JP2017052962A5 - - Google Patents
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- JP2017052962A5 JP2017052962A5 JP2016214773A JP2016214773A JP2017052962A5 JP 2017052962 A5 JP2017052962 A5 JP 2017052962A5 JP 2016214773 A JP2016214773 A JP 2016214773A JP 2016214773 A JP2016214773 A JP 2016214773A JP 2017052962 A5 JP2017052962 A5 JP 2017052962A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- aminooxy
- oligosaccharide
- reactive group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 31
- -1 aminooxy compound Chemical class 0.000 claims 20
- 229920001542 oligosaccharide Polymers 0.000 claims 20
- 150000002482 oligosaccharides Chemical class 0.000 claims 20
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 11
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical group CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 3
- DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims 3
- 150000001266 acyl halides Chemical class 0.000 claims 2
- 150000001350 alkyl halides Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 150000002540 isothiocyanates Chemical class 0.000 claims 2
- UWROMLKEISLXAJ-UHFFFAOYSA-N (aminooxyamino)thiourea Chemical compound NONNC(N)=S UWROMLKEISLXAJ-UHFFFAOYSA-N 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical group ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000002128 sulfonyl halide group Chemical group 0.000 claims 1
- WSRAUHOGHHXDJT-UHFFFAOYSA-N CC(C)(C)OC(NOCC(NN)=O)=O Chemical compound CC(C)(C)OC(NOCC(NN)=O)=O WSRAUHOGHHXDJT-UHFFFAOYSA-N 0.000 description 1
- LISGDTPBJHWLKP-UHFFFAOYSA-N CC(C)(C)OC(NOCC(Oc(c(F)c(cc1F)F)c1F)=O)=O Chemical compound CC(C)(C)OC(NOCC(Oc(c(F)c(cc1F)F)c1F)=O)=O LISGDTPBJHWLKP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88547107P | 2007-01-18 | 2007-01-18 | |
| US60/885,471 | 2007-01-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204593A Division JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018044959A Division JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017052962A JP2017052962A (ja) | 2017-03-16 |
| JP2017052962A5 true JP2017052962A5 (cg-RX-API-DMAC7.html) | 2017-06-08 |
| JP6309592B2 JP6309592B2 (ja) | 2018-04-11 |
Family
ID=39473250
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546533A Active JP5999867B2 (ja) | 2007-01-18 | 2008-01-18 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2014204593A Active JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2016214773A Active JP6309592B2 (ja) | 2007-01-18 | 2016-11-02 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2018044959A Pending JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2020134331A Pending JP2020185011A (ja) | 2007-01-18 | 2020-08-07 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2022113593A Pending JP2022137232A (ja) | 2007-01-18 | 2022-07-15 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2024207922A Pending JP2025029023A (ja) | 2007-01-18 | 2024-11-29 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546533A Active JP5999867B2 (ja) | 2007-01-18 | 2008-01-18 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2014204593A Active JP6039625B2 (ja) | 2007-01-18 | 2014-10-03 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018044959A Pending JP2018109194A (ja) | 2007-01-18 | 2018-03-13 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2020134331A Pending JP2020185011A (ja) | 2007-01-18 | 2020-08-07 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2022113593A Pending JP2022137232A (ja) | 2007-01-18 | 2022-07-15 | アミノオキシ基を含むオリゴ糖およびその複合体 |
| JP2024207922A Pending JP2025029023A (ja) | 2007-01-18 | 2024-11-29 | アミノオキシ基を含むオリゴ糖およびその複合体 |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US8759501B2 (cg-RX-API-DMAC7.html) |
| EP (5) | EP2457920B1 (cg-RX-API-DMAC7.html) |
| JP (7) | JP5999867B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN102978185B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2675968C (cg-RX-API-DMAC7.html) |
| CY (2) | CY1119954T1 (cg-RX-API-DMAC7.html) |
| DK (3) | DK2121713T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2417146T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FIC20220047I1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR22C1061I2 (cg-RX-API-DMAC7.html) |
| HR (3) | HRP20130744T1 (cg-RX-API-DMAC7.html) |
| HU (3) | HUE045046T2 (cg-RX-API-DMAC7.html) |
| IL (3) | IL243117B2 (cg-RX-API-DMAC7.html) |
| LT (3) | LT2457919T (cg-RX-API-DMAC7.html) |
| LU (1) | LUC00290I2 (cg-RX-API-DMAC7.html) |
| NL (1) | NL301210I2 (cg-RX-API-DMAC7.html) |
| NO (2) | NO2457920T3 (cg-RX-API-DMAC7.html) |
| PL (3) | PL2457920T3 (cg-RX-API-DMAC7.html) |
| PT (3) | PT2457920T (cg-RX-API-DMAC7.html) |
| SI (2) | SI2457919T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008089403A2 (cg-RX-API-DMAC7.html) |
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| CA2696699A1 (en) * | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| HUE044381T2 (hu) * | 2008-12-16 | 2019-10-28 | Genzyme Corp | Szintetikus intermedierek oligoszacharid-fehérje konjugátumok elõállításához |
| JP5837486B2 (ja) | 2009-07-03 | 2015-12-24 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | カチオン非依存性マンノース６−リン酸受容体を標的とする化合物 |
| NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| RU2744370C2 (ru) * | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| EP2585108A4 (en) * | 2010-06-24 | 2016-04-13 | Univ Kansas | CONJUGATES WITH AN N-OXIM BINDING AND ASSOCIATED METHODS |
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| MY198085A (en) | 2015-12-30 | 2023-07-31 | Amicus Therapeutics Inc | Augmented acid alpha-glucosidase for the treatment of pompe disease |
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| EA202190416A1 (ru) | 2018-08-02 | 2021-06-23 | Дайн Терапьютикс, Инк. | Мышечно-специфические комлексы и их применение для лечения плече-лопаточно-лицевой мышечной дистрофии |
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| SG11202104207TA (en) * | 2018-11-08 | 2021-05-28 | Kaleido Biosciences Inc | Oligosaccharide compositions and methods of use thereof |
| JP2023513168A (ja) | 2020-02-07 | 2023-03-30 | ノバルティス アーゲー | 標的化された血漿タンパク質分解 |
| JP2023512783A (ja) | 2020-02-08 | 2023-03-29 | ジェンザイム・コーポレーション | ポンペ病を処置するための組成物および方法 |
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2008
- 2008-01-18 ES ES08727910T patent/ES2417146T3/es active Active
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