JP2017502957A5 - - Google Patents
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- JP2017502957A5 JP2017502957A5 JP2016543097A JP2016543097A JP2017502957A5 JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5 JP 2016543097 A JP2016543097 A JP 2016543097A JP 2016543097 A JP2016543097 A JP 2016543097A JP 2017502957 A5 JP2017502957 A5 JP 2017502957A5
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- 208000024827 Alzheimer disease Diseases 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 208000018737 Parkinson disease Diseases 0.000 claims description 5
- 208000002193 Pain Diseases 0.000 claims description 4
- 230000000069 prophylactic effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 229940122357 Monoacylglycerol lipase inhibitor Drugs 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims 85
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 79
- 125000005843 halogen group Chemical group 0.000 claims 79
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 42
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 36
- -1 pyrrolidinylcarbonyl group Chemical group 0.000 claims 26
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000004043 oxo group Chemical group O=* 0.000 claims 19
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 14
- 125000004076 pyridyl group Chemical group 0.000 claims 14
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000003277 amino group Chemical group 0.000 claims 10
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 8
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 8
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 7
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 6
- 125000004193 piperazinyl group Chemical group 0.000 claims 6
- HNJBEVLQSNELDL-YZRHJBSPSA-N pyrrolidin-2-one Chemical group O=C1CC[14CH2]N1 HNJBEVLQSNELDL-YZRHJBSPSA-N 0.000 claims 6
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 5
- 125000001041 indolyl group Chemical group 0.000 claims 5
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims 4
- 125000005974 C6-C14 arylcarbonyl group Chemical group 0.000 claims 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 4
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000003367 polycyclic group Chemical group 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000006085 pyrrolopyridyl group Chemical group 0.000 claims 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 3
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 3
- 206010015037 epilepsy Diseases 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000005945 imidazopyridyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000005116 aryl carbamoyl group Chemical group 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000005554 pyridyloxy group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000004588 thienopyridyl group Chemical group S1C(=CC2=C1C=CC=N2)* 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- KRTLYJDCOZBDAH-OAQYLSRUSA-N (4R)-1-[3-fluoro-5-(2-methylpyridin-3-yl)phenyl]-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolidin-2-one Chemical compound FC=1C=C(C=C(C1)C=1C(=NC=CC1)C)N1C(C[C@H](C1)N1CCN(CC1)C1=NC=CC=N1)=O KRTLYJDCOZBDAH-OAQYLSRUSA-N 0.000 claims 1
- ACWGPXVJPMRMHD-JOCHJYFZSA-N (4R)-4-[4-(1,3-thiazole-4-carbonyl)piperazin-1-yl]-1-[1-[4-(trifluoromethyl)phenyl]indol-5-yl]pyrrolidin-2-one Chemical compound S1C=NC(=C1)C(=O)N1CCN(CC1)[C@@H]1CC(N(C1)C=1C=C2C=CN(C2=CC1)C1=CC=C(C=C1)C(F)(F)F)=O ACWGPXVJPMRMHD-JOCHJYFZSA-N 0.000 claims 1
- GHGYBXQHRZLJLK-LJQANCHMSA-N (4r)-4-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]-1-[1-[5-(trifluoromethyl)pyrimidin-2-yl]indol-5-yl]pyrrolidin-2-one Chemical compound N1=CC(C(F)(F)F)=CN=C1N1C2=CC=C(N3C(C[C@H](C3)N3CCN(CC3)C(=O)C=3SC=CN=3)=O)C=C2C=C1 GHGYBXQHRZLJLK-LJQANCHMSA-N 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 1
