RU2635547C2 - Форма 2 циклоспорина а и способ ее получения - Google Patents

Форма 2 циклоспорина а и способ ее получения Download PDF

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Publication number
RU2635547C2
RU2635547C2 RU2014123468A RU2014123468A RU2635547C2 RU 2635547 C2 RU2635547 C2 RU 2635547C2 RU 2014123468 A RU2014123468 A RU 2014123468A RU 2014123468 A RU2014123468 A RU 2014123468A RU 2635547 C2 RU2635547 C2 RU 2635547C2
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Russia
Prior art keywords
hours
temperature
heating
cyclosporin
cooling
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RU2014123468A
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English (en)
Russian (ru)
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RU2014123468A (ru
Inventor
Ке ВУ
Скотт В. СМИТ
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Аллерган, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2014123468A 2011-11-15 2012-11-14 Форма 2 циклоспорина а и способ ее получения RU2635547C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559830P 2011-11-15 2011-11-15
US61/559,830 2011-11-15
PCT/US2012/064985 WO2013074608A1 (en) 2011-11-15 2012-11-14 Cyclosporine a form 2 and method of making same

Publications (2)

Publication Number Publication Date
RU2014123468A RU2014123468A (ru) 2015-12-27
RU2635547C2 true RU2635547C2 (ru) 2017-11-14

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014123468A RU2635547C2 (ru) 2011-11-15 2012-11-14 Форма 2 циклоспорина а и способ ее получения

Country Status (11)

Country Link
US (4) US8796221B2 (enExample)
EP (2) EP2780358B1 (enExample)
JP (2) JP6204921B2 (enExample)
KR (1) KR102072252B1 (enExample)
CN (1) CN104039813B (enExample)
AU (3) AU2012339693B2 (enExample)
BR (1) BR112014011768A2 (enExample)
CA (1) CA2856034C (enExample)
ES (2) ES2666191T3 (enExample)
RU (1) RU2635547C2 (enExample)
WO (1) WO2013074608A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039813B (zh) * 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
RU2713953C2 (ru) 2014-07-18 2020-02-11 Аллерган, Инк. Суспензионные составы циклоспорина а для субконъюнктивального и периокулярного введения
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
CN113117359B (zh) * 2021-03-05 2022-08-26 湘雅生物医药(湖州)有限公司 一种用于胶原蛋白提取用的无菌式蒸馏瓶
US20260132169A1 (en) 2022-10-20 2026-05-14 Chugai Seiyaku Kabushiki Kaisha Method for producing cyclic peptide crystals
CN120731215A (zh) 2023-03-20 2025-09-30 中外制药株式会社 用于产生环肽的共晶的方法
CN116879437B (zh) * 2023-07-11 2026-04-03 苏州欧康维视生物科技有限公司 一种检测眼用植入剂的体外释放的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211848A (en) * 1987-12-21 1989-07-12 Sandoz Ltd Orthorhomic ciclosporin crystals
RU2098122C1 (ru) * 1991-03-18 1997-12-10 Сандос АГ Фармацевтическая композиция для лечения воспалительных заболеваний или заболеваний, связанных с обструкцией дыхательных путей

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001772A1 (en) 1987-09-03 1989-03-09 University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5382714A (en) * 1994-03-17 1995-01-17 The Catholic University Of America Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof
ATE218359T1 (de) * 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
TW581681B (en) * 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
JP4208281B2 (ja) * 1998-02-26 2009-01-14 キヤノン株式会社 積層型光起電力素子
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en) 2004-01-20 2008-12-24 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
UA113627C2 (xx) * 2011-05-27 2017-02-27 Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
CN104039813B (zh) * 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211848A (en) * 1987-12-21 1989-07-12 Sandoz Ltd Orthorhomic ciclosporin crystals
RU2098122C1 (ru) * 1991-03-18 1997-12-10 Сандос АГ Фармацевтическая композиция для лечения воспалительных заболеваний или заболеваний, связанных с обструкцией дыхательных путей

Also Published As

Publication number Publication date
HK1202124A1 (zh) 2015-09-18
ES2666191T3 (es) 2018-05-03
CN104039813A (zh) 2014-09-10
AU2012339693B2 (en) 2017-09-07
CN104039813B (zh) 2017-08-29
JP6513755B2 (ja) 2019-05-15
US20180312543A1 (en) 2018-11-01
US10017541B2 (en) 2018-07-10
KR20140101790A (ko) 2014-08-20
JP2017210488A (ja) 2017-11-30
CA2856034A1 (en) 2013-05-23
EP2780358A1 (en) 2014-09-24
US20130123193A1 (en) 2013-05-16
AU2019204591B2 (en) 2021-03-25
US8796221B2 (en) 2014-08-05
US9352014B2 (en) 2016-05-31
CA2856034C (en) 2017-12-12
JP6204921B2 (ja) 2017-09-27
JP2014533300A (ja) 2014-12-11
US20140303343A1 (en) 2014-10-09
RU2014123468A (ru) 2015-12-27
AU2017272197A1 (en) 2018-01-04
WO2013074608A1 (en) 2013-05-23
KR102072252B1 (ko) 2020-01-31
BR112014011768A2 (pt) 2017-05-09
EP2780358B1 (en) 2016-03-23
AU2012339693A1 (en) 2014-06-05
EP3067363B1 (en) 2018-01-17
US20160272681A1 (en) 2016-09-22
AU2019204591A1 (en) 2019-07-18
EP3067363A1 (en) 2016-09-14
ES2578154T3 (es) 2016-07-21

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