JP2017503837A5 - - Google Patents
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- Publication number
- JP2017503837A5 JP2017503837A5 JP2016548133A JP2016548133A JP2017503837A5 JP 2017503837 A5 JP2017503837 A5 JP 2017503837A5 JP 2016548133 A JP2016548133 A JP 2016548133A JP 2016548133 A JP2016548133 A JP 2016548133A JP 2017503837 A5 JP2017503837 A5 JP 2017503837A5
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- phenyl
- tetrahydro
- benzo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 17
- 239000012453 solvate Substances 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- -1 azepin-7-yl Chemical group 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims 4
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- XAGZJIQIVXSURR-UHFFFAOYSA-N 1-[4-(trifluoromethyl)phenyl]piperidin-2-one Chemical group C1=CC(C(F)(F)F)=CC=C1N1C(=O)CCCC1 XAGZJIQIVXSURR-UHFFFAOYSA-N 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 125000005518 carboxamido group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- BATAKQAIMRZBKK-HSZRJFAPSA-N (1S)-1-[6-(1-cyclohexyl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCCCC1 BATAKQAIMRZBKK-HSZRJFAPSA-N 0.000 claims 1
- MWVMAOPVOBUOGS-OAQYLSRUSA-N (1S)-1-[6-[1-(2-methylpropyl)-4-methylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound CC(C)CN1CCN(CC2=C1C=CC(=C2)C1=CC=CC(=N1)[C@H](O)CO)S(C)(=O)=O MWVMAOPVOBUOGS-OAQYLSRUSA-N 0.000 claims 1
- UNNIUPFALBGCBG-JOCHJYFZSA-N (1S)-1-[6-[1-(4,4-difluorocyclohexyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCC(F)(F)CC1 UNNIUPFALBGCBG-JOCHJYFZSA-N 0.000 claims 1
- VBRXOOPJTQNXOL-JOCHJYFZSA-N (1S)-1-[6-[1-(oxan-4-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCOCC1 VBRXOOPJTQNXOL-JOCHJYFZSA-N 0.000 claims 1
- TWCUCOUSUASXSV-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCNC2)C1=CC=C(C=C1)C(F)(F)F TWCUCOUSUASXSV-JOCHJYFZSA-N 0.000 claims 1
- JBNWTEGHEKINOR-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-4,1-benzoxazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCOC2)C1=CC=C(C=C1)C(F)(F)F JBNWTEGHEKINOR-JOCHJYFZSA-N 0.000 claims 1
- BGRZHUXTVWBAQC-HSZRJFAPSA-N (1S)-1-[6-[1-[[4-(trifluoromethyl)phenyl]methyl]-3,4-dihydro-2H-quinolin-6-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CC1=CC=C(C=C1)C(F)(F)F)CCC2 BGRZHUXTVWBAQC-HSZRJFAPSA-N 0.000 claims 1
- OTLFVFMAOBMXOK-AREMUKBSSA-N (1S)-1-[6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCN(CC1CC1)C2)C1=CC=C(C=C1)C(F)(F)F OTLFVFMAOBMXOK-AREMUKBSSA-N 0.000 claims 1
- SHPLKCRMHIMWRZ-HSZRJFAPSA-N (1s)-1-[6-[4-methylsulfonyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2h-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound C12=CC=C(C=3N=C(C=CC=3)[C@H](O)CO)C=C2CN(S(=O)(=O)C)CCN1C1=CC=C(C(F)(F)F)C=C1 SHPLKCRMHIMWRZ-HSZRJFAPSA-N 0.000 claims 1
- SQVWEIWPMBSOAY-XMMPIXPASA-N 1-[1-cyclohexyl-7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2CCCCC2)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO SQVWEIWPMBSOAY-XMMPIXPASA-N 0.000 claims 1
- NIGAPNKNXARLOG-RUZDIDTESA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-(dimethylamino)ethanone Chemical compound CN(C)CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO NIGAPNKNXARLOG-RUZDIDTESA-N 0.000 claims 1
- CMWASHALVKNRRD-HSZRJFAPSA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-hydroxyethanone Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(C2)C(=O)CO)C1=CC=C(C=C1)C(F)(F)F CMWASHALVKNRRD-HSZRJFAPSA-N 0.000 claims 1
- DXFJWZMNQMYZKB-XMMPIXPASA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO DXFJWZMNQMYZKB-XMMPIXPASA-N 0.000 claims 1
