WO2017005087A1 - 一种叶黄素饲料添加剂的制备方法 - Google Patents

一种叶黄素饲料添加剂的制备方法 Download PDF

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Publication number
WO2017005087A1
WO2017005087A1 PCT/CN2016/086498 CN2016086498W WO2017005087A1 WO 2017005087 A1 WO2017005087 A1 WO 2017005087A1 CN 2016086498 W CN2016086498 W CN 2016086498W WO 2017005087 A1 WO2017005087 A1 WO 2017005087A1
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WIPO (PCT)
Prior art keywords
lutein
feed additive
lye
fat
saponification
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PCT/CN2016/086498
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English (en)
French (fr)
Inventor
仇丹
陈志荣
石立芳
李建东
蔡林普
梁宇锋
蔡敏聪
赵立峰
Original Assignee
浙江新维普添加剂有限公司
宁波工程学院
浙江新和成股份有限公司
浙江大学
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Application filed by 浙江新维普添加剂有限公司, 宁波工程学院, 浙江新和成股份有限公司, 浙江大学 filed Critical 浙江新维普添加剂有限公司
Priority to US15/740,777 priority Critical patent/US20180184689A1/en
Publication of WO2017005087A1 publication Critical patent/WO2017005087A1/zh

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A23K40/35—Making capsules specially adapted for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)

Abstract

一种控释型叶黄素饲料添加剂的制备方法，其步骤是：将叶黄素浸膏、甘油和油脂混合溶解，在机械搅拌和剪切乳化条件下滴加碱液，使叶黄素酯完全皂化；接着加入油脂并加碱皂化，调节粘度并中和后将混合液喷雾造粒，得到控释型叶黄素饲料添加剂。本方法利用甘油和油脂，经皂化和微胶囊成型，提升了叶黄素在光照、加热和酸性环境下的化学稳定性，该控释型叶黄素饲料添加剂在胃液环境基本不释放而在肠液环境中完全释放，具有更高的生物利用度。

Description

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Figure PCTCN2016086498-appb-000001

Claims (4)

  1. 根据权利要求1所述的叶黄素饲料添加剂的制备方法，其特征在于，步骤(2)中，所述的叶黄素酯的皂化程度由高效液相色谱测定，当叶黄素液相峰面积的归一化百分比大于97％时，视为皂化完全。
  2. 根据权利要求1所述的叶黄素饲料添加剂的制备方法，其特征在于，碱液为30％～50％质量浓度的氢氧化钠或氢氧化钾的水溶液；
    步骤(2)中的碱液与叶黄素浸膏的质量比为30～60：100；
    步骤(4)中的碱液与叶黄素浸膏的质量比为10～50：1。
  3. 根据权利要求1所述的叶黄素饲料添加剂的制备方法，其特征在于，步骤(4)中，加热的温度为40～80℃。
  4. 根据权利要求1所述的叶黄素饲料添加剂的制备方法，其特征在于，步骤(5)中，所用的酸为盐酸，质量百分比浓度为10％～20％。
PCT/CN2016/086498 2015-07-09 2016-06-21 一种叶黄素饲料添加剂的制备方法 WO2017005087A1 (zh)

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US15/740,777 US20180184689A1 (en) 2015-07-09 2016-06-21 A method for preparing lutein feed additive

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CN201510405640.5A CN105053556B (zh) 2015-07-09 2015-07-09 一种叶黄素饲料添加剂的制备方法

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CN106798102B (zh) * 2015-11-26 2020-03-27 内蒙古优然牧业有限责任公司 一种奶牛饲料及应用该饲料得到富含叶黄素乳制品的方法
CN107302925B (zh) * 2016-04-19 2021-08-06 内蒙古伊利实业集团股份有限公司 一种具有改善视力的功能性组合物及其应用
CN106666731B (zh) * 2016-12-29 2020-05-12 浙江新和成股份有限公司 一种稳定的脂溶性营养素微胶囊及其制备方法和应用
CN107467396A (zh) * 2017-08-24 2017-12-15 浙江群大饲料科技股份有限公司 一种快大型三黄鸡颗粒饲料中着色剂的添加方法
CN109645235B (zh) * 2019-02-19 2023-06-09 山东智领生物科技股份有限公司 一种叶黄素酯饲料添加剂及其制备方法
CN110584109A (zh) * 2019-07-26 2019-12-20 山东天音生物科技有限公司 动物油脂包埋叶黄素及其制备方法和用途
CN112704739A (zh) * 2020-12-29 2021-04-27 佛山市南海东方澳龙制药有限公司 一种叶黄素制剂的制备方法及叶黄素制剂

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