genes 0.000 description 1
- 102000051389 ADAMTS5 Human genes 0.000 description 1
- 108091005663 ADAMTS5 Proteins 0.000 description 1
- 102100036612 ATP-binding cassette sub-family A member 6 Human genes 0.000 description 1
- 102100024643 ATP-binding cassette sub-family D member 1 Human genes 0.000 description 1
- 102100028221 Abl interactor 2 Human genes 0.000 description 1
- 206010000871 Acute monocytic leukaemia Diseases 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 206010000890 Acute myelomonocytic leukaemia Diseases 0.000 description 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 102400000630 Acylation stimulating protein Human genes 0.000 description 1
- 101800000415 Acylation stimulating protein Proteins 0.000 description 1
- 102100039075 Aldehyde dehydrogenase family 1 member A3 Human genes 0.000 description 1
- 101710161969 Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 206010058285 Allergy to arthropod bite Diseases 0.000 description 1
- 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 1
- 102100035028 Alpha-L-iduronidase Human genes 0.000 description 1
- 102100026277 Alpha-galactosidase A Human genes 0.000 description 1
- 108010033760 Amphiregulin Proteins 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 102100033393 Anillin Human genes 0.000 description 1
- 208000008822 Ankylosis Diseases 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 102100023005 Anoctamin-3 Human genes 0.000 description 1
- 102100031325 Anthrax toxin receptor 2 Human genes 0.000 description 1
- 101710125926 Anthrax toxin receptor 2 Proteins 0.000 description 1
- 101100328878 Arabidopsis thaliana COL14 gene Proteins 0.000 description 1
- 108010070255 Aspartate-ammonia ligase Proteins 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 208000023345 Autoimmune Diseases of the Nervous System Diseases 0.000 description 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102100026031 Beta-glucuronidase Human genes 0.000 description 1
- 206010004659 Biliary cirrhosis Diseases 0.000 description 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 1
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 102100028237 Breast cancer anti-estrogen resistance protein 1 Human genes 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 102100039396 C-X-C motif chemokine 16 Human genes 0.000 description 1
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 description 1
- 101800001577 C3a anaphylatoxin Proteins 0.000 description 1
- 102400000126 C4a anaphylatoxin Human genes 0.000 description 1
- 101800001547 C4a anaphylatoxin Proteins 0.000 description 1
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 1
- 102400000134 C4d-B Human genes 0.000 description 1
- 101800003829 C4d-B Proteins 0.000 description 1
- 102100032996 C5a anaphylatoxin chemotactic receptor 2 Human genes 0.000 description 1
- 102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 description 1
- 102100031168 CCN family member 2 Human genes 0.000 description 1
- 102100031173 CCN family member 4 Human genes 0.000 description 1
- 101100280481 Caenorhabditis elegans lbp-2 gene Proteins 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 102100032346 Cell cycle progression protein 1 Human genes 0.000 description 1
- 102100023473 Cell growth-regulating nucleolar protein Human genes 0.000 description 1
- 102100034786 Cell migration-inducing and hyaluronan-binding protein Human genes 0.000 description 1
- 206010008025 Cerebellar ataxia Diseases 0.000 description 1
- 102100032402 Charged multivesicular body protein 1a Human genes 0.000 description 1
- 108010014419 Chemokine CXCL1 Proteins 0.000 description 1
- 102000016950 Chemokine CXCL1 Human genes 0.000 description 1
- 108010014421 Chemokine CXCL5 Proteins 0.000 description 1
- 102000016948 Chemokine CXCL5 Human genes 0.000 description 1
- 102000016947 Chemokine CXCL6 Human genes 0.000 description 1
- 108010014423 Chemokine CXCL6 Proteins 0.000 description 1
- 108010066813 Chitinase-3-Like Protein 1 Proteins 0.000 description 1
- 102100033722 Cholesterol 25-hydroxylase Human genes 0.000 description 1
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 102000005870 Coenzyme A Ligases Human genes 0.000 description 1
- 102000012432 Collagen Type V Human genes 0.000 description 1
- 108010022514 Collagen Type V Proteins 0.000 description 1
- 102100036217 Collagen alpha-1(X) chain Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 206010048832 Colon adenoma Diseases 0.000 description 1
- 108010028780 Complement C3 Proteins 0.000 description 1
- 102400000625 Complement C3 alpha chain Human genes 0.000 description 1
- 101710089593 Complement C3 alpha chain Proteins 0.000 description 1
- 102400000627 Complement C3 beta chain Human genes 0.000 description 1
- 101800000262 Complement C3 beta chain Proteins 0.000 description 1
- 108010078015 Complement C3b Proteins 0.000 description 1
- 108010078018 Complement C3d Proteins 0.000 description 1
- 102400000635 Complement C3dg fragment Human genes 0.000 description 1
- 101800000421 Complement C3dg fragment Proteins 0.000 description 1
- 102400000634 Complement C3g fragment Human genes 0.000 description 1
- 101800001174 Complement C3g fragment Proteins 0.000 description 1
- 102400000136 Complement C4 beta chain Human genes 0.000 description 1
- 101800001590 Complement C4 beta chain Proteins 0.000 description 1
- 102400000133 Complement C4-B alpha chain Human genes 0.000 description 1
