AU2012339693B2 - Cyclosporine A Form 2 and method of making same - Google Patents

Cyclosporine A Form 2 and method of making same Download PDF

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Publication number
AU2012339693B2
AU2012339693B2 AU2012339693A AU2012339693A AU2012339693B2 AU 2012339693 B2 AU2012339693 B2 AU 2012339693B2 AU 2012339693 A AU2012339693 A AU 2012339693A AU 2012339693 A AU2012339693 A AU 2012339693A AU 2012339693 B2 AU2012339693 B2 AU 2012339693B2
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AU
Australia
Prior art keywords
suspension
temperature
heating
hours
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012339693A
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English (en)
Other versions
AU2012339693A1 (en
Inventor
Scott W. Smith
Ke Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2012339693A1 publication Critical patent/AU2012339693A1/en
Application granted granted Critical
Publication of AU2012339693B2 publication Critical patent/AU2012339693B2/en
Priority to AU2017272197A priority Critical patent/AU2017272197A1/en
Priority to AU2019204591A priority patent/AU2019204591B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2012339693A 2011-11-15 2012-11-14 Cyclosporine A Form 2 and method of making same Ceased AU2012339693B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017272197A AU2017272197A1 (en) 2011-11-15 2017-12-06 Cyclosporine A Form 2 and method of making same
AU2019204591A AU2019204591B2 (en) 2011-11-15 2019-06-28 Cyclosporine A Form 2 and method of making same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559830P 2011-11-15 2011-11-15
US61/559,830 2011-11-15
PCT/US2012/064985 WO2013074608A1 (en) 2011-11-15 2012-11-14 Cyclosporine a form 2 and method of making same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017272197A Division AU2017272197A1 (en) 2011-11-15 2017-12-06 Cyclosporine A Form 2 and method of making same

Publications (2)

Publication Number Publication Date
AU2012339693A1 AU2012339693A1 (en) 2014-06-05
AU2012339693B2 true AU2012339693B2 (en) 2017-09-07

Family

ID=47222337

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2012339693A Ceased AU2012339693B2 (en) 2011-11-15 2012-11-14 Cyclosporine A Form 2 and method of making same
AU2017272197A Abandoned AU2017272197A1 (en) 2011-11-15 2017-12-06 Cyclosporine A Form 2 and method of making same
AU2019204591A Ceased AU2019204591B2 (en) 2011-11-15 2019-06-28 Cyclosporine A Form 2 and method of making same

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017272197A Abandoned AU2017272197A1 (en) 2011-11-15 2017-12-06 Cyclosporine A Form 2 and method of making same
AU2019204591A Ceased AU2019204591B2 (en) 2011-11-15 2019-06-28 Cyclosporine A Form 2 and method of making same

Country Status (11)

Country Link
US (4) US8796221B2 (enExample)
EP (2) EP2780358B1 (enExample)
JP (2) JP6204921B2 (enExample)
KR (1) KR102072252B1 (enExample)
CN (1) CN104039813B (enExample)
AU (3) AU2012339693B2 (enExample)
BR (1) BR112014011768A2 (enExample)
CA (1) CA2856034C (enExample)
ES (2) ES2666191T3 (enExample)
RU (1) RU2635547C2 (enExample)
WO (1) WO2013074608A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039813B (zh) * 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
RU2713953C2 (ru) 2014-07-18 2020-02-11 Аллерган, Инк. Суспензионные составы циклоспорина а для субконъюнктивального и периокулярного введения
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
CN113117359B (zh) * 2021-03-05 2022-08-26 湘雅生物医药(湖州)有限公司 一种用于胶原蛋白提取用的无菌式蒸馏瓶
US20260132169A1 (en) 2022-10-20 2026-05-14 Chugai Seiyaku Kabushiki Kaisha Method for producing cyclic peptide crystals
CN120731215A (zh) 2023-03-20 2025-09-30 中外制药株式会社 用于产生环肽的共晶的方法
CN116879437B (zh) * 2023-07-11 2026-04-03 苏州欧康维视生物科技有限公司 一种检测眼用植入剂的体外释放的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012166610A1 (en) * 2011-05-27 2012-12-06 Allergan, Inc. A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001772A1 (en) 1987-09-03 1989-03-09 University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5382714A (en) * 1994-03-17 1995-01-17 The Catholic University Of America Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof
ATE218359T1 (de) * 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
TW581681B (en) * 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
JP4208281B2 (ja) * 1998-02-26 2009-01-14 キヤノン株式会社 積層型光起電力素子
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en) 2004-01-20 2008-12-24 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
CN104039813B (zh) * 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012166610A1 (en) * 2011-05-27 2012-12-06 Allergan, Inc. A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof

Also Published As

Publication number Publication date
HK1202124A1 (zh) 2015-09-18
ES2666191T3 (es) 2018-05-03
CN104039813A (zh) 2014-09-10
CN104039813B (zh) 2017-08-29
JP6513755B2 (ja) 2019-05-15
US20180312543A1 (en) 2018-11-01
US10017541B2 (en) 2018-07-10
KR20140101790A (ko) 2014-08-20
JP2017210488A (ja) 2017-11-30
CA2856034A1 (en) 2013-05-23
EP2780358A1 (en) 2014-09-24
US20130123193A1 (en) 2013-05-16
AU2019204591B2 (en) 2021-03-25
US8796221B2 (en) 2014-08-05
US9352014B2 (en) 2016-05-31
CA2856034C (en) 2017-12-12
JP6204921B2 (ja) 2017-09-27
JP2014533300A (ja) 2014-12-11
US20140303343A1 (en) 2014-10-09
RU2014123468A (ru) 2015-12-27
AU2017272197A1 (en) 2018-01-04
WO2013074608A1 (en) 2013-05-23
RU2635547C2 (ru) 2017-11-14
KR102072252B1 (ko) 2020-01-31
BR112014011768A2 (pt) 2017-05-09
EP2780358B1 (en) 2016-03-23
AU2012339693A1 (en) 2014-06-05
EP3067363B1 (en) 2018-01-17
US20160272681A1 (en) 2016-09-22
AU2019204591A1 (en) 2019-07-18
EP3067363A1 (en) 2016-09-14
ES2578154T3 (es) 2016-07-21

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired