JP2017503837A5 - - Google Patents
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- Publication number
- JP2017503837A5 JP2017503837A5 JP2016548133A JP2016548133A JP2017503837A5 JP 2017503837 A5 JP2017503837 A5 JP 2017503837A5 JP 2016548133 A JP2016548133 A JP 2016548133A JP 2016548133 A JP2016548133 A JP 2016548133A JP 2017503837 A5 JP2017503837 A5 JP 2017503837A5
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- phenyl
- tetrahydro
- benzo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 17
- 239000012453 solvate Substances 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- -1 azepin-7-yl Chemical group 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims 4
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- XAGZJIQIVXSURR-UHFFFAOYSA-N 1-[4-(trifluoromethyl)phenyl]piperidin-2-one Chemical group C1=CC(C(F)(F)F)=CC=C1N1C(=O)CCCC1 XAGZJIQIVXSURR-UHFFFAOYSA-N 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 125000005518 carboxamido group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- BATAKQAIMRZBKK-HSZRJFAPSA-N (1S)-1-[6-(1-cyclohexyl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCCCC1 BATAKQAIMRZBKK-HSZRJFAPSA-N 0.000 claims 1
- MWVMAOPVOBUOGS-OAQYLSRUSA-N (1S)-1-[6-[1-(2-methylpropyl)-4-methylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound CC(C)CN1CCN(CC2=C1C=CC(=C2)C1=CC=CC(=N1)[C@H](O)CO)S(C)(=O)=O MWVMAOPVOBUOGS-OAQYLSRUSA-N 0.000 claims 1
- UNNIUPFALBGCBG-JOCHJYFZSA-N (1S)-1-[6-[1-(4,4-difluorocyclohexyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCC(F)(F)CC1 UNNIUPFALBGCBG-JOCHJYFZSA-N 0.000 claims 1
- VBRXOOPJTQNXOL-JOCHJYFZSA-N (1S)-1-[6-[1-(oxan-4-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCOCC1 VBRXOOPJTQNXOL-JOCHJYFZSA-N 0.000 claims 1
- TWCUCOUSUASXSV-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCNC2)C1=CC=C(C=C1)C(F)(F)F TWCUCOUSUASXSV-JOCHJYFZSA-N 0.000 claims 1
- JBNWTEGHEKINOR-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-4,1-benzoxazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCOC2)C1=CC=C(C=C1)C(F)(F)F JBNWTEGHEKINOR-JOCHJYFZSA-N 0.000 claims 1
- BGRZHUXTVWBAQC-HSZRJFAPSA-N (1S)-1-[6-[1-[[4-(trifluoromethyl)phenyl]methyl]-3,4-dihydro-2H-quinolin-6-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CC1=CC=C(C=C1)C(F)(F)F)CCC2 BGRZHUXTVWBAQC-HSZRJFAPSA-N 0.000 claims 1
- OTLFVFMAOBMXOK-AREMUKBSSA-N (1S)-1-[6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCN(CC1CC1)C2)C1=CC=C(C=C1)C(F)(F)F OTLFVFMAOBMXOK-AREMUKBSSA-N 0.000 claims 1
- SHPLKCRMHIMWRZ-HSZRJFAPSA-N (1s)-1-[6-[4-methylsulfonyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2h-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound C12=CC=C(C=3N=C(C=CC=3)[C@H](O)CO)C=C2CN(S(=O)(=O)C)CCN1C1=CC=C(C(F)(F)F)C=C1 SHPLKCRMHIMWRZ-HSZRJFAPSA-N 0.000 claims 1
- SQVWEIWPMBSOAY-XMMPIXPASA-N 1-[1-cyclohexyl-7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2CCCCC2)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO SQVWEIWPMBSOAY-XMMPIXPASA-N 0.000 claims 1
- NIGAPNKNXARLOG-RUZDIDTESA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-(dimethylamino)ethanone Chemical compound CN(C)CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO NIGAPNKNXARLOG-RUZDIDTESA-N 0.000 claims 1
- CMWASHALVKNRRD-HSZRJFAPSA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-hydroxyethanone Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(C2)C(=O)CO)C1=CC=C(C=C1)C(F)(F)F CMWASHALVKNRRD-HSZRJFAPSA-N 0.000 claims 1
- DXFJWZMNQMYZKB-XMMPIXPASA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO DXFJWZMNQMYZKB-XMMPIXPASA-N 0.000 claims 1
- UPKZSBXRVJHEDV-UHFFFAOYSA-N 2-[7-(6-methylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound C(#N)CN1CCN(C2=C(C1)C=C(C=C2)C2=CC=CC(=N2)C)C2=CC=C(C=C2)C(F)(F)F UPKZSBXRVJHEDV-UHFFFAOYSA-N 0.000 claims 1
- PANKKSHDMMARJO-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-N-methylacetamide Chemical compound CNC(=O)CN1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO PANKKSHDMMARJO-XMMPIXPASA-N 0.000 claims 1
- ILUPSHMSCWEPQR-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(CC#N)C2)C1=CC=C(C=C1)C(F)(F)F ILUPSHMSCWEPQR-XMMPIXPASA-N 0.000 claims 1
- QGXTXYHTRXGFNC-OAQYLSRUSA-N 5-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[[4-(trifluoromethyl)phenyl]methyl]-3H-indol-2-one Chemical compound O[C@H](CO)C1=CC=CC(=N1)C=1C=C2CC(N(C2=CC1)CC1=CC=C(C=C1)C(F)(F)F)=O QGXTXYHTRXGFNC-OAQYLSRUSA-N 0.000 claims 1
- GYHQARDUYGKITD-HHHXNRCGSA-N 6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]-4-[(1S)-1,2-dihydroxyethyl]pyridine-2-carbonitrile Chemical compound C1(CC1)CN1CCN(C2=C(C1)C=C(C=C2)C1=CC(=CC(=N1)C#N)[C@@H](CO)O)C1=CC=C(C=C1)C(F)(F)F GYHQARDUYGKITD-HHHXNRCGSA-N 0.000 claims 1
- ZVMHMTHBDNJATF-UHFFFAOYSA-N 7-(6-carbamoylpyridin-2-yl)-N,N-diethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCN(CC)C(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)C(N)=O ZVMHMTHBDNJATF-UHFFFAOYSA-N 0.000 claims 1
- XVIJUQXXWONJQK-JOCHJYFZSA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound NC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO XVIJUQXXWONJQK-JOCHJYFZSA-N 0.000 claims 1
- BUSCEHFTSTUANR-XMMPIXPASA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-N-ethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCNC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO BUSCEHFTSTUANR-XMMPIXPASA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- SJARHIQQBSXEBV-UHFFFAOYSA-N N-[4-[difluoro-(2-fluorophenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]pyrimidine-4-carboxamide Chemical compound N1=CN=C(C=C1)C(=O)NC1=CC=C2C(CCOC2=C1)C(C1=C(C=CC=C1)F)(F)F SJARHIQQBSXEBV-UHFFFAOYSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- QLNJFJADRCOGBJ-LBPDFUHNSA-N propanamide Chemical class CC[13C](N)=O QLNJFJADRCOGBJ-LBPDFUHNSA-N 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- BWSRSZUHBXIXAP-UHFFFAOYSA-N tert-butyl 7-(6-carbamoylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound C(N)(=O)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 BWSRSZUHBXIXAP-UHFFFAOYSA-N 0.000 claims 1
- CSRFDVVNIVYOQK-INIZCTEOSA-N tert-butyl 7-[4-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-6-carbamoylpyrimidin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound NC([C@H](C)NC1=NC(=NC(=C1)C(N)=O)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1)=O CSRFDVVNIVYOQK-INIZCTEOSA-N 0.000 claims 1
- NQTHIHLOHIXQGU-RUZDIDTESA-N tert-butyl 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound O[C@H](CO)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 NQTHIHLOHIXQGU-RUZDIDTESA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461931144P | 2014-01-24 | 2014-01-24 | |
| US61/931,144 | 2014-01-24 | ||
| PCT/US2015/012591 WO2015112801A1 (en) | 2014-01-24 | 2015-01-23 | Pyridines and pyrimidines and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503837A JP2017503837A (ja) | 2017-02-02 |
| JP2017503837A5 true JP2017503837A5 (enExample) | 2018-03-01 |
| JP6526023B2 JP6526023B2 (ja) | 2019-06-05 |
Family
