EA201592247A1 - 4-(5-(4-ХЛОРОФЕНИЛ)-2-(2-ЦИКЛОПРОПИЛАЦЕТИЛ)-1,4-ДИМЕТИЛ-1H-ПИРРОЛ-3-ИЛ)БЕНЗОЛСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА АЛЬФА-7 nAChR - Google Patents
4-(5-(4-ХЛОРОФЕНИЛ)-2-(2-ЦИКЛОПРОПИЛАЦЕТИЛ)-1,4-ДИМЕТИЛ-1H-ПИРРОЛ-3-ИЛ)БЕНЗОЛСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА АЛЬФА-7 nAChRInfo
- Publication number
- EA201592247A1 EA201592247A1 EA201592247A EA201592247A EA201592247A1 EA 201592247 A1 EA201592247 A1 EA 201592247A1 EA 201592247 A EA201592247 A EA 201592247A EA 201592247 A EA201592247 A EA 201592247A EA 201592247 A1 EA201592247 A1 EA 201592247A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyclopropylacetyl
- dimethyl
- chlorophenil
- benzulsulphonamide
- pirrol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Раскрывается соединение-модулятор альфа-7 nAChR рецептора, 4-(5-(4-хлорофенил)-2-(2-циклопропилацетил)-1,4-диметил-1Н-пиррол-3-ил)бензолсульфонамид, его таутомер, его фармацевтически приемлемые соли, фармацевтические композиции, содержащие данное соединение или его соль, и способ лечения разных заболеваний, расстройств или состояний, например болезни Альцгеймера, умеренного когнитивного нарушения, сенильной деменции, сосудистой деменции, деменции при болезни Паркинсона и синдрома дефицита внимания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1937MU2013 | 2013-06-03 | ||
PCT/IB2014/061891 WO2014195848A1 (en) | 2013-06-03 | 2014-06-02 | 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1h-pyrrol-3-yl)benzenesulfonamide as alpha 7 nachr modulator |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201592247A1 true EA201592247A1 (ru) | 2016-04-29 |
Family
ID=50981599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201592247A EA201592247A1 (ru) | 2013-06-03 | 2014-06-02 | 4-(5-(4-ХЛОРОФЕНИЛ)-2-(2-ЦИКЛОПРОПИЛАЦЕТИЛ)-1,4-ДИМЕТИЛ-1H-ПИРРОЛ-3-ИЛ)БЕНЗОЛСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА АЛЬФА-7 nAChR |
Country Status (22)
Country | Link |
---|---|
US (1) | US9447037B2 (ru) |
EP (1) | EP3004054A1 (ru) |
JP (1) | JP2016520642A (ru) |
CN (1) | CN105263905A (ru) |
AP (1) | AP2015008884A0 (ru) |
AR (1) | AR096462A1 (ru) |
AU (1) | AU2014276436B2 (ru) |
BR (1) | BR112015030171A2 (ru) |
CA (1) | CA2912841A1 (ru) |
CL (1) | CL2015003515A1 (ru) |
CR (1) | CR20150646A (ru) |
CU (1) | CU20150168A7 (ru) |
EA (1) | EA201592247A1 (ru) |
IL (1) | IL242837A0 (ru) |
MA (1) | MA38697A1 (ru) |
MX (1) | MX2015016539A (ru) |
PE (1) | PE20160009A1 (ru) |
PH (1) | PH12015502676A1 (ru) |
SG (1) | SG11201509442RA (ru) |
TW (1) | TW201446243A (ru) |
WO (1) | WO2014195848A1 (ru) |
ZA (1) | ZA201600021B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6612874B2 (ja) | 2014-12-16 | 2019-11-27 | アクソファント サイエンシーズ ゲーエムベーハー | α7−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物 |
CA2988968A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
EP3334740A4 (en) | 2015-08-12 | 2019-02-06 | Axovant Sciences GmbH | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS |
ES2901197T3 (es) | 2016-03-22 | 2022-03-21 | Merck Sharp & Dohme | Moduladores alostéricos de los receptores nicotínicos de la acetilcolina |
WO2018187606A1 (en) * | 2017-04-07 | 2018-10-11 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | METHODS AND COMPOSITIONS FOR MODULATING β-AMYLOID/α7-NACHR INTERACTIONS |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
JP2007530635A (ja) | 2004-03-29 | 2007-11-01 | ノイロサーチ アクティーゼルスカブ | 新規尿素誘導体群およびそれらの利用 |
US20060142349A1 (en) | 2004-12-23 | 2006-06-29 | Pfizer Inc | Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor |
ATE481407T1 (de) | 2005-02-16 | 2010-10-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
EA015034B1 (ru) | 2005-09-13 | 2011-04-29 | Янссен Фармацевтика Н.В. | 2-анилин-4-арилзамещенные тиазольные производные |