- UPKZSBXRVJHEDV-UHFFFAOYSA-N 2-[7-(6-methylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound C(#N)CN1CCN(C2=C(C1)C=C(C=C2)C2=CC=CC(=N2)C)C2=CC=C(C=C2)C(F)(F)F UPKZSBXRVJHEDV-UHFFFAOYSA-N 0.000 claims 1
- PANKKSHDMMARJO-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-N-methylacetamide Chemical compound CNC(=O)CN1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO PANKKSHDMMARJO-XMMPIXPASA-N 0.000 claims 1
- ILUPSHMSCWEPQR-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(CC#N)C2)C1=CC=C(C=C1)C(F)(F)F ILUPSHMSCWEPQR-XMMPIXPASA-N 0.000 claims 1
- QGXTXYHTRXGFNC-OAQYLSRUSA-N 5-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[[4-(trifluoromethyl)phenyl]methyl]-3H-indol-2-one Chemical compound O[C@H](CO)C1=CC=CC(=N1)C=1C=C2CC(N(C2=CC1)CC1=CC=C(C=C1)C(F)(F)F)=O QGXTXYHTRXGFNC-OAQYLSRUSA-N 0.000 claims 1
- GYHQARDUYGKITD-HHHXNRCGSA-N 6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]-4-[(1S)-1,2-dihydroxyethyl]pyridine-2-carbonitrile Chemical compound C1(CC1)CN1CCN(C2=C(C1)C=C(C=C2)C1=CC(=CC(=N1)C#N)[C@@H](CO)O)C1=CC=C(C=C1)C(F)(F)F GYHQARDUYGKITD-HHHXNRCGSA-N 0.000 claims 1
- ZVMHMTHBDNJATF-UHFFFAOYSA-N 7-(6-carbamoylpyridin-2-yl)-N,N-diethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCN(CC)C(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)C(N)=O ZVMHMTHBDNJATF-UHFFFAOYSA-N 0.000 claims 1
- XVIJUQXXWONJQK-JOCHJYFZSA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound NC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO XVIJUQXXWONJQK-JOCHJYFZSA-N 0.000 claims 1
- BUSCEHFTSTUANR-XMMPIXPASA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-N-ethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCNC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO BUSCEHFTSTUANR-XMMPIXPASA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- SJARHIQQBSXEBV-UHFFFAOYSA-N N-[4-[difluoro-(2-fluorophenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]pyrimidine-4-carboxamide Chemical compound N1=CN=C(C=C1)C(=O)NC1=CC=C2C(CCOC2=C1)C(C1=C(C=CC=C1)F)(F)F SJARHIQQBSXEBV-UHFFFAOYSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- QLNJFJADRCOGBJ-LBPDFUHNSA-N propanamide Chemical class CC[13C](N)=O QLNJFJADRCOGBJ-LBPDFUHNSA-N 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- BWSRSZUHBXIXAP-UHFFFAOYSA-N tert-butyl 7-(6-carbamoylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound C(N)(=O)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 BWSRSZUHBXIXAP-UHFFFAOYSA-N 0.000 claims 1
- CSRFDVVNIVYOQK-INIZCTEOSA-N tert-butyl 7-[4-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-6-carbamoylpyrimidin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound NC([C@H](C)NC1=NC(=NC(=C1)C(N)=O)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1)=O CSRFDVVNIVYOQK-INIZCTEOSA-N 0.000 claims 1
- NQTHIHLOHIXQGU-RUZDIDTESA-N tert-butyl 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound O[C@H](CO)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 NQTHIHLOHIXQGU-RUZDIDTESA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461931144P | 2014-01-24 | 2014-01-24 | |
| US61/931,144 | 2014-01-24 | ||
| PCT/US2015/012591 WO2015112801A1 (en) | 2014-01-24 | 2015-01-23 | Pyridines and pyrimidines and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503837A JP2017503837A (ja) | 2017-02-02 |
| JP2017503837A5 true JP2017503837A5 (enExample) | 2018-03-01 |
| JP6526023B2 JP6526023B2 (ja) | 2019-06-05 |
Family
ID=53681959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548133A Active JP6526023B2 (ja) | 2014-01-24 | 2015-01-23 | ピリジン類及びピリミジン類並びにその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10047075B2 (enExample) |
| EP (1) | EP3097078B1 (enExample) |
