JP2017509585A5 - - Google Patents
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- JP2017509585A5 JP2017509585A5 JP2016541595A JP2016541595A JP2017509585A5 JP 2017509585 A5 JP2017509585 A5 JP 2017509585A5 JP 2016541595 A JP2016541595 A JP 2016541595A JP 2016541595 A JP2016541595 A JP 2016541595A JP 2017509585 A5 JP2017509585 A5 JP 2017509585A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- compound
- providing
- crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC[C@]1[C@@](C(O*)=O)N(*)C[C@@]1Oc1nc2cc(OC)ccc2nc1C(CC=C)(F)F Chemical compound CC[C@]1[C@@](C(O*)=O)N(*)C[C@@]1Oc1nc2cc(OC)ccc2nc1C(CC=C)(F)F 0.000 description 85
- MZBLZLWXUBZHSL-FZNJKFJKSA-N CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@](C3)([C@@H]3C(F)F)C(NS(C3(C)CC3)(=O)=O)=O)=O)N1C2=O Chemical compound CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@](C3)([C@@H]3C(F)F)C(NS(C3(C)CC3)(=O)=O)=O)=O)N1C2=O MZBLZLWXUBZHSL-FZNJKFJKSA-N 0.000 description 12
- KPBVWEDYWIKGMQ-VYIYSTOKSA-N CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(O)=O)N1C2=O Chemical compound CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(O)=O)N1C2=O KPBVWEDYWIKGMQ-VYIYSTOKSA-N 0.000 description 8
- KVFIQMJEJACPPC-OPRDCNLKSA-N CC(C)(C)[C@@H](C(O)=O)NC(O[C@H]1[C@H](CC=C)C1)=O Chemical compound CC(C)(C)[C@@H](C(O)=O)NC(O[C@H]1[C@H](CC=C)C1)=O KVFIQMJEJACPPC-OPRDCNLKSA-N 0.000 description 7
- UHBJPNXGJDBGEK-SSDLBLMSSA-N CC1(CC1)S(NC([C@@](C1)([C@@H]1C(F)F)N)=O)(=O)=O Chemical compound CC1(CC1)S(NC([C@@](C1)([C@@H]1C(F)F)N)=O)(=O)=O UHBJPNXGJDBGEK-SSDLBLMSSA-N 0.000 description 6
- ZESWCZXSEHLVSF-GMTAPVOTSA-N CC(C)(C)[C@@H](C(O)=O)NC(O[C@H]1[C@H](CCC=C)C1)=O Chemical compound CC(C)(C)[C@@H](C(O)=O)NC(O[C@H]1[C@H](CCC=C)C1)=O ZESWCZXSEHLVSF-GMTAPVOTSA-N 0.000 description 5
- AMVYAAUXULQDBC-ALVVINIESA-N CC[C@H]([C@H](C1)Oc2nc3cc(OC)ccc3nc2C(CC=C)(F)F)[C@@H](C(O)=O)N1C([C@H](C(C)(C)C)NC(O[C@H]1[C@H](CC=C)C1)=O)=O Chemical compound CC[C@H]([C@H](C1)Oc2nc3cc(OC)ccc3nc2C(CC=C)(F)F)[C@@H](C(O)=O)N1C([C@H](C(C)(C)C)NC(O[C@H]1[C@H](CC=C)C1)=O)=O AMVYAAUXULQDBC-ALVVINIESA-N 0.000 description 5
- OAUBWBPEOGCJDI-LFIBNONCSA-N C=CCC(/C(/C#N)=N/c1ccccc1)(F)F Chemical compound C=CCC(/C(/C#N)=N/c1ccccc1)(F)F OAUBWBPEOGCJDI-LFIBNONCSA-N 0.000 description 2
- UEUJSSBQLVLZML-GDNBJRDFSA-N C=CCC(/C(/Cl)=N/c1ccccc1)(F)F Chemical compound C=CCC(/C(/Cl)=N/c1ccccc1)(F)F UEUJSSBQLVLZML-GDNBJRDFSA-N 0.000 description 1
- FSEADHGDCUSINU-UHFFFAOYSA-N C=CCC(C(Nc1ccccc1)=O)(F)F Chemical compound C=CCC(C(Nc1ccccc1)=O)(F)F FSEADHGDCUSINU-UHFFFAOYSA-N 0.000 description 1
- KETKBAXCCLVVML-PRHODGIISA-N C=CC[C@H](C1)[C@@H]1OC(c1cc([N+]([O-])=O)cc([N+]([O-])=O)c1)=O Chemical compound C=CC[C@H](C1)[C@@H]1OC(c1cc([N+]([O-])=O)cc([N+]([O-])=O)c1)=O KETKBAXCCLVVML-PRHODGIISA-N 0.000 description 1
- NLQZYLYKMNXZEK-HQRFULLOSA-N CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC(CC2)C[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@@](C3)(C(NS(C4(C)CC4)(=O)=O)=O)C3=C(F)F)=O)N1C2=O Chemical compound CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC(CC2)C[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@@](C3)(C(NS(C4(C)CC4)(=O)=O)=O)C3=C(F)F)=O)N1C2=O NLQZYLYKMNXZEK-HQRFULLOSA-N 0.000 description 1
