JP2017500017A - 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 - Google Patents

生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 Download PDF

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JP2017500017A
JP2017500017A JP2016532136A JP2016532136A JP2017500017A JP 2017500017 A JP2017500017 A JP 2017500017A JP 2016532136 A JP2016532136 A JP 2016532136A JP 2016532136 A JP2016532136 A JP 2016532136A JP 2017500017 A JP2017500017 A JP 2017500017A
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cells
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JP2017500017A5 (show.php
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ウィリアム シー． ヤン，
ウィリアム シー． ヤン，
ジウイー ル，
ジウイー ル，
ヤオ−ミン フアン，
ヤオ−ミン フアン，
ハン ユアン，
ハン ユアン，
ラシュミ クシルサガル，
ラシュミ クシルサガル，
トーマス リル，
トーマス リル，
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Biogen MA Inc
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2511/00—Cells for large scale production

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JP2016532136A 2013-12-20 2014-12-19 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 Withdrawn JP2017500017A (ja)

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US201361919629P 2013-12-20 2013-12-20
US61/919,629 2013-12-20
PCT/US2014/071701 WO2015095809A1 (en) 2013-12-20 2014-12-19 Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality

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JP2020000268A Withdrawn JP2020054388A (ja) 2013-12-20 2020-01-06 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用
JP2022197095A Pending JP2023022317A (ja) 2013-12-20 2022-12-09 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用

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JP2022197095A Pending JP2023022317A (ja) 2013-12-20 2022-12-09 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用

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US (2) US20160289633A1 (show.php)
EP (1) EP3083933B1 (show.php)
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WO (1) WO2015095809A1 (show.php)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017521057A (ja) * 2014-06-09 2017-08-03 ジェンザイム・コーポレーション シードトレイン法およびその使用
JP2020533983A (ja) * 2017-09-15 2020-11-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 目的のポリペプチドのラージスケールの製造間のオンラインバイオマス静電容量モニタリング
JP2021516971A (ja) * 2018-03-09 2021-07-15 嘉和生物▲薬▼▲業▼有限公司 上流生産プロセスでの段階的な分画による生体高分子の生産方法、生産モジュール、および生産における使用
JP2022527582A (ja) * 2019-04-11 2022-06-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ケト酸を含む細胞培養培地
JP2022540920A (ja) * 2019-07-16 2022-09-20 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 高密度連続接種の細胞培養方法及びその応用
JP2023553117A (ja) * 2020-12-08 2023-12-20 パートナー セラピューティクス インコーポレイテッド 顆粒球マクロファージコロニー刺激因子の製造
US12378517B2 (en) 2014-06-06 2025-08-05 Genzyme Corporation Perfusion culturing methods and uses thereof

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EP3083933B1 (en) 2013-12-20 2026-01-21 Biogen MA Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
JP2018531619A (ja) * 2015-11-02 2018-11-01 アレス トレーディング ソシエテ アノニム 灌流様式において組換えたんぱく質の生産プロファイルを調節する方法
WO2017132185A1 (en) 2016-01-26 2017-08-03 Boehringer Ingelheim International Gmbh Linked perfusion to continuous-flow stirred-tank reactor cell culture system
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EP3724229A1 (en) * 2017-12-11 2020-10-21 Amgen Inc. Continuous manufacturing process for bispecific antibody products
EP3787771A1 (en) * 2018-04-29 2021-03-10 REGENXBIO Inc. Scalable clarification process for recombinant aav production
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
WO2020086408A1 (en) 2018-10-26 2020-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A high-yield perfusion-based transient gene expression bioprocess
JP7453151B2 (ja) * 2018-11-02 2024-03-19 協和キリン株式会社 液体培地の調製方法
EP3914696A4 (en) * 2019-01-25 2022-12-14 Biogen MA Inc. SEED CULTIVATION METHOD FOR THE PRODUCTION OF AAV
JP2022543781A (ja) * 2019-08-01 2022-10-14 ブリストル－マイヤーズ スクイブ カンパニー フェッドバッチ細胞培養におけるタンパク質産生性の改良方法
CA3218684A1 (en) 2021-05-03 2022-11-10 Boehringer Ingelheim International Gmbh Method for producing spesolimab
WO2023114901A2 (en) 2021-12-15 2023-06-22 Oxford Biomedica Solutions Llc Methods and compositions for the production of adeno-associated virus
TW202342740A (zh) * 2022-03-07 2023-11-01 美商奧崔基尼克斯製藥公司 改良的批量aav生產系統和方法
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US12378517B2 (en) 2014-06-06 2025-08-05 Genzyme Corporation Perfusion culturing methods and uses thereof
JP2017521057A (ja) * 2014-06-09 2017-08-03 ジェンザイム・コーポレーション シードトレイン法およびその使用
JP2020533983A (ja) * 2017-09-15 2020-11-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 目的のポリペプチドのラージスケールの製造間のオンラインバイオマス静電容量モニタリング
JP2021516971A (ja) * 2018-03-09 2021-07-15 嘉和生物▲薬▼▲業▼有限公司 上流生産プロセスでの段階的な分画による生体高分子の生産方法、生産モジュール、および生産における使用
JP2022527582A (ja) * 2019-04-11 2022-06-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ケト酸を含む細胞培養培地
JP7684224B2 (ja) 2019-04-11 2025-05-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ケト酸を含む細胞培養培地
JP2022540920A (ja) * 2019-07-16 2022-09-20 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 高密度連続接種の細胞培養方法及びその応用
JP7680418B2 (ja) 2019-07-16 2025-05-20 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド 高密度連続接種の細胞培養方法及びその応用
JP2023553117A (ja) * 2020-12-08 2023-12-20 パートナー セラピューティクス インコーポレイテッド 顆粒球マクロファージコロニー刺激因子の製造

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WO2015095809A1 (en) 2015-06-25
JP2023022317A (ja) 2023-02-14
EP3083933A1 (en) 2016-10-26
US20250382568A1 (en) 2025-12-18
US20160289633A1 (en) 2016-10-06
EP3083933B1 (en) 2026-01-21

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