|
US10265265B2
(en)
|
2007-03-15 |
2019-04-23 |
Drug Delivery Solutions Limited |
Topical composition
|
|
WO2016141341A1
(en)
|
2015-03-04 |
2016-09-09 |
Vanda Pharmaceuticals Inc. |
Method of treatment with tradipitant
|
|
US12365689B2
(en)
|
2015-10-16 |
2025-07-22 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11365198B2
(en)
|
2015-10-16 |
2022-06-21 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11512092B2
(en)
|
2015-10-16 |
2022-11-29 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11524964B2
(en)
|
2015-10-16 |
2022-12-13 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11780848B2
(en)
|
2015-10-16 |
2023-10-10 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
|
|
US10550126B2
(en)
|
2015-10-16 |
2020-02-04 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
KR20250010141A
(ko)
|
2015-10-16 |
2025-01-20 |
애브비 인코포레이티드 |
(3S,4R)-3-에틸-4-(3H-이미다조[1,2-a]피롤로[2,3-e]-피라진-8-일)-N-(2,2,2-트리플루오로에틸)피롤리딘-1-카복스아미드및 이의 고체상 형태의 제조 방법
|
|
MX380022B
(es)
*
|
2016-05-09 |
2025-03-11 |
Anacor Pharmaceuticals Inc |
Formas cristalinas de crisaborol en forma libre, metodo de preparacion y uso de las mismas
|
|
US11447506B2
(en)
|
2016-05-09 |
2022-09-20 |
Anacor Pharmaceuticals, Inc. |
Crystal forms of crisaborole in free form and preparation method and use thereof
|
|
WO2017203514A1
(en)
*
|
2016-05-26 |
2017-11-30 |
Perrigo Api Ltd |
Polymorphs of crisaborole and production processes therefor
|
|
GB201701583D0
(en)
|
2017-01-31 |
2017-03-15 |
Drug Delivery Solutions Ltd |
Topical composition
|
|
US20200172560A1
(en)
*
|
2017-06-05 |
2020-06-04 |
Glenmark Life Science Limited |
Process for preparation of crisaborole
|
|
US11129818B2
(en)
|
2017-06-07 |
2021-09-28 |
Arcutis Biotherapeutics, Inc. |
Topical roflumilast formulation having improved delivery and plasma half life
|
|
US20200155524A1
(en)
*
|
2018-11-16 |
2020-05-21 |
Arcutis, Inc. |
Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
|
|
US9895359B1
(en)
|
2017-06-07 |
2018-02-20 |
Arcutis, Inc. |
Inhibition of crystal growth of roflumilast
|
|
US12042487B2
(en)
|
2018-11-16 |
2024-07-23 |
Arcutis Biotherapeutics, Inc. |
Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
|
|
US20210161870A1
(en)
|
2017-06-07 |
2021-06-03 |
Arcutis Biotherapeutics, Inc. |
Roflumilast formulations with an improved pharmacokinetic profile
|
|
US12011437B1
(en)
|
2017-06-07 |
2024-06-18 |
Arcutis Biotherapeutics, Inc. |
Roflumilast formulations with an improved pharmacokinetic profile
