JP2017502920A5 - - Google Patents
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- JP2017502920A5 JP2017502920A5 JP2016524999A JP2016524999A JP2017502920A5 JP 2017502920 A5 JP2017502920 A5 JP 2017502920A5 JP 2016524999 A JP2016524999 A JP 2016524999A JP 2016524999 A JP2016524999 A JP 2016524999A JP 2017502920 A5 JP2017502920 A5 JP 2017502920A5
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- JP
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- Prior art keywords
- binding fragment
- pharmaceutical composition
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- antibody
- seq
- Prior art date
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- 108010056102 CD100 antigen Proteins 0.000 claims description 42
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 42
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 29
- 239000000427 antigen Substances 0.000 claims description 27
- 102000036639 antigens Human genes 0.000 claims description 27
- 108091007433 antigens Proteins 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 27
- 210000001130 astrocyte Anatomy 0.000 claims description 21
- 230000001404 mediated effect Effects 0.000 claims description 18
- 208000024891 symptom Diseases 0.000 claims description 16
- 208000024827 Alzheimer disease Diseases 0.000 claims description 10
- 210000002569 neuron Anatomy 0.000 claims description 9
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 6
- 102100034384 Plexin-B1 Human genes 0.000 claims description 6
- 101710100559 Plexin-B1 Proteins 0.000 claims description 6
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 6
- 208000010877 cognitive disease Diseases 0.000 claims description 6
- 208000028698 Cognitive impairment Diseases 0.000 claims description 5
- 230000008499 blood brain barrier function Effects 0.000 claims description 5
- 210000001218 blood-brain barrier Anatomy 0.000 claims description 5
- 208000023105 Huntington disease Diseases 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 210000004248 oligodendroglia Anatomy 0.000 claims description 4
- 206010003591 Ataxia Diseases 0.000 claims description 3
- 201000010374 Down Syndrome Diseases 0.000 claims description 3
- 206010061296 Motor dysfunction Diseases 0.000 claims description 3
- 208000009668 Neurobehavioral Manifestations Diseases 0.000 claims description 3
- 208000018737 Parkinson disease Diseases 0.000 claims description 3
- 102100034383 Plexin-B2 Human genes 0.000 claims description 3
- 101710100551 Plexin-B2 Proteins 0.000 claims description 3
- 102000005157 Somatostatin Human genes 0.000 claims description 3
- 108010056088 Somatostatin Proteins 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 3
- 230000007529 anxiety like behavior Effects 0.000 claims description 3
- 208000011235 central nervous system lupus Diseases 0.000 claims description 3
- 230000007850 degeneration Effects 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 208000035475 disorder Diseases 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- 230000006742 locomotor activity Effects 0.000 claims description 3
- 230000023105 myelination Effects 0.000 claims description 3
- 230000016273 neuron death Effects 0.000 claims description 3
- 235000016709 nutrition Nutrition 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 230000011664 signaling Effects 0.000 claims description 3
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 3
- 229960000553 somatostatin Drugs 0.000 claims description 3
- 230000006886 spatial memory Effects 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 230000000946 synaptic effect Effects 0.000 claims description 3
- 230000003399 chemotactic effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 238000012423 maintenance Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 1
- 108010083674 Myelin Proteins Proteins 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 210000005012 myelin Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 51