| JP (1) | JP6526023B2 (enExample) |
| CN (1) | CN106061944A (enExample) |
| WO (1) | WO2015112801A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9120752B2 (en) | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
| JP2013538227A (ja) | 2010-09-17 | 2013-10-10 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン化合物およびその使用 |
| JP2014500303A (ja) | 2010-12-22 | 2014-01-09 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としての置換ピリジン |
| AU2012321111A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013064883A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| AU2013203824A1 (en) | 2012-03-16 | 2013-10-03 | Purdue Pharma L.P. | Substituted pyridines and pryimidines as sodium channel blockers |
| US10138207B2 (en) | 2012-11-09 | 2018-11-27 | Purdue Pharma, L.P. | Benzomorphan analogs and the use thereof |
| EP2935257B1 (en) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| ES2859148T3 (es) | 2013-03-04 | 2021-10-01 | Purdue Pharma Lp | Carboxamidas de pirimidina como bloqueantes de los canales de sodio |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| CN105612152A (zh) | 2013-08-26 | 2016-05-25 | 普渡制药公司 | 氮杂螺[4.5]癸烷衍生物及其用途 |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| EP3083606B1 (en) | 2013-12-20 | 2020-10-28 | Purdue Pharma LP | Pyrimidines and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| WO2015099841A1 (en) | 2013-12-23 | 2015-07-02 | Purdue Pharma L.P. | Indazoles and use thereof |
| EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| US9975854B2 (en) | 2014-05-06 | 2018-05-22 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| US10202382B2 (en) | 2014-06-13 | 2019-02-12 | Purdue Pharma L.P. | Azamorphinan derivatives and use thereof |
| US10131666B2 (en) | 2014-06-13 | 2018-11-20 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| WO2018149359A1 (zh) | 2017-02-17 | 2018-08-23 | 武汉朗来科技发展有限公司 | 三氮唑抗菌衍生物、其药物组合物和用途 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69829048T2 (de) | 1997-04-22 | 2006-02-09 | Euro-Celtique S.A. | Die verwendung von durch carbozyklische und heterozyklische reste substituierte semicarbazonen und thiosemicarbazonen als natriumkanalblocker |
| ES2352739T3 (es) | 1997-11-21 | 2011-02-22 | Purdue Neuroscience Company | 2-aminoacetamidas sustituidas y el uso de las mismas. |
| US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| DE60044395D1 (de) | 1999-03-26 | 2010-06-24 | Euro Celtique Sa | Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung |
| JP2002541215A (ja) | 1999-04-09 | 2002-12-03 | ユーロ−セルティック エス． ア． | ナトリウムチャネル遮断薬組成物およびその使用 |
| AU2868601A (en) | 2000-01-27 | 2001-08-07 | Ribotargets Ltd | Biaryl compounds, their preparation and their use in therapy |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| CZ303632B6 (cs) | 2000-03-24 | 2013-01-23 | Euro-Celtique S.A. | Arylem substituované pyrazoly, triazoly a tetrazoly a jejich pouzití |
| EP1268427A1 (en) | 2000-03-31 | 2003-01-02 | Cocensys, Inc. | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| IL159765A0 (en) | 2001-07-16 | 2004-06-20 | Euro Celtique Sa | Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same |
| AR036873A1 (es) | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| ES2328471T3 (es) | 2002-03-13 | 2009-11-13 | Euro-Celtique S.A. | Pirimidinas aril sustituidas y uso de las mismas. |
| EA200500289A1 (ru) | 2002-07-31 | 2005-06-30 | Еуро-Селтик С. А. | Арилзамещенные бензимидазолы и их использование в качестве блокаторов натриевых каналов |
| MXPA05000813A (es) | 2002-07-31 | 2005-04-19 | Euro Celtique Sa | Compuestos hidrantoina aril sustituidos y su uso como bloqueadores del canal de sodio. |