- BGECPZBXIHJWEY-NJZATKFJSA-N CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC(CC2)C[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(O)=O)N1C2=O Chemical compound CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC(CC2)C[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(O)=O)N1C2=O BGECPZBXIHJWEY-NJZATKFJSA-N 0.000 description 1
- FXYRCPNERSOVPR-DOUFFDQJSA-N CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@@](C3)(C(NS(C4(C)CC4)(=O)=O)=O)C3=C(F)F)=O)N1C2=O Chemical compound CC[C@H]([C@H](C1)Oc2nc(cc(cc3)OC)c3nc2C(CCCC[C@H](C2)[C@@H]2OC(N[C@H]2C(C)(C)C)=O)(F)F)[C@@H](C(N[C@@](C3)(C(NS(C4(C)CC4)(=O)=O)=O)C3=C(F)F)=O)N1C2=O FXYRCPNERSOVPR-DOUFFDQJSA-N 0.000 description 1
- HMQRYTRBTAOYBM-UHFFFAOYSA-N COc1cc2nc(N)c(C(CC=C)(F)F)nc2cc1 Chemical compound COc1cc2nc(N)c(C(CC=C)(F)F)nc2cc1 HMQRYTRBTAOYBM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920446P | 2013-12-23 | 2013-12-23 | |
| US61/920,446 | 2013-12-23 | ||
| PCT/US2014/071319 WO2015100145A1 (en) | 2013-12-23 | 2014-12-18 | Synthesis of a macrocyclic hcv ns3 inhibiting tripeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509585A JP2017509585A (ja) | 2017-04-06 |
| JP2017509585A5 true JP2017509585A5 (cg-RX-API-DMAC7.html) | 2018-01-18 |
| JP6425727B2 JP6425727B2 (ja) | 2018-11-21 |
Family
ID=52278856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541595A Active JP6425727B2 (ja) | 2013-12-23 | 2014-12-18 | 大環状ｈｃｖ ｎｓ３阻害トリペプチド |
Country Status (20)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015017466A1 (en) * | 2013-07-30 | 2015-02-05 | Gilead Connecticut, Inc. | Formulation of syk inhibitors |
| EA029281B1 (ru) | 2013-07-30 | 2018-03-30 | Джилид Коннектикут, Инк. | Полиморф ингибиторов syk |
| ES2724460T3 (es) | 2013-12-23 | 2019-09-11 | Gilead Pharmasset Llc | Síntesis de un tripéptido que inhíbe el NS3 del virus de VHC macrocíclico |
| UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
| US9809576B1 (en) | 2014-07-18 | 2017-11-07 | Abbvie Inc. | Synthetic route to anti-viral agents |
| US9809534B1 (en) * | 2014-07-21 | 2017-11-07 | Abbvie Inc. | Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof |
| US10059969B1 (en) | 2014-10-03 | 2018-08-28 | Abbvie Inc. | Process for the preparation of (S)-2-amino-non-8-enoic acid |
| US10316338B1 (en) | 2015-01-30 | 2019-06-11 | Abb Vie Inc. | Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid |
| US10450291B2 (en) | 2015-06-29 | 2019-10-22 | Central Glass Company, Limited | Method for producing fluorine-containing cyclopropane carboxylic acid compound |
| AU2018215337A1 (en) | 2017-02-01 | 2019-08-22 | Abbvie Inc. | Enzymatic processes for the preparation of (±)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and(±)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid |
| WO2019084740A1 (zh) * | 2017-10-31 | 2019-05-09 | 上海同昌生物医药科技有限公司 | 一种Glecaprevir合成中间体及其胺盐的制备方法 |
| CN107739319A (zh) * | 2017-10-31 | 2018-02-27 | 上海同昌生物医药科技有限公司 | 一种Glecaprevir合成中间体及其胺盐的制备方法 |
| CN107827748A (zh) * | 2017-11-14 | 2018-03-23 | 安徽华胜医药科技有限公司 | 一种乙酸2‑烯丙基环丙酯消旋体的合成方法 |
| KR102519417B1 (ko) | 2018-11-28 | 2023-04-10 | 삼성디스플레이 주식회사 | 스트레처블 표시 장치 |
| AU2020225455A1 (en) | 2019-02-22 | 2021-09-09 | Kronos Bio, Inc. | Solid forms of condensed pyrazines as Syk inhibitors |
