JP2017511321A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017511321A5 JP2017511321A5 JP2016559887A JP2016559887A JP2017511321A5 JP 2017511321 A5 JP2017511321 A5 JP 2017511321A5 JP 2016559887 A JP2016559887 A JP 2016559887A JP 2016559887 A JP2016559887 A JP 2016559887A JP 2017511321 A5 JP2017511321 A5 JP 2017511321A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- formula
- alkyl
- independently
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCCCCCC(C(N1C(*)(*)[Al]*)=O)=CN2C1=NCC2 Chemical compound CCCCCCCCC(C(N1C(*)(*)[Al]*)=O)=CN2C1=NCC2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972689P | 2014-03-31 | 2014-03-31 | |
| US61/972,689 | 2014-03-31 | ||
| PCT/US2015/023362 WO2015153468A1 (en) | 2014-03-31 | 2015-03-30 | Pharmacophore for trail induction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019164086A Division JP6873201B2 (ja) | 2014-03-31 | 2019-09-10 | Ｔｒａｉｌ誘導のためのファーマコフォア |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511321A JP2017511321A (ja) | 2017-04-20 |
| JP2017511321A5 true JP2017511321A5 (cg-RX-API-DMAC7.html) | 2018-05-10 |
| JP6756435B2 JP6756435B2 (ja) | 2020-09-16 |
Family
ID=54241169
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559887A Active JP6756435B2 (ja) | 2014-03-31 | 2015-03-30 | Ｔｒａｉｌ誘導のためのファーマコフォア |
| JP2019164086A Active JP6873201B2 (ja) | 2014-03-31 | 2019-09-10 | Ｔｒａｉｌ誘導のためのファーマコフォア |
| JP2021071035A Active JP7186256B2 (ja) | 2014-03-31 | 2021-04-20 | Ｔｒａｉｌ誘導のためのファーマコフォア |
| JP2022188821A Active JP7688245B2 (ja) | 2014-03-31 | 2022-11-28 | Ｔｒａｉｌ誘導のためのファーマコフォア |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019164086A Active JP6873201B2 (ja) | 2014-03-31 | 2019-09-10 | Ｔｒａｉｌ誘導のためのファーマコフォア |
| JP2021071035A Active JP7186256B2 (ja) | 2014-03-31 | 2021-04-20 | Ｔｒａｉｌ誘導のためのファーマコフォア |
| JP2022188821A Active JP7688245B2 (ja) | 2014-03-31 | 2022-11-28 | Ｔｒａｉｌ誘導のためのファーマコフォア |
Country Status (20)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| AU2014244117B2 (en) | 2013-03-13 | 2018-12-20 | Oncoceutics, Inc. | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
| US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
| KR102453679B1 (ko) * | 2013-11-15 | 2022-10-11 | 온코슈틱스 인코포레이티드 | 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온, 이의 염 및 이의 용도 |
| RS60163B1 (sr) | 2014-03-31 | 2020-05-29 | Scripps Research Inst | Farmakofor koji indukuje trail |
| CA3209515A1 (en) * | 2015-01-30 | 2016-08-04 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy |
| CN104860948B (zh) * | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| KR102801670B1 (ko) * | 2016-01-29 | 2025-04-25 | 온코슈틱스 인코포레이티드 | 이미프리돈에 의한 g 단백질-커플링된 수용체 (gpcr) 조절 |
| AU2017310526B2 (en) | 2016-08-12 | 2021-08-12 | Edwin J. Iwanowicz | Protein kinase regulators |
| US10172862B2 (en) | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| GB2596010B (en) * | 2019-02-11 | 2023-03-01 | Madera Therapeutics Llc | Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents |
| EP3930714A4 (en) | 2019-02-27 | 2022-10-26 | Madera Therapeutics, LLC | USE OF CASEINOLYTIC PROTEASE P FUNCTION AS A BIOMARKER OF DRUG RESPONSE TO IMIPRIDONE-LIKE AGENTS |
| EP4192467A1 (en) | 2020-08-06 | 2023-06-14 | Eötvös Loránd Tudományegyetem | Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity |
| CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
| CN116751199B (zh) * | 2023-06-02 | 2025-03-18 | 中国科学院基础医学与肿瘤研究所(筹) | 一种线粒体蛋白酶靶向嵌合体、制备方法及用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE786028A (fr) * | 1971-07-08 | 1973-01-08 | Boehringer Sohn Ingelheim | 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2150062A1 (de) | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| JPS5374893A (en) | 1976-12-15 | 1978-07-03 | Fujitsu Ltd | Driving method for semiconductor photosensitive device |
| JPS6132833U (ja) | 1984-07-31 | 1986-02-27 | 日信工業株式会社 | デイスクブレ−キ装置 |
| US20050203110A1 (en) * | 2002-05-23 | 2005-09-15 | Coleman Paul J. | Mitotic kinesin inhibitors |
| SI2303264T1 (en) | 2008-06-09 | 2018-08-31 | Allergan, Inc. | Methods for treating alpha-adrenergic mediated states using imidazoline derivatives |