|
|
US11534493B2
(en)
|
2017-09-22 |
2022-12-27 |
Arcutis Biotherapeutics, Inc. |
Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents
|
|
US10329311B1
(en)
|
2017-12-21 |
2019-06-25 |
Olon S.P.A. |
Process for the preparation of crisaborole
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
CN109985000B
(zh)
*
|
2017-12-29 |
2022-09-02 |
苏州旺山旺水生物医药有限公司 |
克立硼罗微乳组合物
|
|
PL3737685T3
(pl)
*
|
2018-01-09 |
2023-10-02 |
Halcyon Labs Private Limited |
Sposób wytwarzania kryzaborolu i jego związków pośrednich
|
|
US10597410B2
(en)
|
2018-02-02 |
2020-03-24 |
Dipharma Francis S.R.L. |
Intermediates and process for the preparation of a crystalline form of a topical anti-inflammatory agent
|
|
PT3749353T
(pt)
|
2018-02-09 |
2025-10-14 |
Chugai Pharmaceutical Co Ltd |
Nemolizumab no tratamento da dermatite atópica com escoriação moderada a grave
|
|
EP3542788A1
(en)
|
2018-03-19 |
2019-09-25 |
MC2 Therapeutics Limited |
Topical composition comprising calcipotriol and betamethasone dipropionate
|
|
CN108210462A
(zh)
*
|
2018-03-29 |
2018-06-29 |
苏州尚宜佳生物科技有限公司 |
一种克立硼罗局部缓释脂质体的制法与应用
|
|
CN108324724A
(zh)
*
|
2018-04-10 |
2018-07-27 |
苏州芝宇生物科技有限公司 |
一种克立硼罗可溶性膜制剂的制法及其应用
|
|
CN110464702A
(zh)
*
|
2018-05-09 |
2019-11-19 |
上海键合医药科技有限公司 |
一种克立硼罗的软膏剂及其制备方法
|
|
JP7492918B2
(ja)
|
2018-06-04 |
2024-05-30 |
アーキュティス・バイオセラピューティクス・インコーポレーテッド |
ロフルミラスト皮膚浸透ラグタイムを改善する方法及び配合物
|
|
CN108992454B
(zh)
*
|
2018-06-20 |
2020-06-02 |
合肥医工医药股份有限公司 |
一种治疗皮肤炎症性疾病的复方药物组合物
|
|
CN108785379A
(zh)
*
|
2018-06-26 |
2018-11-13 |
苏州尚宜佳生物科技有限公司 |
一种克立硼罗清凉缓释膜及其制备方法
|
|
CN108524648A
(zh)
*
|
2018-06-26 |
2018-09-14 |
苏州尚宜佳生物科技有限公司 |
一种克立硼罗复合保健缓释膜及其制备方法
|
|
CN108785372A
(zh)
*
|
2018-06-27 |
2018-11-13 |
苏州尚宜佳生物科技有限公司 |
一种克立硼罗燥湿利尿缓释膜及其制备方法
|
|
CN108938603A
(zh)
*
|
2018-06-27 |
2018-12-07 |
苏州尚宜佳生物科技有限公司 |
一种缓释效果好的克立硼罗缓释膜及其制备方法
|
|
CN108938602A
(zh)
*
|
2018-07-02 |
2018-12-07 |
苏州尚宜佳生物科技有限公司 |
一种吸收效果好的克立硼罗缓释膜及其制备方法
|
|
CN108926547A
(zh)
*
|
2018-07-02 |
2018-12-04 |
苏州尚宜佳生物科技有限公司 |
一种粘贴效果好的克立硼罗缓释膜及其制备方法
|
|
CN108853062A
(zh)
*
|
2018-07-04 |
2018-11-23 |
苏州尚宜佳生物科技有限公司 |
一种肤感克立硼罗缓释膜的制备方法
|
|
CN108853063A
(zh)
*
|
2018-07-04 |
2018-11-23 |
苏州尚宜佳生物科技有限公司 |
一种透气效果好的克立硼罗缓释膜的制备方法
|
|
CN108853064A
(zh)
*
|
2018-07-09 |
2018-11-23 |
苏州尚宜佳生物科技有限公司 |
一种防水透气克立硼罗缓释膜的制备方法
|
|
CN108653246A
(zh)
*
|
2018-07-09 |
2018-10-16 |
苏州尚宜佳生物科技有限公司 |
一种防水效果好的克立硼罗缓释膜的制备方法
|
|
MX2021001258A
(es)
*
|
2018-07-31 |
2021-04-12 |
Mc2 Therapeutics Ltd |
Composicion topica.
