JP2017501744A5 - - Google Patents

Download PDF

Info

Publication number
JP2017501744A5
JP2017501744A5 JP2016557547A JP2016557547A JP2017501744A5 JP 2017501744 A5 JP2017501744 A5 JP 2017501744A5 JP 2016557547 A JP2016557547 A JP 2016557547A JP 2016557547 A JP2016557547 A JP 2016557547A JP 2017501744 A5 JP2017501744 A5 JP 2017501744A5
Authority
JP
Japan
Prior art keywords
antibody
amino acid
seq
acid sequence
hvr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016557547A
Other languages
English (en)
Japanese (ja)
Other versions
JP6549143B2 (ja
JP2017501744A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/069409 external-priority patent/WO2015089117A1/en
Publication of JP2017501744A publication Critical patent/JP2017501744A/ja
Priority to JP2019025337A priority Critical patent/JP6963577B2/ja
Publication of JP2017501744A5 publication Critical patent/JP2017501744A5/ja
Application granted granted Critical
Publication of JP6549143B2 publication Critical patent/JP6549143B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016557547A 2013-12-09 2014-12-09 抗シグレック−8抗体およびその使用の方法 Active JP6549143B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019025337A JP6963577B2 (ja) 2013-12-09 2019-02-15 抗シグレック−8抗体およびその使用の方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361913891P 2013-12-09 2013-12-09
US61/913,891 2013-12-09
PCT/US2014/069409 WO2015089117A1 (en) 2013-12-09 2014-12-09 Anti-siglec-8 antibodies and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019025337A Division JP6963577B2 (ja) 2013-12-09 2019-02-15 抗シグレック−8抗体およびその使用の方法

Publications (3)

Publication Number Publication Date
JP2017501744A JP2017501744A (ja) 2017-01-19
JP2017501744A5 true JP2017501744A5 (cg-RX-API-DMAC7.html) 2019-04-04
JP6549143B2 JP6549143B2 (ja) 2019-07-24

Family

ID=53371783

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016557547A Active JP6549143B2 (ja) 2013-12-09 2014-12-09 抗シグレック−8抗体およびその使用の方法
JP2019025337A Active JP6963577B2 (ja) 2013-12-09 2019-02-15 抗シグレック−8抗体およびその使用の方法
JP2020029472A Withdrawn JP2020078336A (ja) 2013-12-09 2020-02-25 抗シグレック−8抗体およびその使用の方法
JP2022063368A Pending JP2022082715A (ja) 2013-12-09 2022-04-06 抗シグレック-8抗体およびその使用の方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019025337A Active JP6963577B2 (ja) 2013-12-09 2019-02-15 抗シグレック−8抗体およびその使用の方法
JP2020029472A Withdrawn JP2020078336A (ja) 2013-12-09 2020-02-25 抗シグレック−8抗体およびその使用の方法
JP2022063368A Pending JP2022082715A (ja) 2013-12-09 2022-04-06 抗シグレック-8抗体およびその使用の方法

Country Status (24)