ID=53681959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548133A Active JP6526023B2 (ja) | 2014-01-24 | 2015-01-23 | ピリジン類及びピリミジン類並びにその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10047075B2 (enExample) |
| EP (1) | EP3097078B1 (enExample) |
| JP (1) | JP6526023B2 (enExample) |
| CN (1) | CN106061944A (enExample) |
| WO (1) | WO2015112801A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012007836A1 (en) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Pyridine compounds as sodium channel blockers |
| AR083023A1 (es) | 2010-09-17 | 2013-01-23 | Purdue Pharma Lp | Compuestos de piridina y una composicion farmaceutica que los comprende |
| AU2011346751A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| WO2013064883A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| AU2012321111A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| JP6400592B2 (ja) | 2012-11-09 | 2018-10-03 | パーデュー、ファーマ、リミテッド、パートナーシップ | ベンゾモルファン類似体およびその使用 |
| US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| ES2859148T3 (es) | 2013-03-04 | 2021-10-01 | Purdue Pharma Lp | Carboxamidas de pirimidina como bloqueantes de los canales de sodio |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| US9884865B2 (en) | 2013-08-26 | 2018-02-06 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| US9834543B2 (en) | 2013-12-23 | 2017-12-05 | Purdue Pharma L.P. | Indazoles and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| MA39956A (fr) | 2014-05-06 | 2015-11-12 | Purdue Pharma Lp | Analogues du benzomorphane et leur utilisation |
| US10202382B2 (en) | 2014-06-13 | 2019-02-12 | Purdue Pharma L.P. | Azamorphinan derivatives and use thereof |
| MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| WO2018149359A1 (zh) | 2017-02-17 | 2018-08-23 | 武汉朗来科技发展有限公司 | 三氮唑抗菌衍生物、其药物组合物和用途 |
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| JP2001526648A (ja) | 1997-04-22 | 2001-12-18 | コセンシス・インコーポレイテッド | 炭素環及びヘテロ環で置換されたセミカルバゾン及びチオセミカルバゾン、及びその使用 |
| WO1999026614A1 (en) | 1997-11-21 | 1999-06-03 | Euro-Celtique S.A. | Substituted 2-aminoacetamides and the use thereof |
| US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| PL351439A1 (en) | 1999-03-26 | 2003-04-22 | Euro Celtique Sa | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| WO2000061188A1 (en) | 1999-04-09 | 2000-10-19 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
| AU2868601A (en) * | 2000-01-27 | 2001-08-07 | Ribotargets Ltd | Biaryl compounds, their preparation and their use in therapy |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| BR0108819A (pt) | 2000-03-24 | 2002-12-10 | Euro Celtique Sa | Pirazóis triazóis e tetrazóis substituìdos de arila, e o uso dos mesmos |
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| EA032526B1 (ru) | 2011-08-30 | 2019-06-28 | Схди Фаундейшн, Инк. | Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы |
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| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
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| JP6762308B2 (ja) | 2015-02-19 | 2020-09-30 | パーデュー、ファーマ、リミテッド、パートナーシップ | 胃排出の減少方法及び組成物 |
-
2015
- 2015-01-23 WO PCT/US2015/012591 patent/WO2015112801A1/en not_active Ceased
- 2015-01-23 JP JP2016548133A patent/JP6526023B2/ja active Active
- 2015-01-23 CN CN201580005580.6A patent/CN106061944A/zh active Pending
- 2015-01-23 US US15/113,493 patent/US10047075B2/en active Active
- 2015-01-23 EP EP15739774.6A patent/EP3097078B1/en active Active
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