JP2017501725A5 - - Google Patents
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- JP2017501725A5 JP2017501725A5 JP2016542697A JP2016542697A JP2017501725A5 JP 2017501725 A5 JP2017501725 A5 JP 2017501725A5 JP 2016542697 A JP2016542697 A JP 2016542697A JP 2016542697 A JP2016542697 A JP 2016542697A JP 2017501725 A5 JP2017501725 A5 JP 2017501725A5
- Authority
- JP
- Japan
- Prior art keywords
- fcrn antagonist
- region
- pharmaceutical composition
- fcrn
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 43
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 43
- 239000005557 antagonist Substances 0.000 claims 38
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 239000003814 drug Substances 0.000 claims 11
- 150000001413 amino acids Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 150000004676 glycans Chemical class 0.000 claims 5
- 108010073807 IgG Receptors Proteins 0.000 claims 4
- 102000009490 IgG Receptors Human genes 0.000 claims 4
- 206010034277 Pemphigoid Diseases 0.000 claims 4
- 208000037908 antibody-mediated disorder Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 230000000779 depleting effect Effects 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
- 230000007823 neuropathy Effects 0.000 claims 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 239000004606 Fillers/Extenders Substances 0.000 claims 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 201000011152 Pemphigus Diseases 0.000 claims 2
- 206010065159 Polychondritis Diseases 0.000 claims 2
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims 2
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 208000000594 bullous pemphigoid Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 206010065579 multifocal motor neuropathy Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 2
- 206010043207 temporal arteritis Diseases 0.000 claims 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 claims 1
- MJZJYWCQPMNPRM-UHFFFAOYSA-N 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Chemical compound CC1(C)N=C(N)N=C(N)N1OCCCOC1=CC(Cl)=C(Cl)C=C1Cl MJZJYWCQPMNPRM-UHFFFAOYSA-N 0.000 claims 1
- 206010056508 Acquired epidermolysis bullosa Diseases 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000001930 Autoimmune limbic encephalitis Diseases 0.000 claims 1
- 206010064539 Autoimmune myocarditis Diseases 0.000 claims 1
- 206010055128 Autoimmune neutropenia Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102100027221 CD81 antigen Human genes 0.000 claims 1
- 102100027217 CD82 antigen Human genes 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 201000002829 CREST Syndrome Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011038 Cold agglutinin disease Diseases 0.000 claims 1
- 206010009868 Cold type haemolytic anaemia Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 102100032768 Complement receptor type 2 Human genes 0.000 claims 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 claims 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 206010059284 Epidermal necrosis Diseases 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 1
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000984196 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily A member 5 Proteins 0.000 claims 1
- 101000984190 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 1 Proteins 0.000 claims 1
- 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 206010020633 Hyperglobulinaemia Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100025574 Leukocyte immunoglobulin-like receptor subfamily A member 5 Human genes 0.000 claims 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 claims 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 1
- 208000017281 Morvan syndrome Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028570 Myelopathy Diseases 0.000 claims 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 108090000028 Neprilysin Proteins 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 208000025174 PANDAS Diseases 0.000 claims 1
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 claims 1
- 208000008223 Pemphigoid Gestationis Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 102100029216 SLAM family member 5 Human genes 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010072148 Stiff-Person syndrome Diseases 0.000 claims 1
- 206010061372 Streptococcal infection Diseases 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000611 antibody drug conjugate Substances 0.000 claims 1
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 208000036923 autoimmune primary adrenal insufficiency Diseases 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960001838 canakinumab Drugs 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 201000003278 cryoglobulinemia Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 claims 1
- 229960000284 efalizumab Drugs 0.000 claims 1
- 201000011114 epidermolysis bullosa acquisita Diseases 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 229960001743 golimumab Drugs 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
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- 201000011486 lichen planus Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- 230000036473 myasthenia Effects 0.000 claims 1
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- 229960005027 natalizumab Drugs 0.000 claims 1
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- 210000004738 parenchymal cell Anatomy 0.000 claims 1
