JP2017178813A - 癌細胞増殖抑制組成物 - Google Patents
癌細胞増殖抑制組成物 Download PDFInfo
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- JP2017178813A JP2017178813A JP2016065913A JP2016065913A JP2017178813A JP 2017178813 A JP2017178813 A JP 2017178813A JP 2016065913 A JP2016065913 A JP 2016065913A JP 2016065913 A JP2016065913 A JP 2016065913A JP 2017178813 A JP2017178813 A JP 2017178813A
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Abstract
Description
本発明の一態様によると、カルノシン酸およびカルノソールの少なくとも一方、ならびにエピガロカテキンガレートおよびエピカテキンガレートの少なくとも一方を含む、癌細胞増殖抑制組成物が提供される。
本発明の癌細胞増殖抑制組成物は、カルノシン酸およびカルノソールの少なくとも一方(成分A)を含む。
本発明の癌細胞増殖抑制組成物は、成分Aに加えて、エピガロカテキンガレート(EGCG)およびエピカテキンガレート(ECG)の少なくとも一方(成分B)を含む。
本発明の癌細胞増殖抑制組成物は、医療用途(治療または予防目的)で使用されてもまたは健康食品として使用されてもよく、本発明の癌細胞増殖抑制組成物を有効成分として含む以外は、従来と同様の剤形で使用できる。すなわち、本発明の癌細胞増殖抑制組成物は、賦形剤などの製薬上許容できる添加剤と混合して非経口投与、経口投与または外部投与に適した、医薬品、医薬部外品、食品組成物の形態で使用することができる。
(サンプルの調製)
カルノシン酸(和光純薬工業社製)、カルノソール(和光純薬工業社製)、エピガロカテキンガレート(EGCG)(シグマアルドリッチ社製)およびエピカテキンガレート(ECG)(和光純薬工業社製)を、それぞれ、ジメチルスルホキシド(DMSO)に、6.7mM濃度となるように添加して、6.7mM カルノシン酸溶液(サンプル3)、6.7mM カルノソール溶液(サンプル4)、6.7mM EGCG溶液(サンプル5)および6.7mM ECG溶液(サンプル6)を調製した。また、このようにして調製した溶液を用いて、カルノシン酸、カルノソール及びEGCGを1:1:1の混合比(モル比)で含む溶液(合計濃度:20mM、サンプル1)、カルノシン酸、カルノソール及びECGを1:1:1の混合比(モル比)で含む溶液(合計濃度:20mM、サンプル2)を調製した。
ヒト結腸腺癌由来DLD−1細胞を、10(v/v)%FBS含有RPMI1640培地を用いて、5体積%CO2雰囲気下で37℃で培養した。この培養細胞を、12ウェルプレートに1ウェルあたり1×104個になるように1ml播種した。5体積%CO2雰囲気下で37℃で24時間、DLD−1細胞を培養した後、上記サンプル1〜6を、最終濃度が6.7μM(サンプル3(比較例1)、サンプル4(比較例2)、サンプル5(比較例3)、サンプル6(比較例4))または20μM(サンプル1(実施例1)、サンプル2(実施例2))となるように、それぞれ、培地に1μl添加した。また、コントロールには、溶媒のDMSOのみを1μl添加した(サンプル7、比較例5)。
Claims (6)
- カルノシン酸およびカルノソールの少なくとも一方、ならびにエピガロカテキンガレートおよびエピカテキンガレートの少なくとも一方を含む、癌細胞増殖抑制組成物。
- 前記カルノシン酸およびカルノソールの合計量(モル)が、前記エピガロカテキンガレートおよびエピカテキンガレートの合計量(モル)に対して、0.1モル以上15モル以下である、請求項1に記載の癌細胞増殖抑制組成物。
- カルノシン酸、カルノソールならびにエピガロカテキンガレートおよびエピカテキンガレートの少なくとも一方を含む、請求項1または2に記載の癌細胞増殖抑制組成物。
- 造血器系の癌、消化器系の癌、生殖器系の癌、悪性黒色腫(メラノーマ)、肥満細胞腫、および基底細胞癌からなる群より選択される少なくとも一種の疾患の予防および/または治療に使用される、請求項1〜3のいずれか1項に記載の癌細胞増殖抑制組成物。
- ヒトまたはイヌ、ネコおよびウサギからなる群より選択される少なくとも一種のペット動物に経口的に使用される、請求項1〜4のいずれか1項に記載の癌細胞増殖抑制組成物。
- ヒト用健康食品またはペットフード組成物である、請求項1〜5のいずれか1項に記載の癌細胞増殖抑制組成物。
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JP2007513176A (ja) * | 2003-12-05 | 2007-05-24 | ニュー・チャプター・インコーポレーテッド | 前立腺癌を草本組成物で治療する方法 |
JP2008543852A (ja) * | 2005-06-14 | 2008-12-04 | ニュー チャプター,インコーポレイテッド | エイコサノイド代謝を調節する方法 |
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JP2007513176A (ja) * | 2003-12-05 | 2007-05-24 | ニュー・チャプター・インコーポレーテッド | 前立腺癌を草本組成物で治療する方法 |
JP2008543852A (ja) * | 2005-06-14 | 2008-12-04 | ニュー チャプター,インコーポレイテッド | エイコサノイド代謝を調節する方法 |
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JP2017178814A (ja) * | 2016-03-29 | 2017-10-05 | シーシーアイ株式会社 | 癌細胞遊走抑制剤 |
JP2019131528A (ja) * | 2018-02-02 | 2019-08-08 | 国立大学法人金沢大学 | 抗腫瘍剤 |
JP7194958B2 (ja) | 2018-02-02 | 2022-12-23 | 国立大学法人金沢大学 | 抗腫瘍剤 |
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