JP2017128535A - 抗菌性顔料及び抗菌性組成物 - Google Patents
抗菌性顔料及び抗菌性組成物 Download PDFInfo
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- JP2017128535A JP2017128535A JP2016009352A JP2016009352A JP2017128535A JP 2017128535 A JP2017128535 A JP 2017128535A JP 2016009352 A JP2016009352 A JP 2016009352A JP 2016009352 A JP2016009352 A JP 2016009352A JP 2017128535 A JP2017128535 A JP 2017128535A
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- Prior art keywords
- antibacterial
- pigment
- powder
- treatment
- staphylococcus aureus
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- 229940050906 magnesium chloride hexahydrate Drugs 0.000 description 1
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 229910052627 muscovite Inorganic materials 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000010702 perfluoropolyether Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229910052628 phlogopite Inorganic materials 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000001057 purple pigment Substances 0.000 description 1
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- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
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- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
ミキサーにセリサイト100gを入れ、続いてパルミトレイン酸(商品名:cis−9−hexadecenoic acid、東京化成工業(株)製)5.0gをイソプロピルアルコール5.0gに溶解させた溶液を滴下混合し、セリサイトとよく混合した。その後、粉体をミキサーから取り出し、80℃で8時間真空乾燥後粉砕して、パルミトレイン酸が5%処理されたセリサイトを得た。同様の工程にて、球状セルロース粉体(商品名:CELLULOBEADS D−10、大東化成工業(株)製)に同様の表面被覆処理を施し、それぞれのサンプルを得た。
実施例1で製造した5%処理顔料と同様にして、パルミトレイン酸が10%処理されたセリサイト、ならびに球状セルロース粉体のサンプルを得た。
攪拌装置付き3Lビーカーに水1000gを入れ、続いてステアリン酸(商品名:LUNAC S−90V、花王(株)製)5.0gと水酸化ナトリウムを添加して加熱後、この水溶液中にセリサイト100gを入れ十分に攪拌分散させた。さらに塩化マグネシウム六水和物1.8gを添加混合し、酸溶液により中和を行い水洗濾過した。固形分を水分含量が1%以下になるまで乾燥させ、粉砕を行うことにより、ステアリン酸マグネシウムが5%処理されたセリサイトを得た。同様の工程にて、球状セルロース粉体(商品名:CELLULOBEADS D−10、大東化成工業(株)製)に同様の表面被覆処理を施し、それぞれのサンプルを得た。
JIS L1902−2008(繊維製品の抗菌性試験方法及び抗菌効果)9定性試験(ハロー法)に準拠して抗菌性を評価した。試験菌を普通ブイヨン培地で1.0×108cfu/mLに調整し、10倍希釈した菌液をSCD寒天培地へ塗抹し、その中央に試験粉体0.2gを置く。32.5℃にて24時間培養し、粗止帯(ハロー)を観察した。試料の周囲に阻止帯のあるものは+とし、阻止帯のないものは−とした。
JIS L1902−2008(繊維製品の抗菌性試験方法及び抗菌効果)9定性試験(ハロー法)に準拠して抗菌性を評価した。試験菌をGAM寒天培地で前々培養し、GAMブイヨン培地で前培養したものを1.7×107cfu/mLに希釈した。GAM寒天培地へ塗抹し、その中央に試験粉体に少量の精製水を加えたものを置く。37℃にて48時間嫌気培養し、粗止帯(ハロー)を観察した。試料の周囲に阻止帯のあるものは+とし、阻止帯のないものは−とした。
表1に、実施例1,2のパルミトレイン酸処理セリサイト、球状セルロース粉体および比較例1のステアリン酸マグネシウム5%処理セリサイト、及びステアリン酸マグネシウム5%処理球状セルロース粉体の各菌種に対する抗菌効果の結果を示した。
Claims (2)
- 黄色ブドウ球菌及びアクネ菌に対して抗菌性を有するパルミトレイン酸又はその金属塩を顔料粉体表面に担持させてなることを特徴とする抗菌性顔料。
- 請求項1に記載の抗菌性顔料を含有することを特徴とする抗菌性組成物。
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WO2014195872A1 (en) * | 2013-06-04 | 2014-12-11 | Vyome Biosciences Pvt. Ltd. | Coated particles and compositions comprising same |
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JPH0892058A (ja) * | 1994-09-20 | 1996-04-09 | Kanebo Ltd | 皮膚化粧料 |
JPH10101502A (ja) * | 1996-09-25 | 1998-04-21 | Chichibu Onoda Cement Corp | 抗菌剤 |
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