- 101800002398 Complement C4-B alpha chain Proteins 0.000 description 1
- 108010077762 Complement C4b Proteins 0.000 description 1
- 108050001175 Connexin Proteins 0.000 description 1
- 102000010970 Connexin Human genes 0.000 description 1
- 108010031504 Crk Associated Substrate Protein Proteins 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102100031096 Cubilin Human genes 0.000 description 1
- 102100025191 Cyclin-A2 Human genes 0.000 description 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 description 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 description 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 1
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 description 1
- 108010019961 Cysteine-Rich Protein 61 Proteins 0.000 description 1
- 102000005889 Cysteine-Rich Protein 61 Human genes 0.000 description 1
- 102000012466 Cytochrome P450 1B1 Human genes 0.000 description 1
- 108050002014 Cytochrome P450 1B1 Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102100036318 Cytoplasmic phosphatidylinositol transfer protein 1 Human genes 0.000 description 1
- ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 description 1
- 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 1
- 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 description 1
- 102100039606 DNA replication licensing factor MCM3 Human genes 0.000 description 1
- 102100021389 DNA replication licensing factor MCM4 Human genes 0.000 description 1
- 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 description 1
- 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 1
- 101100264065 Danio rerio wnt5b gene Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 208000016192 Demyelinating disease Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 208000019872 Drug Eruptions Diseases 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 102100031788 E3 ubiquitin-protein ligase MYLIP Human genes 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102100030376 Ermin Human genes 0.000 description 1
- 208000006168 Ewing Sarcoma Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102100027267 FERM, ARHGEF and pleckstrin domain-containing protein 1 Human genes 0.000 description 1
- 102100029595 Fatty acyl-CoA reductase 2 Human genes 0.000 description 1
- 102100028313 Fibrinogen beta chain Human genes 0.000 description 1
- 102100028412 Fibroblast growth factor 10 Human genes 0.000 description 1
- 102100028065 Fibulin-5 Human genes 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 206010016946 Food allergy Diseases 0.000 description 1
- 102100028466 Frizzled-8 Human genes 0.000 description 1
- 102100040014 GH3 domain-containing protein Human genes 0.000 description 1
- 102000030782 GTP binding Human genes 0.000 description 1
- 108091000058 GTP-Binding Proteins 0.000 description 1
- 102000030902 Galactosyltransferase Human genes 0.000 description 1
- 108060003306 Galactosyltransferase Proteins 0.000 description 1
- 101100226596 Gallus gallus FABP gene Proteins 0.000 description 1
- 102100034004 Gamma-adducin Human genes 0.000 description 1
- 208000015872 Gaucher disease Diseases 0.000 description 1
- 102100033299 Glia-derived nexin Human genes 0.000 description 1
- 101710183811 Glia-derived nexin Proteins 0.000 description 1
- 102000004366 Glucosidases Human genes 0.000 description 1
- 108010056771 Glucosidases Proteins 0.000 description 1
- 102000053187 Glucuronidase Human genes 0.000 description 1
- 108010060309 Glucuronidase Proteins 0.000 description 1
- 102100030669 Glutamate receptor 3 Human genes 0.000 description 1
- 102100034062 Glutathione hydrolase 5 proenzyme Human genes 0.000 description 1
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- 108700016170 Glycerol kinases Proteins 0.000 description 1
- 102100023849 Glycophorin-C Human genes 0.000 description 1
- 102100032527 Glypican-4 Human genes 0.000 description 1
- 238000003794 Gram staining Methods 0.000 description 1
- 102100036683 Growth arrest-specific protein 1 Human genes 0.000 description 1
- 102100034221 Growth-regulated alpha protein Human genes 0.000 description 1
- 102000002737 Heme Oxygenase-1 Human genes 0.000 description 1
- 108010018924 Heme Oxygenase-1 Proteins 0.000 description 1
- 102100034629 Hemopexin Human genes 0.000 description 1
- 108090000481 Heparin Cofactor II Proteins 0.000 description 1
- 102100030500 Heparin cofactor 2 Human genes 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000929676 Homo sapiens ATP-binding cassette sub-family A member 6 Proteins 0.000 description 1
- 101000724231 Homo sapiens Abl interactor 2 Proteins 0.000 description 1
- 101000959046 Homo sapiens Aldehyde dehydrogenase family 1 member A3 Proteins 0.000 description 1
- 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 description 1
- 101001019502 Homo sapiens Alpha-L-iduronidase Proteins 0.000 description 1
- 101000732632 Homo sapiens Anillin Proteins 0.000 description 1
- 101000757285 Homo sapiens Anoctamin-3 Proteins 0.000 description 1
- 101000975992 Homo sapiens Asparagine synthetase [glutamine-hydrolyzing] Proteins 0.000 description 1
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 description 1
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 1
- 101000899388 Homo sapiens Bone morphogenetic protein 5 Proteins 0.000 description 1
- 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 description 1
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 description 1