- 150000004885 piperazines Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 description 8
- 230000004770 neurodegeneration Effects 0.000 description 5
- 102100029814 Monoglyceride lipase Human genes 0.000 description 4
- 101710116393 Monoglyceride lipase Proteins 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 230000016273 neuron death Effects 0.000 description 4
- 102100033868 Cannabinoid receptor 1 Human genes 0.000 description 3
- 101710187010 Cannabinoid receptor 1 Proteins 0.000 description 3
- 102100036214 Cannabinoid receptor 2 Human genes 0.000 description 3
- 101710187022 Cannabinoid receptor 2 Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 3
- 210000004498 neuroglial cell Anatomy 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000025698 brain inflammatory disease Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010014599 encephalitis Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000001259 mesencephalon Anatomy 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- PKBXKBJNBFXIAB-UHFFFAOYSA-N 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine Chemical compound CN1CCC(=CC1)c1ccccc1.CN1CCC(=CC1)c1ccccc1 PKBXKBJNBFXIAB-UHFFFAOYSA-N 0.000 description 1
- 230000007082 Aβ accumulation Effects 0.000 description 1
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 description 1
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000005064 dopaminergic neuron Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 230000001722 neurochemical effect Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013269244 | 2013-12-26 | ||
| JP2013269244 | 2013-12-26 | ||
| PCT/JP2014/084752 WO2015099196A1 (en) | 2013-12-26 | 2014-12-25 | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502957A JP2017502957A (ja) | 2017-01-26 |
| JP2017502957A5 true JP2017502957A5 (cg-RX-API-DMAC7.html) | 2017-12-07 |
| JP6454349B2 JP6454349B2 (ja) | 2019-01-16 |
Family
ID=52434920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543097A Active JP6454349B2 (ja) | 2013-12-26 | 2014-12-25 | モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9624170B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3087067B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6454349B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015099196A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2951521A1 (en) * | 2014-06-09 | 2015-12-17 | Takeda Pharmaceutical Company Limited | Radiolabeled compounds |
| TW201706265A (zh) | 2015-03-09 | 2017-02-16 | 必治妥美雅史谷比公司 | 做為Ｒｈｏ激酶（ＲＯＣＫ）抑制劑之內醯胺 |
| WO2016158956A1 (ja) | 2015-03-30 | 2016-10-06 | 武田薬品工業株式会社 | 複素環化合物 |
| CA2993269A1 (en) | 2015-07-23 | 2017-01-26 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| US10787423B2 (en) | 2015-09-14 | 2020-09-29 | The National Institute For Biotechnolgy In The Negev Ltd. | Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction |
| CN108290889B (zh) * | 2015-09-14 | 2021-08-10 | 内盖夫国家生物技术研究所 | 新的哌嗪和哌啶衍生物、它们的合成及其在抑制vdac寡聚化、细胞凋亡和线粒体功能障碍中的用途 |
| US10434099B2 (en) * | 2016-09-22 | 2019-10-08 | The National Institute for Biotechnology in the Negev Ltd. | Methods for treating central nervous system disorders using VDAC inhibitors |
| ES2818254T3 (es) * | 2015-10-14 | 2021-04-09 | Bristol Myers Squibb Co | Antagonistas selectivos de NR2B |
| US10610520B2 (en) | 2016-03-31 | 2020-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP6788683B2 (ja) * | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| UA124990C2 (uk) * | 2017-05-23 | 2021-12-22 | Луннбек Ла-Холья Рісьоч Сенте, Інк. | Інгібітори magl на основі піразолу |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| CN107397955A (zh) * | 2017-08-23 | 2017-11-28 | 上海黛妆国际贸易有限公司 | 黑色素基因抑制剂 |
