JP2017210488A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017210488A5 JP2017210488A5 JP2017168227A JP2017168227A JP2017210488A5 JP 2017210488 A5 JP2017210488 A5 JP 2017210488A5 JP 2017168227 A JP2017168227 A JP 2017168227A JP 2017168227 A JP2017168227 A JP 2017168227A JP 2017210488 A5 JP2017210488 A5 JP 2017210488A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- temperature
- heating
- cooling
- cyclosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 238000001816 cooling Methods 0.000 claims 14
- 238000010438 heat treatment Methods 0.000 claims 14
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 11
- 239000002904 solvent Substances 0.000 claims 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 11
- 238000003756 stirring Methods 0.000 claims 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- 229930105110 Cyclosporin A Natural products 0.000 claims 6
- 108010036949 Cyclosporine Proteins 0.000 claims 6
- 229960001265 ciclosporin Drugs 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- RNHDAKUGFHSZEV-UHFFFAOYSA-N 1,4-dioxane;hydrate Chemical compound O.C1COCCO1 RNHDAKUGFHSZEV-UHFFFAOYSA-N 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 206010040026 Sensory disturbance Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims 1
- 208000010217 blepharitis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004175 meibomian gland Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000018464 vernal keratoconjunctivitis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559830P | 2011-11-15 | 2011-11-15 | |
| US61/559,830 | 2011-11-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Division JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017210488A JP2017210488A (ja) | 2017-11-30 |
| JP2017210488A5 true JP2017210488A5 (enExample) | 2018-01-18 |
| JP6513755B2 JP6513755B2 (ja) | 2019-05-15 |
Family
ID=47222337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Expired - Fee Related JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
| JP2017168227A Active JP6513755B2 (ja) | 2011-11-15 | 2017-09-01 | シクロスポリンａの形態２およびその作製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Expired - Fee Related JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8796221B2 (enExample) |
| EP (2) | EP2780358B1 (enExample) |
| JP (2) | JP6204921B2 (enExample) |
| KR (1) | KR102072252B1 (enExample) |
| CN (1) | CN104039813B (enExample) |
| AU (3) | AU2012339693B2 (enExample) |
| BR (1) | BR112014011768A2 (enExample) |
| CA (1) | CA2856034C (enExample) |
| ES (2) | ES2666191T3 (enExample) |
| RU (1) | RU2635547C2 (enExample) |
| WO (1) | WO2013074608A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2666191T3 (es) * | 2011-11-15 | 2018-05-03 | Allergan, Inc. | Un proceso para la cristalización de la forma 2 de la ciclosporina A |
| JP2015519368A (ja) | 2012-06-01 | 2015-07-09 | アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ類似体 |
| CA2955037A1 (en) | 2014-07-18 | 2016-01-21 | Allergan, Inc. | Suspension compositions of cyclosporin a for subconjunctival and periocular injection |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| CN113117359B (zh) * | 2021-03-05 | 2022-08-26 | 湘雅生物医药(湖州)有限公司 | 一种用于胶原蛋白提取用的无菌式蒸馏瓶 |
| KR20250088544A (ko) | 2022-10-20 | 2025-06-17 | 추가이 세이야쿠 가부시키가이샤 | 고리형 펩티드 결정을 제조하는 방법 |
| EP4663653A1 (en) | 2023-03-20 | 2025-12-17 | Chugai Seiyaku Kabushiki Kaisha | Method for producing eutectic of cyclic peptide |
