JP2017210417A - 吸収促進剤 - Google Patents
吸収促進剤 Download PDFInfo
- Publication number
- JP2017210417A JP2017210417A JP2016103295A JP2016103295A JP2017210417A JP 2017210417 A JP2017210417 A JP 2017210417A JP 2016103295 A JP2016103295 A JP 2016103295A JP 2016103295 A JP2016103295 A JP 2016103295A JP 2017210417 A JP2017210417 A JP 2017210417A
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- Prior art keywords
- atemoya
- extract
- absorption enhancer
- endocytosis
- effect
- Prior art date
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Abstract
Description
(1)アテモヤの抽出物を含有することを特徴とする吸収促進剤。
(2)アテモヤの抽出物を含有することを特徴とするエンドサイトーシス促進剤。
(3)アテモヤの抽出物を含有することを特徴とする受容体非依存性エンドサイトーシス促進剤。
(4)(1)〜(3)いずれか記載の剤を含む医薬組成物。
(5)(1)〜(3)いずれか記載の剤を含む化粧品。
(6)(1)〜(3)いずれか記載の剤を含む食品。
アテモヤ(果皮の乾燥品)20gに精製水を400mL加え、90〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してアテモヤ果皮の熱水抽出物5.4gを得た。
アテモヤ(果皮の乾燥品)20gに50%エタノール水溶液を400mL加え、室温で1週間抽出した後、濾過し、その濾液を減圧濃縮し、凍結乾燥してアテモヤ果皮の50%エタノール抽出物5.5gを得た。
アテモヤ(果皮の乾燥品)20gにエタノールを400mL加え、室温で1週間抽出した後、濾過し、その濾液を減圧濃縮し、凍結乾燥してアテモヤ果皮のエタノール抽出物0.6gを得た。
アテモヤ(果実の乾燥品)20gに精製水を400mL加え、90〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してアテモヤ果実の熱水抽出物9.2gを得た。
アテモヤ(種子)20gに精製水を400mL加え、90〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してアテモヤ種子の熱水抽出物1.5gを得た。
実施例1で製造したアテモヤの抽出物(製造例1〜5)の細胞膜を介した薬物や栄養成分の吸収に及ぼす影響を、ニュートラルレッドの細胞内取り込み量を指標に評価した。ニュートラルレッドは、細胞膜を介し生細胞に取り込まれる染色色素の1つである。具体的方法について以下に記載する。
処方 含有量(重量%)
1.アテモヤの抽出物 1.0
2.乾燥コーンスターチ 25.0
3.カルボキシメチルセルロースカルシウム 24.0
4.微結晶セルロース 40.0
5.ポリビニルピロリドン 7.0
6.タルク 3.0
[製造方法]成分1〜5を混合し、次いで10%の水を結合剤として加えて、押出し造粒後乾燥する。成形した顆粒に成分6を加えて混合し打錠する。1錠0.52gとする。
処方 含有量(重量%)
1.アテモヤの抽出物 5.0
2.微結晶セルロース 60.0
3.トウモロコシデンプン 15.0
4.乳糖 18.0
5.ポリビニルピロリドン 2.0
[製造方法]成分1〜5を混合して顆粒化した後、2号硬カプセルに250mg充填してカプセル剤を得る。
処方 含有量(重量%)
1.アテモヤの抽出物 5.0
2.微結晶セルロース 40.0
3.トウモロコシデンプン 55.0
[製造方法]成分1〜3を混合し、常法により散剤を得る。
処方 含有量(重量%)
1.アテモヤの抽出物 0.1
2.スクワラン 5.5
3.オリーブ油 3.0
4.ステアリン酸 2.0
5.ミツロウ 2.0
6.ミリスチン酸オクチルドデシル 3.5
7.ポリオキシエチレンセチルエーテル(20E.O.) 3.0
8.ベヘニルアルコール 1.5
9.モノステアリン酸グリセリン 2.5
10.香料 0.1
11.パラオキシ安息香酸メチル 0.2
12.パラオキシ安息香酸エチル 0.05
13.1,3−ブチレングリコール 8.5
14.精製水 残量
[製造方法]成分2〜9を加熱溶解して混合し、70℃に保ち油相とする。成分1及び11〜14を加熱溶解して混合し、75℃に保ち水相とする。次いで、油相に水相を加えて乳化して、かき混ぜながら冷却し、45℃で成分10を加え、更に30℃まで冷却して製品とする。
処方 含有量(重量%)
1.アテモヤの抽出物 2.0
2.ポリオキシエチレンセチルエーテル(30E.O.) 2.0
3.モノステアリン酸グリセリン 10.0
4.流動パラフィン 5.0
5.セタノール 6.0
6.パラオキシ安息香酸メチル 0.1
7.プロピレングリコール 10.0
8.精製水 残量
[製造方法]成分2〜5を加熱溶解して混合し、70℃に保ち油相とする。成分1及び6〜8を加熱溶解して混合し、75℃に保ち水相とする。油相に水相を加えて乳化し、かき混ぜながら30℃まで冷却して製品とする。
処方 含有量(重量%)
1.アテモヤの抽出物 1.0
2.乾燥コーンスターチ 50.0
3.エリスリトール 40.0
4.クエン酸 5.0
5.ショ糖脂肪酸エステル 3.0
6.香料 1.0
[製造方法]成分1〜4に精製水を適量加えて練和し、押出し造粒した後、乾燥して顆粒を得る。顆粒に成分5及び6を加えて打錠する。1錠1gとする。
処方 含有量(重量%)
1.アテモヤの抽出物 0.1
2.ステビア 0.05
3.リンゴ酸 5.0
4.アスコルビン酸ナトリウム 1.0
5.香料 0.1
6.精製水 残量
[製造方法]成分1〜5を成分6の一部の精製水に撹拌溶解する。次いで、成分6の残りの精製水を加えて混合し、90℃に加熱して50mLのガラス瓶に充填する。
Claims (6)
- アテモヤの抽出物を含有することを特徴とする吸収促進剤。
- アテモヤの抽出物を含有することを特徴とするエンドサイトーシス促進剤。
- アテモヤの抽出物を含有することを特徴とする受容体非依存性エンドサイトーシス促進剤。
- 請求項1〜3いずれか一項記載の剤を含む医薬組成物。
- 請求項1〜3いずれか一項記載の剤を含む化粧品。
- 請求項1〜3いずれか一項記載の剤を含む食品。
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Citations (3)
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CN101259116A (zh) * | 2008-04-28 | 2008-09-10 | 贵州正鑫实业有限公司 | 一种含有布拉他辛部位药精品的外用给药制剂 |
JP2009269842A (ja) * | 2008-05-02 | 2009-11-19 | Nippon Menaade Keshohin Kk | 皮膚外用剤 |
JP2015160843A (ja) * | 2014-02-28 | 2015-09-07 | 株式会社東洋新薬 | 糖化反応阻害剤 |
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CN101259116A (zh) * | 2008-04-28 | 2008-09-10 | 贵州正鑫实业有限公司 | 一种含有布拉他辛部位药精品的外用给药制剂 |
JP2009269842A (ja) * | 2008-05-02 | 2009-11-19 | Nippon Menaade Keshohin Kk | 皮膚外用剤 |
JP2015160843A (ja) * | 2014-02-28 | 2015-09-07 | 株式会社東洋新薬 | 糖化反応阻害剤 |
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