- 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 1
- 101000868001 Homo sapiens C5a anaphylatoxin chemotactic receptor 2 Proteins 0.000 description 1
- 101000945963 Homo sapiens CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 1
- 101000777560 Homo sapiens CCN family member 4 Proteins 0.000 description 1
- 101000868629 Homo sapiens Cell cycle progression protein 1 Proteins 0.000 description 1
- 101000622133 Homo sapiens Cell growth-regulating nucleolar protein Proteins 0.000 description 1
- 101000945881 Homo sapiens Cell migration-inducing and hyaluronan-binding protein Proteins 0.000 description 1
- 101000943264 Homo sapiens Charged multivesicular body protein 1a Proteins 0.000 description 1
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 description 1
- 101000944583 Homo sapiens Cholesterol 25-hydroxylase Proteins 0.000 description 1
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 description 1
- 101000875027 Homo sapiens Collagen alpha-1(X) chain Proteins 0.000 description 1
- 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 description 1
- 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 1
- 101001074657 Homo sapiens Cytoplasmic phosphatidylinositol transfer protein 1 Proteins 0.000 description 1
- 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 1
- 101000963174 Homo sapiens DNA replication licensing factor MCM3 Proteins 0.000 description 1
- 101000615280 Homo sapiens DNA replication licensing factor MCM4 Proteins 0.000 description 1
- 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 description 1
- 101000801505 Homo sapiens DNA topoisomerase 2-alpha Proteins 0.000 description 1
- 101001128447 Homo sapiens E3 ubiquitin-protein ligase MYLIP Proteins 0.000 description 1
- 101001063322 Homo sapiens Ermin Proteins 0.000 description 1
- 101000914701 Homo sapiens FERM, ARHGEF and pleckstrin domain-containing protein 1 Proteins 0.000 description 1
- 101000917301 Homo sapiens Fatty acyl-CoA reductase 2 Proteins 0.000 description 1
- 101000917237 Homo sapiens Fibroblast growth factor 10 Proteins 0.000 description 1
- 101001060252 Homo sapiens Fibulin-5 Proteins 0.000 description 1
- 101001061408 Homo sapiens Frizzled-8 Proteins 0.000 description 1
- 101000886770 Homo sapiens GH3 domain-containing protein Proteins 0.000 description 1
- 101000799011 Homo sapiens Gamma-adducin Proteins 0.000 description 1
- 101001010434 Homo sapiens Glutamate receptor 3 Proteins 0.000 description 1
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 description 1
- 101000926237 Homo sapiens Glutathione hydrolase 5 proenzyme Proteins 0.000 description 1
- 101000905336 Homo sapiens Glycophorin-C Proteins 0.000 description 1
- 101001014682 Homo sapiens Glypican-4 Proteins 0.000 description 1
- 101001072723 Homo sapiens Growth arrest-specific protein 1 Proteins 0.000 description 1
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 1
- 101000993959 Homo sapiens Inositol 1,4,5-trisphosphate receptor-interacting protein Proteins 0.000 description 1
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 description 1
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 description 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 description 1
- 101000944965 Homo sapiens Keratin-associated protein 2-3 Proteins 0.000 description 1
- 101001137642 Homo sapiens Kinase suppressor of Ras 1 Proteins 0.000 description 1
- 101001021858 Homo sapiens Kynureninase Proteins 0.000 description 1
- 101001054649 Homo sapiens Latent-transforming growth factor beta-binding protein 2 Proteins 0.000 description 1
- 101001054646 Homo sapiens Latent-transforming growth factor beta-binding protein 3 Proteins 0.000 description 1
- 101000942133 Homo sapiens Leupaxin Proteins 0.000 description 1
- 101001051093 Homo sapiens Low-density lipoprotein receptor Proteins 0.000 description 1
- 101000834125 Homo sapiens Medium-chain acyl-CoA ligase ACSF2, mitochondrial Proteins 0.000 description 1
- 101000589407 Homo sapiens Membrane progestin receptor gamma Proteins 0.000 description 1
- 101000615030 Homo sapiens Mesenteric estrogen-dependent adipogenesis protein Proteins 0.000 description 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 1
- 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 description 1
- 101000577033 Homo sapiens Monocarboxylate transporter 7 Proteins 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- 101000979249 Homo sapiens Neuromodulin Proteins 0.000 description 1
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 1
- 101001109698 Homo sapiens Nuclear receptor subfamily 4 group A member 2 Proteins 0.000 description 1
- 101001001576 Homo sapiens PSME3-interacting protein Proteins 0.000 description 1
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 description 1
- 101000741974 Homo sapiens Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Proteins 0.000 description 1
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 description 1
- 101000613207 Homo sapiens Pre-B-cell leukemia transcription factor-interacting protein 1 Proteins 0.000 description 1
- 101001109800 Homo sapiens Pro-neuregulin-1, membrane-bound isoform Proteins 0.000 description 1
- 101000766246 Homo sapiens Probable E3 ubiquitin-protein ligase MID2 Proteins 0.000 description 1
- 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 1
- 101001135391 Homo sapiens Prostaglandin E synthase Proteins 0.000 description 1