| US20040152696A1 (en) | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
| WO2005014849A2 (en) | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| US20070299114A1 (en) * | 2004-10-05 | 2007-12-27 | Shionogi & Co., Ltd. | Biaryl Derivatives |
| KR20140063907A (ko) | 2006-03-14 | 2014-05-27 | 산텐 세이야꾸 가부시키가이샤 | 글루코코르티코이드 수용체 결합 활성을 갖는 신규 1,2,3,4-테트라히드로퀴녹살린 유도체 |
| JP2010540628A (ja) * | 2007-10-04 | 2010-12-24 | メルク・シャープ・エンド・ドーム・コーポレイション | カルシウムチャネル遮断薬としてのｎ−置換されたオキシインドリン誘導体 |
| WO2009045386A1 (en) * | 2007-10-04 | 2009-04-09 | Merck & Co., Inc. | N-substituted oxindoline derivatives as calcium channel blockers |
| US20110201815A1 (en) * | 2008-10-15 | 2011-08-18 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative and use thereof for medical purposes |
| PE20120305A1 (es) * | 2008-12-19 | 2012-04-09 | Abbott Lab | Compuestos heterociclicos derivados de benzotiazol y tetrahidroquinolina como inhbidores de bcl-2 y bcl-xl |
| CN105130957A (zh) | 2009-05-29 | 2015-12-09 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
| EP2582666B1 (en) | 2010-06-16 | 2014-08-13 | Purdue Pharma L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
| US9120752B2 (en) | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
| JP2013538227A (ja) | 2010-09-17 | 2013-10-10 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン化合物およびその使用 |
| US9045435B2 (en) | 2010-10-05 | 2015-06-02 | Purdue Pharma, L.P. | Quinazoline compounds as sodium channel blockers |
| JP2014500303A (ja) | 2010-12-22 | 2014-01-09 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としての置換ピリジン |
| HRP20170928T1 (hr) * | 2011-08-30 | 2017-09-22 | Chdi Foundation, Inc. | Inhibitori kinurenin-3-monooksigenaze, farmaceutski pripravci, i postupci za njihovu upotrebu |
| AU2012300567B2 (en) | 2011-09-02 | 2016-03-10 | Purdue Pharma L.P. | Pyrimidines as sodium channel blockers |
| WO2013064883A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| AU2012321111A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| AU2013203824A1 (en) | 2012-03-16 | 2013-10-03 | Purdue Pharma L.P. | Substituted pyridines and pryimidines as sodium channel blockers |
| US9447069B2 (en) * | 2012-04-30 | 2016-09-20 | Innov17 Llc | ROR modulators and their uses |
| TW201414704A (zh) | 2012-07-02 | 2014-04-16 | Biogen Idec Inc | 作爲ＲＯＲ－γ受體之反向促效劑之含聯芳化合物 |
| EP2935257B1 (en) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| ES2859148T3 (es) | 2013-03-04 | 2021-10-01 | Purdue Pharma Lp | Carboxamidas de pirimidina como bloqueantes de los canales de sodio |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| CN105612152A (zh) | 2013-08-26 | 2016-05-25 | 普渡制药公司 | 氮杂螺[4.5]癸烷衍生物及其用途 |
| US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| EP3083606B1 (en) | 2013-12-20 | 2020-10-28 | Purdue Pharma LP | Pyrimidines and use thereof |
| WO2015099841A1 (en) | 2013-12-23 | 2015-07-02 | Purdue Pharma L.P. | Indazoles and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| EP3105217B1 (en) | 2014-02-12 | 2019-05-29 | Purdue Pharma LP | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| AU2016219879A1 (en) | 2015-02-19 | 2017-08-24 | Purdue Pharma L.P. | Methods and compositions for decreasing gastric emptying |
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2015
- 2015-01-23 EP EP15739774.6A patent/EP3097078B1/en active Active
- 2015-01-23 JP JP2016548133A patent/JP6526023B2/ja active Active
- 2015-01-23 US US15/113,493 patent/US10047075B2/en active Active
- 2015-01-23 WO PCT/US2015/012591 patent/WO2015112801A1/en not_active Ceased
- 2015-01-23 CN CN201580005580.6A patent/CN106061944A/zh active Pending