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- 229960003989 tocilizumab Drugs 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
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- 229960003824 ustekinumab Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920547P | 2013-12-24 | 2013-12-24 | |
| US61/920,547 | 2013-12-24 | ||
| PCT/US2014/072087 WO2015100299A1 (en) | 2013-12-24 | 2014-12-23 | Fcrn antagonists and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019002272A Division JP2019076103A (ja) | 2013-12-24 | 2019-01-10 | ＦｃＲｎアンタゴニスト及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501725A JP2017501725A (ja) | 2017-01-19 |
| JP2017501725A5 true JP2017501725A5 (enExample) | 2017-12-14 |
| JP6554473B2 JP6554473B2 (ja) | 2019-07-31 |
Family
ID=52347464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542697A Active JP6554473B2 (ja) | 2013-12-24 | 2014-12-23 | ＦｃＲｎアンタゴニスト及び使用方法 |
| JP2019002272A Pending JP2019076103A (ja) | 2013-12-24 | 2019-01-10 | ＦｃＲｎアンタゴニスト及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019002272A Pending JP2019076103A (ja) | 2013-12-24 | 2019-01-10 | ＦｃＲｎアンタゴニスト及び使用方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10316073B2 (enExample) |
| EP (2) | EP3626738A1 (enExample) |
| JP (2) | JP6554473B2 (enExample) |
| KR (3) | KR102452173B1 (enExample) |
| CN (2) | CN106103476B (enExample) |
| AU (1) | AU2014369999B2 (enExample) |
| BR (1) | BR112016014810B1 (enExample) |
| CA (1) | CA2934644C (enExample) |
| DK (1) | DK3087095T3 (enExample) |
| EA (1) | EA035324B1 (enExample) |
| ES (1) | ES2742682T3 (enExample) |
| FI (1) | FIC20230003I1 (enExample) |
| FR (1) | FR23C1004I2 (enExample) |
| HU (2) | HUE046822T2 (enExample) |
| IL (1) | IL246223B (enExample) |
| LT (2) | LT3087095T (enExample) |
| LU (1) | LUC00284I2 (enExample) |
| MX (1) | MX368804B (enExample) |
| NL (1) | NL301203I2 (enExample) |
| NO (1) | NO2022049I1 (enExample) |
| NZ (1) | NZ722055A (enExample) |
| PL (1) | PL3087095T3 (enExample) |
| PT (1) | PT3087095T (enExample) |
| SG (2) | SG11201605203UA (enExample) |
| WO (1) | WO2015100299A1 (enExample) |
| ZA (2) | ZA201604464B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102452173B1 (ko) | 2013-12-24 | 2022-10-17 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | Fcrn 길항제 및 사용방법 |
| PT3268391T (pt) * | 2015-03-09 | 2021-08-19 | Argenx Bvba | Métodos de redução dos níveis séricos de agentes contendo fc utilizando antagonistas de fcrn |
| FR3038517B1 (fr) * | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| CN106957365B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb8及其应用 |
| CN106957364B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb12及其应用 |
| EP3257866A1 (en) * | 2016-06-17 | 2017-12-20 | Academisch Medisch Centrum | Modified anti-tnf antibody and use thereof in the treatment of ibd |
| CN109689685A (zh) | 2016-07-08 | 2019-04-26 | 斯塔滕生物技术有限公司 | 抗apoc3抗体及其使用方法 |
| GB201618424D0 (en) * | 2016-11-01 | 2016-12-14 | Argenix Bvba | Treatment of antibody mediated disease |
| CN110799210A (zh) | 2016-12-02 | 2020-02-14 | 得克萨斯A&M大学系统 | 选择性消耗抗原特异性抗体的融合蛋白 |
| CA3059133A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| JP7039694B2 (ja) | 2017-10-31 | 2022-03-22 | スターテン・バイオテクノロジー・ベー・フェー | 抗ａｐｏｃ３抗体およびその使用方法 |
| WO2019110823A1 (en) * | 2017-12-08 | 2019-06-13 | Argenx Bvba | Use of fcrn antagonists for treatment of generalized myasthenia gravis |
| BR112020025001A2 (pt) | 2018-06-08 | 2021-03-23 | Argenx Bvba | composições e métodos para o tratamento da trombocitopenia imune |
| BR112021000755A2 (pt) * | 2018-07-20 | 2021-04-13 | Momenta Pharmaceuticals, Inc. | Composições de anticorpo de fcrn |
| WO2020054979A1 (ko) * | 2018-09-12 | 2020-03-19 | 아주대학교산학협력단 | Cd83 억제제를 유효성분으로 포함하는 베체트병의 예방 또는 치료용 조성물 |
| GB2589049C (en) * | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| CA3138072A1 (en) | 2019-06-07 | 2020-12-10 | Argenx Bvba | Pharmaceutical formulations of fcrn inhibitors suitable for subcutaneous administration |
| EP4454711A3 (en) | 2020-01-08 | 2025-01-08 | argenx BV | Methods for treating pemphigus disorders |
| WO2021160116A1 (zh) * | 2020-02-10 | 2021-08-19 | 北京拓界生物医药科技有限公司 | 抗FcRn抗体、其抗原结合片段及其医药用途 |
| CN113769058B (zh) * | 2020-06-10 | 2024-09-06 | 上海宝济药业股份有限公司 | 一种药物组合及其应用 |
| AU2021287998A1 (en) | 2020-06-11 | 2023-02-02 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| EP4359432A2 (en) | 2021-06-23 | 2024-05-01 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Short apoc-ii mimetic peptides and methods of use |
| IL314367A (en) | 2022-01-18 | 2024-09-01 | argenx BV | Antibodies to galectin 10 |
| CA3244139A1 (en) | 2022-02-21 | 2023-08-24 | argenx BV | METHODS OF MYOSITIS TREATMENT USING FCRN ANTAGONISTS |
| US20250250354A1 (en) | 2022-04-13 | 2025-08-07 | Ose Immunotherapeutics | New class of molecules for selective clearance of antibody |
| EP4519300A1 (en) | 2022-05-05 | 2025-03-12 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Short apolipoprotein e mimetic peptides and methods of use |
| IL317653A (en) | 2022-06-15 | 2025-02-01 | argenx BV | FCRN/HSA binding molecules and methods of using them |
| CN115645537A (zh) * | 2022-10-25 | 2023-01-31 | 成都臻拓医药科技有限公司 | FcRn抑制剂在制备抑制自身免疫性疾病复发的药物中的用途 |
| KR20250109198A (ko) * | 2022-11-14 | 2025-07-16 | 아르젠엑스 비브이 | Fcrn 길항제 분자 및 이의 사용 방법 |
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