- 101000579300 Homo sapiens Prostaglandin F2-alpha receptor Proteins 0.000 description 1
- 101001057166 Homo sapiens Protein EVI2A Proteins 0.000 description 1
- 101001057168 Homo sapiens Protein EVI2B Proteins 0.000 description 1
- 101000702391 Homo sapiens Protein sprouty homolog 1 Proteins 0.000 description 1
- 101000848199 Homo sapiens Protocadherin Fat 4 Proteins 0.000 description 1
- 101001062751 Homo sapiens Pseudokinase FAM20A Proteins 0.000 description 1
- 101000744536 Homo sapiens Ras-related protein Rab-27B Proteins 0.000 description 1
- 101000620559 Homo sapiens Ras-related protein Rab-3B Proteins 0.000 description 1
- 101000695838 Homo sapiens Receptor-type tyrosine-protein phosphatase U Proteins 0.000 description 1
- 101001092185 Homo sapiens Regulator of cell cycle RGCC Proteins 0.000 description 1
- 101001095783 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 B Proteins 0.000 description 1
- 101000617796 Homo sapiens SPARC-related modular calcium-binding protein 1 Proteins 0.000 description 1
- 101000864786 Homo sapiens Secreted frizzled-related protein 2 Proteins 0.000 description 1
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 description 1
- 101000708620 Homo sapiens Spermine oxidase Proteins 0.000 description 1
- 101000825726 Homo sapiens Structural maintenance of chromosomes protein 4 Proteins 0.000 description 1
- 101000868422 Homo sapiens Sushi, nidogen and EGF-like domain-containing protein 1 Proteins 0.000 description 1
- 101000800113 Homo sapiens THO complex subunit 2 Proteins 0.000 description 1
- 101000837987 Homo sapiens Tandem C2 domains nuclear protein Proteins 0.000 description 1
- 101000800679 Homo sapiens Testis development-related protein Proteins 0.000 description 1
- 101000845188 Homo sapiens Tetratricopeptide repeat protein 4 Proteins 0.000 description 1
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 description 1
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 description 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 description 1
- 101000652736 Homo sapiens Transgelin Proteins 0.000 description 1
- 101000766332 Homo sapiens Tribbles homolog 1 Proteins 0.000 description 1
- 101000830781 Homo sapiens Tropomyosin alpha-4 chain Proteins 0.000 description 1
- 101000845176 Homo sapiens Tsukushi Proteins 0.000 description 1
- 101000652492 Homo sapiens Tubulin-specific chaperone cofactor E-like protein Proteins 0.000 description 1
- 101000847156 Homo sapiens Tumor necrosis factor-inducible gene 6 protein Proteins 0.000 description 1
- 101000947196 Homo sapiens Uncharacterized protein CXorf38 Proteins 0.000 description 1
- 101000871912 Homo sapiens Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 Proteins 0.000 description 1
- 101000955355 Homo sapiens Xylosyltransferase 1 Proteins 0.000 description 1
- 101000788773 Homo sapiens Zinc finger and BTB domain-containing protein 2 Proteins 0.000 description 1
- 101000857276 Homo sapiens Zinc finger protein GLIS3 Proteins 0.000 description 1
- 241000511976 Hoya Species 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 102000003918 Hyaluronan Synthases Human genes 0.000 description 1
- 108090000320 Hyaluronan Synthases Proteins 0.000 description 1
- 208000024781 Immune Complex disease Diseases 0.000 description 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 102100027004 Inhibin beta A chain Human genes 0.000 description 1
- 102100031533 Inositol 1,4,5-trisphosphate receptor-interacting protein Human genes 0.000 description 1
- 102100032819 Integrin alpha-3 Human genes 0.000 description 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
- 102000003815 Interleukin-11 Human genes 0.000 description 1
- 108090000177 Interleukin-11 Proteins 0.000 description 1
- 206010023198 Joint ankylosis Diseases 0.000 description 1
- 102100026153 Junction plakoglobin Human genes 0.000 description 1
- 102100022926 Keratin, type II cytoskeletal 2 oral Human genes 0.000 description 1
- 101710182897 Keratin-associated protein 2-3 Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102100021001 Kinase suppressor of Ras 1 Human genes 0.000 description 1
- 102100036091 Kynureninase Human genes 0.000 description 1
- ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010029541 Laccase Proteins 0.000 description 1
- 102100027017 Latent-transforming growth factor beta-binding protein 2 Human genes 0.000 description 1
- 208000007811 Latex Hypersensitivity Diseases 0.000 description 1
- 102100027919 Latexin Human genes 0.000 description 1
- 108090000581 Leukemia inhibitory factor Proteins 0.000 description 1
- 102100032352 Leukemia inhibitory factor Human genes 0.000 description 1
- 208000034800 Leukoencephalopathies Diseases 0.000 description 1
- 102100032755 Leupaxin Human genes 0.000 description 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 description 1
- 102100032114 Lumican Human genes 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 1
- 101710097496 Lysophospholipid acyltransferase Proteins 0.000 description 1
- 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 description 1
- 208000015439 Lysosomal storage disease Diseases 0.000 description 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 1
- 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 description 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 description 1
- 241000948268 Meda Species 0.000 description 1