Country Link
US (4) US9546215B2 (cg-RX-API-DMAC7.html)
EP (2) EP3079719B8 (cg-RX-API-DMAC7.html)
JP (4) JP6549143B2 (cg-RX-API-DMAC7.html)
KR (3) KR102311761B1 (cg-RX-API-DMAC7.html)
CN (3) CN114044825A (cg-RX-API-DMAC7.html)
AU (2) AU2014363944B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016013109B1 (cg-RX-API-DMAC7.html)
CA (1) CA2930886C (cg-RX-API-DMAC7.html)
CY (1) CY1122329T1 (cg-RX-API-DMAC7.html)
DK (1) DK3079719T3 (cg-RX-API-DMAC7.html)
ES (1) ES2758508T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20192052T1 (cg-RX-API-DMAC7.html)
HU (1) HUE047283T2 (cg-RX-API-DMAC7.html)
IL (3) IL298470A (cg-RX-API-DMAC7.html)
LT (1) LT3079719T (cg-RX-API-DMAC7.html)
NZ (1) NZ720769A (cg-RX-API-DMAC7.html)
PL (1) PL3079719T3 (cg-RX-API-DMAC7.html)
PT (1) PT3079719T (cg-RX-API-DMAC7.html)
RS (1) RS59567B1 (cg-RX-API-DMAC7.html)
SG (2) SG11201604632PA (cg-RX-API-DMAC7.html)
SI (1) SI3079719T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900714T1 (cg-RX-API-DMAC7.html)
WO (1) WO2015089117A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201603435B (cg-RX-API-DMAC7.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015222757B2 (en) * 2014-02-28 2020-10-08 Allakos Inc. Methods and compositions for treating Siglec-8 associated diseases
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CA2987797A1 (en) * 2015-06-17 2016-12-22 Christopher Robert Bebbington Methods and compositions for treating fibrotic diseases
US10604577B2 (en) * 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
JP2020504135A (ja) * 2017-01-06 2020-02-06 アラコス インコーポレイテッド 慢性閉塞性肺障害を処置するための方法および組成物
KR20200015511A (ko) * 2017-05-05 2020-02-12 알라코스 인크. 염증성 위장 장애를 치료하기 위한 방법 및 조성물
CN110831628A (zh) * 2017-05-05 2020-02-21 爱乐科斯公司 用于治疗过敏性眼病的方法和组合物
US12226492B2 (en) 2017-12-29 2025-02-18 Cornell University Gene therapy for eosinophilic disorders
MX2020011377A (es) * 2018-05-04 2020-11-24 Allakos Inc Metodos y composiciones para el tratamiento de urticaria cronica.
CN113747918A (zh) * 2019-02-15 2021-12-03 爱乐科斯公司 治疗肥大细胞胃炎、肥大细胞食管炎、肥大细胞肠炎、肥大细胞十二指肠炎和/或肥大细胞胃肠炎的方法和组合物
US20220257758A1 (en) * 2019-08-02 2022-08-18 Allakos Inc. Methods of administering anti-siglec-8 antibodies and corticosteroids
EP4048698A4 (en) * 2019-10-24 2023-12-06 Allakos Inc. Methods and compositions for treating irritable bowel syndrome and functional dyspepsia
EP4061840A4 (en) * 2019-11-19 2024-05-15 The Trustees of The University of Pennsylvania ANTI-ALPHA-SYNUCLEIN MONOCLONAL ANTIBODIES, AND CORRESPONDING METHODS OF USE
US20230210989A1 (en) * 2020-06-03 2023-07-06 Kar Muthumani Monoclonal Antibody Against Human Siglec-9 and Use For Immunotherapy
WO2022061032A1 (en) * 2020-09-17 2022-03-24 Allakos Inc. Methods and compositions for treating viral infection
JPWO2022215566A1 (cg-RX-API-DMAC7.html) * 2021-04-05 2022-10-13
EP4518897A1 (en) * 2022-05-06 2025-03-12 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Inhibiting mast cell activation by binding sialic acid-binding immunoglobulin-like lectin-9 (siglec-9)
WO2024043940A1 (en) * 2022-08-25 2024-02-29 Allakos Inc. Methods and compositions for treating atopic dermatitis
WO2024254441A1 (en) * 2023-06-08 2024-12-12 Allakos Inc. Bispecific antibodies to siglec-6 and siglec-8 and methods of use thereof