WO2007093602A1 (en) | 2006-02-16 | 2007-08-23 | Neurosearch A/S | Enantiopure quinuclidinyloxy pyridazines and their use as nicotinic acetylcholine receptor ligands |
JO3019B1 (ar) | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
BRPI0712667A2 (pt) | 2006-06-27 | 2012-09-04 | Abbott Lab | derivados do pirrol e seus métodos de uso |
EP2038278A2 (en) | 2006-06-27 | 2009-03-25 | Abbott Laboratories | Thiazoline and oxazoline derivatives and their methods of use |
CN101796034A (zh) | 2007-08-08 | 2010-08-04 | 神经研究公司 | 用作烟碱型乙酰胆碱受体的调节剂的新颖的1,2,3-三唑衍生物 |
JP5362729B2 (ja) | 2007-10-04 | 2013-12-11 | エフ.ホフマン−ラ ロシュ アーゲー | シクロプロピルアリールアミド誘導体及びその使用 |
CA2701214C (en) | 2007-10-04 | 2016-08-02 | F. Hoffmann-La Roche Ag | Tetrazole-substituted aryl amide derivatives and uses thereof |
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
KR101564303B1 (ko) | 2008-03-19 | 2015-11-06 | 얀센 파마슈티카 엔.브이. | 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸 |
US7786171B2 (en) | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
ES2392795T3 (es) | 2008-04-17 | 2012-12-13 | Proximagen Limited | Indoles como moduladores del receptor nicotínico de acetilcolina de subtipo alfa-7 |
WO2009135944A1 (en) | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
US8563579B2 (en) | 2009-01-15 | 2013-10-22 | Anvyl Llc | α-7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
US20120071469A1 (en) | 2009-05-14 | 2012-03-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
CN103443092B (zh) | 2011-02-03 | 2015-11-25 | 鲁平有限公司 | 用作α7胆碱受体调节剂的吡咯衍生物 |
CU24177B1 (es) * | 2011-02-23 | 2016-04-25 | Lupin Ltd | Derivados de heteroarilo como moduladores de nachr alfa 7 |
JP2014509641A (ja) | 2011-03-31 | 2014-04-21 | ルピン・リミテッド | アルツハイマー病やパーキンソン病などの神経変性疾患の治療に用いられるニコチン性アセチルコリン受容体モジュレータとしてのピロール誘導体 |
WO2013005153A1 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Biaryl derivatives as nachr modulators |
EP2822946A1 (en) | 2012-03-06 | 2015-01-14 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
WO2014111839A1 (en) | 2013-01-16 | 2014-07-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
CA2892682A1 (en) | 2013-03-13 | 2014-09-18 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
-
2014
- 2014-05-30 TW TW103118995A patent/TW201446243A/zh unknown
- 2014-06-02 CA CA2912841A patent/CA2912841A1/en not_active Abandoned
- 2014-06-02 AU AU2014276436A patent/AU2014276436B2/en not_active Ceased
- 2014-06-02 US US14/894,803 patent/US9447037B2/en not_active Expired - Fee Related
- 2014-06-02 CN CN201480031584.7A patent/CN105263905A/zh active Pending
- 2014-06-02 MX MX2015016539A patent/MX2015016539A/es unknown
- 2014-06-02 PE PE2015002547A patent/PE20160009A1/es not_active Application Discontinuation
- 2014-06-02 WO PCT/IB2014/061891 patent/WO2014195848A1/en active Application Filing
- 2014-06-02 EA EA201592247A patent/EA201592247A1/ru unknown
- 2014-06-02 SG SG11201509442RA patent/SG11201509442RA/en unknown
- 2014-06-02 JP JP2016517710A patent/JP2016520642A/ja not_active Withdrawn
- 2014-06-02 MA MA38697A patent/MA38697A1/fr unknown
- 2014-06-02 BR BR112015030171A patent/BR112015030171A2/pt not_active IP Right Cessation
- 2014-06-02 AP AP2015008884A patent/AP2015008884A0/xx unknown
- 2014-06-02 EP EP14732406.5A patent/EP3004054A1/en not_active Withdrawn
- 2014-06-03 AR ARP140102165A patent/AR096462A1/es unknown
-
2015
- 2015-11-27 PH PH12015502676A patent/PH12015502676A1/en unknown
- 2015-11-30 IL IL242837A patent/IL242837A0/en unknown
- 2015-12-01 CL CL2015003515A patent/CL2015003515A1/es unknown
- 2015-12-03 CU CUP2015000168A patent/CU20150168A7/es unknown
- 2015-12-08 CR CR20150646A patent/CR20150646A/es unknown
-
2016
- 2016-01-04 ZA ZA2016/00021A patent/ZA201600021B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR096462A1 (es) | 2015-12-30 |
SG11201509442RA (en) | 2015-12-30 |
EP3004054A1 (en) | 2016-04-13 |