- 102100026674 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Human genes 0.000 description 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102100032334 Membrane progestin receptor gamma Human genes 0.000 description 1
- 208000027007 Meningioma benign Diseases 0.000 description 1
- 102100021078 Mesenteric estrogen-dependent adipogenesis protein Human genes 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 1
- 102100026711 Metalloreductase STEAP2 Human genes 0.000 description 1
- 108700011259 MicroRNAs Proteins 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 102100025311 Monocarboxylate transporter 7 Human genes 0.000 description 1
- 102000000562 Monocarboxylic Acid Transporters Human genes 0.000 description 1
- 101710204259 Monocarboxylic acid transporter Proteins 0.000 description 1
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 description 1
- 208000014767 Myeloproliferative disease Diseases 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 108010082699 NADPH Oxidase 4 Proteins 0.000 description 1
- 102100021872 NADPH oxidase 4 Human genes 0.000 description 1
- 108020002144 NR4 subfamily Proteins 0.000 description 1
- 102000014413 Neuregulin Human genes 0.000 description 1
- 108050003475 Neuregulin Proteins 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 description 1
- 102100023206 Neuromodulin Human genes 0.000 description 1
- 206010072359 Neuromyotonia Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 102100022676 Nuclear receptor subfamily 4 group A member 2 Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102100036139 PSME3-interacting protein Human genes 0.000 description 1
- 102220642281 PTB domain-containing engulfment adapter protein 1_D13A_mutation Human genes 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- 102100038634 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Human genes 0.000 description 1
- 108090000216 Phospholipid Transfer Proteins Proteins 0.000 description 1
- 102000003867 Phospholipid Transfer Proteins Human genes 0.000 description 1
- 102100033616 Phospholipid-transporting ATPase ABCA1 Human genes 0.000 description 1
- 102000009097 Phosphorylases Human genes 0.000 description 1
- 108010073135 Phosphorylases Proteins 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 101710191627 Photosystem II CP43 reaction center protein Proteins 0.000 description 1
- 102000001938 Plasminogen Activators Human genes 0.000 description 1
- 108010001014 Plasminogen Activators Proteins 0.000 description 1
- 102100030264 Pleckstrin Human genes 0.000 description 1
- 208000025237 Polyendocrinopathy Diseases 0.000 description 1
- 102100040882 Pre-B-cell leukemia transcription factor-interacting protein 1 Human genes 0.000 description 1
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 208000024777 Prion disease Diseases 0.000 description 1
- 102100026310 Probable E3 ubiquitin-protein ligase MID2 Human genes 0.000 description 1
- 102100026534 Procathepsin L Human genes 0.000 description 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 1
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 description 1
- 101710180553 Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 description 1
- 102000000471 Prostaglandin F receptors Human genes 0.000 description 1
- 108050008995 Prostaglandin F receptors Proteins 0.000 description 1
- 102100028248 Prostaglandin F2-alpha receptor Human genes 0.000 description 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 1
- 108090000748 Prostaglandin-E Synthases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100027246 Protein EVI2A Human genes 0.000 description 1
- 102100027249 Protein EVI2B Human genes 0.000 description 1
- 101710182619 Protein FAM107B Proteins 0.000 description 1
- 102100026983 Protein FAM107B Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102100021273 Protein Mpv17 Human genes 0.000 description 1
- 101710118436 Protein Mpv17 Proteins 0.000 description 1
- 101710132808 Protein P6 Proteins 0.000 description 1
- 101710133143 Protein U8 Proteins 0.000 description 1
- 102100035296 Protein Wnt-5a Human genes 0.000 description 1
- 101710118736 Protein Wnt-5a Proteins 0.000 description 1
- 101710133193 Protein pid-1 Proteins 0.000 description 1
- 102100030399 Protein sprouty homolog 1 Human genes 0.000 description 1
- 102100028965 Proteoglycan 4 Human genes 0.000 description 1
- 101710127913 Proteoglycan 4 Proteins 0.000 description 1
- 102100034547 Protocadherin Fat 4 Human genes 0.000 description 1
- 102100030553 Pseudokinase FAM20A Human genes 0.000 description 1
- 108010053763 Pyruvate Carboxylase Proteins 0.000 description 1
- 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 description 1
- 102100039767 Ras-related protein Rab-27A Human genes 0.000 description 1
- 102100039765 Ras-related protein Rab-27B Human genes 0.000 description 1
- 102100022306 Ras-related protein Rab-3B Human genes 0.000 description 1
- 102100028516 Receptor-type tyrosine-protein phosphatase U Human genes 0.000 description 1
- 102100035542 Regulator of cell cycle RGCC Human genes 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 208000006289 Rett Syndrome Diseases 0.000 description 1
- 108010053823 Rho Guanine Nucleotide Exchange Factors Proteins 0.000 description 1
- 102100039640 Rho-related GTP-binding protein RhoE Human genes 0.000 description 1
- 108050007494 Rho-related GTP-binding protein RhoE Proteins 0.000 description 1
- 102100038013 Ribonucleoside-diphosphate reductase subunit M2 B Human genes 0.000 description 1
