JP2017506630A5 - - Google Patents

Info

Publication number

JP2017506630A5

JP2017506630A5 JP2016550779A JP2016550779A JP2017506630A5 JP 2017506630 A5 JP2017506630 A5 JP 2017506630A5 JP 2016550779 A JP2016550779 A JP 2016550779A JP 2016550779 A JP2016550779 A JP 2016550779A JP 2017506630 A5 JP2017506630 A5 JP 2017506630A5

Authority

JP

Japan

Prior art keywords

complex

seq

amino acid

group

sequence

Prior art date

2015-02-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000006850 spacer group Chemical group 0.000 claims 7
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 125000005647 linker group Chemical group 0.000 claims 5
• 239000002246 antineoplastic agent Substances 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 102000004503 Perforin Human genes 0.000 claims 3
• 108010056995 Perforin Proteins 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000004968 inflammatory condition Effects 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
• 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 1
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 229940028652 abraxane Drugs 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000003282 alkyl amino group Chemical group 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• -1 bevacizumab Chemical compound 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 239000002131 composite material Substances 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 125000004663 dialkyl amino group Chemical group 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
• 229960005277 gemcitabine Drugs 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 239000002955 immunomodulating agent Substances 0.000 claims 1
• 229960004130 itraconazole Drugs 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229960003301 nivolumab Drugs 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 229960002621 pembrolizumab Drugs 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1