BR112015030171A2 (pt) | 2017-07-25 |
US20160107990A1 (en) | 2016-04-21 |
CL2015003515A1 (es) | 2016-07-01 |
AU2014276436B2 (en) | 2017-03-02 |
AU2014276436A1 (en) | 2015-12-17 |
PE20160009A1 (es) | 2016-02-14 |
PH12015502676A1 (en) | 2016-03-07 |
CU20150168A7 (es) | 2016-06-29 |
CA2912841A1 (en) | 2014-12-11 |
AP2015008884A0 (en) | 2015-11-30 |
MX2015016539A (es) | 2016-04-15 |
TW201446243A (zh) | 2014-12-16 |
MA38697A1 (fr) | 2017-03-31 |
CN105263905A (zh) | 2016-01-20 |
WO2014195848A1 (en) | 2014-12-11 |
US9447037B2 (en) | 2016-09-20 |
IL242837A0 (en) | 2016-02-01 |
CR20150646A (es) | 2016-04-07 |
ZA201600021B (en) | 2017-05-31 |
JP2016520642A (ja) | 2016-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY196243A (en) | Dihydropyrimidine Compounds and Their Application In Pharmaceuticals | |
GEP20186892B (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
UA122346C2 (uk) | ТЕТРАГІДРО-1H-ПІРИДО[3,4-b]ІНДОЛЬНІ АНТИЕСТРОГЕННІ ЛІКАРСЬКІ ПРЕПАРАТИ | |
TN2018000218A1 (en) | Indole carboxamides compounds useful as kinase inhibitors. | |
MX2016006564A (es) | Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos. | |
CL2015000578A1 (es) | Compuesto n-(2-(6-fluoro-1-h-indol-3-il)etil)-3-(2,2,3,3-tetrafluoropropoxi)bencilamina o su sal, antagonista del receptor 5-ht6; composicion farmaceutica; uso en el tratamiento de la enfermedad de alzheimer. | |
EA201890152A1 (ru) | Производные 2,3-дигидро-4h-1,3-бензоксазин-4-онов в качестве модуляторов холинергического мускаринового m1 рецептора | |
EA201591291A1 (ru) | Производные пиримидона и их применение в лечении, облегчении или профилактике вирусного заболевания | |
MY182403A (en) | Dihydropyrimidine compounds and their application in pharmaceuticals | |
TN2017000158A1 (en) | Carbazole derivatives | |
GEP20196949B (en) | 2-amino-6-(difluoromethyl)-5, 5-difluoro-6-phenyl-3, 4, 5, 6-tetra- hydropyridines as bace1 inhibitors | |
EA201592247A1 (ru) | 4-(5-(4-ХЛОРОФЕНИЛ)-2-(2-ЦИКЛОПРОПИЛАЦЕТИЛ)-1,4-ДИМЕТИЛ-1H-ПИРРОЛ-3-ИЛ)БЕНЗОЛСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА АЛЬФА-7 nAChR | |
MX2016011105A (es) | Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona para usarse en el tratamiento de trastornos metabolicos. | |
HRP20200161T1 (hr) | (r)-3-((3s,4s)-3-fluoro-4-(4-hidroksifenil)piperidin-1-il)-1-(4-metilbenzil)pirolidin-2-on i njegovi prolijekovi za liječenje psihijatrijskih poremećaja | |
PH12015501793A1 (en) | Bicyclic compounds | |
NZ737892A (en) | Muscarinic m1 receptor positive allosteric modulators | |
EA035519B9 (ru) | 1,3,4-тиадиазольные соединения и их применение в лечении рака | |
MX2017001603A (es) | Derivados de piperazina como moduladores de los receptores x del higado. | |
PH12015501402A1 (en) | 4-hydroxy-2-methyl-5-(propan-2-ylidene)cyclohex-3-enecarbaldehyde for the prevention and treatment of a cognitive, neurodegenerative or neuronal disease | |
EP3248603A4 (en) | Pharmaceutical composition for prevention, treatment or delay of alzheimer's disease or dementia containing g protein-coupled receptor 19 agent as active ingredient | |
TN2017000448A1 (en) | Tetrahydrofurane-fused aminohydrothiazine derivatives which are useful in the treatment of alzheimer's disease | |
EP3593805A4 (en) | USE OF A VITAMIN COMPOSITION IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE PREVENTION, TREATMENT OR DELAY OF ALZHEIMER'S DISEASE | |
EP3085691A4 (en) | Method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone, thus produced crystalline polymorph of the anhydrous form, use thereof for the treatment of alzheimer's disease, parkinsonism and other neurodegenerative disorders, and pharmaceutical composition | |
TH169359A (th) | ตัวยับยั้งชนิดเลือกเฟ้นคู่ของ p13 ไคเนสเดลต้าและแกมม่า (dual selective pi3 delta and gamma kinase inhibitors) | |
TH183160B (th) | สารประกอบเฮตเทอโรไซคลิค อะซีทาไมด์ |