- 206010039251 Rubber sensitivity Diseases 0.000 description 1
- 108091006193 SLC44 Proteins 0.000 description 1
- 102100021995 SPARC-related modular calcium-binding protein 1 Human genes 0.000 description 1
- 101100127690 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FAA2 gene Proteins 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010048908 Seasonal allergy Diseases 0.000 description 1
- 102100030054 Secreted frizzled-related protein 2 Human genes 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 102100036202 Serum amyloid P-component Human genes 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100032800 Spermine oxidase Human genes 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 102100022842 Structural maintenance of chromosomes protein 4 Human genes 0.000 description 1
- 102100032853 Sushi, nidogen and EGF-like domain-containing protein 1 Human genes 0.000 description 1
- 102100021919 Syncoilin Human genes 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 101710137500 T7 RNA polymerase Proteins 0.000 description 1
- 102100033491 THO complex subunit 2 Human genes 0.000 description 1
- 101100451295 Takifugu rubripes hmox gene Proteins 0.000 description 1
- 102100028544 Tandem C2 domains nuclear protein Human genes 0.000 description 1
- 208000022292 Tay-Sachs disease Diseases 0.000 description 1
- 102100033675 Testis development-related protein Human genes 0.000 description 1
- 102100031279 Tetratricopeptide repeat protein 4 Human genes 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 108060008245 Thrombospondin Proteins 0.000 description 1
- 102000002938 Thrombospondin Human genes 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102100030859 Tissue factor Human genes 0.000 description 1
- 102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 241000159243 Toxicodendron radicans Species 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 108010057666 Transcription Factor CHOP Proteins 0.000 description 1
- 102100030798 Transcription factor HES-1 Human genes 0.000 description 1
- 102100023234 Transcription factor MafB Human genes 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 102100031013 Transgelin Human genes 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 102100026387 Tribbles homolog 1 Human genes 0.000 description 1
- 102100024944 Tropomyosin alpha-4 chain Human genes 0.000 description 1
- 102100031296 Tsukushi Human genes 0.000 description 1
- 102100030286 Tubulin-specific chaperone cofactor E-like protein Human genes 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100032807 Tumor necrosis factor-inducible gene 6 protein Human genes 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 description 1
- 101710159648 Uncharacterized protein Proteins 0.000 description 1
- 102100036175 Uncharacterized protein CXorf38 Human genes 0.000 description 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 102100033637 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 Human genes 0.000 description 1
- 238000001790 Welch's t-test Methods 0.000 description 1
- 208000008383 Wilms tumor Diseases 0.000 description 1
- 101150074422 Wnt5 gene Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000269370 Xenopus <genus> Species 0.000 description 1
- 102100038983 Xylosyltransferase 1 Human genes 0.000 description 1
- 102100025350 Zinc finger and BTB domain-containing protein 2 Human genes 0.000 description 1
- 102100025879 Zinc finger protein GLIS3 Human genes 0.000 description 1
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 108010076089 accutase Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000024340 acute graft versus host disease Diseases 0.000 description 1
- 208000026784 acute myeloblastic leukemia with maturation Diseases 0.000 description 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000001910 anti-glutamatergic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 208000029560 autism spectrum disease Diseases 0.000 description 1
- 208000026764 autoimmune bullous skin disease Diseases 0.000 description 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 201000009467 benign meningioma Diseases 0.000 description 1
- 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 description 1
- 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 description 1
- 102000015005 beta-adrenergic receptor activity proteins Human genes 0.000 description 1
- 108040006818 beta-adrenergic receptor activity proteins Proteins 0.000 description 1
- 201000000053 blastoma Diseases 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 208000019748 bullous skin disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000017455 cell-cell adhesion Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 238000003501 co-culture Methods 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 108010057108 condensin complexes Proteins 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 101150027734 cript gene Proteins 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 108010007093 dispase Proteins 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 201000005311 drug allergy Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 201000000485 dysgerminoma of ovary Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 201000008184 embryoma Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 239000003971 excitatory amino acid agent Substances 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 239000002350 fibrinopeptide Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 210000003976 gap junction Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 102000009543 guanyl-nucleotide exchange factor activity proteins Human genes 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 102000046949 human MSC Human genes 0.000 description 1