- 208000036110 Neuroinflammatory disease Diseases 0.000 description 8
- 230000014950 maintenance of blood-brain barrier Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 2
- 230000002314 neuroinflammatory effect Effects 0.000 description 2
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 208000027061 mild cognitive impairment Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361893814P | 2013-10-21 | 2013-10-21 | |
| US61/893,814 | 2013-10-21 | ||
| US201461979384P | 2014-04-14 | 2014-04-14 | |
| US61/979,384 | 2014-04-14 | ||
| US201462012805P | 2014-06-16 | 2014-06-16 | |
| US62/012,805 | 2014-06-16 | ||
| PCT/US2014/061592 WO2015061330A1 (en) | 2013-10-21 | 2014-10-21 | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018241924A Division JP6875363B2 (ja) | 2013-10-21 | 2018-12-26 | 神経変性障害の処置のためのセマフォリン−4d結合分子の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502920A JP2017502920A (ja) | 2017-01-26 |
| JP2017502920A5 true JP2017502920A5 (enExample) | 2017-11-24 |
| JP6461944B2 JP6461944B2 (ja) | 2019-01-30 |
Family
ID=52826380
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524999A Active JP6461944B2 (ja) | 2013-10-21 | 2014-10-21 | 神経変性障害の処置のためのセマフォリン−4d結合分子の使用 |
| JP2018241924A Active JP6875363B2 (ja) | 2013-10-21 | 2018-12-26 | 神経変性障害の処置のためのセマフォリン−4d結合分子の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018241924A Active JP6875363B2 (ja) | 2013-10-21 | 2018-12-26 | 神経変性障害の処置のためのセマフォリン−4d結合分子の使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9598495B2 (enExample) |
| EP (2) | EP3639853A1 (enExample) |
| JP (2) | JP6461944B2 (enExample) |
| KR (4) | KR20210118246A (enExample) |
| CN (2) | CN116966293A (enExample) |
| AU (3) | AU2014340210B2 (enExample) |
| BR (1) | BR112016009047B1 (enExample) |
| CA (2) | CA2927841C (enExample) |
| DK (1) | DK3060252T3 (enExample) |
| EA (1) | EA033072B1 (enExample) |
| ES (1) | ES2773961T3 (enExample) |
| IL (3) | IL295045B2 (enExample) |
| MX (2) | MX374708B (enExample) |
| NZ (1) | NZ630892A (enExample) |
| PL (1) | PL3060252T3 (enExample) |
| PT (1) | PT3060252T (enExample) |
| SG (2) | SG11201603167YA (enExample) |
| WO (1) | WO2015061330A1 (enExample) |
| ZA (1) | ZA201602686B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2427212T3 (enExample) | 2009-05-08 | 2018-01-20 | ||
| CN104168956A (zh) | 2011-10-11 | 2014-11-26 | 瓦西尼斯公司 | 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途 |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| US10626163B2 (en) * | 2013-01-25 | 2020-04-21 | Brandeis University | Methods of modulating GABAergic inhibitory synapse formation and function |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
| NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| BR112018071686A2 (pt) | 2016-04-22 | 2019-02-19 | Vaccinex, Inc. | exibição de proteínas integrais de membrana em vírions extracelulares envelopados de poxvírus |
| WO2018026715A1 (en) | 2016-08-02 | 2018-02-08 | Vaccinex, Inc. | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
| JP7084689B2 (ja) * | 2016-12-08 | 2022-06-15 | 公益財団法人東京都医学総合研究所 | 脳組織の異常を伴う非ヒト動物の作製方法およびその利用 |
| WO2018156509A1 (en) * | 2017-02-22 | 2018-08-30 | Vaccinex, Inc. | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases |
| DK3600419T5 (en) | 2017-03-20 | 2024-05-27 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
| CN110636858B (zh) * | 2017-05-05 | 2024-03-19 | 瓦西尼斯公司 | 人抗脑信号蛋白4d抗体 |
| CN109410218B (zh) * | 2018-10-08 | 2020-08-11 | 百度在线网络技术(北京)有限公司 | 用于生成车辆损伤信息的方法和装置 |
| EP3693380A1 (en) * | 2019-02-11 | 2020-08-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Dual inhibition of plexin-b1 and plexin-b2 |
| CN117597360A (zh) * | 2020-06-25 | 2024-02-23 | 瓦西尼斯公司 | 脑信号蛋白-4d结合分子在rett综合征治疗中的应用 |
| WO2022137964A1 (ja) * | 2020-12-23 | 2022-06-30 | 国立大学法人大阪大学 | 軟骨・骨・関節疾患の予防または治療用医薬組成物および軟骨・骨・関節疾患の予防または治療用薬剤のスクリーニング方法 |
