JP2017178814A - 癌細胞遊走抑制剤 - Google Patents
癌細胞遊走抑制剤 Download PDFInfo
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- JP2017178814A JP2017178814A JP2016065921A JP2016065921A JP2017178814A JP 2017178814 A JP2017178814 A JP 2017178814A JP 2016065921 A JP2016065921 A JP 2016065921A JP 2016065921 A JP2016065921 A JP 2016065921A JP 2017178814 A JP2017178814 A JP 2017178814A
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- cell migration
- cancer
- cancer cell
- extract
- green tea
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Abstract
Description
本発明の癌細胞遊走抑制剤は、緑茶抽出物およびローズマリー抽出物を10:1〜1:10の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む。
本発明の癌細胞遊走抑制剤の有効成分である緑茶抽出物は、チャノキ(Camellia sinensis)(全体または一部)を適当な溶媒を用い抽出することによって、得られる。ここで、抽出の対象となるチャノキの部分は、特に制限されず、植物体全体、葉、茎、芽、花(ガク、花弁、めしべ、おしべ等を含む)、木質部、木皮部(樹皮)、果実(花托(果肉)、子房、果皮(内果皮、中果皮、外果皮)等を含む)、種子等の地上部;根、根茎、塊茎等の地下部などの植物体の一部などを包含する。上記植物の部分は、単独で抽出に供せられてもあるいは2種以上の混合物の形態で抽出に供せられてもよい。これらのうち、癌細胞遊走抑制/防止効果、安全性などを考慮すると、チャノキの葉(茶葉)を原料として使用することが好ましい。または、チャノキの葉(茶葉)を発酵を防止するために加熱処理したものを抽出に使用してもよい。具体的には、抽出の対象となるチャノキの部分は、チャノキの生葉(茶葉)を蒸して揉み潰し、茶葉の型を整えつつ乾燥する(蒸熱⇒冷却⇒葉打ち⇒粗揉⇒揉捻⇒中揉⇒精捻⇒乾燥⇒篩分と切断⇒木茎分離)ことによって作製される。なお、本明細書では、抽出の対象となるチャノキの部分を、単に「緑茶原料」とも称する。
本発明の癌細胞遊走抑制剤の有効成分であるローズマリー抽出物は、ローズマリー(Rosmarinus officinalis L.)(全体または一部)を適当な溶媒を用い抽出することによって、得られる。ここで、抽出の対象となるローズマリーの部分は、特に制限されず、植物体全体、葉、茎、芽、花(ガク、花弁、めしべ、おしべ等を含む)、木質部、木皮部(樹皮)、果実(花托(果肉)、子房、果皮(内果皮、中果皮、外果皮)等を含む)、種子等の地上部;根、根茎、塊茎等の地下部などの植物体の一部などを包含する。上記植物の部分は、単独で抽出に供せられてもあるいは2種以上の混合物の形態で抽出に供せられてもよい。これらのうち、癌細胞遊走抑制/防止効果、安全性などを考慮すると、ローズマリーの葉を原料として使用することが好ましい。なお、本明細書では、抽出の対象となるローズマリーの部分を、単に「ローズマリー原料」とも称する。
本発明の癌細胞遊走抑制剤は、医療用途(癌転移の抑制または予防目的)で使用されてもまたは健康食品として使用されてもよく、本発明の癌細胞遊走抑制剤を有効成分として含む以外は、従来と同様の剤形で使用できる。すなわち、本発明の癌細胞遊走抑制剤は、賦形剤などの製薬上許容できる添加剤と混合して非経口投与、経口投与または外部投与に適した、医薬品、医薬部外品、食品組成物の形態で使用することができる。
単糖類、オリゴ糖、多糖類、食物繊維、デンプン類(例えば、ワキシーコーンデンプン、コーンデンプン、小麦デンプン、米デンプン、糯米デンプン、馬鈴薯デンプン、甘露デンプン、タピオカデンプン、サゴデンプン、これらに化学的処理を施したものや化学修飾した加工デンプン)や穀物類(例えば、とうもろこし、大麦、小麦、ライ麦、ソルガム、米、ひえ、あわ、アマラサンサス、キヌア)等の炭水化物源;牛、豚、羊、うさぎ、カンガルー等の畜肉や獣肉、その副生成物及び加工品、鶏、七面鳥、うずら等の鳥肉、その副生成物及び家屋品、魚、白身魚等の魚肉、その副生成物及び加工品、ミートミール、ミートボーン、チキンミール、ポータリーミール、フィッシュミール等の上記原料のレタリング等の、動物性タンパク質源;大豆タンパク質、小麦タンパク質、小麦グルテン、コーングルテン等の、植物性のタンパク質源;α−シトステロール、β−シトステロール、スチグマステロール、カンペステロール、α−シトスタノール、β−シトスタノール、スチグマスタノール、カンペスタノール、シクロアルテノール等のフリー体、これらの脂肪酸エステル、フェルラ酸エステル、桂皮酸エステル等のエステル体等の植物ステロール;米ぬか、ふすま等のぬか類、大豆粕等の粕類、野菜エキス等の野菜、ビタミンA、B1、B2、D、E、ナイアシン、パントテン酸、カロチン等のビタミン類などが挙げられる。