- 102000055650 human NRG1 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 208000009326 ileitis Diseases 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 108010019691 inhibin beta A subunit Proteins 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 108010003082 intrinsic factor-cobalamin receptor Proteins 0.000 description 1
- 238000009114 investigational therapy Methods 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 201000005391 latex allergy Diseases 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 206010024627 liposarcoma Diseases 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 238000012737 microarray-based gene expression Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 201000010225 mixed cell type cancer Diseases 0.000 description 1
- 208000029638 mixed neoplasm Diseases 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- 230000001538 myasthenic effect Effects 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 230000032405 negative regulation of neuron apoptotic process Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 239000003076 neurotropic agent Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 208000024691 pancreas disease Diseases 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229940127126 plasminogen activator Drugs 0.000 description 1
- 108010026735 platelet protein P47 Proteins 0.000 description 1
- 239000007739 pm medium Substances 0.000 description 1
- 201000004338 pollen allergy Diseases 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108010067415 progelatinase Proteins 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000012514 protein characterization Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- HUDHMIUZDXZZRC-UHFFFAOYSA-N protogonyautoxin 3 Chemical compound N=C1N(O)C(COC(=O)NS(O)(=O)=O)C2NC(=N)NC22C(O)(O)C(OS(O)(=O)=O)CN21 HUDHMIUZDXZZRC-UHFFFAOYSA-N 0.000 description 1
- 108010033990 rab27 GTP-Binding Proteins Proteins 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 208000017443 reproductive system disease Diseases 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- OWPYRRQQCJKSOL-QTNFYWBSSA-M sodium;(2s)-2,5-diamino-5-oxopentanoic acid;2-oxopropanoate Chemical compound [Na+].CC(=O)C([O-])=O.OC(=O)[C@@H](N)CCC(N)=O OWPYRRQQCJKSOL-QTNFYWBSSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 206010042863 synovial sarcoma Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 208000011317 telomere syndrome Diseases 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000011222 transcriptome analysis Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 230000009959 type I hypersensitivity Effects 0.000 description 1
- 230000028063 type III hypersensitivity Effects 0.000 description 1
- 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 208000034280 venom allergy Diseases 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/195—Heregulin, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461938172P | 2014-02-11 | 2014-02-11 | |
| US61/938,172 | 2014-02-11 | ||
| PCT/IL2015/050159 WO2015121859A1 (en) | 2014-02-11 | 2015-02-11 | Method of qualifying cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2937305A1 CA2937305A1 (en) | 2015-08-20 |
| CA2937305C true CA2937305C (en) | 2020-12-15 |
Family
ID=52682791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2937305A Expired - Fee Related CA2937305C (en) | 2014-02-11 | 2015-02-11 | Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10564149B2 (enExample) |
| EP (1) | EP3105587B1 (enExample) |
| JP (1) | JP6628253B2 (enExample) |
| BR (1) | BR112016018489A2 (enExample) |
| CA (1) | CA2937305C (enExample) |
| IL (1) | IL246943B (enExample) |
| WO (1) | WO2015121859A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
| CA2937305C (en) | 2014-02-11 | 2020-12-15 | Brainstorm Cell Therapeutics Ltd. | Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells |
| US11707488B2 (en) | 2015-08-28 | 2023-07-25 | Rohto Pharmaceutical Co., Ltd. | ROR1-positive mesenchymal stem cells and method for preparing same, pharmaceutical composition containing ROR1-positive mesenchymal stem cells and method for preparing same, and method for preventing or treating disease using ROR1-positive mesenchymal stem cells |
| JP6153653B2 (ja) * | 2015-12-07 | 2017-06-28 | 株式会社Cells Power | 幹細胞培養方法 |
| EP3429360A4 (en) * | 2016-03-16 | 2019-08-28 | Cell Medicine, Inc. | MESENCHYMAL STEM CELLS WITH IMPROVED EFFICACY |
| KR20220126789A (ko) | 2016-07-18 | 2022-09-16 | 브레인스톰 셀 세라퓨틱스 리미티드 | 근위축성 측색 경화증 (als)의 치료 방법 |
| CN108559729B (zh) * | 2018-02-05 | 2022-01-14 | 上海科技大学 | Fam49基因及其编码蛋白的应用 |
| JP2021520790A (ja) | 2018-04-10 | 2021-08-26 | ブレインストーム セル セラペウティクス リミテッド | 細胞型特異的エキソソームおよびそれらの使用 |
| US20220042099A1 (en) * | 2018-10-18 | 2022-02-10 | Quadrant Biosciences Inc. | Molecular and functional characterization of early-stage parkinson's disease and treatments therein |
| WO2020086667A1 (en) | 2018-10-25 | 2020-04-30 | American University | Method for promoting adipocyte differentiation and obesity-related disease treatment |
| CN111979186B (zh) * | 2020-08-21 | 2022-04-08 | 遵义医科大学附属医院 | 一种快速高效体外扩增人间充质干细胞的方法及应用 |