| CN116041181A (zh) * | 2023-01-04 | 2023-05-02 | 广州巨元生化有限公司 | 一种制备4-卤代-2-甲基-2-丁烯酸烃基酯的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200605247B (en) * | 2003-12-15 | 2007-10-31 | Japan Tobacco Inc | N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof |
| CL2008003384A1 (es) * | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
| US8211891B2 (en) | 2008-04-30 | 2012-07-03 | Enanta Pharmaceuticals, Inc. | Difluoromethyl-containing macrocyclic compounds as hepatitis C virus inhibitors |
| ME02132B (me) | 2008-07-22 | 2014-08-22 | Merck Sharp & Dohme | Kombinacije makrocikličnog jedinjenja hinoksalina koje je inhibitor hcv ns3 proteaze sa drugim hcv sredstvima |
| US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2289880A1 (en) * | 2009-07-08 | 2011-03-02 | Bayer CropScience AG | 2-Pyridinylcyclopropylbenzamide fungicides |
| EA029145B1 (ru) * | 2010-09-21 | 2018-02-28 | Энанта Фармасьютикалз, Инк. | Ингибиторы hcv сериновой протеазы, полученные из макроциклического пролина |
| EP2618665A4 (en) * | 2010-09-21 | 2014-08-20 | Merck Sharp & Dohme | HCV NS3 proteinase inhibitor |
| AR084217A1 (es) * | 2010-12-10 | 2013-05-02 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| UA119315C2 (uk) * | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| WO2015095430A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Methods and intermediates for the preparation of macrolactams |
| EP3087086B1 (en) | 2013-12-23 | 2018-11-07 | Gilead Sciences, Inc. | Crystalline forms of a macrocyclic hcv ns3 inhibiting tripeptide |
| ES2724460T3 (es) | 2013-12-23 | 2019-09-11 | Gilead Pharmasset Llc | Síntesis de un tripéptido que inhíbe el NS3 del virus de VHC macrocíclico |
-
2014
- 2014-12-18 ES ES14822040T patent/ES2724460T3/es active Active
- 2014-12-18 SI SI201431166T patent/SI3087085T1/sl unknown
- 2014-12-18 CN CN202010152008.5A patent/CN111320610B/zh active Active
- 2014-12-18 KR KR1020167016776A patent/KR102366697B1/ko active Active
- 2014-12-18 CA CA2934537A patent/CA2934537C/en active Active
- 2014-12-18 JP JP2016541595A patent/JP6425727B2/ja active Active
- 2014-12-18 SG SG11201604482QA patent/SG11201604482QA/en unknown
- 2014-12-18 US US14/576,143 patent/US9440991B2/en active Active
- 2014-12-18 AU AU2014370125A patent/AU2014370125B2/en active Active
- 2014-12-18 PL PL14822040T patent/PL3087085T3/pl unknown
- 2014-12-18 CN CN201480070017.2A patent/CN105849118B/zh active Active
- 2014-12-18 TR TR2019/06413T patent/TR201906413T4/tr unknown
- 2014-12-18 PT PT14822040T patent/PT3087085T/pt unknown
- 2014-12-18 WO PCT/US2014/071319 patent/WO2015100145A1/en not_active Ceased
- 2014-12-18 EA EA201691031A patent/EA201691031A1/ru unknown
- 2014-12-18 NZ NZ720745A patent/NZ720745A/en not_active IP Right Cessation
- 2014-12-18 CN CN202310617293.7A patent/CN116813596A/zh active Pending
- 2014-12-18 MX MX2016008452A patent/MX2016008452A/es unknown
- 2014-12-18 EP EP14822040.3A patent/EP3087085B1/en active Active
- 2014-12-22 TW TW103144804A patent/TWI671292B/zh active
- 2014-12-22 TW TW109137288A patent/TWI762003B/zh active
- 2014-12-22 TW TW108125271A patent/TWI710547B/zh active
- 2014-12-23 AR ARP140104910A patent/AR098959A1/es unknown
-
2016
- 2016-06-06 IL IL246064A patent/IL246064A0/en unknown
- 2016-08-03 US US15/227,527 patent/US10030033B2/en active Active
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