| CN102970868A (zh) * | 2010-04-16 | 2013-03-13 | 柯瑞斯公司 | 具有k-ras突变的癌症的治疗 |
| EP2648517B1 (en) * | 2010-12-06 | 2015-08-05 | Merck Sharp & Dohme Corp. | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| EP2686332A2 (en) * | 2011-03-15 | 2014-01-22 | Chiesi Farmaceutici S.p.A. | Isoxazolidine derivatives |
| US20140287931A1 (en) * | 2011-04-04 | 2014-09-25 | Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
| HUE068623T2 (hu) * | 2011-04-29 | 2025-01-28 | Penn State Res Found | Normál és tumorsejtek kismolekulás TRAIL-génindukclója rákellenes terápiaként |
| US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
| US9376437B2 (en) * | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| AU2014244117B2 (en) * | 2013-03-13 | 2018-12-20 | Oncoceutics, Inc. | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
| WO2015073072A1 (en) * | 2013-11-15 | 2015-05-21 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one |
| US9181237B2 (en) * | 2013-10-04 | 2015-11-10 | Mallinckrodt Llc | Substituted berbines and their synthesis |
| RS60163B1 (sr) * | 2014-03-31 | 2020-05-29 | Scripps Research Inst | Farmakofor koji indukuje trail |
-
2015
- 2015-03-30 RS RS20200336A patent/RS60163B1/sr unknown
- 2015-03-30 ES ES15772254T patent/ES2779979T3/es active Active
- 2015-03-30 HU HUE15772254A patent/HUE049013T2/hu unknown
- 2015-03-30 CN CN202010184181.3A patent/CN111499636B/zh active Active
- 2015-03-30 SM SM20200219T patent/SMT202000219T1/it unknown
- 2015-03-30 RS RS20241340A patent/RS66254B1/sr unknown
- 2015-03-30 SI SI201531141T patent/SI3125898T1/sl unknown
- 2015-03-30 PL PL15772254T patent/PL3125898T3/pl unknown
- 2015-03-30 HU HUE19218049A patent/HUE069651T2/hu unknown
- 2015-03-30 HR HRP20241680TT patent/HRP20241680T1/hr unknown
- 2015-03-30 KR KR1020167029994A patent/KR102473930B1/ko active Active
- 2015-03-30 US US15/126,192 patent/US10239877B2/en active Active
- 2015-03-30 KR KR1020227042050A patent/KR102611067B1/ko active Active
- 2015-03-30 ES ES19218049T patent/ES2999685T3/es active Active
- 2015-03-30 LT LTEP19218049.5T patent/LT3662910T/lt unknown
- 2015-03-30 PL PL19218049.5T patent/PL3662910T3/pl unknown
- 2015-03-30 CA CA2944452A patent/CA2944452C/en active Active
- 2015-03-30 DK DK15772254.7T patent/DK3125898T3/da active
- 2015-03-30 CA CA3158795A patent/CA3158795A1/en active Pending
- 2015-03-30 EP EP15772254.7A patent/EP3125898B1/en active Active
- 2015-03-30 WO PCT/US2015/023362 patent/WO2015153468A1/en not_active Ceased
- 2015-03-30 PT PT192180495T patent/PT3662910T/pt unknown
- 2015-03-30 LT LTEP15772254.7T patent/LT3125898T/lt unknown
- 2015-03-30 AU AU2015241069A patent/AU2015241069B2/en active Active
- 2015-03-30 FI FIEP19218049.5T patent/FI3662910T3/fi active
- 2015-03-30 DK DK19218049.5T patent/DK3662910T3/da active
- 2015-03-30 EP EP24192819.1A patent/EP4470617A3/en active Pending
- 2015-03-30 HR HRP20200478TT patent/HRP20200478T1/hr unknown
- 2015-03-30 CN CN201580021658.3A patent/CN106456643B/zh active Active
- 2015-03-30 PT PT157722547T patent/PT3125898T/pt unknown
- 2015-03-30 SI SI201532040T patent/SI3662910T1/sl unknown
- 2015-03-30 JP JP2016559887A patent/JP6756435B2/ja active Active
- 2015-03-30 EP EP19218049.5A patent/EP3662910B1/en active Active
- 2015-03-30 SM SM20240497T patent/SMT202400497T1/it unknown
-
2019
- 2019-03-20 US US16/359,633 patent/US10633385B2/en active Active
- 2019-09-10 JP JP2019164086A patent/JP6873201B2/ja active Active
-
2020
- 2020-03-20 CY CY20201100267T patent/CY1123093T1/el unknown
- 2020-04-14 US US16/848,032 patent/US20200283440A1/en not_active Abandoned
- 2020-12-11 AU AU2020286314A patent/AU2020286314A1/en not_active Abandoned
-
2021
- 2021-04-20 JP JP2021071035A patent/JP7186256B2/ja active Active
- 2021-07-12 US US17/372,894 patent/US11891392B2/en active Active
-
2022
- 2022-11-28 JP JP2022188821A patent/JP7688245B2/ja active Active
- 2022-12-08 AU AU2022283729A patent/AU2022283729A1/en not_active Abandoned
-
2023
- 2023-12-20 US US18/391,420 patent/US20240190877A1/en active Pending
-
2024
- 2024-07-19 AU AU2024204977A patent/AU2024204977A1/en active Pending