| CN116879437A (zh) * | 2023-07-11 | 2023-10-13 | 苏州欧康维视生物科技有限公司 | 一种检测眼用植入剂的体外释放的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920003601B1 (ko) | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| HU203564B (en) | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5382714A (en) * | 1994-03-17 | 1995-01-17 | The Catholic University Of America | Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof |
| JP3833248B2 (ja) * | 1994-11-03 | 2006-10-11 | ノバルティス・アクチエンゲゼルシャフト | 簡単な組成及び高い生物有効性を有する経口投与のためのシクロスポリンの新規処方物及びその製造法 |
| TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| JP4208281B2 (ja) * | 1998-02-26 | 2009-01-14 | キヤノン株式会社 | 積層型光起電力素子 |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| ES2318453T3 (es) | 2004-01-20 | 2009-05-01 | Allergan, Inc. | Composiciones para terapia localizada del ojo, que comprenden, de preferencia,triamcinolona acetonida y acido hialuronico. |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| US8772245B2 (en) * | 2011-05-27 | 2014-07-08 | Allergan, Inc. | Crystalline form of cyclosporine A, methods of preparation, and methods for use thereof |
| ES2666191T3 (es) * | 2011-11-15 | 2018-05-03 | Allergan, Inc. | Un proceso para la cristalización de la forma 2 de la ciclosporina A |
-
2012
- 2012-11-14 ES ES16156092.5T patent/ES2666191T3/es active Active
- 2012-11-14 RU RU2014123468A patent/RU2635547C2/ru active
- 2012-11-14 KR KR1020147016151A patent/KR102072252B1/ko not_active Expired - Fee Related
- 2012-11-14 EP EP12791059.4A patent/EP2780358B1/en not_active Not-in-force
- 2012-11-14 ES ES12791059.4T patent/ES2578154T3/es active Active
- 2012-11-14 AU AU2012339693A patent/AU2012339693B2/en not_active Ceased
- 2012-11-14 BR BR112014011768A patent/BR112014011768A2/pt not_active Application Discontinuation
- 2012-11-14 US US13/676,339 patent/US8796221B2/en active Active
- 2012-11-14 WO PCT/US2012/064985 patent/WO2013074608A1/en not_active Ceased
- 2012-11-14 EP EP16156092.5A patent/EP3067363B1/en not_active Not-in-force
- 2012-11-14 CN CN201280066581.8A patent/CN104039813B/zh not_active Expired - Fee Related
- 2012-11-14 JP JP2014542396A patent/JP6204921B2/ja not_active Expired - Fee Related
- 2012-11-14 CA CA2856034A patent/CA2856034C/en active Active
-
2014
- 2014-06-19 US US14/309,547 patent/US9352014B2/en active Active
-
2016
- 2016-05-26 US US15/165,997 patent/US10017541B2/en active Active
-
2017
- 2017-09-01 JP JP2017168227A patent/JP6513755B2/ja active Active
- 2017-12-06 AU AU2017272197A patent/AU2017272197A1/en not_active Abandoned
-
2018
- 2018-07-06 US US16/028,956 patent/US20180312543A1/en not_active Abandoned
-
2019
- 2019-06-28 AU AU2019204591A patent/AU2019204591B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017210488A5 (enExample) | ||
| JP2019505533A5 (enExample) | ||
| JP2020518581A5 (enExample) | ||
| JP2019505532A5 (enExample) | ||
| JP2019517463A5 (enExample) | ||
| JP2019504103A5 (enExample) | ||
| JP2015510890A5 (enExample) | ||
| HRP20201275T1 (hr) | Kristalni oblik derivata benzimidazola i postupak njegove proizvodnje | |
| JP2013518118A5 (enExample) | ||
| CN1227233C (zh) | 纯晶形的5－氯－3－(4－甲磺酰基苯基)－6′－甲基－[2,3′]联吡啶及其合成方法 | |
| WO2016107289A1 (zh) | 制备索非布韦晶型6的方法 | |
| RU2014123468A (ru) | Форма 2 циклоспорина а и способ ее получения | |
| JP2019504865A5 (enExample) | ||
| CN105324375A (zh) | 盐酸尼洛替尼的多晶型形式 | |
| BR112012004161B1 (pt) | método para sintetizar uma piperazina neuroestimulativa | |
| JP2017519015A5 (enExample) | ||
| CN103242347A (zh) | 一种盐酸四咪唑的制备方法 | |
| CN104327067B (zh) | 无定形达沙替尼的制备方法 | |
| CN104032567B (zh) | 纺织防水剂 | |
| CN111278820A (zh) | 一种吡啶酮化合物的晶型、盐型及其制备方法 | |
| TWI775753B (zh) | 製備白克列之方法 | |
| JP2013541589A5 (enExample) | ||
| CN102030723B (zh) | 盐酸苯海索的制备方法 | |
| CN106604916A (zh) | 钾离子竞争性酸阻滞剂的晶型及其制备方法 | |
| CN105198865A (zh) | 葛根素二水合物 |