|
|
WO2020051230A1
(en)
*
|
2018-09-04 |
2020-03-12 |
X-Rx, Inc. |
Amorphous pharmaceutical compositions and uses thereof
|
|
US20220002306A1
(en)
*
|
2018-09-29 |
2022-01-06 |
Crystal Pharmaceutical (Suzhou) Co., Ltd. |
Crystal form of upadacitinib and preparation method and use thereof
|
|
CN111217819B
(zh)
*
|
2018-11-27 |
2021-05-14 |
杭州科巢生物科技有限公司 |
乌帕替尼的合成方法
|
|
CA3119773A1
(en)
|
2018-11-30 |
2020-06-04 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
MX2021015995A
(es)
|
2019-06-28 |
2022-03-11 |
Kymera Therapeutics Inc |
Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
|
|
US12558427B2
(en)
|
2019-07-17 |
2026-02-24 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
BR112022005765A2
(pt)
*
|
2019-09-30 |
2022-06-21 |
Abbvie Inc |
Tratamento contra afecções espondiloartríticas e psoriáticas com upadacitinib
|
|
US12551564B2
(en)
|
2019-12-10 |
2026-02-17 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
CN115052627A
(zh)
|
2019-12-17 |
2022-09-13 |
凯麦拉医疗公司 |
Irak降解剂和其用途
|
|
CN115397411B
(zh)
*
|
2020-04-23 |
2025-08-22 |
浙江养生堂天然药物研究所有限公司 |
药物组合及其用途
|
|
EP4167728A4
(en)
*
|
2020-06-17 |
2024-09-04 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
EP4199902A1
(en)
*
|
2020-08-20 |
2023-06-28 |
Pfizer Inc. |
Stable topical formulations of 1(r)-4-(5-(4-methoxy-3-propoxyphenyl)pyridin-3-yl)-1,2-oxaborolan-2-ol
|
|
CN112168774A
(zh)
*
|
2020-11-04 |
2021-01-05 |
南京康川济医药科技有限公司 |
一种巴瑞克替尼乳膏及其制备方法和应用
|
|
EP4255393B1
(en)
|
2020-12-04 |
2025-05-28 |
Arcutis Biotherapeutics, Inc. |
Topical roflumilast formulation having antifungal properties
|
|
CA3202360A1
(en)
|
2020-12-30 |
2022-07-07 |
Nello Mainolfi |
Irak degraders and uses thereof
|
|
US11773103B2
(en)
|
2021-02-15 |
2023-10-03 |
Kymera Therapeutics, Inc. |
IRAK4 degraders and uses thereof
|
|
CA3236265A1
(en)
|
2021-10-29 |
2023-05-04 |
William Leong |
Irak4 degraders and synthesis thereof
|
|
CA3242322A1
(en)
|
2021-12-28 |
2023-07-06 |
Arcutis Biotherapeutics, Inc. |
Topical roflumilast aerosol foams
|
|
CA3248817A1
(en)
*
|
2022-01-20 |
2023-07-27 |
Renata Pharmaceutical (Ireland) Limited |
Extended-release pharmaceutical composition of Upadacitinib
|
|
US12091411B2
(en)
|
2022-01-31 |
2024-09-17 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
AU2023342481A1
(en)
|
2022-09-15 |
2025-04-10 |
Arcutis Biotherapeutics, Inc. |
Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug
|
|
CN115417890A
(zh)
*
|
2022-09-24 |
2022-12-02 |
中山万远新药研发有限公司 |
克立硼罗的新晶型及其制备方法与用途
|
|
CN116715687A
(zh)
*
|
2023-05-25 |
2023-09-08 |
福建南方制药股份有限公司 |
一种工业化制备克立硼罗晶型i的方法
|
|
CN119345120B
(zh)
*
|
2024-12-26 |
2025-03-14 |
新基元(北京)医药科技有限公司 |
一种克立硼罗软膏及其制备方法
|