JP2017500028A5 - - Google Patents

Info

Publication number

JP2017500028A5

JP2017500028A5 JP2016538019A JP2016538019A JP2017500028A5 JP 2017500028 A5 JP2017500028 A5 JP 2017500028A5 JP 2016538019 A JP2016538019 A JP 2016538019A JP 2016538019 A JP2016538019 A JP 2016538019A JP 2017500028 A5 JP2017500028 A5 JP 2017500028A5

Authority

JP

Japan

Prior art keywords

seq

chain variable

variable region

region shown

light chain

Prior art date

2014-12-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 34
• 239000000611 antibody drug conjugate Substances 0.000 claims 33
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 33
• 229940127089 cytotoxic agent Drugs 0.000 claims 26
• 239000002254 cytotoxic agent Substances 0.000 claims 26
• 231100000599 cytotoxic agent Toxicity 0.000 claims 25
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 230000003796 beauty Effects 0.000 claims 8
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 101000864130 Homo sapiens Dipeptidase 3 Proteins 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 102100029857 Dipeptidase 3 Human genes 0.000 claims 5
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• 239000000562 conjugate Substances 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 210000000130 stem cell Anatomy 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
• 229930195731 calicheamicin Natural products 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 230000002611 ovarian Effects 0.000 claims 2
• 208000012988 ovarian serous adenocarcinoma Diseases 0.000 claims 2
• 201000003709 ovarian serous carcinoma Diseases 0.000 claims 2
• 201000010198 papillary carcinoma Diseases 0.000 claims 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 230000001268 conjugating effect Effects 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000011156 evaluation Methods 0.000 claims 1
• 102000053267 human DPEP3 Human genes 0.000 claims 1
• 241000894007 species Species 0.000 claims 1