| EP3689879B1 (en) | 2017-09-29 | 2025-02-12 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10626106B2 (en) * | 2017-12-18 | 2020-04-21 | Gruenenthal Gmbh | Substituted pyrrolidine amides I |
| TW201927769A (zh) * | 2017-12-18 | 2019-07-16 | 德商歌林達有限公司 | 經取代之吡咯啶醯胺ｉｉ |
| KR20200143376A (ko) | 2018-03-13 | 2020-12-23 | 샤이어 휴먼 지네틱 테라피즈 인크. | 혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도 |
| MX2020014098A (es) * | 2018-06-27 | 2021-05-27 | Ptc Therapeutics Inc | Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington. |
| US20220041588A1 (en) * | 2018-09-27 | 2022-02-10 | Fochon Pharmaceuticals, Ltd. | Substituted imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| CN113382990B (zh) | 2019-01-11 | 2024-11-19 | 格吕伦塔尔有限公司 | 取代的吡咯烷酰胺iii |
| US11370803B2 (en) | 2019-09-18 | 2022-06-28 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| CN114728962B (zh) | 2019-09-18 | 2025-09-19 | 武田药品工业有限公司 | 血浆激肽释放酶抑制剂及其用途 |
| CN115667216B (zh) | 2020-04-07 | 2025-02-18 | 赛诺菲 | 用于治疗癌症的作为tead蛋白和hippo-yap1/taz信号传导级联抑制剂的(1h-吲哚-5-基)丙烯酰胺衍生物 |
| EP3892614A1 (en) | 2020-04-07 | 2021-10-13 | Sanofi | (1h-indol-5-yl)acrylamide derivatives as inhibitors of tead proteins and the hippo-yap1/taz signaling cascade for the treatment of cancer |
| CN117396474A (zh) * | 2021-03-17 | 2024-01-12 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂 |
| MX2023013013A (es) * | 2021-05-06 | 2024-03-25 | Exscientia Ai Ltd | Moduladores de proteina cinasa c (pkc)-theta. |
| CN117836014A (zh) * | 2021-09-03 | 2024-04-05 | 豪夫迈·罗氏有限公司 | Magl抑制剂 |
| KR20240128870A (ko) | 2021-12-29 | 2024-08-27 | 싸이 테라퓨틱스, 인크. | 모노아실글리세롤 리파아제(magl) 억제 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1445792A1 (de) | 1964-12-18 | 1969-01-02 | Bayer Ag | Verfahren zur Herstellung von Iminopyrrolidonen |
| US7456210B2 (en) * | 2004-08-02 | 2008-11-25 | Hoffmann-La Roche Inc. | Benzyloxy derivatives |
| JP2009275020A (ja) * | 2008-05-16 | 2009-11-26 | Institute Of Physical & Chemical Research | 細胞増殖阻害剤 |
| KR20120035146A (ko) | 2009-04-22 | 2012-04-13 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 억제제로서의 아제티디닐 다이아미드 |
| TW201103914A (en) * | 2009-04-22 | 2011-02-01 | Janssen Pharmaceutica Nv | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
| RU2558141C2 (ru) * | 2009-04-22 | 2015-07-27 | Янссен Фармацевтика Нв | Гетероароматические и ароматические пиперазинилазетидиниламиды в качестве ингибиторов моноацилглицеринлипазы |
| WO2011041713A2 (en) | 2009-10-02 | 2011-04-07 | Glaxosmithkline Llc | Piperazinyl antiviral agents |
| WO2011050284A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| KR20130101040A (ko) | 2010-09-03 | 2013-09-12 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 억제제로서의 다이-아제티디닐 다이아미드 |
| EP2621918A1 (en) | 2010-09-27 | 2013-08-07 | Janssen Pharmaceutica, N.V. | Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors |
| CA2815350A1 (en) | 2010-10-22 | 2012-04-26 | Janssen Pharmaceutica Nv | Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors |
| JP2014528428A (ja) * | 2011-09-30 | 2014-10-27 | ヤンセン ファーマシューティカ エヌ．ベー． | 代謝症及び関連障害の治療のためのモノアシルグリセロールリパーゼ阻害剤 |
| CA2850100A1 (en) | 2011-09-30 | 2013-04-04 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders |
| MX2014011134A (es) * | 2012-03-19 | 2014-12-10 | Abide Therapeutics Inc | Compuestos de carbamato y preparacion y uso de los mismos. |
-
2014
- 2014-12-25 EP EP14833295.0A patent/EP3087067B1/en active Active
- 2014-12-25 WO PCT/JP2014/084752 patent/WO2015099196A1/en not_active Ceased
- 2014-12-25 JP JP2016543097A patent/JP6454349B2/ja active Active
- 2014-12-25 US US15/108,000 patent/US9624170B2/en active Active
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