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
EP0435911B1 (en) 1988-09-23 1996-03-13 Cetus Oncology Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
US5891693A (en) 1990-01-25 1999-04-06 Alusuisse Holdings A.G. Recombinant DNA methods vectors and host cells
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5508192A (en) 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5264365A (en) 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
CA2116774C (en) 1991-09-19 2003-11-11 Paul J. Carter Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
WO1993022332A2 (en) 1992-04-24 1993-11-11 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
DE69329503T2 (de) 1992-11-13 2001-05-03 Idec Pharma Corp Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
CA2163345A1 (en) 1993-06-16 1994-12-22 Susan Adrienne Morgan Antibodies
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
WO1997038123A1 (en) 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6083715A (en) 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
PT994903E (pt) 1997-06-24 2005-10-31 Genentech Inc Metodos e composicoes para glicoproteinas galactosiladas
EP1028751B1 (en) 1997-10-31 2008-12-31 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
EP1034298B1 (en) 1997-12-05 2011-11-02 The Scripps Research Institute Humanization of murine antibody
EP1068241B1 (en) 1998-04-02 2007-10-10 Genentech, Inc. Antibody variants and fragments thereof
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
PL209786B1 (pl) 1999-01-15 2011-10-31 Genentech Inc Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
PT1176195E (pt) 1999-04-09 2013-07-18 Kyowa Hakko Kirin Co Ltd Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
EP1229125A4 (en) 1999-10-19 2005-06-01 Kyowa Hakko Kogyo Kk PROCESS FOR PREPARING A POLYPEPTIDE
US20030092091A1 (en) * 2000-03-07 2003-05-15 Abrahamson Julie A. Sialoadhesin factor-2 antibodies
WO2001066126A1 (en) * 2000-03-07 2001-09-13 Smithkline Beecham Corporation Sialoadhesin factor-2 antibodies
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
EP1355919B1 (en) 2000-12-12 2010-11-24 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
RU2321630C2 (ru) 2001-08-03 2008-04-10 Гликарт Биотекнолоджи АГ Гликозилированные антитела (варианты), обладающие повышенной антителозависимой клеточной цитотоксичностью
PL213948B1 (pl) 2001-10-25 2013-05-31 Genentech Inc Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132140A1 (en) 2002-04-09 2004-07-08 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
WO2003084570A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. DRUG CONTAINING ANTIBODY COMPOSITION APPROPRIATE FOR PATIENT SUFFERING FROM FcϜRIIIa POLYMORPHISM
PL373256A1 (en) 2002-04-09 2005-08-22 Kyowa Hakko Kogyo Co, Ltd. Cells with modified genome
US20040259150A1 (en) 2002-04-09 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa
JPWO2003084569A1 (ja) 2002-04-09 2005-08-11 協和醗酵工業株式会社 抗体組成物含有医薬
US7749753B2 (en) 2002-04-09 2010-07-06 Kyowa Hakko Kirin Co., Ltd Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
WO2004056312A2 (en) 2002-12-16 2004-07-08 Genentech, Inc. Immunoglobulin variants and uses thereof
CA2542046A1 (en) 2003-10-08 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. Fused protein composition
WO2005035778A1 (ja) 2003-10-09 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. α1,6-フコシルトランスフェラーゼの機能を抑制するRNAを用いた抗体組成物の製造法
RS55723B1 (sr) 2003-11-05 2017-07-31 Roche Glycart Ag Molekuli koji se vezuju za antigen sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
JPWO2005053742A1 (ja) 2003-12-04 2007-06-28 協和醗酵工業株式会社 抗体組成物を含有する医薬
EP2990053A1 (en) 2004-01-20 2016-03-02 KaloBios Pharmaceuticals, Inc. Antibody specificity transfer using minimal essential binding determinants
WO2005116088A2 (en) 2004-05-25 2005-12-08 The Johns Hopkins University Methods and compositions for treating diseases and disorders associated with siglec-8 expressing cells
CA2587158C (en) 2004-11-16 2016-01-12 Kalobios, Inc. Immunoglobulin variable region cassette exchange
EP1951740B1 (en) 2005-11-10 2014-07-16 James Paulson High affinity siglec ligands
WO2007056870A1 (en) 2005-11-21 2007-05-24 The Governors Of The University Of Alberta Methods and compositions for pharmacologically controlled targeted immunotherapy
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
EP2282773B2 (en) 2008-05-02 2025-03-05 Seagen Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
MX2012002427A (es) * 2009-08-28 2012-08-03 Vlst Corp Anticuerpos anticina que se unen a quimiocinas cc multiples.
BR112012006388B1 (pt) 2009-09-22 2022-01-04 Probiogen Ag Método para produzir uma molécula, e, método para produzir uma proteína
US8586044B2 (en) 2010-05-28 2013-11-19 Northwestern University Treatment of chronic pelvic pain syndrome
EP2465873A1 (en) 2010-12-16 2012-06-20 Deutsches Rheuma-Forschungszentrum Berlin Eosinophils as a therapeutic target
JP2014509850A (ja) * 2011-03-06 2014-04-24 メルク セロノ ソシエテ アノニム 低フコース細胞株およびその使用
JP6282232B2 (ja) * 2012-02-10 2018-02-21 ユニバーシティー オブ メリーランド,ボルティモア 抗体及びそのFcフラグメントの酵素化学的糖鎖改変
AU2015222757B2 (en) * 2014-02-28 2020-10-08 Allakos Inc. Methods and compositions for treating Siglec-8 associated diseases
US10604577B2 (en) * 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
CN110831628A (zh) * 2017-05-05 2020-02-21 爱乐科斯公司 用于治疗过敏性眼病的方法和组合物

Similar Documents

Publication Publication Date Title
JP6963577B2 (ja) 抗シグレック−8抗体およびその使用の方法
JP2017501744A5 (cg-RX-API-DMAC7.html)
CA2939931C (en) METHODS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SIGLEC8
CN113747918A (zh) 治疗肥大细胞胃炎、肥大细胞食管炎、肥大细胞肠炎、肥大细胞十二指肠炎和/或肥大细胞胃肠炎的方法和组合物
JP2023086917A (ja) アレルギー性眼疾患を処置するための方法および組成物
JP2024045612A (ja) 慢性蕁麻疹を処置するための方法および組成物
JP2020504135A (ja) 慢性閉塞性肺障害を処置するための方法および組成物
HK40020878A (en) Anti-siglec-8 antibodies and methods of use thereof
EA045206B1 (ru) Способы и композиции для лечения аллергических заболеваний глаз
HK1227743A1 (en) Anti-siglec-8 antibodies and methods of use thereof
HK1227743B (en) Anti-siglec-8 antibodies and methods of use thereof