JP2017509692A - 喘息肺におけるｉｌ−１３活性化の末梢バイオマーカーとしてのジペプチジルペプチターゼ４（ｄｐｐ４／ｃｄ２６） - Google Patents

喘息肺におけるｉｌ−１３活性化の末梢バイオマーカーとしてのジペプチジルペプチターゼ４（ｄｐｐ４／ｃｄ２６） Download PDF

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JP2017509692A
JP2017509692A JP2016566866A JP2016566866A JP2017509692A JP 2017509692 A JP2017509692 A JP 2017509692A JP 2016566866 A JP2016566866 A JP 2016566866A JP 2016566866 A JP2016566866 A JP 2016566866A JP 2017509692 A JP2017509692 A JP 2017509692A
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dpp4
patient
level
seq
asthma
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ストレイチャー，カティ
ヤオ，イーホン
ラネード，コウストゥブー
リャン，メイナ
ヴァインシュテイン，インナ
パイパー，エドワード
メイ，リチャード
ノーデンマーク，ラーズ
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メディミューン，エルエルシー
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/202—Dermatitis

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JP2016566866A 2014-01-27 2015-01-26 喘息肺におけるｉｌ−１３活性化の末梢バイオマーカーとしてのジペプチジルペプチターゼ４（ｄｐｐ４／ｃｄ２６） Pending JP2017509692A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461931878P 2014-01-27 2014-01-27
US61/931,878 2014-01-27
US201461990932P 2014-05-09 2014-05-09
US61/990,932 2014-05-09
PCT/US2015/012885 WO2015112970A1 (en) 2014-01-27 2015-01-26 Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung

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JP2017509692A true JP2017509692A (ja) 2017-04-06
JP2017509692A5 JP2017509692A5 (https=) 2018-03-08

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US (1) US20160363591A1 (https=)
EP (2) EP3685857A1 (https=)
JP (1) JP2017509692A (https=)
KR (1) KR20160113700A (https=)
CN (1) CN105934254A (https=)
AU (1) AU2015209124A1 (https=)
BR (1) BR112016017192A2 (https=)
CA (1) CA2937387A1 (https=)
MX (1) MX2016009491A (https=)
RU (1) RU2016134838A (https=)
SG (1) SG11201606102UA (https=)
WO (1) WO2015112970A1 (https=)

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US10351630B2 (en) 2015-01-09 2019-07-16 Medimmune, Llc Assay to detect human DPP-4
JP2018538249A (ja) * 2015-11-04 2018-12-27 アストラゼネカ アクチボラグ 好酸球性疾患における好酸球標的化治療薬に対する臨床応答の予測変数としてのジペプチジルペプチダーゼ−４およびペリオスチン
KR102460040B1 (ko) 2016-04-27 2022-11-01 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
CN113372446A (zh) 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
KR102557643B1 (ko) * 2016-09-23 2023-07-20 제넨테크, 인크. 아토피성 피부염을 치료하기 위한 il-13 길항제의 용도
CA3049847A1 (en) 2017-02-24 2018-08-30 Trustees Of Boston University Isolation of human lung progenitors derived from pluripotent stem cells
CN109055522A (zh) * 2018-07-03 2018-12-21 吉林大学 C4orf38在制备用于检测或治疗神经性疼痛的产品中的应用
KR102330596B1 (ko) 2018-11-09 2021-11-26 아주대학교산학협력단 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도
CN113155996A (zh) * 2021-03-23 2021-07-23 广州医科大学附属第一医院（广州呼吸中心） 15(s)-羟基二十碳四烯酸在评估变应原特异性免疫治疗效果中的应用
IL317083A (en) 2022-06-17 2025-01-01 Apogee Biologics Inc Antibodies that bind interleukin 13 and methods of use
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US20160363591A1 (en) 2016-12-15
KR20160113700A (ko) 2016-09-30
CA2937387A1 (en) 2015-07-30
WO2015112970A1 (en) 2015-07-30
RU2016134838A3 (https=) 2018-09-27
EP3685857A1 (en) 2020-07-29
RU2016134838A (ru) 2018-03-07
CN105934254A (zh) 2016-09-07
EP3099323A4 (en) 2017-10-04
EP3099323A1 (en) 2016-12-07
AU2015209124A1 (en) 2016-08-18
BR112016017192A2 (pt) 2017-10-10
MX2016009491A (es) 2017-01-13
SG11201606102UA (en) 2016-08-30

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