| US20220347349A1 (en) * | 2021-04-30 | 2022-11-03 | Stemcellago Inc. | Engineered cartilage |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| JP3948971B2 (ja) | 2001-08-30 | 2007-07-25 | サンバイオ,インコーポレイティド | Notch遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法 |
| US7682825B2 (en) * | 2002-02-06 | 2010-03-23 | Sanbio, Inc. | Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene |
| IL152905A0 (en) | 2002-11-17 | 2003-06-24 | Univ Ramot | Dopaminergic markers induction in neuronal-like cells isolated from adult human bone marrow stromal cells: implications for novel gene therapy strategy for parkinsons disease |
| WO2006134602A2 (en) | 2005-06-16 | 2006-12-21 | Ramot At Tel Aviv University Ltd. | Isolated cells and populations comprising same for the treatment of cns diseases |
| US20100021434A1 (en) | 2005-12-08 | 2010-01-28 | Ramot At Tel Aviv University Ltd. | Isolated Oligodendrocyte-Like Cells and Populations Comprising Same for the Treatment of CNS Diseases |
| DK2285951T3 (en) * | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| US20100184033A1 (en) | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| US10485829B2 (en) * | 2009-11-17 | 2019-11-26 | Astellas Institute For Regenerative Medicine | Methods of producing human RPE cells and pharmaceutical preparations of human RPE cells |
| ES2600321T3 (es) * | 2011-08-04 | 2017-02-08 | Ethianum Betriebsgesellschaft Mbh & Co. Kg | Medios para la regeneración del hígado |
| DE102011121982B3 (de) * | 2011-12-22 | 2013-04-18 | Dietmar Hopp Stiftung GmbH | Mesenchymale Stammzellen aus Fettgewebe (ADSC) zur Rekonstruktion von Haut und Weichteilgewebe |
| WO2014011407A2 (en) * | 2012-07-12 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
| CA2937305C (en) | 2014-02-11 | 2020-12-15 | Brainstorm Cell Therapeutics Ltd. | Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells |
-
2015
- 2015-02-11 CA CA2937305A patent/CA2937305C/en not_active Expired - Fee Related
- 2015-02-11 JP JP2016548691A patent/JP6628253B2/ja active Active
- 2015-02-11 EP EP15710010.8A patent/EP3105587B1/en active Active
- 2015-02-11 US US15/113,105 patent/US10564149B2/en active Active
- 2015-02-11 BR BR112016018489A patent/BR112016018489A2/pt not_active Application Discontinuation
- 2015-02-11 WO PCT/IL2015/050159 patent/WO2015121859A1/en not_active Ceased
-
2016
- 2016-07-25 IL IL246943A patent/IL246943B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6628253B2 (ja) | 2020-01-08 |
| EP3105587A1 (en) | 2016-12-21 |
| IL246943A0 (en) | 2016-09-29 |
| US20160334392A1 (en) | 2016-11-17 |
| IL246943B (en) | 2020-05-31 |
| WO2015121859A8 (en) | 2015-10-08 |
| BR112016018489A2 (pt) | 2017-08-08 |
| CA2937305A1 (en) | 2015-08-20 |
| WO2015121859A1 (en) | 2015-08-20 |
| JP2017511876A (ja) | 2017-04-27 |
| US10564149B2 (en) | 2020-02-18 |
| HK1232296A1 (en) | 2018-01-05 |
| EP3105587B1 (en) | 2023-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2937305C (en) | Pharmaceutical composition comprising bone-marrow derived mesenchymal stem cells | |
| Bárcia et al. | What makes umbilical cord tissue‐derived mesenchymal stromal cells superior immunomodulators when compared to bone marrow derived mesenchymal stromal cells? | |
| Heo et al. | Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue | |
| US20120107413A1 (en) | Pre-natal mesenchymal stem cells | |
| US20100105132A1 (en) | Human Mesenchymal stem cells and preparation thereof | |
| KR102124837B1 (ko) | 기질 줄기 세포 | |
| CA2954505C (en) | Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone marrow donors | |
| Branscome et al. | Stem cell extracellular vesicles and their potential to contribute to the repair of damaged CNS cells | |
| Karaöz et al. | A comprehensive characterization study of human bone marrow mscs with an emphasis on molecular and ultrastructural properties | |
| CA3145681A1 (en) | Priming media and methods for stem cell culture and therapy | |
| EP2596097A2 (en) | High telomerase activity bone marrow mesenchymal stem cells, methods of producing the same and pharmaceuticals and treatment methods based thereon | |
| CN101198691B (zh) | 多种系干细胞的分离 | |
| KR20110095218A (ko) | PI3K/AKT/GSK3 경로를 통해 성체줄기세포의 증식, 다분화능 및 재프로그래밍을 촉진하는 CD49f | |
| AU2013389474B2 (en) | Transplantation adjuvant in cell therapy using neural progenitor cells | |
| CN105343894A (zh) | 高效分泌前列腺素e2(pge2)的重组间充质干细胞及其应用 | |
| Dao et al. | Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells | |
| Szade et al. | CD45− CD14+ CD34+ murine bone marrow low-adherent mesenchymal primitive cells preserve multilineage differentiation potential in long-term in vitro culture | |
| AU2023353929A1 (en) | T cell production method | |
| HK1232296B (en) | Method of qualifying cells | |
| Zhang et al. | miR-21 contributes to human amniotic membrane-derived mesenchymal stem cell growth and human amniotic membrane-derived mesenchymal stem cell-induced immunoregulation | |
| Dubon et al. | Substance P modulates properties of bone marrow-derived mesenchymal stem cells | |
| CN113667635A (zh) | 无异源培养基及使用其扩增间充质干细胞的方法 | |
| Sandhu | Master of Veterinary | |
| WO2017032612A1 (en) | Stem cells with enhanced clonogenic, migratory and homing capacities | |
| Guan et al. | In vitro differentiation of human skin-derived mesenchymal stem cells into lymphocytes: Possibility evaluation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200204 |
|
| MKLA | Lapsed |
Effective date: 20220211 |