CN104039813B - 环孢菌素a形式2及其制备方法 - Google Patents

环孢菌素a形式2及其制备方法 Download PDF

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Publication number
CN104039813B
CN104039813B CN201280066581.8A CN201280066581A CN104039813B CN 104039813 B CN104039813 B CN 104039813B CN 201280066581 A CN201280066581 A CN 201280066581A CN 104039813 B CN104039813 B CN 104039813B
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China
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suspension
hours
heating
temperature
water
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Expired - Fee Related
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CN201280066581.8A
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English (en)
Chinese (zh)
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CN104039813A (zh
Inventor
吴科
S·W·史密斯
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Allergan Inc
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Allergan Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280066581.8A 2011-11-15 2012-11-14 环孢菌素a形式2及其制备方法 Expired - Fee Related CN104039813B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559830P 2011-11-15 2011-11-15
US61/559,830 2011-11-15
PCT/US2012/064985 WO2013074608A1 (en) 2011-11-15 2012-11-14 Cyclosporine a form 2 and method of making same

Publications (2)

Publication Number Publication Date
CN104039813A CN104039813A (zh) 2014-09-10
CN104039813B true CN104039813B (zh) 2017-08-29

Family

ID=47222337

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280066581.8A Expired - Fee Related CN104039813B (zh) 2011-11-15 2012-11-14 环孢菌素a形式2及其制备方法

Country Status (11)

Country Link
US (4) US8796221B2 (enExample)
EP (2) EP2780358B1 (enExample)
JP (2) JP6204921B2 (enExample)
KR (1) KR102072252B1 (enExample)
CN (1) CN104039813B (enExample)
AU (3) AU2012339693B2 (enExample)
BR (1) BR112014011768A2 (enExample)
CA (1) CA2856034C (enExample)
ES (2) ES2666191T3 (enExample)
RU (1) RU2635547C2 (enExample)
WO (1) WO2013074608A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013074608A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Cyclosporine a form 2 and method of making same
US9266927B2 (en) 2012-06-01 2016-02-23 Allergan, Inc. Cyclosporin A analogs
KR20170030093A (ko) 2014-07-18 2017-03-16 알레간 인코포레이티드 결막하 및 눈주위 주사를 위한 사이클로스포린 a의 현탁액 조성물
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
CN113117359B (zh) * 2021-03-05 2022-08-26 湘雅生物医药(湖州)有限公司 一种用于胶原蛋白提取用的无菌式蒸馏瓶
WO2024085235A1 (ja) 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法
TW202502802A (zh) 2023-03-20 2025-01-16 日商中外製藥股份有限公司 環狀胜肽共晶體的製造方法
CN116879437A (zh) * 2023-07-11 2023-10-13 苏州欧康维视生物科技有限公司 一种检测眼用植入剂的体外释放的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211848A (en) * 1987-12-21 1989-07-12 Sandoz Ltd Orthorhomic ciclosporin crystals
CN103649108A (zh) * 2011-05-27 2014-03-19 阿勒根公司 环孢素a的晶型、制备方法及其使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3851152T2 (de) 1987-09-03 1995-01-26 Univ Georgia Cyclosporin-augenmittel.
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5382714A (en) * 1994-03-17 1995-01-17 The Catholic University Of America Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof
SK164796A3 (en) * 1994-11-03 1997-06-04 Dresden Arzneimittel Novel cyclosporine preparation forms for oral administration of and process for producing them
TW581681B (en) * 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
JP4208281B2 (ja) * 1998-02-26 2009-01-14 キヤノン株式会社 積層型光起電力素子
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
WO2013074608A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Cyclosporine a form 2 and method of making same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2211848A (en) * 1987-12-21 1989-07-12 Sandoz Ltd Orthorhomic ciclosporin crystals
CN103649108A (zh) * 2011-05-27 2014-03-19 阿勒根公司 环孢素a的晶型、制备方法及其使用方法

Also Published As

Publication number Publication date
US10017541B2 (en) 2018-07-10
EP2780358A1 (en) 2014-09-24
US20140303343A1 (en) 2014-10-09
JP6204921B2 (ja) 2017-09-27
RU2635547C2 (ru) 2017-11-14
US20160272681A1 (en) 2016-09-22
KR20140101790A (ko) 2014-08-20
AU2017272197A1 (en) 2018-01-04
CA2856034C (en) 2017-12-12
JP2017210488A (ja) 2017-11-30
EP3067363A1 (en) 2016-09-14
HK1202124A1 (zh) 2015-09-18
JP6513755B2 (ja) 2019-05-15
BR112014011768A2 (pt) 2017-05-09
CN104039813A (zh) 2014-09-10
RU2014123468A (ru) 2015-12-27
US20130123193A1 (en) 2013-05-16
KR102072252B1 (ko) 2020-01-31
EP2780358B1 (en) 2016-03-23
AU2012339693B2 (en) 2017-09-07
US9352014B2 (en) 2016-05-31
CA2856034A1 (en) 2013-05-23
AU2019204591B2 (en) 2021-03-25
WO2013074608A1 (en) 2013-05-23
US20180312543A1 (en) 2018-11-01
ES2666191T3 (es) 2018-05-03
JP2014533300A (ja) 2014-12-11
ES2578154T3 (es) 2016-07-21
EP3067363B1 (en) 2018-01-17
US8796221B2 (en) 2014-08-05
AU2019204591A1 (en) 2019-07-18
AU2012339693A1 (en) 2014-06-05

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