| CA3231551A1 (en) * | 2021-09-27 | 2023-03-30 | Maurice Zauderer | Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders |
| US20230331863A1 (en) | 2022-02-13 | 2023-10-19 | Vaccinex, Inc. | Combination therapy with semaphorin-4d blockade and htt-lowering agent for treatment of huntington's disease |
| AU2024243083A1 (en) * | 2023-04-03 | 2025-11-20 | Sialbio Co., Ltd. | Pharmaceutical composition for preventing or treating sjogren's syndrome, containing recombinant anti-semaphorin 4d antibody as active ingredient |
| CN117924494B (zh) * | 2024-01-23 | 2025-02-25 | 首都医科大学附属北京积水潭医院 | 特异性结合sema4d的抗原结合蛋白及其应用 |
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| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5070192A (en) | 1988-03-23 | 1991-12-03 | The Johns Hopkins University | Cloned human topoisomerase i: cdna expression, and use for autoantibody detection |
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| US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
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| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| BR112018071686A2 (pt) | 2016-04-22 | 2019-02-19 | Vaccinex, Inc. | exibição de proteínas integrais de membrana em vírions extracelulares envelopados de poxvírus |
| WO2018026715A1 (en) | 2016-08-02 | 2018-02-08 | Vaccinex, Inc. | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
| WO2018156509A1 (en) | 2017-02-22 | 2018-08-30 | Vaccinex, Inc. | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases |
-
2014
- 2014-09-11 NZ NZ630892A patent/NZ630892A/en unknown
- 2014-10-21 KR KR1020217030075A patent/KR20210118246A/ko not_active Ceased
- 2014-10-21 CN CN202310282388.8A patent/CN116966293A/zh active Pending
- 2014-10-21 EP EP19208515.7A patent/EP3639853A1/en active Pending
- 2014-10-21 SG SG11201603167YA patent/SG11201603167YA/en unknown
- 2014-10-21 MX MX2016005050A patent/MX374708B/es active IP Right Grant
- 2014-10-21 IL IL295045A patent/IL295045B2/en unknown
- 2014-10-21 US US14/519,965 patent/US9598495B2/en active Active
- 2014-10-21 DK DK14855074.2T patent/DK3060252T3/da active
- 2014-10-21 KR KR1020237038769A patent/KR20230159633A/ko not_active Ceased
- 2014-10-21 ES ES14855074T patent/ES2773961T3/es active Active
- 2014-10-21 EP EP14855074.2A patent/EP3060252B1/en active Active
- 2014-10-21 PL PL14855074T patent/PL3060252T3/pl unknown
- 2014-10-21 JP JP2016524999A patent/JP6461944B2/ja active Active
- 2014-10-21 BR BR112016009047-0A patent/BR112016009047B1/pt active IP Right Grant
- 2014-10-21 PT PT148550742T patent/PT3060252T/pt unknown
- 2014-10-21 SG SG10201707786QA patent/SG10201707786QA/en unknown
- 2014-10-21 AU AU2014340210A patent/AU2014340210B2/en active Active
- 2014-10-21 KR KR1020227025504A patent/KR102602502B1/ko active Active
- 2014-10-21 IL IL275720A patent/IL275720B/en unknown
- 2014-10-21 CA CA2927841A patent/CA2927841C/en active Active
- 2014-10-21 WO PCT/US2014/061592 patent/WO2015061330A1/en not_active Ceased
- 2014-10-21 EA EA201690813A patent/EA033072B1/ru unknown
- 2014-10-21 CA CA3193983A patent/CA3193983A1/en active Pending
- 2014-10-21 KR KR1020167013445A patent/KR102308493B1/ko active Active
- 2014-10-21 CN CN201480070232.2A patent/CN106029093B/zh active Active
-
2015
- 2015-06-29 US US14/753,882 patent/US9249227B2/en active Active
-
2016
- 2016-04-13 IL IL245089A patent/IL245089B/en active IP Right Grant
- 2016-04-19 MX MX2020009260A patent/MX2020009260A/es unknown
- 2016-04-19 ZA ZA201602686A patent/ZA201602686B/en unknown
-
2017
- 2017-03-21 US US15/465,509 patent/US10385136B2/en active Active
-
2018
- 2018-12-26 JP JP2018241924A patent/JP6875363B2/ja active Active
-
2019
- 2019-07-02 US US16/460,593 patent/US10800853B2/en active Active
- 2019-10-28 AU AU2019257379A patent/AU2019257379B2/en active Active
-
2021
- 2021-04-06 AU AU2021202095A patent/AU2021202095B9/en active Active
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