上記に加えて、一般的にペットフードに使用されるゲル化剤、保型剤、pH調整剤、調味料、防腐剤、栄養補強剤等の他の添加剤を含有してもよい。上記他の添加剤に加えてまたは上記他の添加剤に代えて、ブチルヒドロキシアニソール(BHA)、ジブチルヒドロキシトルエン(BHT)、エトキシキン、tert−ブチルヒドロキノン(TBHQ)、プロピルガレートなどの抗酸化剤を併用することも可能である。上記した各成分の添加量(含有量)は特に制限されず、従来と同様の量が適用できる。
本発明の癌細胞遊走抑制剤による大腸癌細胞遊走抑制効果を、下記創傷治癒アッセイによって評価した。
ローズマリー抽出物(三菱化学フーズ株式会社製、RM−21Bベース)および緑茶抽出物(三井農林株式会社製、ポリフェノン(登録商標)70A、カフェイン含有量:0.5重量%以下)を、ローズマリー抽出物と緑茶抽出物との重量比(ローズマリー抽出物:緑茶抽出物の混合重量比)が1:1(実施例1:サンプル1)となるようにジメチルスルホキシド(DMSO)で調製した(ローズマリー抽出物および緑茶抽出物の混合物の濃度(合計濃度):40mg/ml)。また、比較対象として、ローズマリー抽出物(比較例1:サンプル2)および緑茶抽出物(比較例2:サンプル3)をそれぞれ、DMSOで40mg/mlに調製した。
ヒト結腸腺癌由来DLD−1細胞を、10(v/v)%FBS含有RPMI1640培地を用いて、5体積%CO2雰囲気下で37℃で培養した。この培養細胞を、6ウェルプレートに1ウェルあたり5×104個になるように2ml播種した。5体積%CO2雰囲気下で37℃で72時間、DLD−1細胞を培養した後、マイクロピペット用のチップを用いて細胞を一定の間隔(幅:約240mm)で掻き取った(下記図1の左側の写真参照)。培地を新しい10(v/v)%FBS含有RPMI1640培地に交換し、上記で調製された各サンプル1〜3を、最終濃度が40μg/mlとなるように、培地に2μl添加した。コントロールには、溶媒(DMSO)のみを2μl添加した。各サンプルまたはDMSOを添加した直後(0時間後)および上記添加後5体積%CO2雰囲気下で37℃で10時間培養した後のDLD−1細胞の様子を写真に収め、細胞の遊走能について評価を行った。各写真からランダムに4ヶ所選び、細胞が遊走した面積を画像処理ソフトGNU Image Manipulation Programを用いて計測し、その平均値および標準偏差を計算した。結果を図1および図2に示す。なお、図1中、図1(a)はローズマリー抽出物及び緑茶抽出物の1:1混合物(サンプル1)を、図1(b)はローズマリー抽出物(サンプル2)を、図1(c)は緑茶抽出物(サンプル3)を、および図1(d)はコントロール(DMSOのみ)を、それぞれ、示す。また、図2において、各値は、コントロールの遊走面積を100%としたときの各サンプルを添加したDLD−1細胞の遊走面積を平均値±標準偏差(n=4)として表したものである。図2中、「*」は、ローズマリー抽出物単独及び緑茶抽出物単独と比較した場合、特に有意差がある(p<0.01である)ことを示す。
Claims (5)
- 緑茶抽出物およびローズマリー抽出物を10:1〜1:10の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む、癌細胞遊走抑制剤。
- 緑茶抽出物およびローズマリー抽出物を5:1〜1:5の重量比(緑茶抽出物:ローズマリー抽出物の混合重量比)で含む、請求項1に記載の癌細胞遊走抑制剤。
- 造血器系の癌、消化器系の癌、生殖器系の癌、悪性黒色腫(メラノーマ)、肥満細胞腫、および基底細胞癌からなる群より選択される少なくとも一種の疾患の転移の抑制および/または予防に使用される、請求項1または2に記載の癌細胞遊走抑制剤。
- ヒトまたはイヌ、ネコおよびウサギからなる群より選択される少なくとも一種のペット動物に経口的に使用される、請求項1〜3のいずれか1項に記載の癌細胞遊走抑制剤。
- ヒト用健康食品またはペットフード組成物である、請求項1〜4のいずれか1項に記載の癌細胞遊走抑制剤。
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