JP2017507895A5 - - Google Patents
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- Publication number
- JP2017507895A5 JP2017507895A5 JP2016520312A JP2016520312A JP2017507895A5 JP 2017507895 A5 JP2017507895 A5 JP 2017507895A5 JP 2016520312 A JP2016520312 A JP 2016520312A JP 2016520312 A JP2016520312 A JP 2016520312A JP 2017507895 A5 JP2017507895 A5 JP 2017507895A5
- Authority
- JP
- Japan
- Prior art keywords
- phase
- microparticles
- organic solvent
- risperidone
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012071 phase Substances 0.000 claims 22
- 239000011859 microparticle Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 239000003960 organic solvent Substances 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 10
- 238000001035 drying Methods 0.000 claims 9
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 9
- 229960001534 risperidone Drugs 0.000 claims 9
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 6
- 238000005406 washing Methods 0.000 claims 6
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 4
- 238000010791 quenching Methods 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000001804 emulsifying effect Effects 0.000 claims 3
- 238000010907 mechanical stirring Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2013001821 | 2013-06-20 | ||
| EPPCT/EP2013/001821 | 2013-06-20 | ||
| PCT/EP2014/001652 WO2014202214A1 (en) | 2013-06-20 | 2014-06-18 | Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507895A JP2017507895A (ja) | 2017-03-23 |
| JP2017507895A5 true JP2017507895A5 (enExample) | 2017-07-20 |
| JP6464154B2 JP6464154B2 (ja) | 2019-02-06 |
Family
ID=51022802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016520312A Active JP6464154B2 (ja) | 2013-06-20 | 2014-06-18 | Ｓ字型放出プロファイルを有するポリラクチド−ポリグリコリド微小粒子の調製 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9943484B2 (enExample) |
| JP (1) | JP6464154B2 (enExample) |
| CN (1) | CN105308101B (enExample) |
| AU (1) | AU2014283692B2 (enExample) |
| CA (1) | CA2916301C (enExample) |
| DK (1) | DK3010962T4 (enExample) |
| ES (1) | ES2640486T5 (enExample) |
| FI (1) | FI3010962T4 (enExample) |
| HU (1) | HUE036141T2 (enExample) |
| LT (1) | LT3010962T (enExample) |
| PT (1) | PT3010962T (enExample) |
| RU (1) | RU2658004C2 (enExample) |
| SA (1) | SA515370296B1 (enExample) |
| WO (1) | WO2014202214A1 (enExample) |
| ZA (1) | ZA201509354B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170036768A (ko) * | 2014-07-30 | 2017-04-03 | 메르크 파텐트 게엠베하 | 미세결정성 셀룰로오스를 포함하는 직접 압축성 조성물 |
| JP2016102093A (ja) * | 2014-11-28 | 2016-06-02 | ニプロ株式会社 | 塩基性の求核化合物を含有するマイクロカプセルの製造方法 |
| US20170079985A1 (en) | 2015-09-21 | 2017-03-23 | Teva Pharmaceuticals International Gmbh | Sustained release olanzapine formulations |
| JP2020511483A (ja) | 2017-03-20 | 2020-04-16 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ | 徐放性オランザピン製剤 |
| KR102047983B1 (ko) * | 2017-11-30 | 2019-11-22 | 주식회사 지투지바이오 | 안전성 및 저장 안정성이 향상된 생분해성 미립구의 제조방법 |
| GR1009870B (el) * | 2019-07-09 | 2020-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει ενα ατυπο αντιψυχωσικο φαρμακο και μεθοδος παρασκευης αυτου |
| WO2021134623A1 (zh) * | 2019-12-31 | 2021-07-08 | 广州帝奇医药技术有限公司 | 一种叔胺药物组合物及其产业化批量制备方法 |
| EP4125823A1 (en) | 2020-03-30 | 2023-02-08 | Biological E Limited | Risperidone microspheres, process for their prepartion and uses thereof |
| KR102259589B1 (ko) * | 2020-11-30 | 2021-06-02 | (주)인벤티지랩 | 미소구체 제조 시스템 및 미소구체 제조 방법 |
| EP4277661A1 (en) | 2021-01-18 | 2023-11-22 | Anton Frenkel | Pharmaceutical dosage form |
| EP4297753A4 (en) * | 2021-02-24 | 2025-01-01 | Oakwood Laboratories, Llc | Microsphere formulations comprising lurasidone and methods for making and using the same |
| WO2023281406A1 (en) | 2021-07-06 | 2023-01-12 | Mark Hasleton | Treatment of serotonin reuptake inhibitor withdrawal syndrome |
| GR1010327B (el) * | 2021-10-06 | 2022-10-17 | Φαρματεν Α.Β.Ε.Ε., | Παρατεταμενης αποδεσμευσης ενεσιμο φαρμακευτικο σκευασμα λεβοθυροξινης και μεθοδος παρασκευης αυτου |
| WO2025135778A1 (ko) * | 2023-12-18 | 2025-06-26 | 주식회사 포스테라헬스사이언스 | 약물의 특성에 따른 활성형 미립자의 제조 방법, 이의 제조 방법으로 제조된 활성형 미립자 및 상기 활성형 미립자를 이용한 약물을 포함하는 장기 지속 제형의 제조 방법 |
| WO2025207396A1 (en) * | 2024-03-27 | 2025-10-02 | Avidence Therapeutics, Inc. | Microsphere-based injectable rofecoxib formulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478564A (en) * | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
| US5288496A (en) * | 1990-05-15 | 1994-02-22 | Stolle Research & Development Corporation | Growth promoters for animals |
| AU722884B2 (en) * | 1996-01-24 | 2000-08-10 | United States Government Represented By The Secretary Of The Army | Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres |
| US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US6264987B1 (en) | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| US7690026B2 (en) * | 2005-08-22 | 2010-03-30 | Microsoft Corporation | Distributed single sign-on service |
-
2014
- 2014-06-18 US US14/898,415 patent/US9943484B2/en active Active
- 2014-06-18 ES ES14733524T patent/ES2640486T5/es active Active
- 2014-06-18 LT LTEP14733524.4T patent/LT3010962T/lt unknown
- 2014-06-18 HU HUE14733524A patent/HUE036141T2/hu unknown
- 2014-06-18 FI FIEP14733524.4T patent/FI3010962T4/fi active
- 2014-06-18 CA CA2916301A patent/CA2916301C/en active Active
- 2014-06-18 PT PT147335244T patent/PT3010962T/pt unknown
- 2014-06-18 WO PCT/EP2014/001652 patent/WO2014202214A1/en not_active Ceased
- 2014-06-18 RU RU2016101418A patent/RU2658004C2/ru active
- 2014-06-18 CN CN201480034979.2A patent/CN105308101B/zh active Active
- 2014-06-18 DK DK14733524.4T patent/DK3010962T4/da active
- 2014-06-18 AU AU2014283692A patent/AU2014283692B2/en active Active
- 2014-06-18 JP JP2016520312A patent/JP6464154B2/ja active Active
-
2015
- 2015-12-17 SA SA515370296A patent/SA515370296B1/ar unknown
- 2015-12-23 ZA ZA2015/09354A patent/ZA201509354B/en unknown
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